Article
Oncology
Chun-Ming Li, Jie Zhang, Wu Wu, Zhu Zhu, Feng Li, Di Wu, Xiao-Jun Wang, Chuan-Ming Xie, Jian-Ping Gong
Summary: This study investigated the biological function and potential mechanism of FBXO43 in hepatocellular carcinoma (HCC). The results showed that FBXO43 was upregulated in HCC patient tissues and correlated with poor clinicopathological features. Knockdown of FBXO43 inhibited HCC cell proliferation, migration, and epithelial-mesenchymal transition (EMT), which was mediated by its interaction with cyclin D1 (CCND1) and promotion of CCND1 stability. Targeting the FBXO43-CCND1 axis may provide a new potential strategy for HCC treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Xiao Dong, Zixin Liu, Encheng Zhang, Pingzhao Zhang, Yuqi Wang, Junjie Hang, Qi Li
Summary: The study reveals the significant role of USP39 in cancer, especially in hepatocellular carcinoma with a poor prognosis. Experimental evidence shows that USP39 promotes cell proliferation by regulating the deubiquitination process of SP1 protein, while the counteraction of SP1 can inhibit this effect.
CELLULAR SIGNALLING
(2021)
Article
Biotechnology & Applied Microbiology
Jieyun Sun, Xintian Chen, Xueying Ji, Sen Meng, Wenwen Wang, Pengfei Wang, Jin Bai, Zhongwei Li, Youguo Chen
Summary: TRIM21 expression is decreased in ovarian cancer patients and is associated with shorter survival. It inhibits cancer progression by suppressing cell migration, invasion, and proliferation. Therefore, TRIM21 may serve as a promising biomarker and therapeutic target for ovarian cancer.
Article
Oncology
Jie Sun, Zheng Dong, Zhengyao Chang, Hongfei Liu, Qiyu Jiang, Deyuan Zhang, Shanshan Lu, Xiaodong Jia, Dawei Wu, Aaron Ge, Pan Zhao, Jing Wang, Yinying Lu
Summary: The study found that the expression of MARCH6 was elevated in human HCC samples and was associated with poor prognosis. Over-expression of MARCH6 promoted cell growth and migration of HCC cells, while its knockdown suppressed these functions. Additionally, MARCH6-mediated up-regulation of ATF2 contributed to HCC development, suggesting MARCH6 may be a promising target for HCC diagnosis and treatment.
Article
Oncology
Qi Pan, Lu Wang, Yu Liu, Min Li, Yao Zhang, Wei Peng, Tan Deng, Mei-Ling Peng, Jin-Qiong Jiang, Jiao Tang, Jingjing Wang, Hua-Xin Duan, Sha-Sha Fan
Summary: The study revealed that knockdown of POLQ in hepatocellular carcinoma cells led to decreased proliferation and migration, increased apoptosis, and a higher percentage of cells in G2 phase. Xenografts in mice implanted with shPOLQ cells grew slower and expressed lower levels of Ki67 compared to shCtrl cells. Downstream signaling pathways related to apoptosis showed enhanced phosphorylation of HSP27 and JNK, while mTOR, PRAS40, ERK1/2, and STAT3 pathways were deactivated.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Libing Wang, Mingxin Cui, Daming Cheng, Fengzhi Qu, Jingkun Yu, Yanbin Wei, Ling Cheng, Xiaotang Wu, Xiaogang Liu
Summary: The study revealed that miR-9-5p is highly expressed in HCC cells while ESR1 is poorly expressed; overexpression of miR-9-5p can enhance cell proliferation, invasion, and migration; ESR1 is identified as a downstream target of miR-9-5p in HCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Yening Xiao, Jiamei Ma, Chunliu Guo, Danni Liu, Jing Pan, Xiaoxi Huang
Summary: This study demonstrates that silencing of the CCNB2 gene can inhibit tumor formation and proliferation in nude mice. CCNB2 may accelerate the proliferation and metastasis of hepatocellular carcinoma cells by increasing JAG1 expression.
Article
Oncology
Dawei Yuan, Rulan Ma, Tuanhe Sun, Kun Zhu, Chengxue Dang, Haixia Ye, Kang Li
Summary: The high expression of RSPH14 in hepatocellular carcinoma (HCC) is associated with poor prognosis. Knockdown of RSPH14 can inhibit cell proliferation, migration, and invasion, and promote apoptosis of HCC cells by inhibiting the expression of RelA. RSPH14 may be a potential new treatment target for HCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Mengxing Cai, Jingwen Luo, Chunxiu Yang, Xiaopeng Yang, Cheng Zhang, Lixin Ma, Yibin Cheng
Summary: The study found that ABHD12 is not only associated with the occurrence and development of liver hepatocellular carcinoma, but also with the resistance to Sorafenib. Knocking out ABHD12 can make liver cancer cells more sensitive to sorafenib-induced ferroptosis. The results of the study suggest that ABHD12 may be a potential target for the diagnosis, prognosis, and treatment of liver cancer.
Article
Medicine, Research & Experimental
Jing Yang, Xiujuan Zhang, Leilei Liu, Xin Yang, Qingfu Qian, Bin Du
Summary: The study revealed that c-Src can promote the growth and tumorigenesis of hepatocellular carcinoma cells by activating the Hippo signaling pathway. Additionally, the overexpression of c-Src was negatively correlated with patient survival, while downregulation of c-Src expression could inhibit the growth and migration of HCC cells.
Article
Cell Biology
Xiao-Wei Dang, Qi Pan, Zhen-Hai Lin, Hao-Hao Wang, Lu-Hao Li, Lin Li, Dong-Qi Shen, Pei-Ju Wang
Summary: This study confirmed that DEPDC1B knockdown restricts tumor growth in vitro and in vivo, and it interacts with CDK1, being a potential therapeutic target involved in HCC growth and progression. The results suggest that DEPDC1B plays a key role in HCC and may be a promising target for therapeutic interventions.
Article
Pharmacology & Pharmacy
X-M Zhu, L. Li, L-L Ren, L. Du, Y-M Wang
Summary: The study showed that SNHG17 was significantly upregulated in cancer regions of HCC, and its increased expression level was correlated with tumor size, TNM stage, and poor survival prognosis in HCC patients. Inhibition of SNHG17 significantly inhibited HCC cell proliferation, migration, and invasion, causing cell cycle arrest and apoptosis. These findings suggest that SNHG17 could be a potential therapeutic target for HCC treatment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yihui Ma, Wenwen Sun, Qiangnu Zhang, Bingfang Gao, Wen Cai, QinLiang Liu, Juan Liao, Xinli Wang
Summary: The study identified lncRNA BSG-AS1 as a novel hypoxia-responsive lncRNA in HCC, which promotes proliferation and migration by positively regulating BSG through enhancing mRNA stability. Overexpression of lncRNA BSG-AS1 and BSG are associated with poor prognosis in HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Chuan-jian Shi, Yan-biao Zheng, Fei-fei Pan, Feng-wei Zhang, Peng Zhuang, Wei-ming Fu
Summary: Gallic acid (GA) exerts anti-tumor effects on hepatocellular carcinoma (HCC) by suppressing the MALAT1-Wnt/beta-catenin signaling axis, suggesting its potential as a chemo-prevention and chemotherapy agent for HCC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Liang Ye, Xu Zhang, Peng Wang, Ying Zhang, Shujiao He, Yang Li, Shao Li, Kangyan Liang, Shuguang Liao, Yi Gao, Shuqing Zhou, Qing Peng
Summary: The low concentration of triphenyl phosphate (TPP) may exacerbate the proliferation, invasion, and migration of hepatocellular carcinoma (HCC) cells, acting as a risk factor in the progression of HCC.
ENVIRONMENTAL TOXICOLOGY
(2022)
