Article
Cell Biology
Zhongmei Yang, Nan Shan, Qinyin Deng, Yujue Wang, Yan Hou, Jie Mei, Zhao Wu
Summary: The study found decreased miR-18b expression and increased Notch2 and TIM3/mTORC1 levels in placental tissues of pre-eclampsia patients compared to normal placenta. EV-derived miR-18b promoted trophoblast proliferation and migration by targeting Notch2, ultimately deactivating the TIM3/mTORC1 axis in vivo to reduce blood pressure and urinary protein in pre-eclampsia rats.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Haili Bao, Yang Sun, Ningjie Yang, Na Deng, Zhangli Ni, Yedong Tang, Gaizhen Li, Lili Du, Yan-Ling Wang, Dunjin Chen, Haibin Wang, Shuangbo Kong
Summary: This study demonstrated the essential role of uterine Notch2 in pregnancy recognition and corpus luteum maintenance. Decidual derived Prl8a2 assists pituitary prolactin to sustain corpus luteum function and serum progesterone level during post-implantation phase, contributing to pregnancy recognition and maintenance under the control of uterine canonical Notch signaling.
Article
Biotechnology & Applied Microbiology
Antonella Capuozzo, Sandro Montefusco, Vincenzo Cacace, Martina Sofia, Alessandra Esposito, Gennaro Napolitano, Eduardo Nusco, Elena Polishchuk, Maria Teresa Pizzo, Maria De Risi, Elvira De Leonibus, Nicolina Cristina Sorrentino, Diego Luis Medina
Summary: Through screening clinically approved drugs in MPS-IIIA cells, we found that fluoxetine can enhance lysosomal and autophagic functions, and improve MPS-IIIA pathology and cognitive deterioration by clearing heparan sulfate. We repurposed fluoxetine for potential MPS-IIIA therapeutics.
Article
Multidisciplinary Sciences
Kevin W. O'Connor, Tiantian Liu, Sunkyung Kim, Carlos G. Briseno, Katia Georgopoulos, Theresa L. Murphy, Kenneth M. Murphy
Summary: This study investigates the impact of NOTCH2 signaling on the development of Ly6C(lo) monocytes and identifies transcription factors involved. The results show that NOTCH2 signaling can induce the transition of Ly6C(hi) monocytes into Ly6C(lo) monocytes, and that BCL6 and IRF2 are important for this development process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Liang Wang, Baohui Song, Yan Hu, Jun Chen, Shuaishuai Zhang, Dapeng Chen, Jingyu Wang
Summary: This study demonstrates the protective effects of puerarin in 5-fluorouracil-induced intestinal mucositis by inhibiting the activation of JAK, which suppresses inflammation, oxidative reactions, cell apoptosis, and protects intestinal barrier functions. Puerarin may serve as a potential natural JAK inhibitor in the treatment of 5-FU-induced intestinal mucositis.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Brian T. Gaudette, Carly J. Roman, Trini A. Ochoa, Daniela Gomez Atria, Derek D. Jones, Christian W. Siebel, Ivan Maillard, David Allman
Summary: Little is known about how cells regulate and integrate distinct biosynthetic pathways governing differentiation and cell division. For B lineage cells it is widely accepted that activated cells must complete several rounds of mitosis before yielding antibody-secreting plasma cells. However, we report that marginal zone (MZ) B cells, innate-like naive B cells known to generate plasma cells rapidly in response to blood-borne bacteria, generate functional plasma cells despite cell-cycle arrest. Further, short-term Notch2 blockade in vivo reversed division-independent differentiation potential and decreased transcript abundance for numerous mTORC1-and Myc-regulated genes. Myc loss compromised plasma cell differentiation for MZ B cells, and reciprocally induced ectopic mTORC1 signaling in follicular B cells enabled division-independent differentiation and plasma cell-affiliated gene expression. We conclude that ongoing in situ Notch2/mTORC1 signaling in MZ B cells establishes a unique cellular state that enables rapid division-independent plasma cell differentiation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P. Wicks, Hitoshi Kohsaka, Shinsuke Yasuda
Summary: Muscle cell death in polymyositis is induced by CD8(+) cytotoxic T lymphocytes. Inhibition of necroptosis in muscle cells could be a promising strategy for treating polymyositis and suppressing muscle injury and inflammation.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Dingyan Zhou, Weizhe Liu, Juanjuan Zhang, Yucui Dong, Jiangli Wu, Yu Zhang, Cheng Dai, Tingting Zhang, Gaoshan Yang, Yue Zhang, Aiying Li
Summary: There is currently no effective therapy for pathological cardiac hypertrophy, which can lead to heart failure. Bellidifolin (BEL) is a xanthone component found in Gentianella acuta (G. acuta) that has a protective function for the heart. In this study, it was found that BEL alleviated cardiac dysfunction and pathological changes induced by isoprenaline (ISO) in mice. BEL inhibited the expression of cardiac hypertrophy marker genes and repressed the epigenetic regulator bromodomain-containing protein 4 (BRD4), as well as the Nox4/ROS/ADAM17 signaling pathway. These findings clarify the function and molecular mechanism of BEL in the therapeutic intervention of cardiac hypertrophy.
CELL DEATH DISCOVERY
(2023)
Article
Neurosciences
Zhiwen Shen, Hui Xu, Wen Song, Chuwen Hu, Mingyan Guo, Jinfeng Li, Junhua Li
Summary: The study showed that galectin-1 attenuated cognitive dysfunction induced by surgery in aged mice by inhibiting microglial activity and reducing inflammatory protein expression. Galectin-1 also prevented neuronal loss in the hippocampus and inhibited inflammation in microglial cells, suggesting its potential protective effects on surgery-induced neuroinflammation.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Xianting Sun, Meng Zhou, Jun Pu, Ting Wang
Summary: This study demonstrates the significant role of STA in regulating platelet activation and reducing thrombo-inflammation. STA inhibits platelet activation and decreases platelet-neutrophil interactions, thereby attenuating thrombus formation and thrombo-inflammatory-induced multiorgan damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Ni Cheng, Yaping Zhang, M. Keegan Delaney, Can Wang, Yanyan Bai, Randal A. Skidgel, Xiaoping Du
Summary: The study demonstrates that targeting integrin outside-in signaling in leukocytes and platelets can alleviate inflammation and clotting in septic mice, improving survival rates.
NATURE COMMUNICATIONS
(2021)
Article
Medical Laboratory Technology
Shuangshuang Shu, Han Liu, Jianzhang Yang, Haie Tang, Hao Li, Zhuoliang Liu, Miaomiao Zhou, Fengxin Zhu, Zheng Hu, Ke Ding, Xiaoyun Lu, Jing Nie
Summary: This study systematically investigated the expression and function of ZAK in tubulointerstitial fibrosis (TIF), and found that ZAK was induced in fibrotic kidneys and correlated with the extent of renal fibrosis and decline of kidney function in CKD patients. Depleting ZAK attenuated TIF and inflammation by inhibiting related signaling pathways. Additionally, a novel ZAK inhibitor named 6p was discovered and shown to effectively inhibit TIF in vitro and in vivo.
TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Ting Xie, Zunen Xia, Wei Wang, Xiangjun Zhou, Changgeng Xu
Summary: BMPER inhibits tubular dedifferentiation and fibroblast activation induced by TGF-beta 1, showing therapeutic potential for tubulointerstitial fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: This study investigated the role of interleukin-18 (IL-18) in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The results showed that IL-18 deficiency can attenuate renal tubular damage, necroptosis, cell transdifferentiation, and fibrosis, and this renoprotective effect may be mediated by reducing the switch from M1 to profibrotic M2 macrophages.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Markus Lechner, Thomas Engleitner, Tea Babushku, Marc Schmidt-Supprian, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl
Summary: FoB and MZB cells are functionally distinct mature B cell populations in the spleen, which can be re-programmed through Notch2 activation. The study demonstrates plasticity between these cell types and suggests a potential pathway for MZB cell development in vivo, driven by a singular signaling event.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Masanori Ishizaka, Tomohito Gohda, Miyuki Takagi, Keisuke Omote, Yuji Sonoda, Juan Alejandro Oliva Trejo, Rin Asao, Teruo Hidaka, Katsuhiko Asanuma, Satoshi Horikoshi, Yasuhiko Tomino
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Medicine, Research & Experimental
Yoshiko Hosoe-Nagai, Teruo Hidaka, Ayano Sonoda, Yu Sasaki, Kanae Yamamoto-Nonaka, Takuto Seki, Rin Asao, Eriko Tanaka, Juan Alejandro Oliva Trejo, Fumiko Kodama, Miyuki Takagi, Nobuhiro Tada, Takashi Ueno, Ryuichi Nishinakamura, Yasuhiko Tomino, Katsuhiko Asanuma
LABORATORY INVESTIGATION
(2017)
Article
Multidisciplinary Sciences
Rin Asao, Takuto Seki, Miyuki Takagi, Hiroyuki Yamada, Fumiko Kodama, Yoshiko Hosoe-Nagai, Eriko Tanaka, Juan Alejandro Oliva Trejo, Kanae Yamamoto-Nonaka, Yu Sasaki, Teruo Hidaka, Takashi Ueno, Motoko Yanagita, Yusuke Suzuki, Yasuhiko Tomino, Katsuhiko Asanuma
SCIENTIFIC REPORTS
(2018)
Article
Urology & Nephrology
Katsuhiko Asanuma, Miyuki Akiba-Takagi, Fumiko Kodama, Rin Asao, Yoshiko Nagai, Aida Lydia, Hiromitsu Fukuda, Eriko Tanaka, Terumi Shibata, Hisatsugu Takahara, Teruo Hidaka, Etsuko Asanuma, Eiki Kominami, Takashi Ueno, Yasuhiko Tomino
AMERICAN JOURNAL OF NEPHROLOGY
(2011)
Article
Urology & Nephrology
Aida Lydia, Katsuhiko Asanuma, Kanae Nonaka, Miyuki Takagi, Kyung-Hwan Jeong, Fumiko Kodama, Rin Asao, Etsuko Asanuma, Wiguno Prodjosudjadi, Yasuhiko Tomino
AMERICAN JOURNAL OF NEPHROLOGY
(2012)
Article
Biochemistry & Molecular Biology
Akemi Koyanagi, Chiyoko Sekine, Hideo Yagita
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2012)
Article
Urology & Nephrology
Rin Asao, Katsuhiko Asanuma, Fumiko Kodama, Miyuki Akiba-Takagi, Yoshiko Nagai-Hosoe, Takuto Seki, Yukihtko Takeda, Isao Ohsawa, Satoshi Mano, Kiyoshi Matsuoka, Hiroyuki Kurosawa, Shinya Ogasawara, Yoshiaki Hirayama, Sakari Sekine, Satoshi Horikoshi, Masanori Hara, Yasuhiko Tomino
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2012)
Article
Transplantation
Fumiko Kodama, Katsuhiko Asanuma, Miyuki Takagi, Teruo Hidaka, Etsuko Asanuma, Hiromitsu Fukuda, Takuto Seki, Yukihiko Takeda, Yoshiko Hosoe-Nagai, Rin Asao, Satoshi Horikoshi, Yasuhiko Tomino
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2013)
Article
Multidisciplinary Sciences
Takuto Seki, Katsuhiko Asanuma, Rin Asao, Kanae Nonaka, Yu Sasaki, Juan Alejandro Oliva Trejo, Hiroyuki Kurosawa, Yoshiaki Hirayama, Satoshi Horikoshi, Yasuhiko Tomino, Akihiko Saito
Article
Rheumatology
Chiyoko Sekine, Akemi Koyanagi, Noriko Koyama, Katsuto Hozumi, Shigeru Chiba, Hideo Yagita
ARTHRITIS RESEARCH & THERAPY
(2012)
Article
Multidisciplinary Sciences
Takao Hirano, Akemi Koyanagi, Kaoru Kotoshiba, Yoichi Shinkai, Masataka Kasai, Tomoaki Ando, Ayako Kaitani, Ko Okumura, Jiro Kitaura
SCIENTIFIC REPORTS
(2018)
Article
Urology & Nephrology
Kyung Hwan Jeong, Katsuhiko Asanuma, Aida Lydia, Miyuki Takagi, Rin Asao, Fumiko Kodama, Etsuko Asanuma, Yasuhiko Tomino
Article
Ophthalmology
Waka Ishida, Ken Fukuda, Shuji Sakamoto, Noriko Koyama, Akemi Koyanagi, Hideo Yagita, Atsuki Fukushima
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2011)