Article
Immunology
Garrison Cox, Andres J. Gonzalez, Emmanuel C. Ijezie, Andres Rodriguez, Craig R. Miller, James T. Van Leuven, Tanya A. Miura
Summary: Rhinoviruses (RV) can inhibit pulmonary coronavirus infection, reduce inflammation and tissue damage, and prevent mortality. These findings are important for understanding the interaction between respiratory viruses and the host, and their impact on disease pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Jiangnan Wu, Yanjing Guo, Wei Li, Zihao Zhang, Xinlei Li, Qidi Zhang, Qihang Du, Xinhuan Niu, Xijiang Liu, Gongming Wang
Summary: This study found that exploratory laparotomy induced cognitive function decline in aged mice but not in young mice, accompanied by inflammatory activation of microglia in the hippocampus. Depletion of microglia using a CSF1R inhibitor protected aged mice from POCD. The downregulation of the immune checkpoint Mef2C in aged microglia contributed to microglial priming and neuroinflammation, leading to increased vulnerability to POCD in aged individuals.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Pediatrics
Diksha Shrestha, George Xiangyun Ye, Deborah Stabley, Suhita Gayen nee Betal, Yan Zhu, Lisa Glazewski, Jennifer Holbrook, Meharpreet Sethi, Anne Hesek, Thomas H. Shaffer, Zubair H. Aghai, Sankar Addya, Deepthi Alapati
Summary: The study found that lung inflammation in preterm infants with BPD during the perinatal period leads to short- and long-term dysregulation of genes associated with pulmonary-specific immune cells, potentially increasing the risk of respiratory morbidities associated with environmental pathogens in children and adults with BPD.
PEDIATRIC RESEARCH
(2021)
Article
Fisheries
Andreas Vilcinskas
Summary: Parental investment in offspring involves transferring defense capabilities against pathogens and parasites to the next generation in a phenomenon known as transgenerational immune priming (TGIP). This effect can be passed maternally or paternally, increasing offspring survival when exposed to the same pathogens. Maternal TGIP involves transfer of microbes encountered by mothers to developing eggs, while paternal TGIP is mediated by epigenetic mechanisms, fortifying the immune response broadly.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Mendez-Lopez Texca Tatevari, Contreras-Garduno Jorge, Mendoza-Cuenca Luis, Ramirez-Romero Ricardo
Summary: This study investigated immune priming in insects, finding that host larvae exposed to both low- and high-virulence strains of entomopathogenic nematodes did not exhibit immune priming. Host larvae primed with the highly virulent strain had significantly reduced survival rates, suggesting that immune priming did not occur in this context. Further research is needed to understand the factors underlying these results, such as virulence-associated bacteria or immune evasion strategies.
MICROBIAL PATHOGENESIS
(2021)
Article
Plant Sciences
Pan Shen, Weiji Lin, Xin Ba, Yao Huang, Zhe Chen, Liang Han, Kai Qin, Ying Huang, Shenghao Tu
Summary: Herba taxilli, composed of Taxillus chinensis, is used in traditional Chinese medicine to treat inflammation and arthritis. Quercetin, a key component, shows antiarthritic effects and may act through SIRT1 to target mitochondrial biogenesis in rheumatoid arthritis treatment. Further research is needed to fully understand the mechanisms involved.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Junping Ren, Wenzhe Wu, Ke Zhang, Eun-Jin Choi, Pingyuan Wang, Teodora Ivanciuc, Alex Peniche, Youwen Qian, Roberto P. Garofalo, Jia Zhou, Xiaoyong Bao
Summary: RSV is a common cause of lower respiratory tract infections in young children, and EPAC2 has been identified as a potential therapeutic target for RSV. Deficiency or inhibition of EPAC2 plays a critical role in experimental RSV infection-induced airway diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Shir Sivroni, Hadas E. Sloin, Eran Stark
Summary: This article describes an auditory discrimination paradigm for studying response priming in freely moving mice. The study found that all mice tested showed a priming effect in success rate on the task. Additionally, the results suggest a cognitive mechanism based on differential interference underlying the priming phenomenon.
Article
Clinical Neurology
Elisa Guma, Lani Cupo, Weiya Ma, Daniel Gallino, Luc Moquin, Alain Gratton, Gabriel A. Devenyi, M. Mallar Chakravarty
Summary: Prenatal exposure to maternal immune activation (MIA) and chronic adolescent cannabis use are risk factors for neuropsychiatric disorders. Combined exposure may lead to enduring neuroanatomical and behavioral changes in adulthood.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Lily Keane, Ignazio Antignano, Sean-Patrick Riechers, Raphael Zollinger, Anaelle A. Dumas, Nina Offermann, Maria E. Bernis, Jenny Russ, Frederike Graelmann, Patrick Neil McCormick, Julia Esser, Dario Tejera, Ai Nagano, Jun Wang, Claude Chelala, Yvonne Biederbick, Annett Halle, Paolo Salomoni, Michael T. Heneka, Melania Capasso
Summary: Microglia in aged individuals show increased mTOR signaling and upregulation of inflammatory mediators, resulting in stronger responses to inflammatory stimuli. Genetic ablation of mTOR signaling can reduce microglia activation and inflammation response, alleviating sickness behavior in aged mice.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Microbiology
Kevin R. Cabrera, Duncan A. Hoard, Olivia R. Gibson, Daniel A. Martinez, Zeba R. Wunderlich
Summary: Previous non-lethal infection increases the survival ability of organisms to a second infection, but this is not due to a decrease in bacterial load. Through transcriptome analysis, it was found that a large number of genes were upregulated in only primed flies during infection, indicating different transcriptional programs in response to initial and secondary infections. The study found that infection history leads to differences in immune strategy, transcriptional program, and pathway use in the innate immune response of fruit flies.
Article
Biochemistry & Molecular Biology
Mengling Huang, Ying Zhang, Ying Wang, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li
Summary: Active DNA demethylation plays a critical role in MAMP-triggered immune response in plants, with flg22-induced DNA demethylation tightly associated with the expression of salicylic acid signaling-related and phytoalexin biosynthesis-related genes. Lack of active DNA demethylation compromises immune response.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Cardiac & Cardiovascular Systems
Huzaifa A. Jaliawala, Miloni Parmar, Katherine Summers, Roberto J. Bernardo
Summary: The second hit hypothesis in pulmonary hypertension refers to the development of pulmonary vascular disease in individuals at risk, after an additional exposure or hit to factors with potential injury to the pulmonary circulation, such as drugs or toxins. This article presents a case study of severe pulmonary hypertension diagnosed during the third trimester of pregnancy in a patient with a family history of pulmonary hypertension and a heterozygous mutation in the BMPR2 gene, who also had chronic exposure to prescription amphetamines. The authors hypothesize that exposure to prescription amphetamines could act as a second hit of pulmonary vascular injury in individuals at risk of pulmonary vascular disease.
PULMONARY CIRCULATION
(2022)
Review
Neurosciences
Lisa Rauschenberger, Susanne Knorr, Antonio Pisani, Mark Hallett, Jens Volkmann, Wang Ip
Summary: The role of environmental factors in dystonia onset and development, especially in monogenic and adult-onset dystonia, remains a mystery in dystonia pathophysiology. Evidence suggests a gene-environment interaction, but the specific mechanisms are still unclear.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Ines Maldonado-Lasuncion, Agnes E. Haggerty, Akinori Okuda, Tokumitsu Mihara, Natalia de la Oliva, Joost Verhaagen, Martin Oudega
Summary: Research shows that priming mesenchymal stromal cells (MSC) with macrophage-derived inflammation does not increase the overall therapeutic potential of an MSC transplant in the adult rat contused spinal cord. Primed MSC transplants had lower long-term survival compared to unprimed MSC transplants, but more anti-inflammatory macrophages were present at the injury site.
Article
Critical Care Medicine
Lane M. Smith, Jonathan D. Wells, Vidula T. Vachharajani, Barbara K. Yoza, Charles E. McCall, J. Jason Hoth
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2015)
Article
Endocrinology & Metabolism
Xianfeng Wang, Nancy L. Buechler, Barbara K. Yoza, Charles E. McCall, Vidula T. Vachharajani
Article
Immunology
Patrick Millet, Vidula Vachharajani, Linda McPhail, Barbara Yoza, Charles E. McCall
JOURNAL OF IMMUNOLOGY
(2016)
Correction
Multidisciplinary Sciences
Xianfeng Wang, Nancy L. Buechler, Ayana Martin, Jonathan Wells, Barbara Yoza, Charles E. McCall, Vidula Vachharajani
Review
Immunology
Vidula T. Vachharajani, Tiefu Liu, Xianfeng Wang, Jason J. Hoth, Barbara K. Yoza, Charles E. McCall
JOURNAL OF IMMUNOLOGY RESEARCH
(2016)
Article
Immunology
Vidula Vachharajani, Tiefu Liu, Charles E. McCall
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2014)
Review
Biochemistry & Molecular Biology
Xianfeng Wang, Nancy L. Buechler, Alan G. Woodruff, David L. Long, Manal Zabalawi, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Tie Fu Liu, Vidula T. Vachharajani, Barbara K. Yoza, Charles E. McCall
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Tie Fu Liu, Vidula Vachharajani, Patrick Millet, Manish S. Bharadwaj, Anthony J. Molina, Charles E. McCall
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Review
Cell Biology
Tie Fu Liu, Candice M. Brown, Mohamed El Gazzar, Linda McPhail, Patrick Millet, Anuradha Rao, Vidula T. Vachharajani, Barbara K. Yoza, Charles E. McCall
JOURNAL OF LEUKOCYTE BIOLOGY
(2012)
Article
Cell Biology
Vidula T. Vachharajani, Tiefu Liu, Candice M. Brown, Xianfeng Wang, Nancy L. Buechler, Jonathan David Wells, Barbara K. Yoza, Charles E. McCall
JOURNAL OF LEUKOCYTE BIOLOGY
(2014)
Article
Endocrinology & Metabolism
Vidula Vachharajani, Christie Cunningham, Barbara Yoza, John Carson, Tushar J. Vachharajani, Charles McCall
Article
Multidisciplinary Sciences
Xianfeng Wang, Nancy L. Buechler, Ayana Martin, Jonathan Wells, Barbara Yoza, Charles E. McCall, Vidula Vachharajani
Article
Immunology
XianFeng Wang, Nancy L. Buechler, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
JOURNAL OF INFLAMMATION RESEARCH
(2016)