Article
Biochemistry & Molecular Biology
Yung-Lung Chang, Yao-Feng Li, Chung-Hsing Chou, Li-Chun Huang, Yi-Ping Wu, Ying Kao, Chia-Kuang Tsai
Summary: Diosmin, a natural flavone glycoside, demonstrated inhibitory effects on GBM cell growth, migration, and invasion, as well as modulation of autophagy and cell cycle progression. It showed limited cytotoxicity towards astrocytes and holds potential for new GBM treatment therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bahram Bibak, Farzaneh Shakeri, Zakieh Keshavarzi, Hamid Mollazadeh, Hossein Javid, Mohammad Jalili-Nik, Thozhukat Sathyapalan, Amir R. Afshari, Amirhossein Sahebkar
Summary: Glioblastoma multiforme (GBM) is a typical malignant brain tumor with a grim outcome, but berberine, an isoquinoline alkaloid, may exert anticancer properties by regulating signaling pathways, suggesting its potential therapeutic role for GBM.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wenhui Jia, Hailong Tian, Jingwen Jiang, Li Zhou, Lei Li, Maochao Luo, Ning Ding, Edouard C. Nice, Canhua Huang, Haiyuan Zhang
Summary: This study presents a brain-targeted nanoplatform for glioblastoma multiforme (GBM) treatment, which manipulates autophagy and cuproptosis. The nanoplatform utilizes transferrin receptor-mediated active targeting and pH-responsive delivery to achieve site-specific delivery of regorafenib. By inhibiting autophagosome-lysosome fusion, regorafenib induces lethal autophagy arrest in GBM cells. Additionally, Cu2+ is utilized to facilitate the encapsulation of regorafenib and trigger cuproptosis, resulting in a synergistic effect with regorafenib against GBM.
Article
Oncology
Li-Jeng Chen, Tsai-Ching Hsu, Pei-Jung Yeh, Jia Le Yow, Chia-Ling Chang, Cheng-Hui Lin, Bor-Show Tzang
Summary: The extract of Wedelia chinensis showed significant inhibitory effects on the proliferation and invasion of glioblastoma cells, with differential effects observed on different cell lines. Additionally, the combination of luteolin and apigenin also significantly reduced cell survival and invasive capabilities in glioblastoma cells. Further research is needed to consider these as standard treatments for GBM.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Engineering, Chemical
Monika Paul-Samojedny, Emilia Liduk, Paulina Borkowska, Aleksandra Zielinska, Malgorzata Kowalczyk, Renata Suchanek-Raif, Jan Alojzy Kowalski
Summary: This study investigated the efficacy of celastrol and knockdown of miR-9-2, miR-17, and miR-19 genes in human glioblastoma cells. The combination treatment resulted in reduced cell viability and proliferation, altered cell cycle distribution, and induced apoptosis and autophagy. The mechanism of action appeared to differ for each miRNA knockdown. Silencing the overexpressed miR genes could be an important strategy for developing more effective treatments for glioblastoma.
Review
Oncology
Margarita Kamynina, Salome Tskhovrebova, Jawad Fares, Peter Timashev, Anastasia Laevskaya, Ilya Ulasov
Summary: Glioblastoma (GBM) is the most common and aggressive brain tumor with limited therapeutic options. Gene therapies using self-replicating oncolytic viruses may advance GBM treatment. Autophagy in glioblastoma plays a dual role in cell death and survival.
Article
Biochemistry & Molecular Biology
Monika Paul-Samojedny, Emilia Liduk, Malgorzata Kowalczyk, Paulina Borkowska, Aleksandra Zielinska, Renata Suchanek-Raif, Jan Kowalski
Summary: This study examined the efficacy of combining baicalin (BAI) and knockdown of miR-148a gene in human glioblastoma T98G and U87MG cell lines. The results showed that this combination can effectively inhibit cell proliferation and induce apoptosis and autophagy. This suggests that the knockdown of miR-148a gene in combination with baicalin may be a novel therapeutic strategy for glioblastoma.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Review
Cell Biology
Nadia Al-Sammarraie, Swapan K. Ray
Summary: CRISPR-Cas9 genome editing is crucial in elucidating the genetic regulators of GBM, particularly in vitro systems for identifying novel transcriptional regulators, while in vivo research requires further exploration.
Article
Oncology
Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu, Qing Liu
Summary: CRNDE is a poor prognosis factor for GBM patients, upregulated in TMZ-resistant patients, and closely associated with chemotherapeutic response to TMZ treatment. Knockdown of CRNDE significantly reduces glioma cell viability and proliferation, enhances cell apoptosis, and improves sensitivity to TMZ treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Youngik Yoon, Chae Rin Yoo, Eun Chae Kim, Jaehwan Han, Keejung Yoon
Summary: This study investigates the role of the gene STAC1 in glioblastoma cell invasion and survival. It is found that STAC1 overexpression promotes invasion and inhibits apoptosis, while knockdown of STAC1 has the opposite effect. The study also reveals that STAC1 regulates AKT and calcium channel signaling in glioblastoma cells. These findings provide valuable insights into the pathogenic roles of STAC1 in high-grade glioblastoma and highlight its potential as a promising therapeutic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Review
Biochemistry & Molecular Biology
Amanda J. Manea, Swapan K. Ray
Summary: Glioblastoma is the most common primary brain tumor in adults, with a dismal prognosis and limited treatment advancements in recent years. Therapies focusing on modulation of autophagy have been developed, leading to controversy between autophagy inhibition and promotion as strategies to control glioblastoma growth.
Article
Biology
Kanglei Zhang, Wenxuan Dong, Jiahui Li, Zhonggui Gong, Wenjing Liu, Shuangjiang He, Hui Zou, Ruilong Song, Gang Liu, Zongping Liu
Summary: This study investigated the effects of Cadmium (Cd) on quail kidney injury and the protective effect of Honokiol (HKL) on Cd-induced nephrotoxicity. The results showed that Cd caused significant changes in growth performance, kidney histopathology, antioxidant enzymes, and other parameters, while HKL treatment alleviated oxidative stress and improved kidney function.
Article
Cell Biology
Jia Shi, Xuchen Dong, Haoran Li, Haiyang Wang, Qianqian Jiang, Liang Liu, Liping Wang, Jun Dong
Summary: The study found that nicardipine can enhance the toxic effect of temozolomide against GSCs, promote apoptosis of GSCs, and inhibit autophagy. These effects are related to the activation of mTOR, and the selective inhibition of mTOR by rapamycin can weaken the sensitization of nicardipine to temozolomide.
Article
Clinical Neurology
Ce Wang, Zehao Cai, Yue Huang, Xinrui Liu, Xing Liu, Feng Chen, Wenbin Li
Summary: This article reports an efficient and safe response to three phases of treatment with liposomal honokiol in a patient with recurrent glioblastoma, suggesting its potential as a potent and safe anticancer agent.
FRONTIERS IN NEUROLOGY
(2023)