Article
Nanoscience & Nanotechnology
Xiaomin Yang, Vu Long Tran, Hynd Remita, Farah Savina, Caroline Denis, Dimitri Kereselidze, Benoit Jego, Sandrine Lacombe, Erika Porcel, Charles Truillet
Summary: Personalized medicine approach in radiotherapy requires precise delivery of dose to the tumor. High-Z metal-based nanoparticles as radio-enhancers, featured with PET imaging, show potential for clinical use.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
Jung Eun Park, Jun Young Lee, Jungho Chae, Chang Ho Min, Hee Soon Shin, So Young Lee, Jae Young Lee, Jeong Hoon Park, Jongho Jeon
Summary: Exposure to diesel particulate matter (DPM) can cause severe respiratory diseases and toxic effects on extrapulmonary organs, as shown by molecular imaging and radiolabeling techniques in animal models. DPM was primarily distributed in the lungs, but also translocated to other organs such as the heart, spleen, and liver.
Article
Pharmacology & Pharmacy
Hojun Choi, Myung-Yoon Kim, Dae-Hwan Kim, Hanoul Yun, Byung-Koo Oh, Su-Bin Kim, In-Ho Song, Hyun-Soo Park, Sang-Eun Kim, Cheolhyoung Park, Chulhee Choi
Summary: This study assessed the biodistribution and pharmacokinetics of therapeutic exosomes labeled with Zr-89 in mice and rats. The results showed that the exosomes were mainly distributed in the liver and spleen, with substantial uptake by parenchymal cells. They were also moderately distributed in the kidney, lung, stomach, intestine, urinary bladder, brain, and heart. Exosomes were rapidly cleared from circulation, indicating their rapid uptake by cells and tissues.
Article
Multidisciplinary Sciences
Se Jong Oh, Chul Hyoung Lyoo, Young Hoon Ryu, Jae Yong Choi
Summary: This study compared conventional and software-aided methods for deriving the effective dose. The average error rates for the mean effective dose between the two methods were 3.8% and 1.9%, respectively. The urinary bladder and liver showed the greatest differences in absorbed dose.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovar, Weibo Cai, Milada Sirova, Tomas Etrych
Summary: nanomedicines are being developed as an improved therapeutic option with reduced side effects, and this study introduces tailored nanosystems for the treatment of solid tumors or hematological malignancies. The relationship between the structure of the nanosystem and its distribution in the body was evaluated through independent assessments of the polymer carrier and drug pharmacokinetics. The results showed enhanced tumor accumulation of the polymer carriers in mice with solid tumors, as well as significant accumulation of doxorubicin bound to the polymer carriers in specific tumor types.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Shih-Hsun Cheng, M. Reid Groseclose, Cindy Mininger, Mats Bergstrom, Lily Zhang, Stephen C. Lenhard, Tinamarie Skedzielewski, Zachary D. Kelley, Debra Comroe, Hyundae Hong, Haifeng Cui, Jennifer L. Hoover, Steve Rittenhouse, Stephen Castellino, Beat M. Jucker, Hasan Alsaid
Summary: This study developed a multimodal imaging approach to assess the distribution of an antibacterial drug delivered as a liposomal formulation in a mouse infection model. By combining positron emission tomography (PET) and matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS), the researchers observed an excellent correlation between the radiolabel signal detected by PET and the drug and lipid component signals detected by MALDI IMS.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Inorganic & Nuclear
Daniel F. Earley, Jose Esteban Flores, Amaury Guillou, Jason P. Holland
Summary: In recent years, copper-64 and copper-67 have been considered as a useful theranostic pair in nuclear medicine. This study successfully demonstrates the viability of photochemically induced conjugation methods for the development of copper-based radiotracers for potential applications in diagnostic PET imaging and targeted radionuclide therapy.
DALTON TRANSACTIONS
(2022)
Article
Medicine, Research & Experimental
Su Bin Kim, In Ho Song, Seon Yoo Kim, Hae Young Ko, Hee Seup Kil, Dae Yoon Chi, Frederik L. Giesel, Klaus Kopka, Alexander Hoepping, Joong-Hyun Chun, Hyun Soo Park, Mijin Yun, Sang Eun Kim
Summary: Several radiolabeled PSMA-targeted agents have been developed for detecting prostate cancer and targeted radionuclide therapy. This study characterized the pharmacokinetics and radiation dose of [18F]PSMA-1007 in prostate tumor-bearing mice. The kidney showed the highest accumulation of [18F]PSMA-1007, and the concentration in the tumor reached its peak at 112 min after injection. Treatment with a PSMA inhibitor significantly decreased [18F]PSMA-1007 uptake in the tumor.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, J. V. Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline, Kiran Kumar Solingapuram Sai
Summary: Overproduction of reactive oxygen species (ROS) due to altered redox regulation is common in many cancers. While PET imaging is the standard tool for cancer imaging, there are no clinically-approved PET radiotracers for ROS imaging. An ascorbate-based radioligand, [18F] KS1, shows promise in tracking ROS and demonstrates good safety and translational potential in animal models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Physical
Andrew P. Justl, Giacomo Cerretti, Sabah K. Bux, Susan M. Kauzlarich
Summary: Synthetic organic chemists often use retrosynthetic approach and named reactions to target complex molecules, while complex inorganic compounds can be synthesized through simple mechanochemical reactions of the elements. However, complex phases involving multiple elements can lead to competing phases, which may impact the desired properties. This study elucidates the reaction pathway from the elements to the formation of the complex ternary phase Yb14AlSb11 through quenching experiments, and synthesizes high-purity Yb14MnSb11 and Yb14MgSb11 through stoichiometric reactions.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Kasey P. Devlin, Braulio Gomez, Susan M. Kauzlarich
Summary: Eu5Sn2As6 is a Zintl phase with impressive thermoelectric properties, which can be enhanced by substitution with K or La.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2022)
Article
Physics, Multidisciplinary
Jackson R. Badger, Yundi Quan, Matthew C. Staab, Shuntaro Sumita, Antonio Rossi, Kasey P. Devlin, Kelly Neubauer, Daniel S. Shulman, James C. Fettinger, Peter Klavins, Susan M. Kauzlarich, Dai Aoki, Inna M. Vishik, Warren E. Pickett, Valentin Taufour
Summary: Unconventional superconductors have Cooper pairs with lower symmetries compared to conventional superconductors. This article demonstrates that the time-reversal symmetry breaking in the superconductor LaNiGa2 is enabled by its previously unknown topological electronic band structure. These unique topological features allow LaNiGa2 to break time-reversal symmetry in the absence of other typical ingredients, providing a pathway for identifying a new type of unconventional superconductors based on nonsymmorphic symmetries.
COMMUNICATIONS PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Zheng Ju, Caitlin Crawford, Jesse Adamczyk, Eric S. Toberer, Susan M. Kauzlarich
Summary: This study successfully synthesized core-shell Bi2Te3/Sb2Te3 nanostructured heterojunctions, which have potential in energy waste harvesting and sustainable energy utilization. The material showed high Seebeck coefficient and overall zT value in the out-of-plane direction, possibly due to the energy filtering effect across the heterojunction interfaces.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Allan He, Zihao Shen, Haozhe Wang, Weiwei Xie, Zhen Wang, Luis Garay, James C. Fettinger, Raphael P. Hermann, Yimei Zhu, Valentin Taufour, Susan M. Kauzlarich
Summary: The new Eu(5)Al(3)Sh(6) phase has been synthesized as a pure phase with large, high-quality crystals using Sn flux methods. The structure features disordered Al clusters in the form of dual tetrahedra and exhibits unique electronic properties. Evaluation of its properties includes magnetic behavior, oxidation states, and electronic structure calculations.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Physical
Callista M. Skaggs, Andrew P. Justl, Ankita Biswas, Peter E. Siegfried, Shunshun Liu, Saul H. Lapidus, Wenqian Xu, Zachary T. Messegee, Nirmal J. Ghimire, Prasanna V. Balachandran, Susan M. Kauzlarich, Xiaoyan Tan
Summary: A metastable polycrystalline Ag2GeS3 compound with a polar orthorhombic crystal structure was prepared at 1000 degrees C. It exhibits semiconductor behavior with low lattice thermal conductivity.
CHEMISTRY OF MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Andrew P. Justl, Susan M. Kauzlarich
Summary: Yb14MSb11 (M = Mg, Mn, Zn) are p-type Zintl phases with high thermoelectric efficiencies at 1000 degrees C and melting points above 1200 degrees C under vacuum and/or inert atmosphere. Oxidation behavior of Yb14MSb11 in dry air has been studied, showing different oxidation reactions in the outer layer, inner layer, and core of the material. Yb14ZnSb11 exhibits the best resistance to oxidation and holds promise for further passivation optimization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Ashlee K. Hauble, Caitlin M. Crawford, Jesse M. Adamczyk, Maxwell Wood, James C. Fettinger, Eric S. Toberer, Susan M. Kauzlarich
Summary: Layered Zintl phases with A2MPn2 stoichiometry are potential thermoelectric materials with complex chemistry. This study focuses on Yb2-xEuxCdSb2 solid solution and investigates the impact of defects on thermal and electronic properties. The research reveals that tuning the defect structure can significantly improve the thermoelectric performance.
CHEMISTRY OF MATERIALS
(2022)
Article
Multidisciplinary Sciences
Andrew P. Justl, Francesco Ricci, Andrew Pike, Giacomo Cerretti, Sabah K. Bux, Geoffroy Hautier, Susan M. Kauzlarich
Summary: Yb14MnSb11 and Yb14MgSb11 are considered as excellent high-temperature p-type thermoelectric materials. In this study, it is found that the previously regarded poor thermoelectric material, Yb14ZnSb11, actually possesses the electronic structure features that lead to high thermoelectric performance. The reported low power factor of Yb14ZnSb11 is attributed to the presence of a unique impurity, which can be avoided through a specific synthetic route. The phase-pure Yb14ZnSb11 shows exceptional high-temperature thermoelectric properties, and the favorable band structure features for thermoelectric performance are found to be universal among the Ca14AlSb11 structure type, providing possibilities for high-performance thermoelectric materials.
Article
Chemistry, Physical
Srikanth Balijapelly, Ashlee Hauble, Santhoshkumar Sundaramoorthy, Jeremy Lee Watts, Susan M. Kauzlarich, Aleksandr Chernatynskiy, Amitava Choudhury
Summary: In this article, the synthesis, characterization, and ultralow thermal conductivity of three complex quaternary chalcogenide compounds were reported. These compounds possess complex structures with mixed occupied sites, leading to ultralow thermal conductivities. Spectroscopy and charge transport properties reveal narrow band gaps, low electrical conductivities, and high Seebeck coefficients. One of the compounds exhibits a promising figure of merit at high temperatures.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Rongqing Shang, Allan He, Elizabeth L. Kunz Wille, Na Hyun Jo, James C. Fettinger, Paul C. Canfield, Susan M. Kauzlarich
Summary: The solid solutions of Yb14ZnSb11 with different RE3+ elements were prepared to investigate the intermediate valency of Yb in Yb14ZnSb11. The substitution of Yb with RE3+ elements can impact the valency of Yb ions. Large crystals were grown using Sn-flux, the structure and magnetic susceptibility were studied. The results showed that all compounds crystallize in the Ca14AlSb11 structure type and the RE3+ ions exhibit a size-dependent preference for substitution at the Yb site.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Andrew P. Justl, Sabah K. Bux, Susan M. Kauzlarich
Summary: Yb14MnSb11 is a high-temperature p-type thermoelectric material that can control carrier concentration through site substitution. Substitution of Lu3+ for Yb2+ increases the electrical resistivity and Seebeck coefficient, reducing the peak zT.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Vincenzo Pecunia, S. Ravi P. Silva, Jamie D. Phillips, Elisa Artegiani, Alessandro Romeo, Hongjae Shim, Jongsung Park, Jin Hyeok Kim, Jae Sung Yun, Gregory C. Welch, Bryon W. Larson, Myles Creran, Audrey Laventure, Kezia Sasitharan, Natalie Flores-Diaz, Marina Freitag, Jie Xu, Thomas M. Brown, Benxuan Li, Yiwen Wang, Zhe Li, Bo Hou, Behrang H. Hamadani, Emmanuel Defay, Veronika Kovacova, Sebastjan Glinsek, Sohini Kar-Narayan, Yang Bai, Da Bin Kim, Yong Soo Cho, Agne Zukauskaite, Stephan Barth, Feng Ru Fan, Wenzhuo Wu, Pedro Costa, Javier del Campo, Senentxu Lanceros-Mendez, Hamideh Khanbareh, Zhong Lin Wang, Xiong Pu, Caofeng Pan, Renyun Zhang, Jing Xu, Xun Zhao, Yihao Zhou, Guorui Chen, Trinny Tat, Il Woo Ock, Jun Chen, Sontyana Adonijah Graham, Jae Su Yu, Ling-Zhi Huang, Dan-Dan Li, Ming-Guo Ma, Jikui Luo, Feng Jiang, Pooi See Lee, Bhaskar Dudem, Venkateswaran Vivekananthan, Mercouri G. Kanatzidis, Hongyao Xie, Xiao-Lei Shi, Zhi-Gang Chen, Alexander Riss, Michael Parzer, Fabian Garmroudi, Ernst Bauer, Duncan Zavanelli, Madison K. Brod, Muath Al Malki, G. Jeffrey Snyder, Kirill Kovnir, Susan M. Kauzlarich, Ctirad Uher, Jinle Lan, Yuan-Hua Lin, Luis Fonseca, Alex Morata, Marisol Martin-Gonzalez, Giovanni Pennelli, David Berthebaud, Takao Mori, Robert J. Quinn, Jan-Willem G. Bos, Christophe Candolfi, Patrick Gougeon, Philippe Gall, Bertrand Lenoir, Deepak Venkateshvaran, Bernd Kaestner, Yunshan Zhao, Gang Zhang, Yoshiyuki Nonoguchi, Bob C. Schroeder, Emiliano Bilotti, Akanksha K. Menon, Jeffrey J. Urban, Oliver Fenwick, Ceyla Asker, A. Alec Talin, Thomas D. Anthopoulos, Tommaso Losi, Fabrizio Viola, Mario Caironi, Dimitra G. Georgiadou, Li Ding, Lian-Mao Peng, Zhenxing Wang, Muh-Dey Wei, Renato Negra, Max C. Lemme, Mahmoud Wagih, Steve Beeby, Taofeeq Ibn-Mohammed, K. B. Mustapha, A. P. Joshi
Summary: Ambient energy harvesting has the potential to contribute to sustainable development and power the growth of smart devices in the Internet of Things. Innovative materials are crucial for efficient energy conversion, and this Roadmap provides insights into recent advances and challenges in the field. Promising directions for future research are outlined to fully harness the potential of energy harvesting materials.
JOURNAL OF PHYSICS-MATERIALS
(2023)
Article
Chemistry, Physical
Ashlee K. Hauble, Michael Y. Toriyama, Stephan Bartling, Ali M. Abdel-Mageed, G. Jeffrey Snyder, Susan M. Kauzlarich
Summary: Low-dimensional materials, such as layered Zintl phases, have unique properties that make them desirable for various applications. The complex structure and composition of layered Zintl phases pose challenges in producing phase-pure bulk samples for characterization. Eu11Zn4Sn2As12, a layered Zintl phase of significant complexity, exhibits magnetic, electronic, and thermoelectric properties, making it a promising material for further optimization and exploitation in thermoelectric applications.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Andrew P. Justl, Logan D. Winston, Sabah K. Bux, Susan M. Kauzlarich
Summary: Yb14ZnSb11 is a new member of the high-performance thermoelectric materials family with the potential for forming passivating oxide coatings. The effects of Lu substitution on thermoelectric and oxidation properties are investigated, with low solubility of Lu within the system. Introducing Lu reduces the band gap and Seebeck coefficient, decreasing the high-temperature zT.
ACS APPLIED ENERGY MATERIALS
(2023)
