Article
Biochemistry & Molecular Biology
Fang Zhang, Yong Li, Lipeng Gan, Xiaomei Tong, Dandan Qi, Qihui Wang, Xin Ye
Summary: The study identified lncRNA MAFG-AS1 as upregulated in HBV-related HCC tissues, leading to enhanced proliferation and migration of HCC cells, suggesting its potential oncogenic role in HBV-related HCC development.
Article
Agriculture, Dairy & Animal Science
S. Bi, J. Zhang, L. Zhang, K. Huang, J. Li, L. Cao
Summary: A recent study found that yeast cell wall product (YP) can enhance the immune responses in chickens immunized with NDV vaccine. The study investigated the cell-mediated immune responses elicited by NDV and YP in commercial broilers. The results showed that YP increased the concentration of certain immune factors in the blood and promoted lymphocyte proliferation. The study also found upregulated gene expression in the spleen and jejunum.
Article
Biochemistry & Molecular Biology
Olivia J. J. Scully, Sukanya Shyamasundar, Ken Matsumoto, S. Thameem Dheen, George W. W. Yip, Boon Huat Bay
Summary: Breast carcinoma is the most prevalent cancer in women globally, and its development and progression involve complex genetic and molecular mechanisms. Challenges such as metastasis and drug resistance limit the prognosis of breast cancer, leading to the constant search for better treatment regimes and novel molecular therapeutic targets. C1QBP, a promising molecular target, has been implicated in breast carcinogenesis. This study demonstrates the role of C1QBP in breast cancer progression, specifically in cancer cell growth, and highlights its potential as a target for future breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ka Ming Wong, Jiaxing Song, Yung H. Wong
Summary: Nm23-H1 is a metastasis suppressor protein whose expression is regulated by transcription factors like CTCF and EGR1, potentially affecting the invasion and metastasis of breast cancer.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xinbao Zhang, Yuting Li, Junxiang Ji, Xin Wang, Meng Zhang, Xiangfen Li, Yan Zhang, Zhenhua Zhu, Shou-Dong Ye, Xiaoxiao Wang
Summary: The study demonstrates that Gadd45 family genes play a role in regulating differentiation of mouse ESCs, with Gadd45g activating the MAPK signaling pathway. Additionally, GADD45G functions as a suppressor in human breast cancers, effectively limiting tumor formation and metastasis.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Amandine Alard, Olga Katsara, Tiffany Rios-Fuller, Columba de la Parra, Ugur Ozerdem, Amanda Ernlund, Robert J. Schneider
Summary: Cancer cell plasticity enables cell survival and fate transitions, such as epithelial-to-mesenchymal transition (EMT), which are essential for invasion and metastasis. The DAP5/eIF3d complex plays a crucial role in metastasis, EMT, and tumor directed angiogenesis by selectively translating mRNAs encoding EMT transcription factors, cell migration integrins, metalloproteinases, and cell survival and angiogenesis factors. These findings reveal a surprising level of plasticity in mRNA translation during cancer progression and metastasis.
Article
Cell Biology
Yu Wang, Liming Zhu, Mei Guo, Gang Sun, Kun Zhou, Wenjing Pang, Dachun Cao, Xin Tang, Xiangjun Meng
Summary: The study demonstrated that WHSC1 plays a crucial role in regulating tumorigenesis and chemosensitivity in colorectal cancer through histone modification. Reduction of WHSC1 enhances apoptosis in colon cancer cells and improves chemosensitivity. Targeting WHSC1 and H3K36me2 modification could potentially disrupt CRC progression and overcome chemotherapeutic resistance.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Oncology
Zhili Chu, Sihui Yang, Qianru Li, Jianing Shang, Zilong Ren, Feng Ren
Summary: This study found that Newcastle disease virus (NDV) can inhibit tumor cell proliferation and kill cancer cells. The nonstructural V protein of NDV can regulate viral replication, but its contribution to NDV oncolysis is unclear. The expression of V protein was found to promote the proliferation of HepG2 cells, and transcriptome sequencing revealed changes in the expression/activation of multiple cell proliferation-related genes/signaling pathways in cells overexpressing the V protein. The MAPK and WNT signaling pathways were selected for verification, and blocking these pathways attenuated the promotion of cell proliferation by the V protein.
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Hoa-Jan Lei, Sheng-Yu Wang, Ivy Yenwen Chau, Anna Fen-Yau Li, Yat-Pang Chau, Cheng-Yuan Hsia, Shu-Cheng Chou, Yi-Chu Kao, Gar-Yang Chau
Summary: In patients with hepatocellular carcinoma, HURP expression was found to be associated with certain clinicopathologic features, but not post-resection survival, while Ki-67 expression was identified as an independent prognostic factor for survival. The impact of HURP activity on HCC growth, invasion, and post-resection outcomes in actual patients may be less significant than previously suggested by experimental studies.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Cell Biology
Luiza Steffens Reinhardt, Xiajie Zhang, Kira Groen, Brianna C. Morten, Geoffry N. De Iuliis, Antony W. Braithwaite, Jean-Christophe Bourdon, Kelly A. Avery-Kiejda
Summary: This study found that the response of breast cancer cells to DNA-damaging therapies in standard care is dependent on the expression of p53 isoforms. A high Delta 40p53:p53 alpha ratio causes cells to respond differently to doxorubicin and cisplatin treatments, increasing resistance to doxorubicin and promoting DNA repair, thereby impairing the cells' normal response.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Qin Huo, Siqi Chen, Zhenwei Li, Juan Wang, Jiaying Li, Ni Xie
Summary: The study found that TACC3 is highly expressed in breast cancer tissues and positively correlated with clinical features, potentially serving as a diagnostic indicator. Inhibition of TACC3 promotes cell proliferation and viability of breast cancer cells, while also impacting cell migration. Overall, TACC3 may serve as a prognostic and therapeutic indicator of breast cancer.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Marian Kalocsay, Matthew J. Berberich, Robert A. Everley, Maulik K. Nariya, Mirra Chung, Benjamin Gaudio, Chiara Victor, Gary A. Bradshaw, Robyn J. Eisert, Marc Hafner, Peter K. Sorger, Caitlin E. Mills, Kartik Subramanian
Summary: Quantitative proteomics was performed on 60 human-derived breast cancer cell line models, resulting in the identification and characterization of subtypes of breast cancer. The datasets were found to conform to known transcriptional subtypes and are freely available for public use. These datasets can be used in combination with other measurements to predict drug response, provide context in signaling pathway models, and identify markers of sensitivity or resistance to therapeutics.
Article
Medicine, Research & Experimental
Junfeng Wang, Quanyi Wang, Yinan Guan, Yulu Sun, Xiaozhi Wang, Kaylie Lively, Yuzhen Wang, Ming Luo, Julian A. Kim, E. Angela Murphy, Yongzhong Yao, Guoshuai Cai, Daping Fan
Summary: The expression of miR-155 in breast cancer cells is associated with a favorable antitumor immune profile and better patient outcomes. Overexpression of miR-155 in breast cancer cells enhances T cell influx, delays tumor growth, and increases sensitivity to immune checkpoint blockade therapy. The mechanism involves upregulation of CXCL9/10/11 production mediated by SOCS1 inhibition and increased phosphorylated STAT1/STAT3 ratios. Serum miR-155 levels in breast cancer patients correlate with tumor miR-155 levels and tumor immune status.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Jiqiao Yang, Tao He, Yunhao Wu, Zhoukai Fu, Qing Lv, Shan Lu, Xiaodong Wang, Hongjiang Li, Jing Wang, Jie Chen
Summary: This study evaluated the feasibility and accuracy of nanoparticle-assisted axillary staging (NAAS) in breast cancer patients who converted to ycN0 after neoadjuvant chemotherapy. The results showed that NAAS achieved a better balance between accurate axillary evaluation and less intervention.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Neurosciences
Yuan-Bo Pan, Yiyu Sun, Hong-Jiang Li, Lai-Yang Zhou, Jianmin Zhang, Dong-Fu Feng
Summary: This study provides deeper insights into the function of glial cells in axonal regeneration after injury by comprehensively analyzing the molecular changes using transcriptome analysis. Weighted gene coexpression network analysis identified hub genes that may serve as potential therapeutic targets. Furthermore, the analysis of changes in different glial cell subtypes based on subtype markers revealed time-dependent transition trends, offering clues for modulating glial function in future research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Surgery
Xiaorong Zhong, Ping He, Jie Chen, Xi Yan, Bin Wei, Zhang Zhang, Hong Bu, Jing Li, Tinglun Tian, Qing Lv, Xiaodong Wang, Hongjiang Li, Jing Wang, Juan Huang, Jiaojiao Suo, Xiaoxiao Liu, Hong Zheng, Ting Luo
Summary: The study demonstrates that neoadjuvant pyrotinib plus trastuzumab and albumin-bound paclitaxel effectively promoted total pathological complete response in women with human epidermal growth factor receptor 2-positive early or locally advanced breast cancer. Total pathological complete response rate was 57.1% and objective response rate was 100%, indicating promising efficacy of the treatment regimen.
Article
Medicine, General & Internal
Hongjiang Li, Yannan Ren, Jianxiang Yan, Meiling Huang, Bolin Zheng, Xiangmin Luo, Suzhen Huang, Siqing Cai
Summary: This real-world study retrospectively analyzed 1,053 infertile patients who underwent HSG using ethiodized poppy seed oil. The study found that ethiodized poppy seed oil displayed a satisfying fertility outcome in infertile patients with a tolerable safety profile. The effect of the treatment may be influenced by BMI, history of dysmenorrhea, and paternal abnormity of sperm.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Yifei Huang, Wenhui Zhang, Huiling Xiang, Yanna Liu, Lili Yuan, Liyao Zhang, Shengjuan Hu, Dongli Xia, Jia Li, Min Gao, Xing Wang, Xingsi Qi, Lijun Peng, Ying Song, Xiqiao Zhou, Jing Zeng, Xiaoyan Tan, Mingming Deng, Haiming Fang, Shenglin Qi, Song He, Yongfeng He, Bin Ye, Wei Wu, Tong Dang, Jiangbo Shao, Wei Wei, Jianping Hu, Xin Yong, Chaohui He, Jinlun Bao, Yuening Zhang, Guo Zhang, Rui Ji, Yang Bo, Wei Yan, Hongjiang Li, Yanling Wang, Mengmeng Li, Fengmei Wang, Jia Lian, Chang'en Liu, Ping Cao, Zhenbei Liu, Aimin Liu, Lili Zhao, Shuang Li, Yunhai Wu, Ye Gu, Yan Wang, Yanfei Fang, Pan Jiang, Bin Wu, Chuan Liu, Xiaolong Qi
Summary: This study compared the outcomes of emergency endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) in cirrhotic patients with acute esophageal variceal bleeding (EVB). The results showed that both EIS and EVL were efficient strategies for the treatment of acute EVB, with EIS being a cost-effective option.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Zhi-Yun Yu, Hong-Jiang Li, Meng Wang, Wen-Zheng Luo, Ya-Ke Xue
Summary: This study found a significant correlation between GDNF expression and RET/ERK signaling and SREBP-1 expression in glioma cells. Inhibition of GDNF activity downregulated SREBP-1 expression and lipogenic gene transcription, and reduced glioma cell proliferation.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Engineering, Geological
Hongjiang Li, Shuji Tamura
Summary: This paper presents a comparative study on the behavior of partially head-restrained piles and compares the lateral performance of new piles affected by pile-head restraints with that of single piles in virgin sites. The paper discusses the intrinsic correlation between the lateral pile capacity and the factor linking partially head-restrained piles to pure free- and fixed-head piles, and also derives analytical models for the correlation between pile-head restraint percentage and pile capacity. The proposed method is validated using numerical and literature examples, highlighting its advantages in determining the lateral pile capacity considering head restraints.
Article
Chemistry, Physical
Pu Wu, Jin Wen, Yurui Wang, Zhou Liu, Renxing Lin, Hongjiang Li, Haowen Luo, Hairen Tan
Summary: This study successfully developed thermally stable mixed lead-tin NBG perovskite solar cells (PSCs) by using only formamidinium (FA) for the A-site cation. Solution-processed indium tin oxide nanocrystals (ITO NCs) were deployed to replace the organic charge transport layer, simplifying the architecture of all-perovskite tandem devices. With optimized tunnel junction and thermally stable all-FA NBG perovskite, a high power conversion efficiency (PCE) of 26.3% was achieved in all-perovskite tandems, demonstrating the efficiency and thermal stability of these solar cells.
ADVANCED ENERGY MATERIALS
(2022)
Article
Multidisciplinary Sciences
Hongjiang Li, Liang Han, Donglin Dong
Summary: This paper studies the method of monitoring water-conducting fractured zones in a rock mass using an adaptive filtering algorithm. By filtering the signals after wavelet packet decomposition, low-frequency interference can be effectively suppressed. Simulation results show that this method can improve the signal-to-noise ratio and reduce the root-mean-square error. The application of field data also proves the feasibility of this method.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Quanyi Long, Feilong Zhao, Hongjiang Li
Summary: Second primary malignancy (SPM) is common in breast cancer (BC). This study found that SPM predominantly occurs in the breast and in patients with HER2(-)/HR(+) subtype, significantly affecting survival rates. Clinical features can partially predict the occurrence of SPM, suggesting the need for screenings in postmenopausal elderly patients, especially those with HER2(-)/HR(+) subtype.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xin Luo, Haowen Luo, Hongjiang Li, Rui Xia, Xuntian Zheng, Zilong Huang, Zhou Liu, Han Gao, Xueling Zhang, Songlin Li, Zhiqiang Feng, Yifeng Chen, Hairen Tan
Summary: An anion-engineered additive strategy is developed to control the crystallization process of wide-bandgap perovskite films on industrially textured silicon, resulting in improved film crystallinity and reduced trap density. This strategy enables the fabrication of 28.6%-efficient perovskite/silicon tandem solar cells, which retain over 80% of their initial performance after 2000 hours of operation under full 1-sun illumination.
ADVANCED MATERIALS
(2023)
Article
Environmental Sciences
Ruisi Huang, Hongyu Cao, Ting Huang, Hongjiang Li, Qian Tang, Lihao Wang, Xuefang Zheng
Summary: The abuse of fluoroquinolones antibiotics causes resistance and pollution. This study investigates the photodegradation mechanisms and environmental factors affecting the degradation of fleroxacin. Six possible photodegradation reaction paths were proposed and simulated. The main reactions involve the departure of the piperazine ring and the substitution of fluorine atom. Factors such as pH and substances like NaN3 and Ca2+ were found to influence the photodegradation process.
Article
Chemistry, Inorganic & Nuclear
Hongjiang Li, Lixu Xie, Zhi Tan, Jie Xing, Xu Li, Hao Chen, Fei Wang, Manjing Tang, Jianguo Zhu, Yuan Cheng
Summary: This study suggests a simple approach to achieve excellent piezoelectric performances in potassium sodium niobate (KNN)-based ceramics by optimizing the content of nonstoichiometric Nb5+. Excessive Nb5+ significantly influences the microstructural features and electrical properties of the ceramics, improving their temperature stability. The results show that a high Curie temperature (TC), large electromechanical coupling factor (kp), and high piezoelectric constant (d33) can be simultaneously obtained in the KNN-based ceramics with nonstoichiometric Nb5+.
INORGANIC CHEMISTRY
(2022)
Article
Medicine, General & Internal
Yunhao Wu, Yana Qi, Jiqiao Yang, Ruoning Yang, Weijing Lui, Ya Huang, Xin Zhao, Ruixian Chen, Tao He, Shan Lu, Zhu Wang, Hongjiang Li, Xin Sun, Qintong Li, Li Zhou, Jie Chen
Summary: This study found that chemotherapy may improve the prognosis of elderly breast cancer patients, especially for certain subpopulations that benefit more from chemotherapy treatment.
JOURNAL OF EVIDENCE BASED MEDICINE
(2022)
Article
Energy & Fuels
Tiantian Li, Jian Xu, Renxing Lin, Sam Teale, Hongjiang Li, Zhou Liu, Chenyang Duan, Qian Zhao, Ke Xiao, Pu Wu, Bin Chen, Sheng Jiang, Shaobing Xiong, Haowen Luo, Sushu Wan, Ludong Li, Qinye Bao, Yuxi Tian, Xueping Gao, Jin Xie, Edward H. Sargent, Hairen Tan
Summary: Operating stability is a priority issue for all-perovskite tandem solar cells. Inorganic CsPbI3-xBrx perovskites show promise as alternatives due to their good photostability. By inserting a passivating dipole layer at the interface between organic transport layers and inorganic perovskite, the energetic mismatch is reduced and charge extraction is accelerated, resulting in improved efficiency.