Functions of SAGA in development and disease

c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain

(2015)   Oncotarget

The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity

(2013) Godelieve Smeenk et al.   Annual Review of Biochemistry

Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation

(2013) M. Malatesta et al.   CANCER RESEARCH

The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2)

(2013) Robyn T. Sussman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-small Cell Lung Cancer via Promotion of E2F1, Cyclin D1, and Cyclin E1 Expression

(2013) Long Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex

(2013) S. M. Armour et al.   MOLECULAR AND CELLULAR BIOLOGY

Developmental signaling pathways in cancer stem cells of solid tumors

(2012) Christina Karamboulas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

(2012) K. Kamieniarz et al.   GENES & DEVELOPMENT

ATAC-king the complexity of SAGA during evolution

(2012) G. Spedale et al.   GENES & DEVELOPMENT

Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7

(2012) S. A. Furrer et al.   HUMAN MOLECULAR GENETICS

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells

(2012) Verónica Martínez-Cerdeño et al.   PLoS One

USP22 Is Useful as a Novel Molecular Marker for Predicting Disease Progression and Patient Prognosis of Oral Squamous Cell Carcinoma

(2012) Songlin Piao et al.   PLoS One

Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes

(2012) S. D. McCullough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

USP22 Acts as an Oncogene by the Activation of BMI-1-Mediated INK4a/ARF Pathway and Akt Pathway

(2011) Yan-Long Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A new chapter in the transcription SAGA

(2011) Nadine L Samara et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation

(2011) Chuanbing Bian et al.   EMBO JOURNAL

USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1

(2011) Boyko S Atanassov et al.   EMBO REPORTS

Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model

(2011) Yi Chun Chen et al.   HUMAN MOLECULAR GENETICS

Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer

(2011) Youxue Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Ubp8 and SAGA Regulate Snf1 AMP Kinase Activity

(2011) M. A. Wilson et al.   MOLECULAR AND CELLULAR BIOLOGY

SAGA and ATAC Histone Acetyl Transferase Complexes Regulate Distinct Sets of Genes and ATAC Defines a Class of p300-Independent Enhancers

(2011) Arnaud R. Krebs et al.   MOLECULAR CELL

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes

(2011) K. K. Lee et al.   Molecular Systems Biology

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

c- and N-myc Regulate Neural Precursor Cell Fate, Cell Cycle, and Metabolism to Direct Cerebellar Development

(2010) Alice Wey et al.   CEREBELLUM

Multiple faces of the SAGA complex

(2010) Evangelia Koutelou et al.   CURRENT OPINION IN CELL BIOLOGY

Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton

(2010) Wenchu Lin et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair

(2010) Han-Sae Lee et al.   EMBO JOURNAL

The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates

(2010) Meritxell Orpinell et al.   EMBO JOURNAL

Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer

(2010) Yan-Long Liu et al.   JOURNAL OF SURGICAL ONCOLOGY

Chromatin remodelling during development

(2010) Lena Ho et al.   NATURE

Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity

(2010) F. Duclot et al.   NEUROSCIENCE

GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage

(2010) Ruifeng Guo et al.   NUCLEIC ACIDS RESEARCH

The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes

(2009) Zita Nagy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

(2009) Jorrit V Tjeertes et al.   EMBO JOURNAL

Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

(2009) Boyko S. Atanassov et al.   MOLECULAR CELL

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network

(2009) N. M. van Strien et al.   NATURE REVIEWS NEUROSCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos

(2008) Wenchu Lin et al.   DEVELOPMENTAL DYNAMICS

Human ATAC Is a GCN5/PCAF-containing Acetylase Complex with a Novel NC2-like Histone Fold Module That Interacts with the TATA-binding Protein

(2008) Yuan-Liang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of ATAC-specific acetylation of histone H4 at Lys12 reduces binding of JIL-1 to chromatin and phosphorylation of histone H3 at Ser10

(2008) A. Ciurciu et al.   JOURNAL OF CELL SCIENCE

The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development

(2008) S. Guelman et al.   MOLECULAR AND CELLULAR BIOLOGY

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

(2008) Yue Zhao et al.   MOLECULAR CELL

The hippocampus and memory: insights from spatial processing

(2008) Chris M. Bird et al.   NATURE REVIEWS NEUROSCIENCE

ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding

(2008) Tamaki Suganuma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY