Article
Biochemistry & Molecular Biology
Miguel Tillo, William C. Lamanna, Chrissa A. Dwyer, Daniel R. Sandoval, Ariane R. Pessentheiner, Norah Al-Azzam, Stephane Sarrazin, Jon C. Gonzales, Shih-Hsin Kan, Alexander Y. Andreyev, Nicholas Schultheis, Bryan E. Thacker, Charles A. Glass, Patricia I. Dickson, Raymond Y. Wang, Scott B. Selleck, Jeffrey D. Esko, Philip L. S. M. Gordts
Summary: Lysosomal storage diseases result in energy imbalance and metabolic abnormalities in MPS IIIa mice, including hypertriglyceridemia, reduced lipid storage, increased activity of brown adipose tissue (BAT), leading to hyperthermia, increased appetite, increased thirst, and increased energy expenditure. These changes are caused by impaired fusion of autophagosomes and lysosomes, resulting in increased mitochondria content in brown adipose tissue.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Vanessa Mhanna, Gwladys Fourcade, Pierre Barennes, Valentin Quiniou, Hang P. Pham, Paul-Gydeon Ritvo, Faustine Brimaud, Bruno Gouritin, Guillaume Churlaud, Adrien Six, Encarnita Mariotti-Ferrandiz, David Klatzmann
Summary: The study reveals that the diversity of activated/memory Treg and effector T cell repertoires in NOD mice is significantly higher than in normal mice, and administration of IL-2 can restore expansions of these clonotypes and prevent diabetes development. IL-2-expanded T cell repertoires are enriched with islet-antigen specific TCRs.
Article
Multidisciplinary Sciences
Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loic Sauteur, Denise Winter, Christelle Le Foll, Catherine Bregere, Raphael Guzman, Alex Odermatt, Marianne Boeni-Schnetzler, Marc Y. Donath
Summary: Defective insulin processing due to deficiency of insulin prohormone convertase 1/3 (PC1/3) leads to hyperglycemia and hyperphagic obesity. Impaired insulin maturation, rather than impaired pro-islet amyloid polypeptide processing, is the cause of obesity. Insulin therapy can prevent hyperphagia. Furthermore, decreased PC1/3 expression levels in pancreatic islets are negatively correlated with body mass index in humans.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Kevin Schneider, Sanja Arandjelovic
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the human population. It is characterized by joint swelling and bone erosion, causing disability and even death. Immune dysregulation, including circulating autoantibodies and inflammatory mediators, plays an important role in the development of RA. Studies have shown that inducing cell death through apoptosis can reduce the severity of the disease. Apoptotic cells are cleared by phagocytes through a process called efferocytosis, which has anti-inflammatory properties. Dysfunctions in efferocytosis have been linked to autoimmune diseases, while administration of apoptotic cells in RA models effectively inhibits inflammation. However, the signaling pathways and clearance mediators involved in RA are still not well understood.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Cell Biology
Lei Yuan, Peiyao Li, Qian Zheng, Hui Wang, Hui Xiao
Summary: Ubiquitination and deubiquitination play important roles in apoptosis and apoptotic cell clearance, and are crucial for normal development and immune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Yuki Hiradate, Ryua Harima, Rin Yanai, Kenshiro Hara, Kazue Nagasawa, Makoto Osada, Tomoe Kobayashi, Makoto Matsuyama, Shin-ichiro Kanno, Akira Yasui, Kentaro Tanemura
Summary: Spermiogenesis is a unique process involving deformation of sperm head morphology and flagella formation. Axdnd1 knockout mice exhibited impaired spermiogenesis, leading to sterility. AXDND1 is essential for spermatogenesis in mice, and its mutations have been found in non-obstructive azoospermia patients, suggesting Axdnd1 KO mice as a potential model for future studies on NOA treatment.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
N. Yang, Q. Zhang, S. Ye, T. Lu, M. Sun, L. Wang, M. Wang, Y. H. Pan, S. Dang, W. Zhang
Summary: The study revealed that Adamts18 plays a crucial role in early branching morphogenesis of embryonic submandibular salivary glands, and in adulthood, it modulates local inflammation, autoimmune reaction, and myofibroblast activation to prevent fibrosis in the submandibular glands.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Fengfeng Mao, Meng-Xuan Wang, Xinfeng Hou, Zhongmin Zhou, Yan-Yan Yan, Ling-Juan Fang, Zexi Tan, Wei-Yuan Fang, Teng Liu, Wenhui He, Cong Li, Xin-Bao Xie, Shi-Qi Lu, Jianhua Sui, Fengchao Wang, Jun Han, Jian-She Wang, Wenhui Li
Summary: NTCP is a bile acid transporter and serves as an entry receptor for hepatitis B virus and hepatitis D virus. Genetic variation in NTCP can cause hypercholanemia in neonates. Gallbladder abnormalities are found in mice and human infants with NTCP variants.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biology
Minjoo Han, Gyoungah Ryu, Seong-Ah Shin, Jangeun An, Huiji Kim, Daeho Park, Dae-Hee Lee, Chang Sup Lee
Summary: The clearance of apoptotic cells is essential for maintaining tissue and organism homeostasis, which is promptly mediated by phagocytes. Phagocytes not only eliminate inflammatory responses but also play important physiological roles, such as in differentiation and development. Defective clearance of apoptotic cells can lead to severe inflammation and autoimmune responses.
Article
Immunology
Dan He, Qiangdongzi Mao, Jialin Jia, Zhiyu Wang, Yu Liu, Tingting Liu, Bangwei Luo, Zhiren Zhang
Summary: This study reveals that the pentose phosphate pathway (PPP) regulates the clearance of tolerogenic apoptotic cells (ACs) and immune tolerance. ACs decrease the levels of PPP-related genes and metabolites in macrophages. The PPP agonist AG1 increases PPP activity but greatly reduces macrophage phagocytosis of ACs and enhances the inflammatory response during efferocytosis. MiR-323-5p regulates the expression of PPP-related genes and its levels increase during efferocytosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shiqiao Ye, Cankun Wang, Zhaohui Xu, Hui Lin, Xiaoping Wan, Yang Yu, Subhodip Adhicary, Joe Z. Zhang, Yang Zhou, Chun Liu, Matthew Alonzo, Jianli Bi, Angelina Ramirez-Navarro, Isabelle Deschenes, Qin Ma, Vidu Garg, Joseph C. Wu, Ming-Tao Zhao
Summary: This study demonstrates that NOTCH1 is crucial for the differentiation and proliferation of human cardiac cells. The absence of NOTCH1 leads to defective ventricular-like cardiomyocyte differentiation and impaired cell proliferation. These findings shed light on the mechanisms underlying hypoplastic left heart syndrome.
CIRCULATION RESEARCH
(2023)
Article
Genetics & Heredity
Nuno Maia, Sven Potelle, Hamide Yildirim, Sandrine Duvet, Shyam K. Akula, Celine Schulz, Elsa Wiame, Alexander Gheldof, Katherine O'Kane, Abbe Lai, Karen Sermon, Maia Proisy, Philippe Loget, Tania Attie-Bitach, Chloe Quelin, Ana Maria Fortuna, Ana Rita Soares, Arjan P. M. de Brouwer, Emile Van Schaftingen, Marie-Cecile Nassogne, Christopher A. Walsh, Katrien Stouffs, Paula Jorge, Anna C. Jansen, Francois Foulquier
Summary: This study reports on six individuals, including two fetuses, with bi-allelic pathogenic variants in MAN2C1 gene from four different families. These individuals exhibit dysmorphic features, congenital anomalies, and brain abnormalities. The pathogenicity of MAN2C1 variants is confirmed, and it is demonstrated that these variants lead to accumulation and delay in the processing of fOSs in cells.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoliang Liu, Hebo Zhang, Bijun Zhang, Jianqiao Tu, Xiaoming Li, Yanyan Zhao
Summary: The study showed that Nedd4-2 haploinsufficiency can increase susceptibility to seizures in mice, and impaired ubiquitination of the Kir4.1 channel may be related to this.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Cong Liu, Xing Gao, Ruo-Xi Shi, Ying-Ying Wang, Xuan-Cheng He, Hong-Zhen Du, Baoyang Hu, Jianwei Jiao, Chang-Mei Liu, Zhao-Qian Teng
Summary: This study aims to elucidate the role and mechanisms of microglial TGM2 in the brain. Deletion of microglial Tgm2 causes impaired synaptic pruning, reduced anxiety, and increased cognitive deficits in mice. At the molecular level, the phagocytic genes are significantly down-regulated in TGM2-deficient microglia. This study reveals a novel role of microglial TGM2 in regulating synaptic remodeling and cognitive function, indicating its essentiality for proper neural development.
CELL PROLIFERATION
(2023)
Article
Genetics & Heredity
Nika Schuermans, Salima El Chehadeh, Dimitri Hemelsoet, Jeremie Gautheron, Marie-Christine Vantyghem, Sonia Nouioua, Meriem Tazir, Corinne Vigouroux, Martine Auclair, Elke Bogaert, Sara Dufour, Fumiya Okawa, Pascale Hilbert, Nike Van Doninck, Marie-Caroline Taquet, Toon Rosseel, Griet De Clercq, Elke Debackere, Carole Van Haverbeke, Ferroudja Ramdane Cherif, Jon Andoni Urtizberea, Jean-Baptiste Chanson, Benoit Funalot, Francois-Jerome Authier, Sabine Kaya, Wim Terryn, Steven Callens, Bernard Depypere, Jo Van Dorpe, Arnaud V. Vanlander, Patrick Verloo, Paul J. Coucke, Bruce Poppe, Francis Impens, Noboru Mizushima, Christel Depienne, Isabelle Jeru, Bart Dermaut, Program Undiagnosed Dis UD PrOZA
Summary: This study identified homozygous loss-of-function variants in the PLAAT3 gene associated with a novel lipodystrophy syndrome and neurological features. The loss of PLAAT3 was found to cause a PPAR gamma-dependent defect in white adipose tissue differentiation and function.
Article
Physiology
Yohei Yamaguchi, Gentaro Iribe, Toshiyuki Kaneko, Ken Takahashi, Takuro Numaga-Tomita, Motohiro Nishida, Lutz Birnbaumer, Keiji Naruse
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Hideshi Ihara, Yuki Kakihana, Akane Yamakage, Kenji Kai, Takahiro Shibata, Motohiro Nishida, Ken-ichi Yamada, Koji Uchida
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Physiology
Takuro Numaga-Tomita, Sayaka Oda, Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura, Motohiro Nishida
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2019)
Review
Physiology
Tomohiro Tanaka, Akiyuki Nishimura, Kazuhiro Nishiyama, Takumi Goto, Takuro Numaga-Tomita, Motohiro Nishida
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Takuro Numaga-Tomita, Tsukasa Shimauchi, Sayaka Oda, Tomohiro Tanaka, Kazuhiro Nishiyama, Akiyuki Nishimura, Lutz Birnbaumer, Yasuo Mori, Motohiro Nishida
Article
Biochemistry & Molecular Biology
Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Takashi Toyama, Kazuhiro Nishiyama, Yasuhiro Shinkai, Takuro Numaga-Tomita, Daiju Yamazaki, Yasunari Kanda, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida
Article
Multidisciplinary Sciences
Suhaini Binti Sudi, Tomohiro Tanaka, Sayaka Oda, Kazuhiro Nishiyama, Akiyuki Nishimura, Caroline Sunggip, Supachoke Mangmool, Takuro Numaga-Tomita, Motohiro Nishida
SCIENTIFIC REPORTS
(2019)
Review
Cell Biology
Takuro Numaga-Tomita, Motohiro Nishida
Article
Multidisciplinary Sciences
Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada
Summary: This study constructed a library of 465 oxPCs using mass spectrometry and found that doubly oxygenated polyunsaturated fatty acid (PUFA)-PCs are generated in the early phase of acetaminophen-induced acute liver failure.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda
Summary: This study identified the highly expressed LPA receptor 3 in ALDH-positive TNBC cells and elucidated the regulatory role of the LPA-TRPC3 signaling axis in BCSCs. The findings provide important insights into potential therapeutic targets for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Summary: In this study, a long-acting Thioredoxin (Trx) was prepared by fusing human Trx with human serum albumin (HSA) and its efficacy in treating drug-induced heart failure was evaluated. The results showed that HSA-Trx administration suppressed the adverse effects of drug-induced cardiomyopathy, including heart weight decrease, myocardial fibrosis increase, and markers for myocardial damage. HSA-Trx also inhibited oxidative stress and inflammation, as well as the expression of myocardial atrophy factors. The findings suggest that HSA-Trx can improve the pathological condition associated with doxorubicin-induced cardiomyopathy.
Review
Pharmacology & Pharmacy
Yuri Kato, Kazuhiro Nishiyama, Akiyuki Nishimura, Takamasa Noda, Kaori Okabe, Takahiro Kusakabe, Yasunari Kanda, Motohiro Nishida
Summary: This article discusses the global research efforts and outcomes of drug repurposing for the treatment of COVID-19, and introduces a new protein-protein interaction that is common to COVID-19 aggravation and heart failure.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, Hitoshi Kurose, Sang Geon Kim, Yasuteru Urano, Takashi Ohshima, Motohiro Nishida
Summary: Inhibition of TRPC6 channel activity in vascular smooth muscle cells promotes blood flow recovery in peripheral artery disease. The drug 1-BP can inhibit this channel activity, leading to improved peripheral circulation and skeletal muscle mass. Additionally, 1-BP can increase vascular nitric oxide bioavailability and enhance blood flow recovery in patients with endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Kazuhiro Nishiyama, Kohei Ariyoshi, Akiyuki Nishimura, Yuri Kato, Xinya Mi, Hitoshi Kurose, Sang Geon Kim, Motohiro Nishida
Summary: Nonalcoholic steatohepatitis (NASH) is a disease characterized by inflammation and fibrosis that progresses from nonalcoholic fatty liver (NAFL). The study reveals that the P2Y(6) receptor (P2Y(6)R) is upregulated in NASH liver and positively correlates with the expression of CCL2 and Coll1a1. However, the functional deficiency of P2Y(6)R does not seem to affect the progression of liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Akiko Ogawa, Seiya Ohira, Yuri Kato, Tatsuya Ikuta, Shota Yanagida, Xinya Mi, Yukina Ishii, Yasunari Kanda, Motohiro Nishida, Asuka Inoue, Fan-Yan Wei
Summary: The antiviral drug remdesivir used for COVID-19 treatment has been found to have cardiovascular side effects, but the underlying mechanism was unclear. Through screening and modeling, researchers discovered that remdesivir acts as a selective, partial agonist for the UTS2R receptor, leading to cardiac malfunctions. Antagonizing UTS2R signaling was found to effectively attenuate the cardiac effects of remdesivir.
COMMUNICATIONS BIOLOGY
(2023)