Article
Acoustics
David Q. Le, Virginie Papadopoulou, Paul A. Dayton
Summary: The study found that under certain parameters in therapeutic ultrasound, microbubble coalescence is likely to occur, generating bubbles much larger than those found in commercial contrast agents; however, in diagnostic contrast-enhanced ultrasound imaging, coalescence is unlikely to happen.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Acoustics
Alicia Clark, Sierra Bonilla, Dingjie Suo, Yeruham Shapira, Michalakis Averkiou
Summary: High-intensity focused ultrasound (HIFU) is a non-invasive tool approved for the treatment of various diseases. Studying the interaction between microbubble concentration and pressure amplitude in HIFU treatments can optimize treatment outcomes.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jide He, Zenan Liu, Xuehua Zhu, Haizhui Xia, Huile Gao, Jian Lu
Summary: This article reviews the research progress of ultrasound-mediated microbubble cavitation in the treatment of solid tumors, emphasizing its potential to reverse chemoresistance, improve efficacy sensitization response, and reduce adverse side effects.
Article
Biochemistry & Molecular Biology
Martynas Maciulevicius, Diana Navickaite, Sonam Chopra, Baltramiejus Jakstys, Saulius Satkauskas
Summary: Research has shown that different calcium concentrations affect cell membrane permeability and cell viability during sonoporation, with ultrasound-microbubble cavitation playing a significant role. The study also indicates that inertial cavitation activities are directly involved in calcium delivery via sonoporation, leading to rapid cell death.
Article
Acoustics
Cynthia D. Anderson, Chad B. Walton, Ralph V. Shohet
Summary: This study compared the effects of focused and unfocused UTMD for delivering reporter plasmids to the liver and heart in mice, finding optimal hepatic expression with double depth targeting and stronger cardiac expression with focused UTMD. The transfection patterns differed between the two approaches, with intense foci observed using focused UTMD. The study suggests that focused ultrasound presents a new frontier in UTMD-directed gene therapy, showing distinct cavitation mechanisms for both approaches.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Mechanical
Hossein Azizi Sormoli, Afsaneh Mojra, Ghassem Heidarinejad
Summary: High-intensity focused ultrasound (HIFU) has great potential in cancer treatment, but there are challenges in using acoustic energy to treat vascularized tumors, such as reduced treatment efficiency due to blood flow cooling. A novel strategy is proposed by injecting Levovist contrast agent solution in the vascularized tumor, which improves cancer treatment by considering the interaction between Levovist microbubbles and ultrasonic waves. The results show that MB oscillation increases temperature rise, advances irreversible damage, and expands the necrotic area, indicating the effectiveness of injecting Levovist contrast agent solution in reducing treatment time and avoiding multiple sonication.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yading Zhao, Dandan Shi, Lu Guo, Mengmeng Shang, Xiao Sun, Dong Meng, Shan Xiao, Xiaoxuan Wang, Jie Li
Summary: This study developed a novel acidity-responsive nanoscale ultrasound contrast agent, L-Arg@PTX nanodroplets, for co-delivery of paclitaxel and L-arginine. These nanodroplets exhibited uniform size and high drug loading efficiency, enabling good ultrasound diagnostic imaging capability and improved tumor aggregation. Combined with ultrasound targeted microbubble destruction (UTMD), the nanodroplets increased cellular reactive oxygen species, alleviating hypoxia and increasing cytotoxic T lymphocytes infiltration, and synergistically enhancing immunotherapy with PTX-induced immunogenic cell death.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lei Chen, Bingwan Dong, Liu Jiang, Jixin Zhang, Luzeng Chen, Tiancheng Li, Yuhong Shao, Xiuming Sun
Summary: SonoVue effectively demonstrated the lymphatic drainage region for all enrolled thyroid malignancies, with a sentinel lymph node detection rate of 96.77% and a diagnostic accuracy for lymph node metastasis of 86.67% and 91.67% in the central and lateral compartments, respectively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rachel Chapla, Katherine T. Huynh, Carolyn E. Schutt
Summary: Targeted delivery of therapeutics is crucial for reducing systemic toxicity and optimizing therapeutic efficacy. Ultrasound-controlled targeting is an externally-stimulated drug delivery strategy, using ultrasound waves to stimulate gas-filled microbubbles and deliver attached cargo to surrounding cells. The attachment of nanocarrier particles to microbubbles greatly enhances drug delivery capabilities.
Article
Engineering, Chemical
Martin P. Walsh, Rohan Tikekar, Nitin Nitin, Steven Wrenn
Summary: This study investigates the effectiveness of high-frequency ultrasound-induced microbubble cavitation on bacterial inactivation using liposomal bilayers as a model for bacterial cell membranes. The addition of a positive charge on micmbubbles increased their proximity to liposomes, but dampened microbubble's oscillation. Microstreaming from stable cavitation at 3.3 MHz led to approximately 19% mixing of phospholipids, while inertial cavitation at 1.0 MHz increased this mixing to 50%.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Martynas Maciulevicius, Mindaugas Tamosiunas, Diana Navickaite, Saulius Satkauskas, Mindaugas S. Venslauskas
Summary: In this study, the efficiency of delivering the anticancer drug doxorubicin into cells using cell sonoporation was investigated. The results showed that inertial cavitation is an efficient technique for the release and intracellular transfer of doxorubicin. Cell death caused by doxorubicin was related to intranuclear and extranuclear mechanisms as revealed by cell confocal imaging. The rate of forward scattering was found to have a high and significant correlation with doxorubicin delivery efficiency and cell viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Acoustics
Xiaoxiao Zhao, Alex Wright, David E. Goertz
Summary: Therapeutic focused ultrasound combined with encapsulated microbubbles have the ability to induce different bioeffects in the microvasculature. This study examines how the behavior and emissions of microbubbles change with different channel diameters and pressures. The results provide new insights into microbubble behavior in small vessels at higher pressures.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Seunghyun Lee, Hoyoon Jeon, Shinyong Shim, Maesoon Im, Jinsik Kim, Jung Hoon Kim, Byung Chul Lee
Summary: It has been demonstrated that unfocused ultrasound with microbubbles and an interchangeable acoustic lens can enhance drug delivery efficiency by overcoming the limitations of a narrow pressure field. A concave lens suitable for an ultrasound-phased array probe was designed to optimize microbubble destruction, leading to successful drug delivery enhancement in in vitro and animal experiments. This system shows promise in providing sufficient ultrasound irradiation to microbubbles for improved drug delivery effectiveness.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Mike Bismuth, Sharon Katz, Tamar Mano, Ramona Aronovich, Dov Hershkovitz, Agata A. Exner, Tali Ilovitsh
Summary: Scaling down the size of microbubble contrast agents to the nanometer level enables noninvasive cancer therapy, as nanobubbles can trigger potent mechanical effects in tumors under low frequency ultrasound. This approach provides a unique platform for safe, noninvasive, and low energy tumor mechanotherapy.
Article
Acoustics
Cong Li, Suling Hu, Yan Yue
Summary: This study investigated the effect of ultrasound microbubble-mediated VHL on ovarian cancer cells, revealing enhanced VHL expression, inhibited proliferation and migration, promoted apoptosis, and altered expression of proteins associated with cellular functions. Ultrasound microbubble technology increased VHL transfection efficiency and enhanced its biological impact on ovarian cancer cells.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
