Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Plant Sciences
Valentin Joly, Yannick Jacob
Summary: This study summarizes recent discoveries in plants regarding the role of H3.1 in chromatin replication, genomic stability, epigenetic inheritance, and its interaction with DNA polymerase epsilon.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Article
Plant Sciences
Karolina Kolarova, Martina Nespor Dadejova, Tomas Loja, Gabriela Lochmanova, Eva Sykorova, Martina Dvorackova
Summary: The disruption of the H2A-H2B histone chaperone NUCLEOSOME ASSEMBLY PROTEIN 1 (NAP1) can suppress the loss-of-function phenotype of FAS1, leading to wild-type growth, decreased sensitivity to genotoxic stress, and suppression of telomere and 45S rDNA loss in Arabidopsis thaliana. This study demonstrates the essential role of NAP1 proteins in DNA repair in the absence of functional CAF-1, which is coupled to nucleosome assembly through modulation of H3 levels in the nucleus.
Review
Biochemistry & Molecular Biology
Pin Zhao, Samiullah Malik
Summary: This review describes how phosphorylation affects the transcription activity and other functions of DNA/histone modifying enzymes. Although the phosphorylated sites of these enzymes have been classified and partially explained, further research is still needed to determine their relationship with disease-associated transcriptional regulation.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lucia Falbo, Vincenzo Costanzo
Summary: Research has shown that in early embryonic development of certain metazoans, there is a transition in the number of replication origins to ensure accurate DNA replication. This novel form of epigenetic memory may impact various areas of vertebrate biology.
Article
Genetics & Heredity
Ioannis Tsirkas, Daniel Dovrat, Yang Lei, Angeliki Kalyva, Diana Lotysh, Qing Li, Amir Aharoni
Summary: The study demonstrates that the WHD and PIP domains of Cac1p play distinct roles in DNA replication and genome stability. Mutations in the WHD domain slow down replication fork progression, while mutations in the PIP domain affect late-S/Anaphase duration and mutation rate.
Article
Plant Sciences
Maria Vaquero-Sedas, Miguel A. Vega-Palas
Summary: Telomeric regions in Arabidopsis have a bimodal chromatin structure, with telomeres lacking both euchromatic and heterochromatic marks, followed by heterochromatic subtelomeres. The presence of heterochromatic modifications in subtelomeres may play a significant role in telomere biology.
Review
Biochemistry & Molecular Biology
N. Jeelan Basha, S. M. Basavarajaiah
Summary: Histone-modifying enzymes play a crucial role in the epigenetic regulation of cellular functions. However, deregulation of these enzymes can lead to various disorders. This review focuses on heterocycles as target-specific inhibitors of histone-modifying enzymes, specifically histone acetyltransferases. It also discusses recent reports and future perspectives of these heterocycles in epigenetic therapy.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Review
Urology & Nephrology
Anbarasu Kumaraswamy, Katherine R. Welker Leng, Thomas C. Westbrook, Joel A. Yates, Shuang G. Zhao, Christopher P. Evans, Felix Y. Feng, Todd M. Morgan, Joshi J. Alumkal
Summary: This study systematically reviewed the role of epigenetic factors in prostate cancer from 2015 to 2020, highlighting key preclinical and translational data. Findings from both preclinical and clinical studies were reviewed and summarized, along with a discussion on 12 ongoing clinical studies with epigenetic targeted therapies.
Article
Multidisciplinary Sciences
Tanay Thakar, Ashna Dhoonmoon, Joshua Straka, Emily M. Schleicher, Claudia M. Nicolae, George-Lucian Moldovan
Summary: This study reveals that lagging strand ssDNA gaps interfere with nucleosome assembly and drive replication fork degradation in BRCA-deficient cells. Correcting PCNA unloading defects and activating a compensatory histone deposition pathway can restore fork stability in BRCA-deficient cells.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Jing Zhang, Long-Min Chen, Yuan Zou, Shu Zhang, Fei Xiong, Cong-Yi Wang
Summary: Type 1 diabetes (T1D) is an autoimmune disease caused by severe destruction of insulin-producing beta cells, with both genetic predisposition and environmental factors playing critical roles in its pathogenesis. Epigenetics serves as a bridge linking T1D risk genes and environmental exposures, modulating gene expression relevant to T1D development beyond DNA sequence changes.
CHINESE MEDICAL JOURNAL
(2021)
Review
Genetics & Heredity
Ian Hammond-Martel, Alain Verreault, Hugo Wurtele
Summary: A broad range of DNA lesions, whether spontaneous or genotoxic, can hinder the progression of replication forks. The DNA damage response mechanism that promotes completion of DNA replication involves dynamic changes in chromatin structure, including two key processes known as histone recycling/parental histone segregation and de novo chromatin assembly, which impact cellular responses to DNA replication roadblocks.
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Xiaomin Ma, Xin Wang, Guangbing Zheng, Guiqin Tan, Fangyu Zhou, Wenwen Wei, Dan Tian, Hongsong Yu
Summary: Behçet's disease is a chronic multisystem autoimmune disease with complex pathogenesis involving genetics, environmental factors, and gut microbiota. Previous studies have indicated that external environmental factors and abnormalities in epigenetic modification may impact the development of BD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Editorial Material
Biochemistry & Molecular Biology
Kaifu Chen, Zheng Hu, Zheng Xia, Dongyu Zhao, Wei Li, Jessica K. Tyler
MOLECULAR AND CELLULAR BIOLOGY
(2016)
Article
Genetics & Heredity
Yanai Zhan, Maria Kost-Alimova, Xi Shi, Elisabetta Leo, Jennifer P. Bardenhagen, Hannah E. Shepard, Srikanth Appikonda, Bhavatarini Vangamudi, Shuping Zhao, Trang N. Tieu, Shiming Jiang, Timothy P. Heffernan, Joseph R. Marszalek, Carlo Toniatti, Giulio Draetta, Jessica Tyler, Michelle Barton, Philip Jones, Wylie S. Palmer, Mary K. Geck Do, Jannik N. Andersen
EPIGENETICS & CHROMATIN
(2015)
Article
Cell Biology
Candice L. Wike, Hillary K. Graves, Arpit Wason, Reva Hawkins, Jay Gopalakrishnan, Jill Schumacher, Jessica K. Tyler
Article
Cell Biology
Putzer J. Hung, Bo-Ruei Chen, Rosmy George, Caleb Liberman, Abigail J. Morales, Pedro Colon-Ortiz, Jessica K. Tyler, Barry P. Sleckman, Andrea L. Bredemeyer
Editorial Material
Multidisciplinary Sciences
Siu Sylvia Lee, Jessica K. Tyler
Editorial Material
Genetics & Heredity
Jessica K. Tyler
TRENDS IN GENETICS
(2016)
Article
Genetics & Heredity
Hillary K. Graves, Pingping Wang, Matthew Lagarde, Zhihong Chen, Jessica K. Tyler
EPIGENETICS & CHROMATIN
(2016)
Article
Biology
Wallace H. Liu, Sarah C. Roemer, Yeyun Zhou, Zih-Jie Shen, Briana K. Dennehey, Jeremy L. Balsbaugh, Jennifer C. Liddle, Travis Nemkov, Natalie G. Ahn, Kirk C. Hansen, Jessica K. Tyler, Mair E. A. Churchill
Article
Biology
Candice L. Wike, Hillary K. Graves, Reva Hawkins, Matthew D. Gibson, Michelle B. Ferdinand, Tao Zhang, Zhihong Chen, Damien F. Hudson, Jennifer J. Ottesen, Michael G. Pokier, Jill Schumacher, Jessica K. Tyler
Article
Biology
Xuan Li, Jessica K. Tyler
Article
Multidisciplinary Sciences
Mohammad B. Hossain, Rehnuma Shifat, David G. Johnson, Mark T. Bedford, Konrad R. Gabrusiewicz, Nahir Cortes-Santiago, Xuemei Luo, Zhimin Lu, Ravesanker Ezhilarasan, Erik P. Sulman, Hong Jiang, Shawn S. C. Li, Frederick F. Lang, Jessica Tyler, Mien-Chie Hung, Juan Fueyo, Candelaria Gomez-Manzano
Review
Multidisciplinary Sciences
Sangita Pal, Jessica K. Tyler
Editorial Material
Biochemistry & Molecular Biology
Rhiannon R. Aguilar, Jessica K. Tyler
Article
Multidisciplinary Sciences
Li-Ting Diao, Chin-Chuan Chen, Briana Dennehey, Sangita Pal, Pingping Wang, Zie-Jie Shen, Angela Deem, Jessica K. Tyler
Article
Multidisciplinary Sciences
Sangita Pal, Hillary Graves, Ryosuke Ohsawa, Ting-Hsiang Huang, Pingping Wang, Laura Harmacek, Jessica Tyler