HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Essentials of Th17 cell commitment and plasticity

(2013) P. Muranski et al.   BLOOD

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling

(2013) Laura V. Danai et al.   JOURNAL OF LIPID RESEARCH

Expression and prognostic significance of MAP4K4 in lung adenocarcinoma

(2012) Mei-Hua Qiu et al.   PATHOLOGY RESEARCH AND PRACTICE

Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans

(2012) Tina Sartorius et al.   PLoS One

The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

(2011) Casey T. Weaver et al.   Annual Review of Pathology-Mechanisms of Disease

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

(2011) Huai-Chia Chuang et al.   NATURE IMMUNOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Prominent Bone Loss Mediated by RANKL and IL-17 Produced by CD4+ T Cells in TallyHo/JngJ Mice

(2011) Hee Yeon Won et al.   PLoS One

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway

(2010) M. Galgani et al.   JOURNAL OF IMMUNOLOGY

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

(2010) M. Jagannathan-Bogdan et al.   JOURNAL OF IMMUNOLOGY

IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity

(2010) L. A. Zuniga et al.   JOURNAL OF IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Human IL6 enhances leptin action in mice

(2009) M. Sadagurski et al.   DIABETOLOGIA

Silencing Mitogen-activated Protein 4 Kinase 4 (MAP4K4) Protects Beta Cells from Tumor Necrosis Factor-α-induced Decrease of IRS-2 and Inhibition of Glucose-stimulated Insulin Secretion

(2009) Karim Bouzakri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation

(2008) Lianyun Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression of MAP4K4 Is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

(2008) J. J. Liang et al.   CLINICAL CANCER RESEARCH

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

(2008) I. Nieto-Vazquez et al.   DIABETES

Muscle-Specific IRS-1 Ser->Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

(2008) K. Morino et al.   DIABETES

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

(2008) S. Franckhauser et al.   DIABETOLOGIA

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

TRAF6 Autoubiquitination-Independent Activation of the NFκB and MAPK Pathways in Response to IL-1 and RANKL

(2008) Matthew C. Walsh et al.   PLoS One