Review
Biochemistry & Molecular Biology
Jing Zhang, Xianxin Zheng, Peiyan Wang, Jianxun Wang, Wei Ding
Summary: ARC is a highly effective and multifunctional inhibitor of apoptosis expressed in postmitotic cells like cardiomyocytes and skeletal muscle cells. It has a cardioprotective role by inhibiting cardiomyocyte death in various ways, such as reducing apoptotic response to stresses like extrinsic apoptosis induced by death receptor ligands, Ca2+ homeostasis, ER stress, oxidative stress, and hypoxia.ARC also plays a regulatory role in other types of cell death and can cause physiological and pathological changes in the heart.
Review
Biochemistry & Molecular Biology
Kun Liu, Dongfeng Lan, Chunyang Li, Songpo Liu, Xiaofang Dai, Tao Song, Xianyao Wang, Qinghong Kong, Zhixu He, Jun Tan, Jidong Zhang
Summary: Apoptosis repressor with caspase recruitment domain (ARC) acts as a powerful and multifunctional inhibitor of apoptosis, mainly expressed in postmitotic cells, including cardiomyocytes. ARC is known for its unique N-terminal caspase recruitment domain and caspase recruitment domain. It has been reported to play a cardioprotective role in ischaemia/reperfusion (I/R) injury, preventing cardiomyocytes from damage caused by various catastrophes. Recent studies have revealed its potential regulatory role in tumorigenesis, particularly in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways.
Article
Cell Biology
Wendy M. McKimpson, Yun Chen, James A. Irving, Min Zheng, Jeremy Weinberger, Wilson Lek Wen Tan, Zenia Tiang, Alistair M. Jagger, Streamson C. Chua, Jeffrey E. Pessin, Roger S-Y Foo, David A. Lomas, Richard N. Kitsis
Summary: This research identifies a pathway in which the cell death inhibitor ARC paradoxically becomes a killer during diabetes, leading to beta cell death in type 2 diabetes. Additionally, the downregulation of serpins synthesized and secreted by beta cells, especially the loss of the serpin alpha(1)-antitrypsin, triggers beta cell death by disrupting cell anchorage. The administration of alpha(1)-antitrypsin can prevent alpha cell death and metabolic abnormalities in mice with diabetes, suggesting a potential therapeutic target for this syndrome.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Li, Ting Chen, Xiaofen Wu, Xiao Jiang, Peng Luo, E. Zixuan, Chaoqun Hu, Chunhua Ren
Summary: Apoptosis is a critical biological process for embryonic development, tissue differentiation, and organism homeostasis. A novel apoptosis-inducing factor called AIF-2 has been identified in sea cucumbers, and it is involved in heavy metal-induced apoptosis, contributing to the understanding of the caspase-independent apoptotic pathway in ancient echinoderm species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Leo Razakamanantsoa, Neeraj R. Rajagopalan, Yasushi Kimura, Michele Sabbah, Isabelle Thomassin-Naggara, Francois H. Cornelis, Govindarajan Srimathveeravalli
Summary: Irreversible electroporation (IRE) can cause apoptosis, necrosis, oncosis, or pyroptosis. The mode of cell death following IRE is determined by intracellular ATP levels. Cell death after IRE is insensitive to caspase inhibition and is correlated with ATP loss, which cannot be rescued by ATP supplementation.
BIOELECTROCHEMISTRY
(2023)
Article
Pediatrics
Zhengwang Wen, Yuhan Xia, Yingying Zhang, Yuxi He, Chao Niu, Rongzhou Wu, Chunxiang Zhang, Chang Jia, Xing Rong, Maoping Chu
Summary: This study found that the level of SIGIRR was downregulated in Kawasaki disease, while caspase-8 level was increased. The SIGIRR-caspase-8 signaling pathway plays a crucial role in the pathology of Kawasaki disease.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Khawlhring Lalrinzuali, Mathipi Vabeiryureilai, Ganesh Chandra Jagetia
Summary: The study revealed that the extracts of Sonapatha have significant cytotoxic effects on HeLa cells, especially the ethanol extract, which reduces clonogenicity, increases DNA fragmentation, apoptosis, and necrosis indices.
BIOORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Nico Wittmann, Ann-Kathrin Behrendt, Neha Mishra, Lukas Bossaller, Almut Meyer-Bahlburg
Summary: The study presents a flow cytometric method for identifying inflammasome-activated monocytes, detailing optimal conditions for human blood sample testing. Researchers hope this technique can be used for investigating the pathogenesis of various diseases.
Article
Medicine, Research & Experimental
Toshihide Kashihara, Risa Mukai, Shin-ichi Oka, Peiyong Zhai, Yasuki Nakada, Zhi Yang, Wataru Mizushima, Tsutomu Nakahara, Junco S. Warren, Maha Abdellatif, Junichi Sadoshima
Summary: The heart utilizes multiple adaptive mechanisms to maintain pump function, with YAP playing a crucial role in inducing compensatory cardiac hypertrophy through promoting glycolysis and upregulating the GLUT1 gene. This leads to the accumulation of glycolytic metabolites and ultimately promotes cardiac hypertrophy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Xiali Qin, Yu Gu, Tianyu Liu, Chen Wang, Weilong Zhong, Bangmao Wang, Hailong Cao
Summary: This review summarizes the current research progress on fungal dysbiosis in CRC, discusses the potential mechanisms of fungi in CRC development, and explores potential therapeutic strategies for CRC treatment. This contributes to a better understanding of the correlation between fungal community and CRC, with modulating fungal community being a promising target against CRC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Cell Biology
Sebastian J. Theobald, Jessica Graeb, Melanie Fritsch, Isabelle Suarez, Hannah S. Eisfeld, Sandra Winter, Maximilian Koch, Christoph Hoelscher, Manolis Pasparakis, Hamid Kashkar, Jan Rybniker
Summary: Through a clinical cohort study, we found that necrotic lesions correlate with IL-1 beta plasma levels as a marker of inflammasome activation. Mtb triggers mitochondrial permeability transition leading to extensive macrophage necrosis requiring NLRP3 inflammasome activation. This study identifies mitochondria as central regulators capable of distinguishing cytokine secretion and lytic cell death in pathogen-induced regulated necrosis.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Wan-feng Xu, Quan Zhang, Chu-jie Ding, Hui-yong Sun, Yuan Che, Hai Huang, Yun Wang, Jia-wei Wu, Hai-ping Hao, Li-juan Cao
Summary: This study developed a class of GSDME-derived inhibitors that can inhibit caspase-3 activity, preventing pyroptosis and apoptosis events, and alleviating liver injury in a mouse model.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Qinghan Ren, Guoquan Zhang, Ruiting Yan, Dezheng Zhou, Li Huang, Qianwen Zhang, Wen Li, Guowei Huang, Zhenshu Li, Jing Yan
Summary: Research has shown that folate deficiency in either parents can affect the biological functions of neural cells in offspring. This deficiency can impair the methionine cycle and lead to damage to the central nervous system. The study found that parental folate deficiency caused apoptosis of neural cells in neonatal rats, with the greatest effect seen when both parents were deficient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jinsu An, So Yeon Kim, Eun Gyeong Yang, Hak Suk Chung
Summary: Recognition of intracellular lipopolysaccharide (LPS) by Caspase-4 is critical for host defense. In this study, a high-throughput screening system was devised to identify inhibitors of the LPS and Casp-4 interaction. Inhibition of LPS-Casp-4 interaction may be a promising strategy for treating infectious diseases and sepsis induced by LPS.
Article
Biochemistry & Molecular Biology
Izabela Buniowska, Norbert Wronski, Malgorzata Insinska-Rak, Marek Sikorski, Agnieszka Wolnicka-Glubisz
Summary: This study compared the effects of 3MeTARF and riboflavin on A431 cancer cells under irradiation. The results showed that 3MeTARF more effectively activated MAPK and induced cell death in skin cancer cells, suggesting its therapeutic potential in photodynamic oxidation processes.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Health Care Sciences & Services
Zhi Li, Wen Ge, Chunyan Han, Mengwei Lv, Yanzhong He, Juntao Su, Ban Liu, Yangyang Zhang
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2020)
Article
Biotechnology & Applied Microbiology
Ban Liu, Xin Shi, Keke Ding, Mengwei Lv, Yongjun Qian, Shijie Zhu, Changfa Guo, Yangyang Zhang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xin Shi, Xuelian Shao, Ban Liu, Mengwei Lv, Pratik Pandey, Changfa Guo, Ruilin Zhang, Yangyang Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cardiac & Cardiovascular Systems
Mengwei Lv, Bo Hu, Wen Ge, Zhi Li, Qi Wang, Chunyan Han, Ban Liu, Yangyang Zhang
Summary: Occult renal dysfunction is a significant risk factor for postoperative acute kidney injury and in-hospital mortality in patients undergoing OPCABG surgery. Patients with occult renal dysfunction have higher risks for complications and adverse outcomes following surgery.
HEART LUNG AND CIRCULATION
(2021)
Article
Physiology
Ban Liu, Xiang Li, Cuimei Zhao, Yuliang Wang, Mengwei Lv, Xin Shi, Chunyan Han, Pratik Pandey, Chunhua Qian, Changfa Guo, Yangyang Zhang
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Mengwei Lv, Fei Gao, Ban Liu, Pratik Pandey, Yipeng Feng, Yingwei Wang, Yangyang Zhang, Zhi Li
Summary: The retrospective study involving 1471 patients undergoing coronary artery bypass graft (CABG) surgery in China found that obesity was associated with reduced 30-day postoperative mortality. There was an obesity paradox, with overweight patients having a protective effect against long-term mortality, especially in the off-pump CABG subgroup.
MEDICAL SCIENCE MONITOR
(2021)
Article
Genetics & Heredity
Cuimei Zhao, Jingjing Liu, Wen Ge, Zhi Li, Mengwei Lv, Yipeng Feng, Xuebo Liu, Ban Liu, Yangyang Zhang
Summary: Through analyzing the blood samples of AMI patients and normal controls, 142 differentially expressed circRNAs were identified. Functional characterization revealed that circRNAs were mainly involved in seven pathways, such as the Runt-related transcription factor-1 (RUNX1) expression and activity-related pathway.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Bo Hu, Fei Gao, Mengwei Lv, Ban Liu, Yu Shi, Xi Chen, Yipeng Feng, Xiaoqi Meng, Zhi Li, Yangyang Zhang
Summary: The study found that cTnT is a better indicator than CK-MB, and its peak value and peak occurrence are related to midterm mortality in patients undergoing OPCABG, with stronger predictive ability.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cell Biology
Jingjing Liu, Xianting Ke, Luxin Wang, Yangyang Zhang, Jian Yang
Summary: The study identified a critical role of CIRP in protecting against MCT-induced PAH by regulating the expression of CAV1 and CAVIN1, suggesting potential new therapeutic targets for PAH intervention.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Yuying Gu, Lingtong Shan, Ban Liu, Mengwei Lv, Xi Chen, Tao Yan, Yu Shi, Jiapeng Chen, Zhi Li, Yangyang Zhang
Summary: In patients undergoing CABG, NYHA classification, CAD classification, valvular disease, IABP implantation, pulmonary hypertension, previous PCI, bypass graft number, cardiopulmonary bypass, and preoperative cTnT are independent risk factors of PMI.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
Jin Yao, Xiao-Qun Wang, Yu-Jie Li, Kun Shan, Hong Yang, Yang-Ning-Zhi Wang, Mu-Di Yao, Chang Liu, Xiu-Miao Li, Yi Shen, Jing-Yu Liu, Hong Cheng, Jun Yuan, Yang-Yang Zhang, Qin Jiang, Biao Yan
EMBO MOLECULAR MEDICINE
(2022)
Article
Genetics & Heredity
Bo Hu, Wen Ge, Yuliang Wang, Xiaobin Zhang, Tao Li, Hui Cui, Yongjun Qian, Yangyang Zhang, Zhi Li
Summary: Atrial fibrillation (AF) is associated with an increased risk of heart failure, dementia, and stroke. Proteomics and metabolomics analyses revealed distinct metabolite and protein profiles between valvular and non-valvular AF patients, indicating potential different mechanisms underlying the two types of AF. The study identified specific biomarkers and metabolic pathways associated with each type of AF, providing insights for prognosis and potential treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Fei Gao, Lingtong Shan, Chong Wang, Xiaoqi Meng, Jiapeng Chen, Lixiang Han, Yangyang Zhang, Zhi Li
Summary: The study evaluated the performance of EuroSCORE II and STS score in predicting in-hospital and medium-term mortality of patients undergoing CABG. Both scoring systems showed good predictive power for in-hospital mortality, but their performance decreased over time.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Yang Zhao, Chengqing Jiang, Jiaying Lu, Yihan Sun, Yingyu Cui
Summary: Proanthocyanidins (PA) and anthocyanins are polyphenol compounds widely found in various parts of plants. They have shown excellent antioxidant, anti-cancer, and other pharmacological effects. Recent reviews and meta-analyses indicate their value in the prevention and management of cardiometabolic disease. More research is needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Yan-Xi Zeng, Sen Wang, Lu Wei, Ying-Yu Cui, Yi-Han Chen
AMERICAN JOURNAL OF CHINESE MEDICINE
(2020)