Epigenetic diet: impact on the epigenome and cancer

Resveratrol and cellular mechanisms of cancer prevention

(2011) Yogeshwer Shukla et al.   Annals of the New York Academy of Sciences

Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells

(2011) Claudia Kürbitz et al.   CANCER SCIENCE

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss

(2011) Fermin I. Milagro et al.   FASEB JOURNAL

Epigallocatechin-3 Gallate Inhibits Invasion, Epithelial−Mesenchymal Transition, and Tumor Growth in Oral Cancer Cells

(2011) Pei-Ni Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Novel Solubility-Enhanced Curcumin Formulation Showing Stability and Maintenance of Anticancer Activity

(2011) Fang Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Autism Spectrum Disorders and Epigenetics

(2011) Daria Grafodatskaya et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

(2011) Yuanyuan Li et al.   PLoS One

Maternal Genome-Wide DNA Methylation Patterns and Congenital Heart Defects

(2011) Shimul Chowdhury et al.   PLoS One

Defining normal and abnormal fetal growth: promises and challenges

(2010) Jun Zhang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Additive effects of trastuzumab and genistein on human breast cancer cells

(2010) Claus Lattrich et al.   ANTI-CANCER DRUGS

Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics

(2010) Alexander Link et al.   BIOCHEMICAL PHARMACOLOGY

Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo

(2010) Phan LCHB Tran et al.   BMC CANCER

Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways

(2010) Jairam Vanamala et al.   BMC CANCER

Cancer Epigenetics

(2010) Rodolphe Taby et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Development of curcumin as an epigenetic agent

(2010) Siqing Fu et al.   CANCER

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer

(2010) Shahana Majid et al.   CANCER

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

(2010) Limin Shu et al.   CANCER AND METASTASIS REVIEWS

Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer

(2010) Yuji Sagara et al.   Cancer Epidemiology

Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

(2010) X. Cui et al.   Cancer Prevention Research

Chemoprevention of Head and Neck Cancer with Green Tea Polyphenols

(2010) J. W. Kim et al.   Cancer Prevention Research

Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF

(2010) Shadan Ali et al.   CANCER RESEARCH

Impact on DNA Methylation in Cancer Prevention and Therapy by Bioactive Dietary Components

(2010) Y. Li et al.   CURRENT MEDICINAL CHEMISTRY

Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer

(2010) Rong Lu et al.   Epigenetics

Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells

(2010) Barbara Stefanska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol and red wine, healthy heart and longevity

(2010) Dipak K. Das et al.   HEART FAILURE REVIEWS

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis

(2010) Susan J. Duthie   JOURNAL OF INHERITED METABOLIC DISEASE

Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells

(2010) Andreas J. Papoutsis et al.   JOURNAL OF NUTRITION

Bioavailability Enhancement of Curcumin by Complexation with Phosphatidyl Choline

(2010) Nishant Kumar Gupta et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells

(2010) Yuanyuan Li et al.   Molecular Cancer

Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell lines

(2010) Qi-Qi Mao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Tea polyphenol (−)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells

(2010) Shih-Hsin Tu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-κB pathway and subsequently downregulating expression of matrix metalloproteinases

(2010) Po-Len Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs

(2010) Ajay Goel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer

(2010) A Lujambio et al.   ONCOGENE

Suppression of the Inflammatory Cascade is Implicated in Resveratrol Chemoprevention of Experimental Hepatocarcinogenesis

(2010) Anupam Bishayee et al.   PHARMACEUTICAL RESEARCH

(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line

(2010) F. Farabegoli et al.   PHYTOMEDICINE

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Elevated levels of selenium in the typical diet of Amazonian riverside populations

(2010) Mélanie Lemire et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Recent advances in histone deacetylase targeted cancer therapy

(2010) Isamu Hoshino et al.   SURGERY TODAY

Molecular targets of epigenetic regulation and effectors of environmental influences☆☆☆

(2010) Supratim Choudhuri et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Frequent gene hypermethylation in laryngeal cancer cell lines and the resistance to demethylation induction by plant polyphenols

(2010) Jarosław Paluszczak et al.   TOXICOLOGY IN VITRO

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

(2010) Syed M. Meeran et al.   Clinical Epigenetics

Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention

(2009) Ka Lung Cheung et al.   AAPS Journal

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

(2009) Mohammad Athar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular mechanisms by which selenoproteins affect cancer risk and progression

(2009) Pin Zhuo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

(2009) Dirk Kuck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Serum Folate and Cancer Mortality Among U.S. Adults: Findings from the Third National Health and Nutritional Examination Survey Linked Mortality File

(2009) Q. Yang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of RelA Acetylation

(2009) K.-C. Choi et al.   CANCER RESEARCH

Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

(2009) Y. Li et al.   CANCER RESEARCH

Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma

(2009) Anupam Bishayee et al.   CANCER TREATMENT REVIEWS

The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival

(2009) S. Balasubramanian et al.   CARCINOGENESIS

BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer

(2009) S. Majid et al.   CARCINOGENESIS

Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM

(2009) K. L. Cheung et al.   CARCINOGENESIS

Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

(2009) Thomas E. Kraft et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Garlic and its potential for prevention of colorectal cancer and other conditions

(2009) David H Alpers   CURRENT OPINION IN GASTROENTEROLOGY

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Comparison of the Effects of Phenethyl Isothiocyanate and Sulforaphane on Gene Expression in Breast Cancer and Normal Mammary Epithelial Cells

(2009) Urvi Telang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms

(2009) Yuanyuan Li et al.   INTERNATIONAL JOURNAL OF CANCER

Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells

(2009) Kamal Yavari et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Advanced separation methods of food anthocyanins, isoflavones and flavanols

(2009) Josep Valls et al.   JOURNAL OF CHROMATOGRAPHY A

Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

(2009) Emily Ho et al.   JOURNAL OF NUTRITION

Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells

(2009) Wing Pui Tsang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oral administration of resveratrol in suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells

(2009) Ya-Ling Weng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-κB

(2009) Jane Chiu et al.   NUTRITION

Soy Isoflavones Have an Antiestrogenic Effect and Alter Mammary Promoter Hypermethylation in Healthy Premenopausal Women

(2009) Wenyi Qin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

(2009) G Boily et al.   ONCOGENE

Pharmacokinetics and Pharmacodynamics of Broccoli Sprouts on the Suppression of Prostate Cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice: Implication of Induction of Nrf2, HO-1 and Apoptosis and the Suppression of Akt-dependent Kinase Pathway

(2009) Young-Sam Keum et al.   PHARMACEUTICAL RESEARCH

The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells

(2009) Jarosław Paluszczak et al.   TOXICOLOGY LETTERS

Environmental signals and transgenerational epigenetics

(2009) Michael K Skinner et al.   Epigenomics

Antioxidative and anti-carcinogenic activities of tea polyphenols

(2008) Chung S. Yang et al.   ARCHIVES OF TOXICOLOGY

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol inhibits hypoxia-induced metastasis potential enhancement by restricting hypoxia-induced factor-1α expression in colon carcinoma cells

(2008) Hongzhong Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells

(2008) K Kato et al.   BRITISH JOURNAL OF CANCER

Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy

(2008) K Tikoo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Element Composition of Tea Leaves and Tea Infusions and Its Impact on Health

(2008) Fwu-Ming Shen et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Cancer Prevention: Epigenetics Steps Up to the Plate

(2008) J.-P. Issa   Cancer Prevention Research

Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification

(2008) S. Majid et al.   CANCER RESEARCH

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

(2008) H. Nian et al.   CARCINOGENESIS

Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells

(2008) Nong Xiang et al.   CARCINOGENESIS

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Chemoprevention of Cancer by Isothiocyanates and Anthocyanins: Mechanisms of Action and Structure-Activity Relationship

(2008) C. Fimognari et al.   CURRENT MEDICINAL CHEMISTRY

Modulation of gene methylation by genistein or lycopene in breast cancer cells

(2008) Audrey King-Batoon et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Impaired Reproductive Development in Sons of Women Occupationally Exposed to Pesticides during Pregnancy

(2008) Helle R. Andersen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Mechanisms of combined action of different chemopreventive dietary compounds

(2008) Theo M. de Kok et al.   EUROPEAN JOURNAL OF NUTRITION

DNA methylomes, histone codes and miRNAs: Tying it all together

(2008) Sònia Guil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Retracted: Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

(2008) Nobuyuki Kikuno et al.   INTERNATIONAL JOURNAL OF CANCER

Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells

(2008) Kristin R. Landis-Piwowar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways

(2008) Quanyi Lu et al.   Journal of Hematology & Oncology

Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function

(2008) Caroline Bertram et al.   JOURNAL OF PHYSIOLOGY-LONDON

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

(2008) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

Chromatin-remodelling mechanisms in cancer

(2008) Laura Lafon-Hughes et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates

(2008) Roderick H Dashwood et al.   NUTRITION REVIEWS

Synergistic Effect of 5-Aza-2′-Deoxycytidine and Genistein in Combination Against Leukemia

(2008) Noël J.-M. Raynal et al.   ONCOLOGY RESEARCH

RNAi-mediated downregulation of urokinase plasminogen activator receptor inhibits proliferation, adhesion, migration and invasion in oral cancer cells

(2008) Xinhua Liang et al.   ORAL ONCOLOGY

Ultraviolet Radiation-induced Transcription is Associated with Gene-specific Histone Acetylation

(2008) Brian P. Pollack et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Maternal Cocaine Administration in Mice Alters DNA Methylation and Gene Expression in Hippocampal Neurons of Neonatal and Prepubertal Offspring

(2008) Svetlana I. Novikova et al.   PLoS One

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells

(2008) Suvarna Bhamre et al.   PROSTATE

Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity

(2008) Sebla B. Kutluay et al.   VIROLOGY

Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG

(2007) Joel B. Berletch et al.   JOURNAL OF CELLULAR BIOCHEMISTRY