期刊
NATURE COMMUNICATIONS
卷 1, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms1151
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资金
- DOD [W81XWH-04-1-0657]
- NIH [CA110104]
- NSF [CHE-0840438]
- Camille and Henry Dreyfus Teacher-Scholar Award
- UPenn Chemistry Department
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0820996] Funding Source: National Science Foundation
Cryptophane-A, comprised of two cyclotriguaiacylenes joined by three ethylene linkers, is a prototypal organic host molecule that binds reversibly to neutral small molecules via London forces. Of note are trifunctionalized, water-soluble cryptophane-A derivatives, which exhibit exceptional affinity for xenon in aqueous solution. In this paper, we report high-resolution X-ray structures of cryptophane-A and trifunctionalized derivatives in crown-crown and crown-saddle conformations, as well as in complexes with water, methanol, xenon or chloroform. Cryptophane internal volume varied by more than 20% across this series, which exemplifies 'induced fit' in a model host-guest system.
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