Article
Chemistry, Medicinal
Neha Kalmankar, Hrudya Hari, Ramanathan Sowdhamini, Radhika Venkatesan
Summary: The study reveals that cyclotides from Clitoria ternatea have neuroprotective effects against Aβ-induced toxicity in transgenic Caenorhabditis elegans, delaying paralysis and improving chemotaxis defects. The protection is likely mediated by inhibiting Aβ oligomerization and reducing Aβ deposits, indicating cyclotides as a potential pharmacophore scaffold for neurodegenerative diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
S. Sreekala, Usha Devi Muraleedharan
Summary: This study identified a novel 8.5 kDa cationic peptide from C. ternatea seeds with significant antimicrobial activity against various pathogens and high antioxidant potential. The peptide showed resistance to pH and heat treatment, but was sensitive to protease. Mass spectrometry analysis revealed unique characteristics of this peptide, setting it apart from known cyclotides in C. ternatea. Insights have been gained into the functional characteristics of this novel cationic peptide, suggesting its potential for medicinal applications.
PROTEIN AND PEPTIDE LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Neha V. Kalmankar, Padmanabhan Balaram, Radhika Venkatesan
Summary: Cyclotides, a class of macrocyclic plant peptides, were analyzed from Clitoria ternatea using LC-MS and MS/MS techniques. Variations in product ion distributions were observed in cyclotides belonging to different structural subfamilies based on the number and positions of proline residues. The distinct fragmentation pattern of prototypical cyclotides of each structural subfamily was used to rapidly identify and sequence a novel cyclotide ctr pep 30 from this plant.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Tam T. T. Tran, Gia-Hoa Tran, Son T. Cu, Son H. Pham, Tuan H. N. Nguyen, Tien T. Dang
Summary: This study evaluated different extraction methods for cyclotides derived from mature pods of Clitoria ternatea and successfully identified 14 cyclotide-like molecules. The mixture of cyclotides M1 and M2 exhibited significant antibacterial activity. The findings suggest the potential application of cyclotides derived from the mature pods of C. ternatea as environmentally friendly antimicrobial agents.
Article
Multidisciplinary Sciences
Ethel Jeyaseela Jeyaraj, Yau Yan Lim, Wee Sim Choo
Summary: The research successfully developed an efficient column chromatography method to obtain the anthocyanin-rich fraction from Clitoria ternatea flower and characterized its composition, antioxidant, antibacterial, and cytotoxic activities. The anthocyanin-rich fraction demonstrated potent antioxidant and antibacterial activities, but showed higher cytotoxicity against human embryonic kidney cell line.
SCIENTIFIC REPORTS
(2022)
Review
Plant Sciences
Gayan Chandrajith Vidana Gamage, Yau Yan Lim, Wee Sim Choo
Summary: Clitoria ternatea plant is commonly grown as an ornamental plant with great medicinal value. Its flower, also known as blue pea or butterfly pea flower, contains high abundance of polyacylated anthocyanins known as ternatins. Blue pea flower anthocyanins have potential applications in food, antioxidant, and antimicrobial industries.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Food Science & Technology
Merve Bacanli, Ozgur Esim, Hakan Erdogan, Meral Sarper, Onur Erdem, Yalcin Ozkan
Summary: This study evaluated the cytotoxicity and genotoxicity of paclitaxel nanoencapsulated with PLGA in human neuroblastoma cells. Results showed that PLGA nanoparticles can be considered as a biocompatible carrier system for drug delivery and might be a promising agent against neuroblastoma.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Sy-Yu Shiau, Yanli Yu, Jing Li, Wenbo Huang, Haixia Feng
Summary: This study investigated the effects of different concentrations of Clitoria ternatea flower extract (CTFE) on the color, texture, phytochemicals, and sensory quality of dried and cooked noodles. Results showed that dried noodles with 30% CTFE had the highest levels of anthocyanins, polyphenols, DPPH radical scavenging capacity, and reducing power. Cooking significantly reduced anthocyanin levels and blue color, while increasing the greenness of the noodles. Noodles with 20-30% CTFE showed higher color preference, and despite a reduction in cutting force and tensile strength, sensory attributes were similar to noodles without CTFE.
Article
Environmental Sciences
Amira Elfarnawany, Faramarz Dehghani
Summary: The study analyzed the effects of paclitaxel on non-neuronal cells of sensory neurons in the dorsal root ganglia (DRG). It was found that paclitaxel reduced cell viability, increased cell death, and inhibited cell proliferation. These effects were concentration- and time-dependent, indicating adverse effects of paclitaxel on non-neuronal cells of sensory neurons.
Article
Polymer Science
Milad Sheydaei, Milad Edraki, Seyyed Mehdi Radeghi Mehrjou
Summary: In this study, Clitoria ternatea (CT) was incorporated into sodium montmorillonite (Na+-MMT), and the resulting nanoparticles (CT-MMT) were added to sol-gel-based hybrid silanol coatings (SGC). The presence of CT in the structure of CT-MMT was confirmed by various characterization techniques. The addition of CT-MMT improved the corrosion resistance of the coatings and also exhibited antimicrobial properties against gram-positive and gram-negative bacteria.
Article
Biochemistry & Molecular Biology
Joao Vitor do Nascimento, Kaylaine Amorim Silva, Vanessa Cipriani Giuliangeli, Ane Louise Dionizio Mendes, Lorena Paloma Piai, Roger Nabeyama Michels, Tatiane Cristina Dal Bosco, Gylles Ricardo Stroher, Marianne Ayumi Shirai
Summary: This study evaluated the release of phenolic compounds from biodegradable films with Clitoria ternatea flower extract and their compostability. The results showed that the antioxidant activity and total phenolic compounds were dependent on the dose of ECT. The presence of ECT affected the composting process and mechanical properties of the films, and the type of simulating fluid influenced the release of polyphenols.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Physical
Rumana Farheen Sagade Muktar Ahmed, Shashi Kumar Kumara Swamy, Gurumurthy Sangam Chandrasekhar, Sangamesha Madanahalli Ankanathappa, Arunkumar Chandrasekhar, Krishnaveni Sannathammegowda
Summary: The development of biopolymer-based high-performance triboelectric nanogenerators (TENGs) is crucial for green energy technologies and innovative electronics. In this study, a novel TENG composed of polyvinyl alcohol (PVA) functionalized with electron-donating groups from the Clitoria ternatea flower extract was proposed. The compatibility of the composite film in energy harvesting devices was tested, and it was found that the enhanced tribopositivity of the composite was due to intermolecular hydrogen bonding. The PVA-CT TENG exhibited higher open-circuit voltage and short-circuit current compared to other materials, as well as long-term stability. Additionally, the output of the TENG increased with an increase in relative humidity. The PVA-CT TENG also showed efficient charging of capacitors, powering LEDs, and acting as a self-powered smart counter. This study contributes to the development of eco-friendly materials for TENG fabrication and extends its applications in the Internet of Things, facilitating the building of futuristic smart cities.
SURFACES AND INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Nishigandha Sa, P. Tejaswani, Sweta Priyadarshini Pradhan, Khider Ali Alkhayer, Anindita Behera, Pratap Kumar Sahu
Summary: Diabetes is a chronic metabolic disorder that causes complications due to oxidative stress and cell damage. Plant-derived phytomolecules with super-antioxidant properties show promise in treating diabetes. Metal nanoparticles, synthesized using a green approach, exhibit significant anti-diabetic and antioxidant activities in a diabetic rat model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Yoshua Liberty Filio, Haris Maulana, Reviana Aulia, Tarkus Suganda, Trixie Almira Ulimaz, Virda Aziza, Vergel Concibido, Agung Karuniawan
Summary: This study evaluated the genotypes of butterfly pea based on yield and yield attributes, considering the interactions with the environment. The results showed that certain genotypes exhibited stability and high yield based on different measurements such as AMMI, GGE biplot, and sustainability index. Three genotypes (G2, G14, and G16) were identified as superior genotypes for flower production and potential materials for plant breeding programs.
Article
Pharmacology & Pharmacy
Hua-Wei Chen, Yu-Wei Chang, Wu-Po Fang
Summary: This study focused on microencapsulation of Clitoria ternatea petal extracts by high-pressure processing at room temperature, producing a series of CTP liposomes with an average particle size of 240.7 nm at 300 MPa, higher encapsulation efficiency, and a narrower particle size distribution.
Article
Integrative & Complementary Medicine
Zhang Sen, Ma Jie, Yang Jingzhi, Wang Dongjie, Zhang Dongming, Chen Xiaoguang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)
Article
Pharmacology & Pharmacy
Sen Zhang, Yonghong Fu, Dongjie Wang, Jing Wang
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2018)
Article
Integrative & Complementary Medicine
Sen Zhang, Hongqi Xin, Yan Li, Dongming Zhang, Jing Shi, Jingzhi Yang, Xiaoguang Chen
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2013)
Article
Biotechnology & Applied Microbiology
Geng Zhang, Yi Xu, Sen Zhang, Huifang Zhou
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Weida Wang, Zhaojun Li, Yuanyuan Chen, Haijie Wu, Sen Zhang, Xiaoguang Chen
Article
Oncology
Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang, Jiaxin Li
Summary: This study identified four LncRNA-mRNA pairs, including LOC641518-LEF1, which may play a central role in breast cancer bone metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Meng Jin, Li Kong, Ying Han, Sen Zhang
Summary: The study showed that curcumin can enhance the chemosensitivity of HCC cells to 5-Fu by promoting apoptosis, arresting the cell cycle at G2/M phase, and blocking the PI3K/AKT/mTOR signaling pathway. In vivo, curcumin also significantly increased the sensitivity of H22 cells to 5-Fu and inhibited tumor growth, with gut microbiota playing a key role in its effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Weida Wang, Li Sheng, Yuanyuan Chen, Zhaojun Li, Haijie Wu, Jie Ma, Dongming Zhang, Xiaoguang Chen, Sen Zhang
Summary: The study evaluated the renal protective effect of Hydrangea Paniculata, Sieb (HP) in an experimental model of membranous nephritis (MN) and explored its underlying mechanisms. HP administration improved renal function, reduced dyslipidemia and histopathological injuries. mRNA sequencing indicated anti-inflammation and anti-fibrosis effects of HP, possibly through down-regulating the complement activation and PI3K-AKT pathways. Pharmacokinetic studies identified skimmin and 7-hydoxycoumarin (7-HC) as major compounds in HP. Inflammatory macrophage IL10 production was inhibited by skimmin and 7-HC through blocking PI3K-AKT and NF Kappa B signaling pathways. HP protected tubulointerstitium from complement attack by reducing C3 self-production and auto-cleavage in tubular cells.
Article
Plant Sciences
Ying Zhang, Zhaojun Li, Haijie Wu, Jing Wang, Sen Zhang
Summary: The study evaluates the renal protective effect of esculetin against the progression of lupus nephritis and finds that esculetin can significantly improve renal function and pathology. It exhibits antioxidant and anti-inflammatory properties and acts on LN through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Haijie Wu, Xiaoguang Chen, Sen Zhang, Jiaxin Li
Summary: The gut microbiota, as the largest immune organ in humans, plays multiple physiological functions and is symbiotic with the human host. Dysbiosis of the gut microbiota has been associated with almost all human diseases, and several star bacteria have emerged as potential tools for disease treatment.
Article
Biochemistry & Molecular Biology
Xiao-Kai Zhan, Xi-Kun Liu, Sen Zhang, Hong Chen
Summary: ICOS/ICOSL may be associated with the prognosis of lung cancer and could serve as potential therapeutic targets in non-small cell lung cancer. This study analyzed the expression of ICOS and ICOSL in lung tumor tissues and found that their expression levels were correlated with patient survival.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Weida Wang, Mingjin Wang, Tingting Du, Zhenyan Hou, Shen You, Sen Zhang, Ming Ji, Nina Xue, Xiaoguang Chen
Summary: The metabolic enzyme SHMT2 plays a crucial role in the one-carbon metabolic pathway and is associated with tumor progression. It was found to stabilize HIF1α and contribute to the hypoxic adaptation of gastric cancer cells. Knockdown of SHMT2 inhibited cell proliferation, colony formation, invasion, and migration in gastric cancer cell lines. SHMT2 depletion disrupted redox homeostasis and glycolytic function in hypoxic circumstances, regulated the VEGF and STAT3 pathways, and reduced gastric cancer growth in xenograft experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Zhaojun Li, Xingguang Zhang, Haijie Wu, Zhiling Ma, Xikun Liu, Jie Ma, Dongming Zhang, Li Sheng, Xiaoguang Chen, Sen Zhang
Summary: Hydrangea paniculata extracts have a renal protective effect on membranous nephritis by reversing gut microbiome dysbiosis and improving colonic integrity, leading to the production of beneficial metabolites.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Sen Zhang, Yan Li, Hongyan Li, Xuguang Zheng, Xiaoguang Chen
BIOMEDICAL REPORTS
(2013)
Article
Medicine, Research & Experimental
Sen Zhang, Hongyan Li, Yan Li, Furong Zhang, Yue Liu, Xiaoguang Chen
BIOMEDICAL REPORTS
(2013)
