Article
Oncology
Ida K. Karlsson, Malin Ericsson, Yunzhang Wang, Juulia Jylhava, Sara Hagg, Anna K. Dahl Aslan, Chandra A. Reynolds, Nancy L. Pedersen
Summary: The study found associations between leukocyte DNA methylation and level of cognitive abilities but not with change in cognitive abilities. These associations were significantly attenuated in within-pair analyses, indicating they are influenced in part by genetic factors.
CLINICAL EPIGENETICS
(2021)
Review
Medicine, General & Internal
Adam Li, Zane Koch, Trey Ideker
Summary: Numerous studies have shown that epigenetic age is associated with various factors and can be computed based on DNA methylation patterns. The focus of research needs to shift from accurate age prediction to understanding the links between the epigenome and aging mechanisms. Current research areas include epigenetic clocks and investigation of the epigenome to build a mechanistic theory of aging and inform clinical practice.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Immunology
Seyma Katrinli, Yuanchao Zheng, Aarti Gautam, Rasha Hammamieh, Ruoting Yang, Suresh Venkateswaran, Varun Kilaru, Adriana Lori, Rebecca Hinrichs, Abigail Powers, Charles F. Gillespie, Aliza P. Wingo, Vasiliki Michopoulos, Tanja Jovanovic, Erika J. Wolf, Regina E. McGlinchey, William P. Milberg, Mark W. Miller, Subra Kugathasan, Marti Jett, Mark W. Logue, Kerry J. Ressler, Alicia K. Smith
Summary: The study identified two differentially methylated regions associated with PTSD, one in the gene body of HLA-DPB1 and one in the promoter of SPATC1L. These regions also showed associations with nearby sequence variations and the expression of their respective genes.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Environmental Sciences
Yuan Chun Ding, Susan Hurley, June-Soo Park, Linda Steele, Michele Rakoff, Yun Zhu, Jinying Zhao, Mark LaBarge, Leslie Bernstein, Shiuan Chen, Peggy Reynolds, Susan L. Neuhausen
Summary: The study revealed associations between PBDE levels and DNA methylation, with these methylation changes being significantly associated with breast cancer risk.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell Biology
Pedro S. Marra, Takehiko Yamanashi, Kaitlyn J. Crutchley, Nadia E. Wahba, Zoe-Ella M. Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Masaaki Iwata, Hyunkeun Ryan Cho, Gen Shinozaki
Summary: This study analyzed genome-wide DNA methylation data from diabetic patients and found that metformin may prolong lifespan through epigenetic modifications and other mechanisms, such as AMPK and inflammatory pathways.
Article
Environmental Sciences
Ryu Miura, Atsuko Ikeda-Araki, Toru Ishihara, Kunio Miyake, Chihiro Miyashita, Tamie Nakajima, Sumitaka Kobayashi, Mayumi Ishizuka, Takeo Kubota, Reiko Kishi
Summary: Prenatal exposure to phthalates, specifically DEHP, is associated with changes in DNA methylation levels in cord blood, particularly with genes related to metabolism, endocrine system, and signal transduction. These methylation changes are inversely associated with newborns' ponderal index and may mediate the impact of DEHP exposure on fetal growth. Further research is needed to fully understand the predictive value of DNA methylation for offspring obesity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Multidisciplinary
Siyu Wei, Junxian Tao, Jing Xu, Xingyu Chen, Zhaoyang Wang, Nan Zhang, Lijiao Zuo, Zhe Jia, Haiyan Chen, Hongmei Sun, Yubo Yan, Mingming Zhang, Hongchao Lv, Fanwu Kong, Lian Duan, Ye Ma, Mingzhi Liao, Liangde Xu, Rennan Feng, Guiyou Liu, Yongshuai Jiang
Summary: EWAS has been utilized for a decade to analyze DNA methylation variation in complex diseases, and has gradually become a hot topic of current studies. The progress of EWAS research, contributions to clinical applications, achievements in typical diseases, challenges encountered, and bold predictions for future development are all discussed.
Article
Environmental Sciences
Ainash Childebayeva, Jaclyn M. Goodrich, Nathan Chesterman, Fabiola Leon-Velarde, Maria Rivera-Ch, Melisa Kiyamu, Tom D. Brutsaert, Abigail W. Bigham, Dana C. Dolinoy
Summary: The study found that individuals in Cerro de Pasco had higher levels of Pb compared to those in Lima, with males having higher levels than females. Pb was positively associated with hemoglobin, and in Cerro de Pasco, blood Pb decreased with distance from the mine. Associations were identified between Pb and specific genes related to neurological function through differential methylation analysis.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Oncology
Boghuma K. Titanji, Marta Gwinn, Vincent C. Marconi, Yan Sun
Summary: This review summarizes the current state of epigenetic epidemiologic studies of people with HIV, identifies the main challenges of this approach, and highlights future directions for the field. Emerging epigenetic epidemiologic studies can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the research coverage of diverse populations affected by the global HIV pandemic.
CLINICAL EPIGENETICS
(2022)
Article
Engineering, Environmental
Xiyang Cai, Kaixuan Li, Xia Meng, Qinglin Song, Su Shi, Wenran Li, Yue Niu, Li Jin, Haidong Kan, Sijia Wang
Summary: This study is the first epigenome-wide association study on ozone exposure conducted in a large-scale Han Chinese cohort. The study identified DNA methylation changes on CpGs and regions, as well as related gene functions and pathways.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Biochemical Research Methods
Junyan Song, Pei-Fen Kuan
Summary: This study conducted a systematic assessment of computational deconvolution methods and their role in estimating cell type proportions. The proposed framework, methylDeConv, integrates multiple deconvolution methods and allows for the construction of an extended reference library with cell-type-specific CpG selection. The study found that deconvolution based on the extended reference library is critical for accurate cell proportion estimation in non-blood tissues.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Oncology
Alena Kalyakulina, Igor Yusipov, Elena Kondakova, Maria Giulia Bacalini, Cristina Giuliani, Tatiana Sivtseva, Sergey Semenov, Artem Ksenofontov, Maria Nikolaeva, Elza Khusnutdinova, Raisa Zakharova, Maria Vedunova, Claudio Franceschi, Mikhail Ivanchenko
Summary: This study is the first epigenetic study of the Yakutian population, revealing region-specific differentially methylated regions associated with adaptation to climatic conditions and aging processes. It was also found that epigenetic age acceleration of the Yakutian population is significantly higher than that of the Central Russia population, and males age faster than females.
CLINICAL EPIGENETICS
(2023)
Article
Genetics & Heredity
Kai Wang, Shujie Wang, Xiang Ji, Dong Chen, Qi Shen, Yang Yu, Pingxian Wu, Xuewei Li, Guoqing Tang
Summary: This study aimed to identify CpG sites associated with DNA methylation levels and meat quality traits in Yorkshire pigs. Genome-wide methylation levels were measured using RRBS, and linear mixed-effect models were used to examine associations. Eight CpG sites were associated with drip loss, two CpG sites with yellowness, and five CpG sites with lightness. No significant associations were found with pH levels or meat redness. This study provides new insights into the epigenetic molecular mechanisms of meat quality traits in pigs.
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Nicole Lafontaine, Purdey J. Campbell, Juan E. Castillo-Fernandez, Shelby Mullin, Ee Mun Lim, Phillip Kendrew, Michelle Lewer, Suzanne J. Brown, Rae-Chi Huang, Phillip E. Melton, Trevor A. Mori, Lawrence J. Beilin, Frank Dudbridge, Tim D. Spector, Margaret J. Wright, Nicholas G. Martin, Allan F. McRae, Vijay Panicker, Gu Zhu, John P. Walsh, Jordana T. Bell, Scott G. Wilson
Summary: This study identified associations between blood-based DNAm and both fT3 and TSH, shedding light on the mechanisms underlying thyroid hormone action and/or pituitary-thyroid axis function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Oncology
Maria Pia Campagna, Alexandre Xavier, Jeannette Lechner-Scott, Vicky Maltby, Rodney J. Scott, Helmut Butzkueven, Vilija G. Jokubaitis, Rodney A. Lea
Summary: The interaction between genetic and environmental factors drives the development of complex diseases, with the role of the epigenome in disease pathophysiology gaining attention. Epigenome-wide association studies (EWASes) investigating the association between phenotype and epigenetic variants, particularly DNA methylation, have increased in number in recent years due to advancements in technology. Studies focusing on methylation data in blood samples have been recommended as a cost-effective approach, with novel areas of EWAS analysis expanding to include longitudinal study designs and statistical deconvolution for identifying cell-specific differential methylation.
CLINICAL EPIGENETICS
(2021)
