Article
Biochemistry & Molecular Biology
Dan Wu, Hua Tan, Weijun Su, Dongmei Cheng, Guanwen Wang, Juan Wang, Ding A. Ma, George M. Dong, Peiqing Sun
Summary: The study identified MZF1 as a transcriptional factor that recruits CHD7 to the p16(INK4A) promoter, mediating oncogenic ras-induced senescence in primary human cells. Reduced MZF1 expression in some cancers is associated with poor patient survival, suggesting MZF1 may act as a tumor suppressor.
Article
Hematology
Charlotte Hellmich, Edyta Wojtowicz, Jamie A. Moore, Jayna J. Mistry, Aisha Jibril, Benjamin B. Johnson, James G. W. Smith, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth
Summary: The metabolism and function of hematopoietic progenitor cells (HPCs) are changed with aging, leading to impaired leukocyte response to infection. Additionally, aged mesenchymal stromal cells (MSCs) in the bone marrow niche exhibit a senescent phenotype, and targeting senescent MSCs can improve the mitochondrial function of HPCs when stressed with infection.
Article
Cell Biology
Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Liu
Summary: The Telomerase RNA component (TERC) knockout leads to p53-dependent premature replicative senescence and apoptosis of pulmonary stem cells, which can be significantly reduced by p53 deficiency. These findings demonstrate the association between TERC deficiency-induced telomere DDR and pulmonary aging.
Article
Biochemistry & Molecular Biology
Boshi Wang, Marta Varela-Eirin, Simone M. Brandenburg, Alejandra Hernandez-Segura, Thijmen van Vliet, Elisabeth M. Jongbloed, Saskia M. Wilting, Naoko Ohtani, Agnes Jager, Marco Demaria
Summary: Cellular senescence is a state of stable growth arrest that is desired in tumor suppressive interventions. Treatment with anti-cancer drugs can cause premature senescence of non-malignant cells. However, exposure to CDK4/6 inhibitors induces a senescence-like program in non-malignant cells without the negative effects observed in therapy-induced senescent cells.
Article
Oncology
Wei Zhao, Huanye Mo, Runkun Liu, Tianxiang Chen, Nan Yang, Zhikui Liu
Summary: KAT6A is upregulated in hepatocellular carcinoma (HCC) tissues and cell lines and is associated with malignant prognostic features and shorter survival. It acetylates lysine 23 of histone H3 (H3K23), enhances the association between the nuclear receptor binding protein TRIM24 and H3K23ac, and activates the transcription and expression of SOX2, leading to HCC tumorigenesis.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Moriyah Naama, Moran Rahamim, Valery Zayat, Shulamit Sebban, Ahmed Radwan, Dana Orzech, Rachel Lasry, Annael Ifrah, Mohammad Jaber, Ofra Sabag, Hazar Yassen, Areej Khatib, Silvina Epsztejn-Litman, Michal Novoselsky-Persky, Kirill Makedonski, Noy Deri, Debra Goldman-Wohl, Howard Cedar, Simcha Yagel, Rachel Eiges, Yosef Buganim
Summary: Researchers have discovered that GATA3, OCT4, KLF4, and MYC (GOKM) combination can generate functional human trophoblast stem cells (hiTSCs) from fibroblasts without the need for pluripotency. Through transcriptomic analysis, H3K4me2 deposition, and chromatin accessibility, it was found that GOKM exerts greater chromatin opening activity compared to OSKM. Additionally, GOKM efficiently generates hiTSCs from fibroblasts that lack pluripotency genes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jingkun Zeng, Stephanie A. Hills, Eiko Ozono, John F. X. Diffley
Summary: Whole-genome duplication (WGD) is a frequent event in cancer evolution, and the p53 tumor suppressor plays a dual role in this process. It can act as a barrier to WGD by blocking the proliferation of tetraploid cells, but it can also promote mitotic bypass, a key step in WGD. In wild-type p53 tumors, WGD is often associated with activation of the E2F pathway, particularly the amplification of CCNE1. High expression of cyclin E1 causes replicative stress, leading to G2 phase arrest. p53, along with its downstream target p21 and Wee1, inhibits mitotic cyclin-dependent kinase activity, activating APC/CCdh1 and promoting mitotic bypass.
Article
Oncology
Garrett L. Ruff, Kristin E. Murphy, Zachary R. Smith, Paula M. Vertino, Patrick J. Murphy
Summary: Chromatin patterns can stratify tumors based on cancer subtype and disease progression. Differences in DNA motifs for the transcription factor FOXA1 are significant in hormone receptor-positive tumors, while motifs for SOX9 are different in Basal-like tumors.
Article
Biochemistry & Molecular Biology
Tobias Friedrich, Francesca Ferrante, Leo Pioger, Andrea Nist, Thorsten Stiewe, Jean-Christophe Andrau, Marek Bartkuhn, Benedetto Daniele Giaimo, Tilman Borggrefe
Summary: The study investigates the role of transcription factor RBPJ in the Notch signaling pathway. It is found that RBPJ not only participates in the Notch co-activator complex, but also functions as a repressor, playing a crucial role in regulating Notch target genes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Jia-Yun Chen, Clemens Hug, Jose Reyes, Chengzhe Tian, Luca Gerosa, Fabian Frohlich, Bas Ponsioen, Hugo J. G. Snippert, Sabrina L. Spencer, Ashwini Jambhekar, Peter K. Sorger, Galit Lahav
Summary: Oncogene-induced senescence is a phenomenon where abnormal oncogene expression leads to non-proliferative state in non-transformed cells. The heterogeneity in cellular response during oncogenic induction remains unclear. However, our study on human epithelial cells revealed that a narrow range of BRAFV600E expression resulted in a wide range of downstream ERK activities, which displayed a non-monotonic relationship with proliferation. We identified four distinct ERK response classes that together contribute to ERK-proliferation response and generation of heterogeneity.
Article
Multidisciplinary Sciences
Yuanhui Liu, Nancy G. Azizian, Delaney K. Sullivan, Yulin Li
Summary: The mTOR pathway is identified as a determinant of chemosensitivity, and inhibition of mTOR promotes the persistence of a chemotherapy-resistant cancer-cell subpopulation. Activation of the mTOR pathway increases chemosensitivity and predicts better survival among various human cancers.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Hong Zhang, Qin Yuan Huo, Yi Qin Gao
Summary: Research has found that protein gH1 has a sequence-dependent binding with DNA, leading to conformational changes in nucleosomes and affecting their compaction and accessibility of core histones. This finding is important for understanding gene regulation signals.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Neurosciences
Hanyi Chen, Alexandra Young, Neil P. Oxtoby, Frederik Barkhof, Daniel C. Alexander, Andre Altmann
Summary: This study examines the generalisability of data-driven Alzheimer's disease (AD) progression models using the SuStaIn algorithm. The results show consistent subtypes of atrophy in both datasets and high consistency in individuals' subtypes and stage assignments. The study also reveals associations between AD atrophy subtypes and risk factors.
Article
Oncology
Anna Strzeszewska-Potyrala, Karolina Staniak, Joanna Czarnecka-Herok, Mahmoud-Reza Rafiee, Marcin Herok, Grazyna Mosieniak, Jeroen Krijgsveld, Ewa Sikora
Summary: The study identified ZNF84 as a critical regulator of senescence in p53-mutated tumors, showing that its knock-down inhibited p21 expression and increased proliferation, while also reducing genotoxic effects of doxorubicin. Additionally, ZNF84 deficiency was associated with changes in transcriptomic profiles and lower survival rates in colon cancer patients, suggesting its potential as a target for novel therapies in p53-null cancers.
Article
Oncology
Rackhyun Park, Minsu Jang, Yea-In Park, Yeonjeong Park, Sim Namkoong, Jin Lee, Junsoo Park
Summary: This study demonstrates that elevated levels of CTRP1 in obesity significantly contribute to tumor progression, potentially by regulating the tumor suppressor p53. The molecular mechanisms linking obesity with cancer remain largely uninvestigated.
Review
Obstetrics & Gynecology
Julien Bouckenheimer, Said Assou, Sebastien Riquier, Cyrielle Hou, Nicolas Philippe, Caroline Sansac, Thierry Lavabre-Bertrand, Therese Commes, Jean-Marc Lemaitre, Anthony Boureux, John De Vos
HUMAN REPRODUCTION UPDATE
(2017)
Article
Multidisciplinary Sciences
Juan Carlos Rivera-Mulia, Romain Desprat, Claudia Trevilla-Garcia, Daniela Cornacchia, Helene Schwerer, Takayo Sasaki, Jiao Sima, Tyler Fells, Lorenz Studerc, Jean-Marc Lemaitre, David M. Gilbert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Eduardo Fernandez-Rebollo, Birgit Mentrup, Regina Ebert, Julia Franzen, Giulio Abagnale, Torsten Sieben, Alina Ostrowska, Per Hoffmann, Pierre-Francois Roux, Bjoern Rath, Michele Goodhardt, Jean-Marc Lemaitre, Oliver Bischof, Franz Jakob, Wolfgang Wagner
SCIENTIFIC REPORTS
(2017)
Article
Infectious Diseases
Sara Salinas, Orianne Constant, Caroline Desmetz, Jonathan Barthelemy, Jean-Marc Lemaitre, Ollivier Milhavet, Nicolas Nagot, Vincent Foulongne, Florence E. Perrin, Juan-Carlos Saiz, Sylvie Lecollinet, Philippe Van de Perre, Yannick Simonin
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Cell Biology
Juan Carlos Rivera-Mulia, Helene Schwerer, Emilie Besnard, Romain Desprat, Claudia Trevilla-Garcia, Jiao Sima, Paul Bensadoun, Anissa Zouaoui, David M. Gilbert, Jean-Marc Lemaitre
Article
Multidisciplinary Sciences
Julien Bouckenheimer, Patricia Fauque, Charles-Henri Lecellier, Celine Bruno, Therese Commes, Jean-Marc Lemaitre, John De Vos, Said Assou
SCIENTIFIC REPORTS
(2018)
Editorial Material
Cell & Tissue Engineering
Vincent Gatinois, Romain Desprat, Fabienne Becker, Lydiane Pichard, Florence Bernex, Carole Corsini, Franck Pellestor, Jean-Marc Lemaitre
STEM CELL RESEARCH
(2019)
Article
Cell & Tissue Engineering
Lydiane Pichard, Jean-Marc Brondelo, Fabienne Becker, Romain Desprat, Frederic De Ceuninck, Philippe Pastoureau, Danielle Noel, Christian Jorgensen, Jean-Marc Lemaitre
STEM CELL RESEARCH
(2020)
Article
Cell & Tissue Engineering
Vincent Gatinois, Romain Desprat, Fabienne Becker, Lydiane Pichard, Florence Bernex, Bertrand Isidor, Franck Pellestor, Jean-Marc Lemaitre
STEM CELL RESEARCH
(2020)
Article
Cell & Tissue Engineering
Said Assou, Nicolas Girault, Mathilde Plinet, Julien Bouckenheimer, Caroline Sansac, Marion Combe, Joffrey Mianne, Chloe Bourguignon, Mathieu Fieldes, Engi Ahmed, Therese Commes, Anthony Boureux, Jean-Marc Lemaitre, John De Vos
Article
Biochemistry & Molecular Biology
Satish Sati, Boyan Bonev, Quentin Szabo, Daniel Jost, Paul Bensadoun, Francois Serra, Vincent Loubiere, Giorgio Lucio Papadopoulos, Juan-Carlos Rivera-Mulia, Lauriane Fritsch, Pauline Bouret, David Castillo, Josep L. Gelpi, Modesto Orozco, Cedric Vaillant, Franck Pellestor, Frederic Bantignies, Marc A. Marti-Renom, David M. Gilbert, Jean-Marc Lemaitre, Giacomo Cavalli
Article
Cell & Tissue Engineering
Vincent Gatinois, Romain Desprat, Lydiane Pichard, Fabienne Becker, Alice Goldenberg, Xavier Balguerie, Franck Pellestor, Jean-Marc Lemaitre
STEM CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Anaelle Bailly, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Cell reprogramming techniques, including RNA-based strategies, have shown great potential in treating various diseases and improving healthspan and longevity.
Article
Biochemistry & Molecular Biology
Giuseppe Fusi, Michael Constantinides, Christina Fissoun, Lydiane Pichard, Yves-Marie Pers, Rosanna Ferreira-Lopez, Veronique Pantesco, Christophe Poulet, Olivier Malaise, Dominique De Seny, Jean-Marc Lemaitre, Christian Jorgensen, Jean-Marc Brondello
Summary: Senescent cells play a role in tissue degeneration and contribute to age-related diseases such as osteoarthritis. This study investigates how the senescence-driven microenvironment affects the fate of MSCs and contributes to the progression of osteoarthritis.