Article
Multidisciplinary Sciences
Maisa Nasser, Amit Meller
Summary: This study accurately quantifies fluorescent species with similar chromatic signatures using time-resolved fluorescence via Time Correlated Single Photon Counting (TCSPC), introducing a modified maximum likelihood estimator. Experimental results demonstrate that 100 to 200 photons per fluorophore are sufficient for accurate estimation of the dye ratio.
Article
Chemistry, Multidisciplinary
Simone Brannetti, Serena Gentile, Alejandro Chamorro-Garcia, Luca Barbero, Erica Del Grosso, Francesco Ricci
Summary: In this study, we have developed Lateral Flow Assays (LFAs) using DNA-based structures decorated with reporter tags and recognition elements as functional elements. By re-engineering tile-based DNA tubular structures, we can decorate them with recognition elements of different nature and orthogonal fluorescent dyes, enabling the detection of a wide range of targets with nanomolar sensitivity and high specificity using sandwich and competitive multiplex lateral flow platforms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Optics
Ying Huang, Weiping Wang, Lei Qiao, Xiaoyan Hu, Tao Chu
Summary: The programmable, low-threshold, optically controlled nonlinear activation functions demonstrated in the experiment rely on on-chip integrated Ge-Si photoelectric detectors and silicon electro-optical switches, and they achieve high inference accuracies in low-power PNNs.
Article
Optics
Luis Torrijos-Moran, Diego Perez-Galacho, Daniel Perez-Lopez
Summary: This study proposes an alternative approach to MZI-based programmable photonic circuits using slow-light-enhanced periodic bimodal waveguides as programmable units. The experimental results show a two-orders of magnitude improvement in integration density compared to conventional MZIs and a new design for matrix multiplication operations.
LASER & PHOTONICS REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Nada Farag, Milan Dordevic, Erica Del Grosso, Francesco Ricci
Summary: This paper demonstrates an approach to achieve dynamic and reversible decoration of DNA-based scaffolds. Engineered DNA tiles with enzyme-responsive strands conjugated to different molecular labels are used. These strands are designed to be recognized and degraded by specific enzymes, inducing the replacement of them with new strands attached to different labels. Multiple enzyme-responsive strands allow for dynamic, orthogonal, and reversible decoration of DNA structures. The approach enables the control of the distribution of different labels on the same scaffold without crosstalk, leading to DNA scaffolds with different antibody recognition patterns.
ADVANCED MATERIALS
(2023)
Article
Biology
Haining Zhong, Cesar C. Ceballos, Crystian Massengill, Michael A. Muniak, Lei Ma, Maozhen Qin, Stefanie Kaech Petrie, Tianyi Mao
Summary: CRISPIE is a method that enables precise and reversible labeling of endogenous proteins using CRISPR/Cas9 technology, by inserting a specific designed donor module. This method allows efficient insertion and removal of protein sequences, resulting in nearly error-free insertion junctions.
Article
Multidisciplinary Sciences
Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Chenyun Sun, Qian Zhang, Lei Zhao, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang, Chunhai Fan
Summary: We demonstrate a general-purpose DNA integrated circuit (DIC) system by integrating multilayer DNA-based programmable gate arrays (DPGAs), which can be reconfigured and programmed to implement a wide range of circuits. We also show that DNA origami registers can control the asynchronous execution of cascaded DPGAs, and the integration of a DPGA with an analog-to-digital converter can be used for disease classification.
Article
Chemistry, Physical
Hiromu Kashida, Hayato Kawai, Hidenori Azuma, Yasuyuki Araki, Takehiko Wada, Hiroyuki Asanuma
Summary: By utilizing a DNA scaffold to analyze homo-FRET between pyrene moieties, the efficiency of energy transfer was successfully detected with excellent agreement to Forster theory. These findings will guide the design of novel molecular probes and light-harvesting antennae.
Article
Nanoscience & Nanotechnology
Li Ping Cao, Yao Wang, Yan Bai, Yong Jian Jiang, Chun Mei Li, Hua Zuo, Yuan Fang Li, Shu Jun Zhen, Cheng Zhi Huang
Summary: This study developed a homogeneous entropy-driven biomolecular assay based on DNA photonic nanowires, utilizing FRET technology to detect thrombin and achieve a detection dynamic range of 5-25 nM with a detection limit of 2.7 nM by disrupting the FRET of the PN. This strategy provides an alternative platform for biomarker clinical diagnosis, significantly expanding the application fields of DNA PNs in analytical chemistry.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
George Sarantoglou, Adonis Bogris, Charis Mesaritakis, Sergios Theodoridis
Summary: This study proposes a Bayesian learning framework for silicon photonic accelerators, which can significantly reduce operational power consumption while slightly sacrificing classification accuracy. The full Bayesian scheme also provides information about the sensitivity of phase shifters, which can simplify the driving system.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2022)
Article
Biophysics
Tomoyuki Taguchi, Machi Ishikawa, Momoko Ichikawa, Takashi Tadenuma, Yuko Hirakawa, Tomoko Yoshino, Yoshiaki Maeda, Hiyori Takeuchi, Daisuke Nojima, Takeo Tanaami, Tadashi Matsunaga, Tsuyoshi Tanaka
Summary: In this study, a novel DNA microarray system was developed that eliminates the need for labeling, amplification, or washing of target nucleic acid fragments. By using specially designed DNA probes, the system allows for quick and specific detection of DNA and RNA within a short period of time.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Xuerui Gong, Shilun Feng, Zhen Qiao, Yu-Cheng Chen
Summary: Optofluidic biolasers have been developed for biomedical analysis with strong light-matter interactions, and a microdroplet laser array allows for image-based lasing analysis of dynamic biological changes. This method is more sensitive than fluorescence analysis and enables high-throughput monitoring of living organisms on a chip.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Ryota Tanomura, Rui Tang, Go Soma, Shota Ishimura, Takuo Tanemura, Yoshiaki Nakano
Summary: This article introduces a 6-port dual-polarization (DP) optical unitary processor (OUP) with polarization-splitter-rotators, implemented on a compact silicon photonic chip based on the multi-plane light conversion (MPLC) concept. It demonstrates all-optical MIMO demultiplexing of a 300-Gbps 3-mode DP quadrature phase-shift-keying (QPSK) signal at 1540, 1550, and 1560-nm wavelengths with an energy consumption of approximately 1.5 pJ/bit. All-optical MIMO is transparent to signal format and the energy cost decreases with increasing baudrate, making it an attractive approach for reducing power consumption in future ultra-high-capacity MDM systems.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jyoti, Jose Munoz, Martin Pumera
Summary: Graphene quantum dot-based microrobots demonstrate potential for optical real-time monitoring of DNA, offering high sensitivity and selectivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Chieh-Szu Huang, Sergii Yakunin, Jonathan Avaro, Xinyue Kang, Maryna I. Bodnarchuk, Marianne Liebi, Xuemei Sun, Rene M. Rossi, Maksym V. Kovalenko, Luciano F. Boesel
Summary: In recent years, Forster resonance energy transfer (FRET) and related topics have gained significant attention due to their scientific and potential applications. Researchers have found that amphiphilic polymer co-networks (APCNs) can serve as versatile matrix materials for efficient FRET between hydrophobic inorganic donors and hydrophilic organic acceptors. APCNs have demonstrated great potential in photonic energy transfer steering.
ADVANCED ENERGY MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Joel M. Hales, Ani Khachatrian, Stephen Buchner, Adrian Ildefonso, Daniele M. Monahan, Stephen D. Lalumondiere, Dale Mcmorrow
Summary: By scanning the charge-deposition profile produced by a pulsed laser throughout a device, the spatially dependent charge-collection efficiency (CCE) can be determined. The efficiency curves can be applied to charge-deposition curves for heavy ions and pulsed X-rays to calculate collected charge values that show very good agreement with experimental results. The profiles extracted using the laser can help predict charge-collection data from other excitation sources and improve modeling efforts by determining sensitive volumes.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Kaitlyn L. Ryder, Landen D. Ryder, Andrew L. Sternberg, John A. Kozub, En Xia Zhang, Stephen D. LaLumondiere, Daniele M. Monahan, Jeremy P. Bonsall, Ani Khachatrian, Stephen P. Buchner, Dale McMorrow, Joel M. Hales, Yuanfu Zhao, Liang Wang, Chuanmin Wang, Robert A. Weller, Ronald D. Schrimpf, Sharon M. Weiss, Robert A. Reed
Summary: A silicon epitaxial diode is subjected to heavy-ion, focused X-ray, and pulsed laser single-event transient experiments, where collected charge, transient rise times, and transient fall times are compared across different sources. The differences in transient shape characteristics observed between sources can be attributed to basic charge collection mechanisms.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
George N. Tzintzarov, Adrian Ildefonso, Jeffrey W. Teng, Milad Frounchi, Albert Djikeng, Prahlad Iyengar, Patrick S. Goley, Ani Khachatrian, Joel Hales, Ryan Bahr, Stephen P. Buchner, Dale Mcmorrow, John D. Cressler
Summary: Experimental results show that the extinction of optical power in waveguides due to optical single-event transients (OSETs) is dependent on the number of injected electron-hole pairs. The fractional extinction remains constant regardless of the optical power level, raising concerns about using integrated silicon photonics for radiation-intensive applications.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Review
Materials Science, Multidisciplinary
S. J. Pearton, Assel Aitkaliyeva, Minghan Xian, Fan Ren, Ani Khachatrian, Adrian Ildefonso, Zahabul Islam, Md Abu Jafar Rasel, Aman Haque, A. Y. Polyakov, Jihyun Kim
Summary: Wide bandgap semiconductors such as SiC and GaN face challenges in space and avionic applications due to susceptibility to radiation damage, while ultra-wide bandgap semiconductors like Ga2O3, diamond, and BN show promising radiation resistance characteristics for high-energy applications. More research is needed on the response of these semiconductor materials to radiation, especially in single event effects.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2021)
Review
Materials Science, Multidisciplinary
S. J. Pearton, Aman Haque, Ani Khachatrian, Adrian Ildefonso, Leonid Chernyak, Fan Ren
Summary: Radiation effects play a critical role in the reliability of SiC and GaN power electronics, with single event effects (SEE) being a key concern. Opportunities for comprehensive assessment and mitigation strategies are discussed in this paper.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Landen D. Ryder, Kaitlyn L. Ryder, Andrew L. Sternberg, John A. Kozub, Ani Khachatrian, Steven P. Buchner, Dale Mcmorrow, Joel M. Hales, Yuanfu Zhao, Liang Wang, Chuanmin Wang, Robert A. Weller, Ronald D. Schrimpf, Sharon M. Weiss, Robert A. Reed
Summary: The method reported involves conducting nonlinear optical simulations to model the 3-D charge distributions from a laser pulse, and incorporating these distributions into a charge transport solver to model the charge movement. The output allows for direct comparison between experimental and simulated current transients, showing good agreement in both total injected charge and temporal characteristics. This a priori simulation approach proves to be a predictive tool with broad versatility and minimal reliance on approximations.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Adrian Ildefonso, Jacob P. Kimball, Ani Khachatrian, Yaw Mensah, Jeffrey W. Teng, George N. Tzintzarov, Sunil G. Rao, Arya Moradinia, John D. Cressler, Dale McMorrow
Summary: This article applies the k-nearest neighbors algorithm to detect and correct single-event upsets, specifically focusing on the SEUs caused by single-event transients in RF systems carrying modulated data. By performing pulsed-laser measurements and training separate k-NN algorithms, the number of symbol upsets is reduced by 30% and the algorithm achieves a correct classification rate of 99.2%.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Joel M. Hales, Ani Khachatrian, Adrian Ildefonso, Stephen Buchner, Dennis Adams, David Wheeler, Scott Messenger, Codie Mishler, Nicholas Budzinski, Scott Jordan, Roger Van Art, Dale McMorrow
Summary: This study uses pulsed-laser testing to accurately determine the single-event latchup (SEL) thresholds for static random-access memories (SRAMs) on a mixed-signal application-specific integrated circuit (ASIC). It demonstrates two approaches that can be effective tools for evaluating SEL susceptibilities and mitigation strategies.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Pujan K. C. Mishu, Moon-Kyu Cho, Ani Khachatrian, Stephen P. Buchner, Dale Mcmorrow, Pauline Paki, John D. Cressler, Ickhyun Song
Summary: The advantages and tradeoffs of using inverse-mode SiGe HBT biasing circuitry in RF VCOs were investigated and compared with conventional forward-mode VCOs. The high-frequency performance of the inverse-mode VCOs may be degraded, but they offer acceptable performance at lower frequencies. Additionally, the inverse-mode VCOs show reduced single-event effects and better reliability under radiation compared to conventional VCOs.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Ebrahim M. Al Seragi, Subhra Dash, K. Muthuseenu, John D. Cressler, Hugh J. Barnaby, Ani Khachatrian, Stephen P. Buchner, Dale McMorrow, Saeed Zeinolabedinzadeh
Summary: This article introduces novel radiation hardening design techniques to reduce single-event effects on high-frequency receivers in space. The effectiveness is investigated through modifications to the mixer and matching considerations, with measurements conducted during normal receiver operation. The proposed radiation hardened receiver is validated through simulations and experiments using transient current pulses and a pulsed laser setup.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Xinyi Xia, Jian-Sian Li, Ribhu Sharma, Fan Ren, Md Abu Jafar Rasel, Sergei Stepanoff, Nahid Al-Mamun, Aman Haque, Douglas E. Wolfe, Sushrut Modak, Leonid Chernyak, Mark E. Law, Ani Khachatrian, S. J. Pearton
Summary: This paper presents a review of experimental and simulation radiation damage results in Ga2O3. Ga2O3 is expected to have similar radiation resistance as GaN and SiC, but with orders of magnitude difference compared to GaAs. The study highlights the importance of examining all types of radiation, as Ga2O3 devices may be used in both space and terrestrial applications.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Tolen Nelson, Daniel G. Georgiev, Michael R. Hontz, Raghav Khanna, Adrian Ildefonso, Andrew D. Koehler, Karl Hobart, Ani Khachatrian, Dale McMorrow
Summary: The study examines the effect of various trapping centers on single-event transients (SETs) in GaN high-electron-mobility transistors (HEMTs) through calibrated technology computer-aided design (TCAD) simulations. A computational model of a single-channel, Schottky-gate HEMT is developed and validated using static characteristics and single-photon absorption laser data. The simulations reveal a 2-D electron gas (2-DEG) enhancement effect in SETs, resulting in additional collected charge beyond the generated charge. The origins of this effect are investigated, showing an increase in the occupation rate of surface donor traps as charge influx develops in the charge track. Variations in trap characteristics are introduced, and their impact on internal charge collection processes is analyzed. It is further demonstrated that the SET drain current closely follows the transient decay of occupation rate back to the original dc level, indicating the dominance of surface donor traps in the SET response.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Joel M. Hales, Adrian Ildefonso, Stephen P. Buchner, Ani Khachatrian, Greg Allen, Dale McMorrow
Summary: A newly developed pulsed-laser testing approach using a quasi-Bessel beam (QBB) is applied to predict the heavy-ion generated single-event transient (SET) response in an LM124 operational amplifier. The QBB accurately reproduces the transient features measured in the broadbeam heavy-ion data, showing strong agreement with worst-case transients. Importantly, the QBB is capable of predicting ion-induced SET response without any fitting or adjustable parameters.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Jeffrey H. Warner, Eric Faraci, Chi Pham, Ani Khachatrian, Dale McMorrow
Summary: The SET response of the RIC7S113 gate driver was characterized using pulsed laser and heavy ion accelerator testing, and the SET response between the two methods were compared.
2022 IEEE RADIATION EFFECTS DATA WORKSHOP (REDW) (IN CONJUNCTION WITH 2022 NSREC)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Joel M. Hales, Ani Khachatrian, Jeffrey Warner, Stephen Buchner, Dale McMorrow
Summary: This research aims to develop an accurate and simplified approach for quantitative pulsed-laser testing.
2019 19TH EUROPEAN CONFERENCE ON RADIATION AND ITS EFFECTS ON COMPONENTS AND SYSTEMS (RADECS)
(2022)