Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγLigand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease

Sphingomyelin Synthase 2 Activity and Liver Steatosis

(2013) Yue Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD36 Enhances Fatty Acid Uptake by Increasing the Rate of Intracellular Esterification but Not Transport across the Plasma Membrane

(2013) Su Xu et al.   BIOCHEMISTRY

Hepatic Steatosis with Relation to Increased Expression of Peroxisome Proliferator-Activated Receptor-γ in Insulin Resistant Mice

(2013) Hikaru Satoh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes

(2013) Jung-Ran Noh et al.   FOOD CHEMISTRY

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Zanthoxylum piperitum DC Ethanol Extract Suppresses Fat Accumulation in Adipocytes and High Fat Diet-Induced Obese Mice by Regulating Adipogenesis

(2013) So Young GWON et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes

(2013) Hui Chen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Peroxisome Proliferator-Activated Receptors-Alpha and Gamma Are Targets to Treat Offspring from Maternal Diet-Induced Obesity in Mice

(2013) D'Angelo Carlo Magliano et al.   PLoS One

The Eicosapentaenoic Acid Metabolite 15-Deoxy-δ12,14-Prostaglandin J3 Increases Adiponectin Secretion by Adipocytes Partly via a PPARγ-Dependent Mechanism

(2013) Jennifer Lefils-Lacourtablaise et al.   PLoS One

Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation

(2013) Sara Manteiga et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Lactobacillus plantarumLG42 Isolated from Gajami Sik-Hae Inhibits Adipogenesis in 3T3-L1 Adipocyte

(2013) Jeong-Eun Park et al.   Biomed Research International

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

(2012) J. Xu et al.   DIABETES

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Fatty liver and anti-oxidant enzyme activities along with peroxisome proliferator-activated receptors γ and α expressions in the liver of Wilson's disease

(2012) Hironori Nagasaka et al.   MOLECULAR GENETICS AND METABOLISM

Nuclear receptor PPAR -regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

(2012) Y. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase

(2012) Z. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

(2012) Zenglin Liao et al.   RESPIRATORY RESEARCH

A Novel Mechanism for Hepatic Lipid Accumulation: A Physiological Role for Hepatic PPARγ-fsp27 Signal

(2012) Kimihiko Matsusue   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

(2012) Luis A. Videla et al.   PPAR Research

PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO

(2012) Simone Polvani et al.   PPAR Research

Role of peroxisome proliferator-activated receptor gamma agonist in improving hepatic steatosis: Possible molecular mechanism

(2012) Cheol-Young Park et al.   Journal of Diabetes Investigation

Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease

(2011) Ingrid C. Gaemers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

(2011) Jinhan He et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

(2011) Liang Bai et al.   HEPATOLOGY

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice

(2011) Shin Kumadaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27

(2011) Rachel J. Roth Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2

(2011) Brandon C. Sos et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

(2011) A. Handberg et al.   JOURNAL OF INTERNAL MEDICINE

Role of lipid droplet proteins in liver steatosis

(2011) Toshikatsu Okumura   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin–proteasome degradation

(2011) Zhigang Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Physiological Role for Fat Specific Protein 27/Cell Death-Inducing DFF45-Like Effector C in Adipose and Liver

(2010) Kimihiko Matsusue   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

(2010) D. Weismann et al.   DIABETOLOGIA

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet

(2010) Seong-Il Kang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat

(2010) Tomomi Yamazaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis

(2010) Lixin Zhu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

(2010) Tamotsu Tsukahara et al.   MOLECULAR CELL

Downregulation ofADIPOQandPPARγ2Gene Expression in Subcutaneous Adipose Tissue of Obese Adolescents With Hepatic Steatosis

(2010) Romy Kursawe et al.   Obesity

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

(2010) Valerio Costa et al.   PPAR Research

Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver

(2010) Alexandra Rogue et al.   PPAR Research

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

(2010) Anne Bugge et al.   PPAR Research

Lipid droplets at a glance

(2009) Y. Guo et al.   JOURNAL OF CELL SCIENCE

Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice

(2009) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Peroxisome proliferator-activated receptor gamma (PPARγ): Is the genomic activity the only answer?

(2009) Michaela Luconi et al.   STEROIDS

Cellular fatty acid uptake: a pathway under construction

(2009) Xiong Su et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)

(2008) Robert Ehehalt et al.   BMC CELL BIOLOGY

Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor γ complex and correlates with liver steatosis

(2008) Eun Kim et al.   JOURNAL OF HEPATOLOGY

MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes

(2008) Claire Z. Larter et al.   JOURNAL OF HEPATOLOGY

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

(2008) G MUSSO et al.   PROGRESS IN LIPID RESEARCH