Article
Medicine, Research & Experimental
Samir A. Salama, Mostafa M. Elshafey
Summary: The study demonstrated that galangin has a significant protective effect against iron-induced hepatotoxicity, reducing liver iron content, serum ferritin level, and oxidative stress. Galangin exerts its effects through various mechanisms, including up-regulation of Nrf2, PPAR gamma, and down-regulation of NF-cB signaling pathways.
Article
Pharmacology & Pharmacy
Ying-Li Liu, Qiu-Zan Zhang, Yan-Rong Wang, Li-Na Fu, Jing-Shu Han, Jing Zhang, Bang-Mao Wang
Summary: Astragaloside IV showed beneficial effects on NAFLD in rats by reducing serum liver function indicators and inflammatory cytokines levels, improving NAFLD activity score, and regulating the TLR4/MyD88 signaling pathway in liver tissues.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Sachin Sharma, Dounia Le Guillou, Jennifer Y. Chen
Summary: The burden of chronic liver disease is increasing worldwide, and fibrosis is a common pathway leading to cirrhosis. Cellular stress responses play an important role in fibrogenesis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Sachin Sharma, Dounia Le Guillou, Jennifer Y. Chen
Summary: The burden of chronic liver disease is increasing worldwide, with fibrosis being a common pathway leading to cirrhosis. This review examines the role of cellular stress responses in fibrogenesis, specifically in hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells, and macrophages. It highlights the involvement of cellular stress in nonalcoholic steatohepatitis (NASH) and liver fibrosis progression, particularly through endoplasmic reticulum stress and oxidative stress.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Samir A. Salama, Ahmed M. Mohamadin, Mohamed S. Abdel-Bakky
Summary: Arctigenin exhibited a protective effect against cadmium-induced nephrotoxicity by improving renal function, reducing oxidative damage, alleviating endoplasmic reticulum stress, and targeting Nrf2 and NF-κB signaling pathways.
Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Samir A. Salama, Mohamed S. Abdel-Bakky, Alaa A. Mohamed
Summary: This study investigated the protective effects of the natural alkaloid leonurine against iron-induced hepatotoxicity in rats. The results showed that leonurine suppressed ferroptosis, oxidative damage, and inflammation in the liver tissues. It also enhanced the antioxidant potential and improved histopathological abnormalities. Mechanistically, leonurine modulated the Nrf2 and NF-kappa B signaling pathways. These findings highlight the hepatoprotective activity of leonurine against iron-induced hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Gong-Rak Lee, Hye In Lee, Narae Kim, Jiae Lee, Minjeong Kwon, Ye Hee Kang, Hyeong Ju Song, Chang-Yeol Yeo, Woojin Jeong
Summary: This study investigated the role of LC8 in nonalcoholic steatohepatitis (NASH) and explored its potential mechanism. The results showed that LC8 can alleviate NASH induced by an MCD diet by inhibiting NF-kappa B and reducing oxidative stress. Therefore, enhancing intracellular LC8 could be a potential therapeutic strategy for NASH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
P. Snega Priya, Raghul Murugan, Bader O. Almutairi, Selvaraj Arokiyaraj, P. Shanjeev, Jesu Arockiaraj
Summary: This study investigated the protective effects of cordycepin against gut inflammation induced by Cadmium (Cd) exposure. The results showed that cordycepin significantly reduced Cd-induced embryotoxicity and oxidative stress. It also normalized the levels of liver-related biomarkers affected by Cd exposure and downregulated the expression of inflammatory genes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Miao Shen, Hanghai Pan, Jinjing Ke, Fei Zhao
Summary: This study reveals the potential involvement of the NF-kappa B/miR-155-5p/STC1 axis in the progression of NAFLD. It suggests that increased expression of miR-155-5p induced by NF-kappa B inhibits STC1 expression, resulting in hepatic mitochondrial dysfunction and promoting the occurrence and development of NAFLD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Immunology
Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou
Summary: Puerarin improves high-fat and high-fructose diet-induced nonalcoholic fatty liver disease (NAFLD) by modulating liver lipid accumulation, liver function, oxidative stress, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Stergios A. Polyzos, Antonis Goulas
Summary: NAFLD is a highly prevalent liver disease without any approved treatment. This study explores the potential association between hepatic RANKL upregulation and the pathogenesis of NAFLD, suggesting denosumab as a potential candidate for NASH in drug-repurposing studies.
MEDICAL HYPOTHESES
(2021)
Review
Cell Biology
Pedro Soares, Catia Silva, Daniel Chavarria, Filomena S. G. Silva, Paulo J. Oliveira, Fernanda Borges
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive disease that leads to paralysis and death due to respiratory failure. Current ALS drugs only provide mild relief to patients. Recent advances in understanding ALS biology have identified potential targets for drug development, including mitochondria and oxidative stress, iron metabolism and ferroptosis, and regulators of hypoxia and inflammation. This review focuses on discussing the latest advances in ALS drug development and proposes the rational design of multi-target ligands as a potential effective therapy for ALS.
AGEING RESEARCH REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Jia Li, Junbo Bai, Nafeisha Tuerdi, Kaifang Liu
Summary: Interstitial Cells of Cajal (ICC) are crucial for peristaltic contractions in the gastrointestinal and urinary tract. This study investigates the molecular signals of oxidative stress and apoptosis in ICC induced by tumor necrosis factor-alpha (TNF-alpha). The results demonstrate that TNF-alpha induces inflammation, oxidative stress, and cell apoptosis in ICC. Additionally, MEG3 mediates these effects through the miR-21/IKKB-NF-kappa B axis. This study enhances our understanding of ICC-related diseases at the molecular level.
Review
Medicine, General & Internal
Agnieszka Karkucinska-Wieckowska, Ines C. M. Simoes, Piotr Kalinowski, Magdalena Lebiedzinska-Arciszewska, Krzysztof Zieniewicz, Piotr Milkiewicz, Magdalena Gorska-Ponikowska, Paolo Pinton, Afshan N. Malik, Marcin Krawczyk, Paulo J. Oliveira, Mariusz R. Wieckowski
Summary: According to the 'multiple-hit' hypothesis, both nitro-oxidative stress and mitochondrial abnormalities are key factors in the progression of NAFLD. It is difficult to determine whether mitochondrial dysfunction or oxidative stress are primary events or consequences of NAFLD development, but they play significant roles in the transition from simple steatosis to more severe NAFLD stages.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)