Article
Pharmacology & Pharmacy
Yakun Li, Bingyang Xu, Jun Yang, Lu Wang, Xiaosheng Tan, Xiaofan Hu, Lingjuan Sun, Song Chen, Lan Zhu, Xiaoping Chen, Gang Chen
Summary: Liraglutide exerts protective effects against renal ischemia-reperfusion injury by inhibiting HMGB1 nuclear-cytoplasmic translocation and release, partially dependent on GLP-1R. This demonstrates its therapeutic potential in the prevention and treatment of organ IRI.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jinwoo Myung, Jin-Ho Beom, Ju-Hee Kim, Ji-Sun Woo, Incheol Park, Sung-Phil Chung, Yong-Eun Chung, Je-Sung You
Summary: This study found that the administration of recombinant klotho (rKL) protein can attenuate the inflammation and cell death caused by myocardial ischemia and reperfusion injury (I/R) by inhibiting the extracellular release of HMGB1. This provides a theoretical basis for the clinical adjunctive treatment of acute myocardial infarction.
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zhuolun Song, Hui Han, Xiaodong Ge, Sukanta Das, Romain Desert, Dipti Athavale, Wei Chen, Sai Santosh Babu Komakula, Daniel Lantvit, Natalia Nieto
Summary: This study investigated the protective role of intracellular neutrophil-derived HMGB1 in early allograft dysfunction after liver transplantation. The results showed that the absence of Hmgb1 in recipient myeloid cells exacerbated graft injury. Therefore, intracellular HMGB1 plays an important role in protecting against early graft injury after liver transplantation.
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Guangyu Zhang, Xiaoding Wang, Chao Li, Qinfeng Li, Yu A. An, Xiang Luo, Yingfeng Deng, Thomas G. Gillette, Philipp E. Scherer, Zhao Wang
Summary: The study demonstrates the significant role of the ISR in myocardial ischemia/reperfusion injury by selectively suppressing mitochondrial protein synthesis and reducing oxidative stress to improve cell survival and mitigate reperfusion damage.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zihui Zhang, Wenhua Jiang, Chan Zhang, Yue Yin, Nan Mu, Yishi Wang, Lu Yu, Heng Ma
Summary: Through a multi-level study from molecule to animal model, these findings uncover the key role of frataxin in inhibiting cardiomyocyte ferroptosis and provide new strategies and perspectives for the treatment of myocardial I/R injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Lina Bai, Junhua Yang, Hong Zhang, Wei Liao, Yunguang Cen
Summary: The study found that the knockdown of APPL1 in myocardial ischemia leads to increased apoptosis and inflammation, while overexpression of APPL1 can inhibit myocardial ischemia/hypoxia-reperfusion injury by inactivating the APAF-1/Caspase9 signaling pathway. The findings suggest that APPL1 may be a promising target for the treatment of myocardial ischemia.
Article
Engineering, Biomedical
Xiaolei Sun, Rifeng Gao, Wenjia Li, Yongchao Zhao, Heng Yang, Hang Chen, Hao Jiang, Zhen Dong, Jingjing Hu, Jin Liu, Yunzeng Zou, Aijun Sun, Junbo Ge
Summary: ALDH2 activation in mitochondrial transplantation shows potential for treating myocardial I/R injury. Activation of ALDH2 and treatment with Alda-1 promote oxygen consumption rate and mechanical function of cardiomyocytes after mitochondrial transplantation. Mitochondrial transplantation inhibits cardiomyocyte apoptosis induced by hypoxia-reoxygenation, while promotion of mechanical function is observed only after mitochondrial Alda-1 treatment and transplantation.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Guixi Mo, Xin Liu, Yiyue Zhong, Jian Mo, Zhiyi Li, Daheng Li, Liangqing Zhang, Yijun Liu
Summary: This study revealed the important role of IP3R1 in myocardial ischemia/reperfusion by regulating Ca2+ levels, inflammation, and pyroptosis to improve injury. The binding of ERP44 to IP3R1 can inhibit Ca2+ overload, alleviating pyroptosis and myocardial ischemia/reperfusion injury.
CELL DEATH DISCOVERY
(2021)
Article
Gastroenterology & Hepatology
Rebecca A. Sosa, Allyson Q. Terry, Fady M. Kaldas, Yi-Ping Jin, Maura Rossetti, Takahiro Ito, Fang Li, Richard S. Ahn, Bita V. Naini, Victoria M. Groysberg, Ying Zheng, Antony Aziz, Jessica Nevarez-Mejia, Ali Zarrinpar, Ronald W. Busuttil, David W. Gjertson, Jerzy W. Kupiec-Weglinski, Elaine F. Reed
Summary: The study identified disulfide-HMGB1 as a mechanistic biomarker and therapeutic target for minimizing sterile inflammation during human liver ischemia-reperfusion injury.
Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Cardiac & Cardiovascular Systems
Qi Li, Mengping Xu, Zhuqing Li, Tingting Li, Yilin Wang, Qiao Chen, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Chengzhi Lu
Summary: The study showed that maslinic acid could effectively alleviate myocardial inflammation and apoptosis in a dose-dependent manner both in vitro and in vivo, by suppressing inflammatory cytokines and modulating apoptosis-related proteins. The cardioprotective effect of maslinic acid may be partly due to its regulation of the HMGB1/TLR4/NF-kappa B pathway, offering a new therapeutic strategy for MI/RI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)