期刊
NATURE COMMUNICATIONS
卷 4, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/ncomms2529
关键词
-
资金
- Swiss Nano Science Institute (SNI) through the NanoArgovia program (VIP project)
- Swiss commission for technology and innovation (CTI)
- Swiss federal office for professional education and technology (OPET)
- Swiss national science foundation (SNSF)
- Eurostar program (project Envirus)
- French CNRS
- Universite de Strasbourg
Major stumbling blocks in the production of fully synthetic materials designed to feature virus recognition properties are that the target is large and its self-assembled architecture is fragile. Here we describe a synthetic strategy to produce organic/inorganic nanoparticulate hybrids that recognize non-enveloped icosahedral viruses in water at concentrations down to the picomolar range. We demonstrate that these systems bind a virus that, in turn, acts as a template during the nanomaterial synthesis. These virus imprinted particles then display remarkable selectivity and affinity. The reported method, which is based on surface imprinting using silica nanoparticles that act as a carrier material and organosilanes serving as biomimetic building blocks, goes beyond simple shape imprinting. We demonstrate the formation of a chemical imprint, comparable to the formation of biosilica, due to the template effect of the virion surface on the synthesis of the recognition material.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据