Review
Endocrinology & Metabolism
Renu A. Kowluru, Ghulam Mohammad
Summary: Diabetes is a life-long disease that damages the body's microvasculature and macrovasculature, affecting metabolic and molecular pathways. External factors such as environmental factors, lifestyle, and pollutants can also regulate gene expression and contribute to disease development. Epigenetic modifications play a crucial role in the development of diabetes and its complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Anastasia Kottorou, Aspasia Tzezou
Summary: Breast cancer, the most common cancer in women, poses a challenge in therapeutic management for hormone receptor-positive patients due to resistance mechanisms. Molecular mechanisms involved in endocrine resistance include changes in hormone receptor signaling, activation of parallel pathways, cell cycle regulator modifications, transcription factor activation, and stem cell activity changes. Epigenetic changes, such as DNA methylation, histone modifications, and ncRNAs alterations, play a pivotal role not only in breast cancer progression but also in resistance to endocrine therapy.
Review
Cell Biology
Luis Terrazas-Salgado, Alejandra Garcia-Gasca, Miguel Betancourt-Lozano, Raul Llera-Herrera, Isabel Alvarado-Cruz, Beatriz Yanez-Rivera
Summary: This review discusses the advantages of using zebrafish as an experimental animal model to study transgenerational epigenetic processes upon exposure to xenobiotics. The focus is on DNA methylation, with additional discussion on post-translational modifications of histones and non-coding RNAs related to xenobiotic exposure in zebrafish. The revision of methods used to study epigenetic changes in zebrafish reveals their relevance and reproducibility in epigenetics-related research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
C. Alejandra Monraz-Mendez, Rebeca Escutia-Gutierrez, Jonathan Samael Rodriguez-Sanabria, Marina Galicia-Moreno, Hugo Christian Monroy-Ramirez, Laura Sanchez-Orozco, Jesus Garcia-Banuelos, Ricardo De la Rosa-Bibiano, Arturo Santos, Juan Armendariz-Borunda, Ana Sandoval-Rodriguez
Summary: This study found that Moringa oleifera aqueous extract has a hepatoprotective role in a model of NASH, improving biochemical, histological, and hepatic gene and miRNA expression.
Review
Cell Biology
Arianna Mangiavacchi, Gabriele Morelli, Valerio Orlando
Summary: Non-coding DNA makes up about 98.5% of the human genome and has been re-evaluated to reveal its importance in cell regulation through the presence of non-coding RNAs (ncRNAs). This review focuses on the relationship between chromatin-interacting RNAs, such as long non-coding RNA (lncRNA), enhancer RNA (eRNA), non-coding natural antisense transcript (ncNAT), circular RNA (circRNA), and the epigenome, highlighting their role in regulating gene expression and their impact on human diseases, particularly cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bartosz Lenda, Marta Zebrowska-Nawrocka, Grzegorz Turek, Ewa Balcerczak
Summary: Gliomas, particularly glioblastoma, are aggressive brain tumors with limited treatment options and poor prognosis. Although gliomas do not undergo classical epithelial to mesenchymal transition (EMT), EMT-like processes contribute to their invasive nature and intracranial metastasis. Various EMT transcription factors have been described to play important roles in glioma progression, with a focus on molecules like SNAI, TWIST, and ZEB. This review highlights the impact of miRNA, lncRNA, and other epigenetic modifications on the regulation of EMT transcription factors in gliomas, emphasizing the need to uncover the molecular mechanisms and identify novel therapeutic targets for improved diagnosis and prognosis of glioma patients.
Review
Biochemistry & Molecular Biology
Kevin Mangum, Katherine Gallagher, Frank M. Davis
Summary: Abdominal aortic aneurysm (AAA) is a life-threatening disease with a lack of pharmaceutical treatment options. Previous studies have shown that epigenetic modifications play a crucial regulatory role in the development of AAA. This review discusses the roles and significance of epigenetic modifications in AAA animal models and their relevance to human pathology.
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Chemistry, Medicinal
Dan Zhang, Jifa Zhang, Yuxi Wang, Guan Wang, Pan Tang, Yun Liu, Yiwen Zhang, Liang Ouyang
Summary: Parkinson's disease (PD) is a multifactorial disease caused by a complex interplay between genetic and epigenetic factors. Recent studies have revealed the epigenetic mechanisms involved in PD, such as DNA methylation, histone modifications, and microRNA (miRNA) regulation. Epigenetic regulators could be potential therapeutic targets in neurodegenerative disorders. This review summarizes the mechanisms of epigenetic regulation in PD and discusses the use of inhibitors and activators of these regulators, as well as the neuroprotective effects of small molecule epigenetic modulators. Additionally, the contribution of miRNAs to the underlying mechanisms of PD and miRNA-based therapies are also discussed.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Deirdra Venney, Adone Mohd-Sarip, Ken Mills
Summary: Myeloid malignancy encompasses a range of diseases including MPN, MDS, and AML, with genomic studies revealing numerous somatic mutations and highlighting the importance of epigenetic mutations in disease progression. Key genes like DNMT3A, TET2, ASXL1, EZH2, and IDH1/2 play critical roles in disease pathogenesis. Advances in understanding disease progression, mutational profiles, and therapeutic potential are continually improving our knowledge of myeloid malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Qingfan Yang, Yu Chen, Rui Guo, Yalan Dai, Liyao Tang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Jing Shen, Tao Yi, Zhangang Xiao, Qinglian Wen
Summary: Gastric cancer is a common gastrointestinal tumor, and despite advancements in early diagnosis and treatment, prognosis remains poor. Therefore, understanding the molecular mechanisms of gastric cancer development and progression is crucial for improving diagnostic and treatment options. Recent research has identified the role of epigenetics, including chromatin remodeling, DNA methylation, and histone modifications, in tumor progression. Studies have shown that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Pharmacology & Pharmacy
Zijun Zhou, Xiaoming Li, Zhiqing Liu, Lixun Huang, Yuying Yao, Liuyou Li, Jian Chen, Rongxin Zhang, Jia Zhou, Lijing Wang, Qian-Qian Zhang
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Genetics & Heredity
Bin Han, Wei Jiang, Pan Cui, Kai Zheng, Chun Dang, Junjie Wang, He Li, Lin Chen, Rongxin Zhang, Qing Mei Wang, Zhenyu Ju, Junwei Hao
Summary: In this study, it was found that PGC-1 alpha expression in microglia was increased shortly after ischemic stroke, leading to reduced neurological deficits and decreased production of proinflammatory cytokines. Additionally, PGC-1 alpha promoted autophagy and mitophagy through ULK1, ultimately reducing NLRP3 activation.
Article
Immunology
Chengzhi Wang, Xin Li, Lijuan Zhang, Ying Chen, Ruijie Dong, Jieyou Zhang, Jingyi Zhao, Xiangdong Guo, Guangze Yang, Yan Li, Chao Gu, Qing Xi, Rongxin Zhang
Summary: High expression of miR-194-5p in pancreatic cancer patients is associated with a better survival rate and inhibits the expression of PD-L1. Overexpression of miR-194-5p suppresses the progression of pancreatic cancer, promotes the infiltration of CD8+ T cells in tumor immune microenvironments, and enhances IFN-gamma production of CD8+ T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lijuan Zhang, Kai Zhang, Jieyou Zhang, Jinrong Zhu, Qing Xi, Huafeng Wang, Zimu Zhang, Yingnan Cheng, Guangze Yang, Hongkun Liu, Xiangdong Guo, Dongmei Zhou, Zhenyi Xue, Yan Li, Qi Zhang, Yurong Da, Li Liu, Zhinan Yin, Zhi Yao, Rongxin Zhang
Summary: The study reveals that deficiency of FATS inhibits tumor growth and promotes an anti-tumor function of macrophages by inducing a phenotypic shift, demonstrating FATS as a potential target for cancer immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Liangpeng Wei, Zhenyi Xue, Baihui Lan, Shiyang Yuan, Yuanyuan Li, Cunle Guo, Rongxin Zhang, Ran Ding, Hui Shen
Summary: The study found that arctigenin can restrict excessive neural activity in the preclinical stage of experimental autoimmune encephalomyelitis (EAE) and restore neuronal activity and communication in the remission stage. Arctigenin also reduces excitotoxicity caused by calcium influx in the EAE model, demonstrating a neuroprotective effect.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Junchen Li, Lixun Huang, Zinan He, Minggui Chen, Yi Ding, Yuying Yao, Youfa Duan, Zixuan Li, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Xiaoming Li, Jianwei Dai, Lijing Wang, Qian-Qian Zhang
Summary: Andrographolide (Andro), a traditional anti-inflammatory drug, has shown anti-tumor effects in breast cancer treatment by inhibiting cell proliferation and promoting apoptosis via activation of signaling pathways. The study suggests that Andro may exert its potential anti-cancer effects on luminal-like breast cancer by suppressing NF-kappa B expression to regulate miR-21-5p and further promote PDCD4. This indicates that Andro could be a promising antitumor agent for the treatment of luminal-like breast cancer in clinical settings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Lingbi Jiang, Mingming Yang, Shihui He, Zhengyang Li, Haobin Li, Ting Niu, Dehuan Xie, Yan Mei, Xiaodong He, Lili Wei, Pinzhu Huang, Mingzhe Huang, Rongxin Zhang, Lijing Wang, Jiangchao Li
Summary: The study reveals the essential role of MMP12 in controlling cancer-related weight loss and the crosstalk between tumor cells and macrophages in muscle tissues, where tumor cells secrete IL-6 inducing macrophages to up-regulate MMP12.
Article
Oncology
Jinrong Zhu, Yongqi Wu, Shaoxi Lao, Jianfei Shen, Yijian Yu, Chunqiang Fang, Na Zhang, Yan Li, Rongxin Zhang
Summary: The study shows that overexpression of TRIM54 is associated with HCC progression, promoting proliferation and metastasis; inhibiting TRIM54 can significantly suppress HCC development; Targeting the TRIM54/Axin1/beta-catenin signaling axis could be a promising therapeutic strategy for HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Qifeng Deng, Xinrui Li, Chunqiang Fang, Xin Li, Jing Zhang, Qing Xi, Yan Li, Rongxin Zhang
Summary: Cordycepin is an extract from Cordyceps militaris that has been shown to have anti-inflammatory and anti-tumor properties without toxicity. It inhibits the growth and migration of colon cancer cells and promotes apoptosis in a dose-dependent manner. Cordycepin modulates the tumor immune microenvironment, increasing the number of CD4+ T cells, CD8+ T cells, M1 type macrophages, and NK cells. It also reduces the expression of CD47 and TSP1, allowing for enhanced phagocytosis of cancer cells by macrophages. Cordycepin may be a potential immunotherapeutic drug for colon cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Summary: This study demonstrates the important immunosuppressive effect of parthenolide (PTL) on autoimmune inflammation. PTL can alleviate clinical symptoms by inhibiting inflammatory cell infiltration, reducing inflammation, and demyelination. It also regulates the immune response by inhibiting the reactivation of specific T cells and the differentiation of CD4(+) T cells into pathogenic Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dewei Ye, Jianyu Yao, Wenfa Du, Cuishan Chen, Yong Yang, Kaixuan Yan, Jufei Li, Ying Xu, Shufei Zang, Yuying Zhang, Xianglu Rong, Rongxin Zhang, Aimin Xu, Jiao Guo
Summary: The miR-223/NE axis was found to be a key regulator of NETs in acute liver failure (ALF), exacerbating oxidative stress and neutrophilic inflammation, and potentiating hepatocellular damage and liver necrosis during ALF development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Yongqi Wu, Jing Zhang, Sihui Yu, Yan Li, Jinrong Zhu, Kai Zhang, Rongxin Zhang
Summary: Inflammation is a defense mechanism that can protect the host, but continuous inflammation can lead to chronic inflammatory diseases. Pyroptosis, a type of cell death related to inflammation, is closely associated with the development of inflammatory diseases.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Jinrong Zhu, Yongqi Wu, Yijian Yu, Yan Li, Jianfei Shen, Rongxin Zhang
Summary: MYBL1 upregulation is associated with poor prognosis and increased angiogenesis in hepatocellular carcinoma (HCC). MYBL1 overexpression enhances HCC cell metastasis and resistance to sorafenib treatment by upregulating ANGPT2 expression.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Huijiao Lu, Mengyi Zhu, Lin Qu, Hongwei Shao, Rongxin Zhang, Yan Li
Summary: This study explores the correlation between HMGB1 expression and patient prognosis in a multicancer context, as well as its association with the tumor immune microenvironment and immune infiltration. The findings suggest that HMGB1 could serve as a potential biomarker for improving clinical prognosis and antitumor immunotherapy efficacy.
Article
Physiology
Z. Z. Ge, Y. B. Wu, Z. Y. Xue, K. Zhang, R. X. Zhang
Summary: This study explored the therapeutic effects of the Pin1 inhibitor juglone on EAE in mice, showing that juglone significantly alleviated inflammation and demyelination in EAE and suppressed the expression of pathogenic T cells. The findings suggest that juglone has potential therapeutic benefits for autoimmune diseases and MS.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
