Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors

Cortical Expression of Peroxisome Proliferator-activated Receptor-α after Human Brain Contusion

(2013) D Feng et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Structural Features and Transcriptional Activity of Chicken PPARs (α,β, andγ)

(2013) Ichiro Takada et al.   PPAR Research

Plasma mannose-binding lectin is stimulated by PPARα in humans

(2012) Maryam Rakhshandehroo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi

(2012) Federico Penas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation

(2012) Gloria Schlegel et al.   BMC Veterinary Research

Regulatory T Cells Expressing PPAR-γ Control Inflammation in Obesity

(2012) Masahide Hamaguchi et al.   Cell Metabolism

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism

(2012) Mi Young Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

PPARα as a therapeutic target in inflammation-associated diseases

(2012) Philippe Gervois et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Analysis of the role of hepatic PPARγ expression during mouse liver regeneration

(2012) Vered Gazit et al.   HEPATOLOGY

15-deoxy-Δ12,14-prostaglandin J2reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice

(2012) Zhen Han et al.   HEPATOLOGY

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

(2012) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR105 Ablation Prevents Inflammation and Improves Insulin Sensitivity in Mice with Diet-Induced Obesity

(2012) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Endothelial Cell Peroxisome Proliferator-Activated Receptor   Reduces Endotoxemic Pulmonary Inflammation and Injury

(2012) A. T. Reddy et al.   JOURNAL OF IMMUNOLOGY

Activation of Peroxisome Proliferator-Activated Receptorγby Rosiglitazone Inhibits Lipopolysaccharide-Induced Release of High Mobility Group Box 1

(2012) Jung Seok Hwang et al.   MEDIATORS OF INFLAMMATION

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Gemfibrozil, a Lipid Lowering Drug, Inhibits the Activation of Primary Human Microglia Via Peroxisome Proliferator-Activated Receptor β

(2012) Malabendu Jana et al.   NEUROCHEMICAL RESEARCH

Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart

(2012) Anastasia Georgiadi et al.   PHYSIOLOGICAL GENOMICS

Regulation of Chemokine and Chemokine Receptor Expression by PPARγ in Adipocytes and Macrophages

(2012) M. T. Audrey Nguyen et al.   PLoS One

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

(2012) Heidi E. Kocalis et al.   PLoS One

Protection from liver fibrosis by a peroxisome proliferator-activated receptor   agonist

(2012) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Impact of PPARγGenetic Variants on IBD Susceptibility and IBD Disease Course

(2012) Jessica Mwinyi et al.   PPAR Research

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Peroxisome Proliferator–Activated Receptor-α Gene Level Differently Affects Lipid Metabolism and Inflammation in Apolipoprotein E2 Knock-In Mice

(2011) Fanny Lalloyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Disruption of Endothelial Peroxisome Proliferator-Activated Receptor γ Accelerates Diet-Induced Atherogenesis in LDL Receptor-Null Mice

(2011) Aijuan Qu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In depth analysis of genes and pathways of the mammary gland involved in the pathogenesis of bovine Escherichia coli- mastitis

(2011) Bart Buitenhuis et al.   BMC GENOMICS

Generation and characterization of a humanized PPARδ mouse model

(2011) B Gross et al.   BRITISH JOURNAL OF PHARMACOLOGY

Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning

(2011) Dongshan Yang et al.   CELL RESEARCH

Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella)

(2011) Shan He et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice

(2011) Maria Pini et al.   CYTOKINE

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Modulation of inflammatory response and parasitism by 15-Deoxy-Δ12,14 prostaglandin J2 in Trypanosoma cruzi-infected cardiomyocytes

(2011) Eugenia Hovsepian et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Administration of PPARβ/δ agonist reduces copper-induced liver damage in mice: possible implications in clinical practice

(2011) Alvaro A. Sanchez-Siles et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Brain PPAR-γ promotes obesity and is required for the insulin–sensitizing effect of thiazolidinediones

(2011) Min Lu et al.   NATURE MEDICINE

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human Hepatocytes

(2011) Alexandra Rogue et al.   PLoS One

Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes

(2011) Alexandra Rogue et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Peroxisomal3-keto-acyl-CoA thiolase BGene Expression Is under the Dual Control of PPARα and HNF4α in the Liver

(2011) J. Chamouton et al.   PPAR Research

Protective Role of Peroxisome Proliferator–activated Receptor-β/δ in Septic Shock

(2010) Amar Kapoor et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of rosiglitazone, an agonist of the peroxisome proliferator-activated receptor γ, on intestinal damage induced byEscherichia colilipopolysaccharide in weaned pigs

(2010) Wei Fan et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells

(2010) David Álvarez-Guardia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of T cell PPAR γ in mice with experimental inflammatory bowel disease

(2010) Amir J Guri et al.   BMC GASTROENTEROLOGY

Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection

(2010) Saroj K Mohapatra et al.   BMC INFECTIOUS DISEASES

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

(2010) C. Duval et al.   DIABETES

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

(2010) F. Engin et al.   DIABETES OBESITY & METABOLISM

PPARα contributes to colonic protection in mice with DSS-induced colitis

(2010) Yasu-Taka Azuma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Induction of peroxisomal proliferator-activated receptor γ and peroxisomal proliferator-activated receptor γ coactivator 1 by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue1,2

(2010) P. García-Rojas et al.   JOURNAL OF ANIMAL SCIENCE

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukotriene B4Is a Physiologically Relevant Endogenous Peroxisome Proliferator-activated Receptor-α Agonist

(2010) Venkata R. Narala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPARγ

(2010) Nicholas P. Evans et al.   JOURNAL OF NUTRITION

Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease

(2010) R Hontecillas et al.   Mucosal Immunology

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

(2010) Maryam Rakhshandehroo et al.   PPAR Research

Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARγ signaling as potential mechanism for the negative relationships between immune response and lipid metabolism

(2009) Kasey M Moyes et al.   BMC GENOMICS

Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes: Dissociation of Adipocyte Hypertrophy From Inflammation

(2009) C. Y. Han et al.   DIABETES

Peroxisome Proliferator-Activated Receptor-α Control of Lipid and Glucose Metabolism in Human White Adipocytes

(2009) Carole Ribet et al.   ENDOCRINOLOGY

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

(2009) S. Ghisletti et al.   GENES & DEVELOPMENT

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

Activation of peroxisome proliferator-activated receptor-γ potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge

(2009) Yulan Liu et al.   Innate Immunity

Comparison of PPARδ and PPARγ in inhibiting the pro-inflammatory effects of C-reactive protein in endothelial cells

(2009) Yao-Jen Liang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Glucocorticoids and Thiazolidinediones Interfere with Adipocyte-mediated Macrophage Chemotaxis and Recruitment

(2009) David Patsouris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratinocyte-derived Chemokine in Obesity

(2009) Jaap G. Neels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARδ agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair

(2009) Maoyin Pang et al.   JOURNAL OF HEPATOLOGY

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination

(2009) Antoinette Defaux et al.   Journal of Neuroinflammation

MBX-102/JNJ39659100, a Novel Peroxisome Proliferator-Activated Receptor-Ligand with Weak Transactivation Activity Retains Antidiabetic Properties in the Absence of Weight Gain and Edema

(2009) Francine M. Gregoire et al.   MOLECULAR ENDOCRINOLOGY

Minireview: Won’t Get Fooled Again: The Nonmetabolic Roles of Peroxisome Proliferator-Activated Receptors (PPARs) in the Heart

(2009) Pamela Lockyer et al.   MOLECULAR ENDOCRINOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver

(2009) Linda M. Sanderson et al.   PHYSIOLOGICAL GENOMICS

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

PPAR  blocks glucocorticoid receptor  -mediated transactivation but cooperates with the activated glucocorticoid receptor   for transrepression on NF- B

(2009) N. Bougarne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α MODULATES THE ANTI-INFLAMMATORY EFFECT OF GLUCOCORTICOIDS IN A MODEL OF INFLAMMATORY BOWEL DISEASE IN MICE

(2009) Luisa Riccardi et al.   SHOCK

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response

(2008) Mark Bouwens et al.   BMC GENOMICS

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major

(2008) Hiromi Oku et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Activation of Peroxisome Proliferator-Activated Receptor  /  Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor- B Activity via Extracellular Signal-Related Kinase 1/2

(2008) R. Rodriguez-Calvo et al.   DIABETES

Systemic and Distal Repercussions of Liver-Specific Peroxisome Proliferator-Activated Receptor-α Control of the Acute-Phase Response

(2008) Roxane M. Mansouri et al.   ENDOCRINOLOGY

Cloning of peroxisome proliferators activated receptors in the cobia (Rachycentron canadum) and their expression at different life-cycle stages under cage aquaculture

(2008) Mei-Ling Tsai et al.   GENE

Genome-wide profiling of PPAR :RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

(2008) R. Nielsen et al.   GENES & DEVELOPMENT

Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742

(2008) Z. Haskova et al.   INFLAMMATION RESEARCH

Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue

(2008) Rinke Stienstra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Pathways Are Activated during Cardiomyocyte Hypertrophy and Attenuated by Peroxisome Proliferator-activated Receptors PPARα and PPARδ

(2008) Pascal J. H. Smeets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney

(2008) Kenneth R. Feingold et al.   JOURNAL OF LIPID RESEARCH

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/−bone marrow

(2008) Chaitra Marathe et al.   JOURNAL OF LIPID RESEARCH

Effect of Peroxisome Proliferator–activated Receptor-α Ligands in the Interaction Between Adipocytes and Macrophages in Obese Adipose Tissue

(2008) Takuya Toyoda et al.   Obesity

Transcriptomic analysis of PPARα-dependent alterations during cardiac hypertrophy

(2008) Pascal J. H. Smeets et al.   PHYSIOLOGICAL GENOMICS

Peroxisome Proliferator-Activated Receptorβ/δin the Brain: Facts and Hypothesis

(2008) M. G. Hall et al.   PPAR Research

Suppression of Pro-inflammatory Adhesion Molecules by PPAR-δ in Human Vascular Endothelial Cells

(2007) Yanbo Fan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

(2007) Gijs H. Goossens   PHYSIOLOGY & BEHAVIOR