Article
Obstetrics & Gynecology
Jessica Subira, Anna Algaba, Sheila Vazquez, Roser Taroncher Dasi, Guillermo Molla Robles, Susana Monzo Fabuel, Virginia Baydal, Amparo Ruiz Herreros, Nuria Garcia Camunas, Jose Maria Rubio Rubio
Summary: The study indicated that the use of testosterone before IVF did not increase the number of mature oocytes retrieved in poor ovarian response patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Medicine, General & Internal
Jihyun Kim, Hoyoung Lee, Tae-Young Choi, Joong Il Kim, Byoung-Kab Kang, Myeong Soo Lee, Jong Kil Joo, Kyu Sup Lee, Sooseong You
Summary: The study showed that network-optimized acupuncture followed by IVF treatment significantly increased the number of retrieved mature oocytes in women with poor ovarian response, especially in those aged over 37 years and undergoing multiple controlled ovarian hyperstimulation cycles. The negative correlation between the number of retrieved mature oocytes and consecutive controlled ovarian hyperstimulation cycles was not observed in the acupuncture + IVF group, suggesting that acupuncture may be considered as a beneficial treatment option for women facing poor ovarian response and advanced maternal age or multiple IVF cycles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Man Di, Xiaohong Wang, Jing Wu, Hongya Yang
Summary: Delayed start GnRH antagonist and microdose GnRH agonist are the two superior regimens in the treatment of poor ovarian response, providing favorable clinical outcomes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Medicine, General & Internal
Huisheng Yang, Chensi Zheng, Qiyan Zheng, Huanfang Xu, Xiaotong Li, Mingzhao Hao, Yigong Fang
Summary: Controlled ovarian hyperstimulation (COH) is a routine regimen used in IVF/ICSI treatment, and poor ovarian responders (PORs) often have higher follicle stimulating hormone levels and fewer retrieved oocytes. Researchers have proposed strategies and protocols to improve pregnancy outcomes for PORs, but clinical decisions regarding COH protocols for PORs remain controversial.
Review
Obstetrics & Gynecology
Evangelia T. Katsika, Julia K. Bosdou, Dimitrios G. Goulis, Grigoris F. Grimbizis, Efstratios M. Kolibianakis
Summary: This study found that testosterone pretreatment with transdermal gel in poor responders undergoing ovarian stimulation for IVF was associated with increased clinical pregnancy and live birth rates. Additionally, there was an increase in the number of cumulus-oocyte complexes retrieved and improvements in ovarian stimulation parameters and endometrial thickness. However, no significant differences were observed in other key outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Public, Environmental & Occupational Health
Oshrit Lebovitz, Jigal Haas, Nitzan Mor, Eran Zilberberg, Adva Aizer, Michal Kirshenbaum, Raoul Orvieto, Ravit Nahum
Summary: Poor ovarian responders face challenges in fertility treatments, and age and the number of retrieved oocytes are key factors affecting live birth. Patients younger than 40 years who meet the Bologna criteria have a higher probability of live birth.
Article
Obstetrics & Gynecology
N. Massin, I Abdennebi, G. Porcu-Buisson, N. Chevalier, E. Descat, C. Pietin-Vialle, S. Goro, M. Brussieux, M. Pinto, M. Pasquier, H. Bry-Gauillard
Summary: This study compares the effectiveness of two treatment protocols in assisting conception for patients with poor ovarian response, and the results show that there is no significant difference in the number of oocytes retrieved between the dual ovarian stimulation in the same cycle and two consecutive antagonist cycles.
HUMAN REPRODUCTION
(2023)
Review
Endocrinology & Metabolism
Jared Buratto, Ben Kirk, Steven Phu, Sara Vogrin, Gustavo Duque
Summary: This study investigated the effects of testosterone therapy on musculoskeletal health and clinical outcomes in men. The study found that testosterone therapy can increase hip bone density and total lean mass in men within 6 months, but its effects on lumbar spine bone density and handgrip strength are unclear. More research is needed to further understand the safety and efficacy of testosterone on musculoskeletal health and clinical outcomes.
ENDOCRINE PRACTICE
(2023)
Article
Obstetrics & Gynecology
Abbas Aflatoonain, Lida Saeed, Robabe Hosseinisadat
Summary: The study found that androgen administration in poor responders undergoing in vitro fertilization can reduce the total dose of gonadotropins, but it does not improve pregnancy outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Shan Liu, Yasu Lv, Minghui Liu, Shuo Han, Xiaoqun Liu, Zhiming Zhao, Wei Cui, Aijun Yang, Yuan Li
Summary: The study investigated the clinical efficacy and cost-effectiveness of a modified GnRH antagonist protocol based on LH levels in normal responders undergoing assisted reproductive technology treatment. The results showed that the LH-based protocol had similar clinical efficacy to the conventional protocol, but was more cost-effective in terms of cumulative ongoing pregnancy rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Qiao-Song Han, Yue Zhou, Jing-Yan Song, Wen Chen, Zhen-Gao Sun
Summary: This study aims to evaluate the efficacy and safety of the traditional Chinese medicine formula Erzhi Tiangui (EZTG) as a complementary treatment for advanced-age women with poor ovarian response undergoing in vitro fertilization and embryo transfer. The study will be conducted at 10 tertiary hospitals and will enroll 480 women who fulfill the 2011 Bologna criteria. The results of this study will provide robust evidence of the efficacy and safety of EZTG formula.
Review
Obstetrics & Gynecology
Shuang Yang, Nenghui Liu, Yanping Li, Lei Zhang, Rongya Yue
Summary: The delayed start antagonist protocol shows potential value as an alternative for poor ovarian responders by reducing cycle cancellation rate, increasing clinical pregnancy rate, and having a comparable miscarriage rate compared to conventional protocols. Further large-scale randomized controlled trials with more scientific design are needed to confirm its validity and draw a sound conclusion.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Quoc Huy Hoang, Hung Sy Ho, Huong Thuy Do, Tien Viet Nguyen, Hong Phuong Nguyen, Minh Tam Le
Summary: The study demonstrated that applying TTG in infertile women with POR may improve outcomes of IVF, but extending the application of TTG to 6 weeks did not significantly improve the response to ovarian stimulation or pregnancy outcomes compared to 4 weeks of pretreatment.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Xiaoting Zhou, Xiaomei Wu, Xi Luo, Jingyi Shao, Dongqun Guo, Bo Deng, Ze Wu
Summary: This meta-analysis investigated the effects of vitamin D supplementation on in vitro fertilization (IVF) outcomes in infertile women with vitamin D deficiency. The results showed that vitamin D supplementation was associated with improved chemical pregnancy rate, but did not benefit clinical pregnancy rate and other secondary outcomes. Further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Andrology
Parris Diaz, Rohit Reddy, Ruben Blachman-Braun, Isaac Zucker, Alexandra Dullea, Daniel C. Gonzalez, Eliyahu Kresch, Ranjith Ramasamy
Summary: This study evaluated the impact of different testosterone treatment preparations on 17-OHP and serum testosterone levels in hypogonadal men. The results showed that short-acting nasal testosterone had no significant impact on serum 17-OHP levels compared to long-acting testosterone formulations. However, all testosterone formulations increased serum testosterone levels at follow-up. This suggests that short-acting testosterone formulations may be beneficial for hypogonadal men seeking to maintain fertility potential while on TRT.
WORLD JOURNAL OF MENS HEALTH
(2023)
