期刊
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
卷 5, 期 6, 页码 733-750出版社
WILEY
DOI: 10.1002/wsbm.1238
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资金
- American Cancer Society
- Cornell University
- National Institutes of Health [CA168997]
- National Science Foundation [MCB-1243588]
There has been a surge of interest in understanding the regulation of metabolic networks involved in disease in recent years. Quantitative models are increasingly being used to interrogate the metabolic pathways that are contained within this complex disease biology. At the core of this effort is the mathematical modeling of central carbon metabolism involving glycolysis and the citric acid cycle (referred to as energy metabolism). Here, we discuss several approaches used to quantitatively model metabolic pathways relating to energy metabolism and discuss their formalisms, successes, and limitations. (C) 2013 Wiley Periodicals, Inc.
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