HDAC4: mechanism of regulation and biological functions

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

HDAC4 controls histone methylation in response to elevated cardiac load

(2013) Mathias Hohl et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington’s Disease-Related Mechanisms

(2013) Ana Jovicic et al.   PLoS One

Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts

(2013) S K Huang et al.   Cell Death & Disease

Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

(2012) J. T. Isaacs et al.   CANCER RESEARCH

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

(2012) Moon-Chang Choi et al.   MOLECULAR CELL

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the E -miR-155 transgenic mouse model

(2012) S. K. Sandhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

(2012) B. S. Sailaja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC4-Regulated STAT1 Activation Mediates Platinum Resistance in Ovarian Cancer

(2011) E. A. Stronach et al.   CANCER RESEARCH

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

(2011) Olivia Lenoir et al.   DIABETES

MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4

(2011) Ying-Jie Guan et al.   FASEB JOURNAL

The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma

(2011) Ji-hang Yuan et al.   HEPATOLOGY

HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia

(2011) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4

(2011) Catherine E. Winbanks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

(2011) Johannes Backs et al.   JOURNAL OF CELL BIOLOGY

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins

(2011) Izhak Kehat et al.   JOURNAL OF CELL BIOLOGY

HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway

(2011) Hong P. Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer

(2011) Xiaoxin S Xu et al.   Journal of Hematology & Oncology

Peroxisome proliferator-activated receptor γ is inhibited by histone deacetylase 4 in cortical neurons under oxidative stress

(2011) Yang Yang et al.   JOURNAL OF NEUROCHEMISTRY

Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems

(2010) Stephen R. Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells

(2010) Joost P.G. Sluijter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

(2010) J Zhang et al.   BRITISH JOURNAL OF CANCER

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis

(2010) Yuting Sun et al.   JOURNAL OF CELL BIOLOGY

OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cells

(2010) Russell C. Addis et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility

(2010) Nadia Cernotta et al.   MOLECULAR BIOLOGY OF THE CELL

Association of histone deacetylase genes with schizophrenia in Korean population

(2010) Tae Kim et al.   PSYCHIATRY RESEARCH

FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the Locus

(2009) R. Liu et al.   CANCER RESEARCH

Histone deacetylase 4 promotes TGF-β1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy

(2009) Ming Pei et al.   DIFFERENTIATION

Regional and subcellular distribution of HDAC4 in mouse brain

(2009) Michael J. Darcy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Parathyroid Hormone-Related Peptide Represses Chondrocyte Hypertrophy through a Protein Phosphatase 2A/Histone Deacetylase 4/MEF2 Pathway

(2009) E. Kozhemyakina et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells

(2009) B Song et al.   ONCOGENE

The   isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

(2009) J. Backs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

(2008) Tetsuro Ago et al.   CELL

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity

(2008) Todd J. Cohen et al.   FASEB JOURNAL

Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

(2008) Hee-Won Seo et al.   FEBS LETTERS

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

(2008) Nupur Raychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile Activity

(2008) Mahesh P. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

A Histone Deacetylase 4/Myogenin Positive Feedback Loop Coordinates Denervation-dependent Gene Induction and Suppression

(2008) Huibin Tang et al.   MOLECULAR BIOLOGY OF THE CELL

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

(2008) D Mottet et al.   ONCOGENE

PP2A Regulates HDAC4 Nuclear Import

(2007) Gabriela Paroni et al.   MOLECULAR BIOLOGY OF THE CELL