Article
Food Science & Technology
Yan Luan, Daniel Leclerc, Marta Cosin-Tomas, Olga V. Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A. Caudill, Rima Rozen
Summary: High folic acid intake during pregnancy can lead to placental metabolic and gene expression changes, particularly in angiogenesis, which may contribute to abnormal behavior in pups. These results are relevant for determining a safe upper limit for folate intake during pregnancy.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rebecca Simonian, Emanuela Pannia, Rola Hammoud, Ramil R. Noche, Xiucheng Cui, Eva Kranenburg, Ruslan Kubant, Paula Ashcraft, Brandi Wasek, Teodoro Bottiglieri, James J. Dowling, G. Harvey Anderson
Summary: This study evaluated the effects of mthfr deficiency and folic acid supplementation on energy homeostasis and metabolism using a novel zebrafish model. The genetic loss of mthfr function in zebrafish resulted in lipid accumulation, aberrant cholesterol metabolism, and impaired energy homeostasis. Folic acid supplementation mimicked some of these effects and exacerbated them in mthfr-deficient zebrafish.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Wrzosek, Klaudia Slusarczyk
Summary: This study examined the influence of the MTHFR C677T variant on BMI and its role as a risk factor for obesity. The results showed that the MTHFR 677TT genotype is not directly related to a higher BMI in Polish adults but has a detrimental effect on folate concentrations in individuals with high BMI values.
Article
Psychology, Multidisciplinary
Gurjinder Kaur, Rajan Gaur, Mamta Kumari Thakur, Kallur Nava Saraswathy
Summary: The study conducted among a largely vegetarian population from North India found that depression is a multi-factorial condition with higher rates among females. Folate deficiency and hyperhomocysteinemia were identified as potential risk factors for moderate/severe depression. Folate repletion was found to play a compensatory role for vitamin B12 deficiency in depressed individuals.
CURRENT PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kah Kheng Goh, Cynthia Yi-An Chen, Tzu-Hua Wu, Chun-Hsin Chen, Mong-Liang Lu
Summary: The high prevalence of metabolic syndrome in persons with schizophrenia has led to investigations into the common pathways connecting these two conditions, which may be underpinned by oxytocin system dysfunction. Current evidence suggests the existence of overlapping neurobiological features between metabolic risk factors and psychiatric symptoms, highlighting the potential role of oxytocin in understanding the pathogenesis of schizophrenia and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ye-Seul Koo, Yong-Jae Lee, Jae-Min Park
Summary: This study investigated the association between serum folate levels and MetS in premenopausal Korean women, finding an inverse relationship between serum folate levels and the risk of developing MetS.
Review
Biochemistry & Molecular Biology
Lyazzat Kaldygulova, Talshyn Ukybassova, Gulzhanat Aimagambetova, Andrey Gaiday, Akylbek Tussupkaliyev
Summary: The rationale and importance of folic acid supplementation during pregnancy for preventing fetal congenital defects are widely accepted. Adequate folate levels can reduce the risk of spontaneous abortions and support normal placental blood flow, promoting appropriate fetal growth. Additionally, there is emerging evidence that long-term folic acid supplementation can effectively prevent preeclampsia, a complication unique to humans during pregnancy that contributes to worldwide maternal and perinatal mortality. Folate supplementation helps to decrease elevated levels of homocysteine, which is associated with the risk of preeclampsia.
Article
Public, Environmental & Occupational Health
Derrick A. Bennett, Sarah Parish, Iona Y. Millwood, Yu Guo, Yiping Chen, Iain Turnbull, Ling Yang, Jun Lv, Canqing Yu, George Davey Smith, Yongjun Wang, Yilong Wang, Richard Peto, Rory Collins, Robin G. Walters, Liming Li, Zhengming Chen, Robert Clarke
Summary: In Chinese adults, the MTHFR C677T polymorphism is associated with an increased risk of stroke, highlighting the importance of further trials involving folic acid and mandatory folic acid fortification programs for stroke prevention in low-folate populations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Genetics & Heredity
Melissa Roufael, Tania Bitar, Yonna Sacre, Christian Andres, Walid Hleihel
Summary: Autism Spectrum Disorder (ASD) has seen a rapid increase in incidence and disturbances in folate or methionine metabolism have been found in individuals with ASD. Changes in metabolite concentrations associated with this cycle could be potential biomarkers and therapeutic targets for ASD. High levels of homocysteine and low levels of vitamins B12 and folate, influenced by poor diet and genetic predispositions, have been linked to ASD. Nutritional supplements have shown potential benefits for treating ASD, but more research is needed.
Review
Endocrinology & Metabolism
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Juan C. Cabrera-Guzman, Percy Herrera-Anazco, Vicente A. Benites-Zapata
Summary: This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and homocysteine (Hcy) levels with MetS. The results showed that higher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were positively associated with MetS. Folate levels were not associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stephanie Fryar-Williams, Joerg Strobel, Peter Clements, Karen K. Szumlinski
Summary: This review investigates the role of the MTHFR gene in schizophrenia and explores the pathways affected by its activity. The findings suggest that these pathways may be potential markers for the diagnosis and treatment of mental illnesses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Emily A. Bopp, Ethan A. Poweleit, Marley O. Cox, Jenni E. Farrow, Jeffrey R. Strawn, Luis R. Patino Duran, Cynthia A. Prows, Melissa P. DelBello, Laura B. Ramsey
Summary: This study retrospectively examined the use of adjunctive L-methylfolate in adolescents with depression. The results showed that the MTHFR genotype of the patients influenced the prescription of L-methylfolate, but augmentation with L-methylfolate was not significantly associated with treatment response. Limitations of this study included its retrospective design and limited data availability.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Yosra Bejaoui, Sara Alresheq, Sophie Durand, Marie Vilaire-Meunier, Louise Maillebouis, Ayman Al Haj Zen, Andre Megarbane, Nady El Hajj
Summary: This study investigated DNA methylation signatures and epigenetic aging in individuals with Down Syndrome (DS) with and without breast cancer. The results revealed differentially methylated sites and regions associated with changes in gene expression in breast cancer patients. However, there was no difference in epigenetic age acceleration between breast cancer and non-cancer DS patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Yu Wang, Meizhi Du, Jillian Vallis, Matin Shariati, Patrick S. Parfrey, John R. Mclaughlin, Peizhong Peter Wang, Yun Zhu
Summary: Polymorphic variants in MTRR and MTHFR genes may be associated with survival in patients with CRC, and this gene-CRC outcome association seems to be modulated by alcohol drinking and fruit intake.
Article
Health Care Sciences & Services
Anastasiia S. Boiko, Irina A. Mednova, Elena G. Kornetova, Anastasiia A. Goncharova, Arkadiy Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: Metabolic syndrome (MetS) is a common complication of schizophrenia that is exacerbated by long-term use of antipsychotics. The study found that levels of leptin were significantly increased in MetS patients, while ghrelin levels were significantly decreased. There were fewer significant correlations between ghrelin and other hormones in MetS patients compared to those without MetS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Sport Sciences
James R. Bagley, Kyle J. Burghardt, Ryan McManus, Bradley Howlett, Pablo B. Costa, Jared W. Coburn, Jose A. Arevalo, Moh H. Malek, Andrew J. Galpin
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2020)
Article
Psychiatry
A. Zarina Kraal, Allison C. Moll, Nicole R. Arvanitis, Kristen M. Ward, Ryan J. Doughert, Tyler B. Grove, Kyle J. Burghardt, Vicki L. Ellingrod
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Article
Clinical Neurology
Kyle J. Burghardt, Bradley H. Howlett, Elani Sanders, Sabrina E. Dass, Zaher Msallaty, Abduallah Mallisho, Berhane Seyoum, Zhengping Yi
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Kyle J. Burghardt, Audrey S. Khoury, Zaher Msallaty, Zhengping Yi, Berhane Seyoum
Review
Pharmacology & Pharmacy
Kyle J. Burghardt, Kristen M. Ward, Bradley H. Howlett, Paul R. Burghardt
Summary: Teaching genetics and pharmacogenetics with personal genotyping (PGT) can improve student attitudes, perceptions, and knowledge.
Article
Endocrinology & Metabolism
Aktham Mestareehi, Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi
Summary: The study found that metformin significantly increased PP2A activity in the skeletal muscle of 8 lean healthy insulin-sensitive participants, providing insight into metformin's mechanism of action in human skeletal muscle.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Neurosciences
Kyle J. Burghardt, Griffin Calme, Michael Caruso, Bradley H. Howlett, Elani Sanders, Zaher Msallaty, Abdullah Mallisho, Berhane Seyoum, Yue A. Qi, Xiangmin Zhang, Zhengping Yi
Summary: This study aimed to measure protein abundance in the skeletal muscle of patients on long-term treatment with atypical antipsychotics (AAP) or mood stabilizers. Significant differences in proteomic profiles were identified between the AAP group and the mood stabilizer group, suggesting that proteinomic characteristics may be associated with the metabolic side effects caused by these medications.
Review
Pharmacology & Pharmacy
Kyle Jon Burghardt, Wasym Mando, Berhane Seyoum, Zhengping Yi, Paul Ryen Burghardt
Summary: This systematic review and meta-analysis examined the evidence of hormonal, inflammatory, and metabolic biomarker studies of antipsychotic treatment in study designs using healthy volunteers. The findings suggest that antipsychotics may have strong effects on several biomarkers independent of psychiatric disease, but further replication work is needed for many biomarkers.
Review
Genetics & Heredity
Thomas Rowbal, Megan Kajy, Kyle J. Burghardt
Summary: This study aims to understand the mechanisms of antipsychotics through epigenetics. The findings demonstrate that the studies of the epigenome and antipsychotic treatment are highly heterogeneous in nature. This can inform future studies to target cross-cutting gene sets and pathways.
Article
Pharmacology & Pharmacy
Kyle J. Burghardt, Bradley H. Howlett, Audrey S. Khoury, Stephanie M. Fern, Paul R. Burghardt
Summary: This study compared the bibliometrics based on doctoral degrees within United States colleges of pharmacy and found significant differences in scholarly metrics between different degrees. Future research should focus on exploring potential variables that explain these differences.
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2021)
Meeting Abstract
Neurosciences
Nicole Zabik, Allesandra Iadipaolo, Craig Peters, Kyle Burghardt, Christine Rabinak
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Information Science & Library Science
Kyle J. Burghardt, Bradley H. Howlett, Audrey S. Khoury, Stephanie M. Fern, Paul R. Burghardt
Article
Public, Environmental & Occupational Health
Kyle J. Burghardt, Bradley H. Howlett, Stephanie M. Fern, Paul R. Burghardt
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2020)
Meeting Abstract
Neurosciences
Hilary Marusak, Craig Peters, Allesandra Iadipaolo, Farrah Elrahal, Kyle Burghardt, Christine Rabinak
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Kyle J. Burghardt, Kristen M. Ward, Elani J. Sanders, Bradley H. Howlett, Berhane Seyoum, Zhengping Yi
