标题
Small-molecule chromatin-modifying agents: therapeutic applications
作者
关键词
-
出版物
Epigenomics
Volume 2, Issue 2, Pages 307-324
出版商
Future Medicine Ltd
发表日期
2010-04-14
DOI
10.2217/epi.10.7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Sodium Butyrate Induces Human Colon Carcinoma HT-29 Cell Apoptosis through a Mitochondrial Pathway
- (2013) L Wang et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
- (2010) Jiahuai Tan et al. Journal of Hematology & Oncology
- Gateways to clinical trials
- (2010) A. Tomillero et al. METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
- A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma
- (2009) Monica Galli et al. ANNALS OF HEMATOLOGY
- Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia
- (2009) Kristie A. Blum et al. BRITISH JOURNAL OF HAEMATOLOGY
- Histone deacetylase inhibitors that target tubulin
- (2009) Jörg Schemies et al. CANCER LETTERS
- Enhancing the apoptotic and therapeutic effects of HDAC inhibitors
- (2009) Ailsa J. Frew et al. CANCER LETTERS
- Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing
- (2009) Chunping Xu et al. CHEMISTRY & BIOLOGY
- The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors
- (2009) Astrid Spannhoff et al. ChemMedChem
- Epigenetic Modifiers: Basic Understanding and Clinical Development
- (2009) R. L. Piekarz et al. CLINICAL CANCER RESEARCH
- Clinical Studies of Histone Deacetylase Inhibitors
- (2009) H. M. Prince et al. CLINICAL CANCER RESEARCH
- Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise
- (2009) Antonello Mai et al. CURRENT PHARMACEUTICAL DESIGN
- Non-Cancer Uses of Histone Deacetylase Inhibitors: Effects on Infectious Diseases and β-Hemoglobinopathies+
- (2009) Dante Rotili et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Histone acetyl transferases as emerging drug targets
- (2009) Frank J. Dekker et al. DRUG DISCOVERY TODAY
- Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes
- (2009) Angela Nebbioso et al. EMBO REPORTS
- Histone acetyltransferase inhibitors and preclinical studies
- (2009) Fabio Manzo et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report
- (2009) D. Ritchie et al. HAEMATOLOGICA
- Trans-regulation of Histone Deacetylase Activities through Acetylation
- (2009) Yi Luo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone deacetylase inhibitors: Potential in cancer therapy
- (2009) P.A. Marks et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens
- (2009) M. A. Pfaller et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Histone Deacetylase Inhibitors in Cancer Therapy
- (2009) Andrew A. Lane et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma
- (2009) Richard L. Piekarz et al. JOURNAL OF CLINICAL ONCOLOGY
- Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo
- (2009) M. S.Q. Kortenhorst et al. MOLECULAR CANCER THERAPEUTICS
- Recent progress in the biology and physiology of sirtuins
- (2009) Toren Finkel et al. NATURE
- "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
- (2009) Andrea Savarino et al. Retrovirology
- Antimalarial Activity of Phenylthiazolyl-Bearing Hydroxamate-Based Histone Deacetylase Inhibitors
- (2008) G. S. Dow et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues
- (2008) K. T. Andrews et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
- (2008) Nagma Khan et al. BIOCHEMICAL JOURNAL
- Therapeutic role of sirtuins in neurodegenerative disease
- (2008) Tiago Fleming Outeiro et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
- (2008) G. Garcia-Manero et al. BLOOD
- Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator
- (2008) Sonia Lain et al. CANCER CELL
- HDAC family: What are the cancer relevant targets?
- (2008) Olaf Witt et al. CANCER LETTERS
- A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors
- (2008) N. L. Steele et al. CLINICAL CANCER RESEARCH
- Isoform-Selective Histone Deacetylase Inhibitors
- (2008) Takayoshi Suzuki et al. CURRENT PHARMACEUTICAL DESIGN
- Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
- (2008) H. Maeda et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease
- (2008) Judit Pallos et al. HUMAN MOLECULAR GENETICS
- New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations
- (2008) Antonello Mai et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead
- (2008) Antonello Mai et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Cancer treatment of the future: Inhibitors of histone methyltransferases
- (2008) Astrid Spannhoff et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases
- (2008) C. James Chou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain
- (2008) Matthew J. Bottomley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase I Study of MGCD0103 Given As a Three-Times-Per-Week Oral Dose in Patients With Advanced Solid Tumors
- (2008) Lillian L. Siu et al. JOURNAL OF CLINICAL ONCOLOGY
- Residues in the 11 Å Channel of Histone Deacetylase 1 Promote Catalytic Activity: Implications for Designing Isoform-Selective Histone Deacetylase Inhibitors†
- (2008) Sujith V. W. Weerasinghe et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Series of Potent and Selective, Triazolylphenyl-Based Histone Deacetylases Inhibitors with Activity against Pancreatic Cancer Cells andPlasmodium falciparum
- (2008) Yufeng Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells
- (2008) V. Duong et al. MOLECULAR CANCER RESEARCH
- The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
- (2008) Alejandro Villagra et al. NATURE IMMUNOLOGY
- The many roles of histone deacetylases in development and physiology: implications for disease and therapy
- (2008) Michael Haberland et al. NATURE REVIEWS GENETICS
- Paths of Convergence: Sirtuins in Aging and Neurodegeneration
- (2008) Li Gan et al. NEURON
- SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
- (2008) O Binda et al. ONCOGENE
- Deacetylation of cortactin by SIRT1 promotes cell migration
- (2008) Y Zhang et al. ONCOGENE
- Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
- (2008) E Lara et al. ONCOGENE
- HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model
- (2008) Myriam Rai et al. PLoS One
- The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
- (2008) E. A. Thomas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A Activation and Class II Histone Deacetylases Nuclear Shuttling
- (2007) Barbara Illi et al. CIRCULATION RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search