Article
Genetics & Heredity
Sabrina B. Frederiksen, Lise L. Holm, Martin R. Larsen, Thomas K. Doktor, Henriette S. Andersen, Michelle L. Hastings, Yimin Hua, Adrian R. Krainer, Brage S. Andresen
Summary: This study identified that splicing factor SRSF10 binds to ISS-N1 and regulates SMN1 and SMN2 splicing with different strengths based on the length of their RS domain. The ratio between SRSF10 isoforms is crucial for splicing regulation, suggesting a potential therapeutic target for spinal muscular atrophy.
Review
Biochemistry & Molecular Biology
Lulzim Shkreta, Aurelie Delannoy, Anna Salvetti, Benoit Chabot
Summary: SRSF10, a member of the SR protein family, plays crucial roles in metabolism, embryonic heart development, and neurological processes. Its overexpression in cancer has functional consequences, and it could be a potential therapeutic target for cancer and viral infections.
Review
Cell Biology
Eleonora Franze, Irene Marafini, Edoardo Troncone, Silvia Salvatori, Giovanni Monteleone
Summary: Colorectal carcinoma (CRC) is tightly controlled by tumor-associated immune cells and stromal cells, with interleukin-34 (IL-34) playing a crucial role in regulating the pro-tumoral functions of various cell types in the CRC microenvironment.
CELL DEATH DISCOVERY
(2021)
Editorial Material
Cell & Tissue Engineering
Elyad Lezmi, Nissim Benvenisty
Summary: Assessing and enhancing the safety of human pluripotent stem cell (hPSC)-based treatments are crucial due to the tumorigenic potential of hPSCs. Understanding the molecular features and genetic aberrations associated with tumorigenicity is important for developing precautionary and safety measures in hPSC therapy.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Qi Yu, Tongtong Wu, Wenhong Xu, Junyuan Wei, Anqi Zhao, Miaomiao Wang, Meiying Li, Guangfan Chi
Summary: This article reviews the structure and molecular functions of PTBP1 and summarizes its roles and mechanisms in various diseases, including controversial studies. The prospects of targeting PTBP1 in new clinical therapeutic approaches are discussed.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Heping Cao, Kandan Sethumadhavan, Xiaoyu Wu, Xiaochun Zeng, Lin Zhang
Summary: This study investigated the effects of cottonseed extracts on cell viability and gene expression in human colon cancer cells. The results showed that cottonseed extracts had minor effects on cell viability, but glandless seed kernel extract significantly reduced mRNA levels of many genes involved in glucose transport, lipid biosynthesis, and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Roslyn Tedja, Ayesha B. Alvero, Alexandra Fox, Carlos Cardenas, Mary Pitruzzello, Hussein Chehade, Tejeshwhar Bawa, Nicholas Adzibolosu, Radhika Gogoi, Gil Mor
Summary: This study established an in vitro model of epithelial-to-mesenchymal transition (EMT) and identified the main genomic signature associated with the E/M hybrid state. The results showed that cells in the E/M hybrid state gain stable anoikis resistance, invasive capacity, and tumorigenic potential. The hepatocyte growth factor (HGF)/c-MET pathway was identified as a major driver of cells in the E/M hybrid state.
Article
Oncology
Nisitha Wijewantha, Sanam Sane, Morgan Eikanger, Ryan M. Antony, Rashaun A. Potts, Lydia Lang, Khosrow Rezvani, Grigoriy Sereda
Summary: This study developed a new potential anticancer therapeutic by encapsulating eugenol in casein-coated nanoparticles, which can be selectively delivered to and released in colorectal cancer cells. Eugenol induces apoptosis in CRC cells and reduces their migration and invasion ability, without toxicity on normal cells.
Article
Oncology
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Summary: This study indicates that obesity promotes ATGL-mediated colonic tumorigenesis and establishes the therapeutic significance of ATGL in obesity-driven colon cancer progression.
Article
Pharmacology & Pharmacy
Busra Yuksel, Aysen Asli Hizli Deniz, Fikrettin Sahin, Kazim Sahin, Nezaket Turkel
Summary: Currently, the use of cannabinoids is limited to improving chemotherapy's adverse effects, and their palliative administration is associated with positive prognosis and decreased tumor progression in different types of tumors. Non-psychoactive cannabinoids such as CBD and CBG have shown antineoplastic effects in cell line and animal models, but their potential as chemotherapeutic agents requires further investigation. Clinical and epidemiological evidence, along with experimental findings, suggest that micronutrients like curcumin and piperine may provide a safer approach in preventing tumorigenesis and recurrence. In this study, a triple combination of CBD/CBG, curcumin, and piperine showed synergistic anti-tumorigenic effects in colon adenocarcinoma by activating the Hippo YAP signaling pathway in the HCT116 cell line.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Liu Yang, Na Li, Meng Wang, Yan-Hua Zhang, Lu-Da Yan, Wen Zhou, Zhi-Qiong Yu, Xiao-Chun Peng, Jun Cai
Summary: Non-small cell lung cancer (NSCLC) accounts for a majority of lung cancer cases and is commonly diagnosed at an advanced stage with low survival rates. Activation of telomerase, particularly through telomerase reverse transcriptase (TERT), is associated with the malignant characteristics and prognosis of NSCLC, offering potential therapeutic applications for the treatment of this disease.
Article
Oncology
Damian Jacenik, Ioannis Karagiannidis, Ellen J. Beswick
Summary: Th2 cells play a crucial role in inhibiting the growth of gastrointestinal tumors by generating apoptotic factors and affecting the recruitment of macrophages and eosinophils, leading to the production of cytotoxic factors. In addition, Th2 cells result in excessive secretion of IL-5, which is associated with the inhibition of gastrointestinal tumor growth. Moreover, Th2 cells and eosinophils are directly responsible for killing gastrointestinal cancer cells.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Darshan Mehta, Sayoni Roy, Priyanka Joshi, Mitali Parab, Sanjeev K. Waghmare
Summary: Breast cancer stem cells (BCSCs) are slow cycling cells that escape traditional chemo-radiotherapy, contributing to resistance and recurrence. This study isolated BCSCs using the marker CD44+/CD24-/low and found that they had a high percentage of mammospheres in the CSC population. The tumorigenic potential of BCSCs was observed in vivo, and the overexpression of sPLA2-IIA in breast cancer cells was found to be associated with cell proliferation and metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Guangfeng Geng, Changlu Xu, Nan Peng, Yue Li, Jinhua Liu, Jing Wu, Jing Liang, Yushan Zhu, Lihong Shi
Summary: PTBP1 in dendritic cells plays a crucial role in regulating MHC II expression, antitumour immunity, and asthma exacerbation, highlighting its potential as a therapeutic target for cancer treatment.
Article
Multidisciplinary Sciences
Xinyuan Chena, Harry Taegyun Yang, Beatrice Zhang, John W. Phillips, Donghui Cheng, Frank Rigo, Owen N. Witte, Yi Xing, Douglas L. Black
Summary: The MYC proto-oncogene contributes to the pathogenesis of more than half of human cancers by transcriptionally up-regulating the splicing machinery and causing misregulation of alternative splicing. However, our understanding of how splicing changes are directed by MYC is limited. In this study, a signaling pathway-guided splicing analysis was performed to identify MYC-dependent splicing events, including an HRAS cassette exon repressed by MYC. Mechanistically, hnRNP H and hnRNP F were found to activate the HRAS cassette exon through binding to specific cis-regulatory elements. Loss of hnRNP H and F altered cell cycle progression and induced apoptosis in prostate cancer cells. These findings reveal mechanisms for MYC-dependent regulation of splicing and suggest potential therapeutic targets in prostate cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nutrition & Dietetics
Shanjun Tan, Qingyang Meng, Yi Jiang, Qiulin Zhuang, Qiulei Xi, Jiahao Xu, Jinou Zhao, Xiangyu Sui, Guohao Wu
Summary: This study focused on post-discharge patients at nutritional risk following colorectal cancer surgery and found that the use of oral nutritional supplements can reduce skeletal muscle loss, sarcopenia prevalence, and improve chemotherapy tolerance compared to dietary advice alone.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Qingyang Meng, Shanjun Tan, Yi Jiang, Jun Han, Qiulei Xi, Qiulin Zhuang, Guohao Wu
Summary: This study showed that post-discharge oral nutritional supplements (ONS) with dietary advice improved nutritional outcomes, skeletal muscle maintenance, chemotherapy tolerance, and some quality of life variables in patients after surgery for gastric cancer.
CLINICAL NUTRITION
(2021)
Article
Surgery
Shanjun Tan, Feng Zhou, Zhige Zhang, Junjie Wang, Jiahao Xu, Qiulin Zhuang, Qingyang Meng, Qiulei Xi, Yi Jiang, Guohao Wu
Summary: The study found that beta-1 blocker significantly reduces the release of inflammatory mediators and protects intestinal barrier function, thereby reducing systemic and local inflammatory responses after open abdominal surgery.
Letter
Nutrition & Dietetics
Shanjun Tan, Guohao Wu
CLINICAL NUTRITION
(2021)
Review
Endocrinology & Metabolism
Junjie Wang, Shanjun Tan, Guohao Wu
Summary: Sarcopenia is common in cancer patients and has negative impacts. Oral nutritional supplements and physical activity show potential in managing this condition, but more education and training are needed to overcome barriers.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2021)
Article
Nutrition & Dietetics
Jun Han, Lei Shen, Zheng Zhan, Yuguo Liu, Chang Zhang, Ruochen Guo, Yangjun Luo, Zhiqin Xie, Ying Feng, Guohao Wu
Summary: This study identified that MALAT1 is associated with adipose loss in cancer-associated cachexia by regulating adipogenesis through PPAR-gamma, potentially serving as a novel target for diagnosis and treatment of cancer-associated cachexia in the clinic.
NUTRITION & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Hua Liu, Hongna Shang, Huan Yang, Wenjie Liu, Daisuke Tsugama, Ken-Ichi Nonomura, Aimin Zhou, Wenwu Wu, Tetsuo Takano, Shenkui Liu
Summary: The development of floral organs is regulated by a complex network of homeotic genes, and the signaling of gibberellin (GA) is essential for this process. In this study, researchers discovered that the protein MAC5A, which contains an RNA-binding motif, is involved in the development of sepals, petals, and stamens. MAC5A interacts with RBE, a repressor of AG expression, and is required for normal stamen development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xiaoxue Ye, Shuo Wang, Xijuan Zhao, Ni Gao, Yao Wang, Yanmei Yang, Ernest Wu, Cheng Jiang, Yuxiang Cheng, Wenwu Wu, Shenkui Liu
Summary: Long non-coding RNAs (lncRNAs) play important roles in regulating gene expression under salt stress. This study identified 2988 high-confidence lncRNAs, including 1183 salt-induced differentially expressed lncRNAs, in Populus trichocarpa. It was found that lncRNAs can regulate neighboring genes in a cis-regulatory manner and contribute to distant gene expression in a trans-regulatory manner. Additionally, a specific lncRNA, Ptlinc-NAC72, was shown to regulate the expression and functional roles of homologous genes PtNAC72.A/B under long-term salt stress.
Article
Plant Sciences
Shuo Wang, Yirong Shen, Liangyu Guo, Lingling Tan, Xiaoxue Ye, Yanmei Yang, Xijuan Zhao, Yuqi Nie, Deyin Deng, Shenkui Liu, Wenwu Wu
Summary: This study identified 36 TCP genes in Populus trichocarpa and found that this significant innovation was mainly due to recent whole genome duplication (rWGD) after the divergence from Arabidopsis. The study also showed that the expressions of these genes varied among different plant parts and could be regulated by abiotic stresses. Furthermore, a cold-associated regulatory module was identified, suggesting the neofunctionalization of PtrTCP genes in response to environmental changes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fuqiang Cui, Xiaoxiao Li, Wenwu Wu, Wenbo Luo, Ying Wu, Mikael Brosche, Kirk Overmyer
Summary: MYB108/BOS1 enhances cell death in the gain-of-function mutant bos1-1 after fungal infection and mechanical wounding. Programmed cell death (PCD) is integral to plant life and required for stress responses, immunity, and development. Our understanding of the regulation of PCD is incomplete, especially concerning regulators involved in multiple divergent processes. The botrytis-susceptible (bos1) mutant of Arabidopsis is highly susceptible to fungal infection by Botrytis cinerea (Botrytis). BOS1 (also known as MYB108) regulates cell death propagation during plant responses to wounding. The bos1-1 allele contains a T-DNA insertion in the 5 '-untranslated region upstream of the start codon. This insertion results in elevated expression of BOS1/MYB108. We used clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated nuclease 9 (Cas9) system (CRISPR/Cas9) to create new bos1 alleles with disrupted exons, and found that these lines lacked the typical bos1-1 wounding and Botrytis phenotypes. They did exhibit reduced fertility, as was previously observed in other bos1 alleles. Resequencing of the bos1-1 genome confirmed the presence of a mannopine synthase (MAS) promoter at the T-DNA left border. Expression of the BOS1 gene under control of the MAS promoter in wild-type plants conferred the characteristic phenotypes of bos1-1: Botrytis sensitivity and response to wounding. Multiple overexpression lines demonstrated that BOS1 was involved in regulation of cell death propagation in a dosage-dependent manner. Our data indicate that bos1-1 is a gain-of-function mutant and that BOS1 function in regulation of fertility and Botrytis response can both be understood as misregulated cell death.
Article
Biochemistry & Molecular Biology
Yuqi Nie, Liangyu Guo, Fuqiang Cui, Yirong Shen, Xiaoxue Ye, Deyin Deng, Shuo Wang, Jianhua Zhu, Wenwu Wu
Summary: The study reveals the origin and evolution of C-repeat binding factors/dehydration-responsive element binding protein 1s (CBFs/DREB1s) and their regulatory network. It shows that CBF/DREB1 is an innovation evolved from tandem duplication-derived DREB III gene and has expanded in ancient and modern plants through gene duplication. The duplication events mainly occurred during periods of significant global temperature decrease and the duplicated CBF/DREB1 genes contributed to the rewiring of the regulatory network for cold tolerance in plants.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liangyu Guo, Shuo Wang, Yuqi Nie, Yirong Shen, Xiaoxue Ye, Wenwu Wu
Summary: Most eudicot plants did not undergo recent whole-genome duplication (R-WGD), but they were still able to adapt to environmental changes. In this study, researchers found that the AP2/ERF transcription factor family was retained after R-WGDs in some eudicot plants and showed exceptional response to cold stimulation. By comparing plants with and without R-WGD, the study revealed convergent expansions of the AP2/ERF III and IX subfamilies through independent duplications and tandem duplications (TDs) after R-WGDs. These expansions coincided with times of global cooling, particularly around and/or after the Cretaceous-Paleogene (K-Pg) boundary. The co-retention and expansion of AP2/ERF III C-repeat binding factor (CBF) duplicates contributed to rewiring of cold-specific regulatory networks in different eudicot lineages.
PLANT COMMUNICATIONS
(2022)
Article
Plant Sciences
Liangyu Guo, Zhiming Xu, Shuo Wang, Yuqi Nie, Xiaoxue Ye, Xuejiao Jin, Jianhua Zhu, Wenwu Wu
Summary: This study investigates the regulatory networks involved in cold responses in three different species of rosids. It demonstrates that some transcription factors and RNA-binding proteins are conserved in the cold response across rosids, and it reveals a hierarchical regulation of differentially expressed genes and alternative splicing genes. The study also identifies a common enrichment related to circadian rhythm in the cold response pathways in all three studied species.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Thermodynamics
Yang Li, Maolin Yu, Yinming Bai, Zhaoyang Hou, Huijie Zhang, Wenwu Wu
Summary: In this study, heat conductive paths were created on the bearing seat and spindle housing to enhance heat dissipation. The temperature distributions of models with and without heat conductive paths were investigated. It was found that the heat dissipation significantly improved with the use of heat conductive paths, and increasing the number and diameter of paths led to lower internal temperatures and reduced temperature difference.
ADVANCES IN MECHANICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Shuo Wang, Yixian Zhang, Xiaoxue Ye, Yirong Shen, Hua Liu, Xijuan Zhao, Liangyu Guo, Lu Cao, Yunfei Du, Wenwu Wu
Summary: Based on high-throughput sequencing, this study selected 11 representative angiosperm species and examined their transcriptome changes during cold adaptation. The findings provide valuable insights into the conserved and evolutionary mechanisms of angiosperms in response to cold stress.
