Article
Agriculture, Dairy & Animal Science
Yutaka Suzuki, Sachi Chiba, Koki Nishihara, Keiichi Nakajima, Akihiko Hagino, Won-Seob Kim, Hong-Gu Lee, Tomonori Nochi, Toru Suzuki, Sang-Gun Roh
Summary: This study explored the role of chemerin in promoting bovine mammary epithelial cell growth and protecting against oxidative stress, suggesting its potential as a therapeutic target for diseases in the bovine mammary gland.
Article
Cell Biology
Jessica Elswood, Scott J. Pearson, H. Ross Payne, Rola Barhoumi, Monique Rijnkels, Weston W. Porter
Summary: Through studying the differentiation and metabolism of mammary epithelial cells, it was found that mitophagy occurs selectively during the differentiation process. Inhibiting autophagy impairs cell differentiation, while the PRKN protein is necessary for cell differentiation.
Article
Agriculture, Dairy & Animal Science
Rong Xuan, Tianle Chao, Xiaodong Zhao, Aili Wang, Yunpeng Chu, Qing Li, Yilin Zhao, Zhibin Ji, Jianmin Wang
Summary: This study investigated the structural and transcriptome changes of mammary gland tissue in nonlactating dairy goats during late lactation, the dry period, and late gestation. The results showed significant structural changes and cell apoptosis in the mammary gland tissue. Transcriptome analysis identified 1,381 genes with differential expression at the three developmental stages. Genes related to cell growth, apoptosis, immunity, nutrient transport, synthesis, and metabolism exhibited adaptive transcriptional changes.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
C. Delavaud, H. Fougere, J. Bertrand-Michel, L. Bernard
Summary: This study examines the effects of diets supplemented with different lipids on plasma lipid composition in dairy cows and goats. The results indicate species-specific and diet-dependent variations in plasma lipid fractions, which in turn affect milk fat synthesis.
Article
Cell Biology
Shujun Wang, Lu Zhang, Rong Xuan, Qing Li, Zhibin Ji, Tianle Chao, Jianmin Wang, Chunlan Zhang
Summary: This study identified and analyzed key genes with m(6)A modification during mammary gland development and lactation in dairy goats using MeRIP-seq and RNA-seq techniques. The results showed extensive m(6)A methylation in mammary tissues, and these methylated genes were mainly involved in the growth and apoptosis of mammary epithelial cells through signaling pathways, such as the MAPK and phospholipase D pathways, affecting the development and lactation of mammary gland.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Veterinary Sciences
Wangsheng Zhao, Michael Adjei, Hongmei Wang, Yueling Yangliu, Jiangjiang Zhu, Huijuan Wu
Summary: ADIPOR1 plays a central role in regulating milk fat metabolism by influencing the transcription of genes such as SREBF1, ACACA, FASN, SCD, ATGL, and HSL in goat mammary gland. Overexpression and knockdown of ADIPOR1 resulted in significant changes in the expression levels of these genes, demonstrating its crucial role in the process. Additionally, treatment with AdipoRon led to a significant increase in the mRNA expression of most genes related to milk fat metabolism in GMECs.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Developmental Biology
Johanna Englund, Alexandra Ritchie, Leander Blaas, Hanne Cojoc, Nalle Pentinmikko, Julia Dohla, Sharif Iqbal, Manuel Patarroyo, Pekka Katajisto
Summary: This study demonstrates the crucial role of Lama5 in mammary gland development and remodeling, potentially through affecting the Wnt4-mediated signaling pathway between HR+ luminal cells and basal epithelial cells, which in turn impacts gland growth and differentiation.
Article
Agriculture, Dairy & Animal Science
G. F. Bomfim, G. K. F. Merighe, S. A. de Oliveira, J. A. Negrao
Summary: The study found that CORT can promote mammary development and milk yield in lactating goats, but excessive CORT added in vitro may have a negative impact on apoptosis of mammary epithelial cells.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Cell Biology
Amritha Varshini Hanasoge Somasundara, Matthew A. Moss, Mary J. Feigman, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Macy Vollbrecht, Siran Li, Jude Kendall, Semir Beyaz, John E. Wilkinson, Camila O. dos Santos
Summary: Pregnancy induces expansion of NKT-like immune cells and upregulation of immune signaling molecules in mammary epithelial cells. Lack of CD1d expression or activated NKT cells may lead to mammary oncogenesis.
Article
Agriculture, Dairy & Animal Science
ZhiFei Zhang, Wei Du, WenYi Liu, Braden T. Wong, HuiLing Zheng
Summary: The study found that prepartum injections of 5-HTP did not affect the basic composition of colostrum, but increased serum serotonin concentrations on specific days before parturition. Goats injected with 5-HTP had higher serum calcium concentrations on day 4 postpartum, as well as higher serum parathyroid hormone-related protein levels on specific days before and after parturition.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Wenying Zhang, Changhui Zhang, Jun Luo, Huifen Xu, Jianxin Liu, Juan J. Loor, Hengbo Shi
Summary: This study provides evidence of a physiological link between LXRB and SREBP1 in ruminant mammary cells, demonstrating their important role in the synthesis of PUFA by regulating genes encoding elongases and desaturases. Targeting this network may have broad effects on lipid homeostasis in the ruminant mammary gland.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Quanwei Zhang, Xu Bai, Ting Lin, Xueying Wang, Bohao Zhang, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao
Summary: This study discovered the occurrence of ferroptosis in the mammary glands of Holstein cows with clinical mastitis. Differentially expressed proteins associated with iron homeostasis and apoptosis were identified, with heme oxygenase-1 (HMOX1) and ferritin heavy chain 1 (FTH1) playing crucial roles. The expression levels of HMOX1 and FTH1 were significantly up-regulated in mammary epithelial cells (MECs) compared to healthy cows, and LPS induction further increased their expression levels and iron accumulation. These findings provide insights for the prevention and treatment of clinical mastitis in dairy animals mediated by ferroptosis.
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Karolina Kowalska, Dominika Ewa Habrowska-Gorczynska, Marta Justyna Koziel, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: Mycotoxins are common food and feed pollutants, with potential toxicity. This study found that AOH significantly affects cell viability and motility, inducing oxidative stress, DNA damage, and cell cycle arrest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jenifer Monks, David J. Orlicky, Andrew E. Libby, Monica Dzieciatkowska, Mark S. Ladinsky, James L. McManaman
Summary: This study uncovers the molecular mechanisms of LD-APM interactions and highlights the role of Perilipin-2 in apocrine lipid secretion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Computer Science, Software Engineering
Xin Ning, Fangzhe Nan, Shaohui Xu, Lina Yu, Liping Zhang
Summary: This article summarizes existing methods for frontal face generation and compares their performance. Through these methods, we can gain a better understanding of the advantages and key issues in frontal face generation, and look towards future development trends.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2023)
Article
Computer Science, Software Engineering
Yaxuan Lu, Weijun Li, Xin Ning, Xiaoli Dong, Liping Zhang, Linjun Sun, Chuantong Cheng
Summary: This paper proposes an image quality assessment algorithm based on multiscale and dual domains fusion, which improves the accuracy and robustness of the assessment by considering human visual scale characteristics. Experimental results demonstrate that the proposed algorithm performs well on different types of images and databases.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2023)
Review
Computer Science, Software Engineering
Xin Ning, Xinran Wang, Shaohui Xu, Weiwei Cai, Liping Zhang, Lina Yu, Wenfa Li
Summary: This article summarizes the recent research on Co-training algorithm, which is a main method of semi-supervised learning in machine learning. It introduces the main steps of relevant Co-training algorithms and discusses the existing problems. Suggestions for improvement and future development directions are also provided.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2023)
Article
Computer Science, Information Systems
Liping Zhang, Yue Zhu, Wei Ren, Yixin Zhang, Kim-Kwang Raymond Choo
Summary: E-health systems are important during the COVID-19 pandemic, but ensuring data security is challenging, especially when data comes from insecure devices. This study proposes a lightweight privacy-preserving three-factor authenticated key agreement scheme for resource-constrained e-health systems, with minimal computational cost.
IEEE TRANSACTIONS ON SERVICES COMPUTING
(2023)
Article
Engineering, Electrical & Electronic
Pengcheng Zheng, Shibin Zhang, Yang Chen, Liping Zhang, Jinbo Wu, Hulin Yao, Xiaoli Fang, Xiaomeng Zhao, Kai Huang, Xin Ou
Summary: This work demonstrates gigahertz wideband acoustic delay lines (ADLs) with record-breaking propagation-Q using a thin-film X-cut lithium niobate on silicon carbide (LiNbO3-on-SiC) platform. With the help of SiC's high bulkwave velocity and excellent mechanical Q, the SH-SAW excited by unidirectional transducers propagates in LiNbO3-on-SiC's top surface with low acoustic loss. The fabricated ADLs show scalable center frequencies, wide fractional bandwidth, and a record-high propagation-Q, indicating the great potential of the LiNbO3-on-SiC acoustic platform for signal processing applications.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Chemistry, Physical
Shi-Li Tang, De-Jun Li, Feng-Jie Ma, Lu-Lin Zhang, Bo Lian, Yuan-Zheng Cheng, Li-Ping Zhang
Summary: Three copper(II) complexes were synthesized and characterized, and their interactions with HS-DNA/BSA were investigated. The complexes were found to interact with HS-DNA via an intercalative mode and quench the intrinsic fluorescence of BSA through a static mechanism. The fluorescence data indicated that the complexes exhibited good binding affinity to BSA, with only one available binding site. The complexes displayed cytotoxicity against tumor cells and induced apoptosis in MCF-7 and HeLa cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Health Care Sciences & Services
Fan Wang, Liping Zhang, Junxia Jiao
Summary: This study demonstrates the clinical value of multi-parameter MRI and colour B-ultrasound elastography in thyroid nodules. The combined diagnosis of MRI and B-ultrasound elastography shows higher accuracy and specificity in diagnosing benign and malignant thyroid nodules.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Engineering, Electrical & Electronic
Liping Zhang, Shibin Zhang, Hulin Yao, Jinbo Wu, Pengcheng Zheng, Dan Ling, Kai Huang, Xin Ou
Summary: In this study, a method to reduce acoustic energy loss and demonstrate GHz ultra-high Q acoustic wave resonators based on the LTOSiC substrate has been proposed. By modulating the ratio of the LiTaO3 film thickness to interdigital transducer pitch, the adjoined polarization components of the guided SH-SAW can be diminished, reducing the acoustic energy loss effectively. The modulated dispersive SH-SAW resonator shows excellent Bode-Q and FoM values, indicating the feasibility of developing low-loss acoustic devices for wireless communications on the LTOSiC substrate.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Computer Science, Information Systems
Jing Wu, Pan Zhou, Qimei Chen, Zichuan Xu, Xiaofeng Ding, Hao Jiang
Summary: With the rapid growth of IoT, smart home has developed rapidly in recent years to assist those who need family medical support. A smart home and cross-cloud-and-edge computing-based nursing system is proposed in this article to integrate healthcare with AAL technologies and provide ADLs to those who need care. To meet the requirements of low latency, high stability, and real-time analysis and response, a novel distributed joint edge-cloud structure is introduced. Additionally, the blockchain and differential privacy are used to ensure security and privacy in the system.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yumin Wei, Liping Zhang, Chao Wang, Zefeng Li, Mingjie Luo, Guomin Xie, Xingjiu Yang, Mengyuan Li, Shuyue Ren, Dongbing Zhao, Ran Gao, Jia-Nan Gong
Summary: This study found that BCL-XL is a potential therapeutic target in gastric cancer. Selective BCL-XL inhibitors and VHL-based PROTAC BCL-XL can effectively kill gastric cancer cells that rely on BCL-XL for survival. However, copy number variations of BCL2L1 cannot reliably predict BCL-XL expression, but the BCL-XL protein level can serve as a useful biomarker for predicting the sensitivity of gastric cancer cells to BCL-XL-targeting compounds.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Liping Zhang, Shibin Zhang, Jinbo Wu, Pengcheng Zheng, Hongyan Zhou, Hulin Yao, Zhongxu Li, Kai Huang, Huarui Sun, Xin Ou
Summary: This article introduces the high-performance shear horizontal surface acoustic wave (SH-SAW) and longitudinal leaky SAW (LL-SAW) devices using Lithium Tantalate (LiTaO3) thin films on silicon carbide (SiC) substrate. The demonstrated LTOSiC hetero-substrate achieved exciting results on device frequency, quality factor (Q), temperature coefficient of frequency (TCF), and thermal transport properties. The resonators show scalable resonances and the filters exhibit desirable center frequencies, insertion loss, and out-of-band rejection. Overall, LTOSiC serves as an advanced material platform for acoustic devices in the 5G-frequency range 1 (5G-FR1) bands.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Jinbo Wu, Shibin Zhang, Pengcheng Zheng, Liping Zhang, Hulin Yao, Xiaoli Fang, Xuedi Tian, Xiaomeng Zhao, Tao Wu, Xin Ou
Summary: This work presents a MEMS filter utilising a first-order antisymmetric Lamb wave (A1) mode with a fractional bandwidth (FBW) exceeding 24%. The A1 mode resonators, based on locally thinned 128 degrees Y-cut lithium niobate (LiNbO3) films, demonstrate excellent effective electromechanical coupling coefficients (k(eff)(2)) of 43.6% and 39.8% for series and shunt resonators, respectively, enabling the realization of ultrawideband RF acoustic filters. The fabricated A1 mode filter, with a center frequency of 1.79 GHz, achieves a minimum insertion loss of 0.61 dB and a maximum 3-dB FBW of 24.6%. After further optimizations, these A1 mode filters have great potential as broadband acoustic-only filters for 5G New Radio bands.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Liping Zhang, Shibin Zhang, Jinbo Wu, Pengcheng Zheng, Hulin Yao, Yang Chen, Kai Huang, Xiaomeng Zhao, Min Zhou, Xin Ou
Summary: This paper proposes a novel one-port 3D acoustic resonator based on the lithium niobate thin film on conductive silicon carbide substrate (LNCSiC). The fabricated resonator shows coupled frequency responses of the shear-horizontal surface acoustic wave (SH-SAW), the longitudinal leaky SAW (LL-SAW), and the high-overtone bulk acoustic waves (HBAWs). These hybrid resonators have the potential to open up new applications in radio frequency communications, 3D imaging, and sensing.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Article
Cell Biology
Peng Wang, Xupeng Liu, Ziyue Yao, Yu Chen, Lanfang Luo, Kun Liang, Jun-Hao Elwin Tan, Min-Wen Jason Chua, Yan-Jiang Benjamin Chua, Shilin Ma, Liping Zhang, Wenwu Ma, Shuqing Liu, Wenhua Cao, Luyao Guo, Lu Guang, Yuefan Wang, He Zhao, Na Ai, Yun Li, Chunwei Li, Ruiqi Rachel Wang, Bin Tean Teh, Lan Jiang, Kang Yu, Ng Shyh-Chang
Summary: During homeostasis and after injury, adult muscle stem cells (MuSCs) can activate and mediate muscle regeneration. Lin28a(+) MuSCs, which resemble embryonic muscle progenitors, have enhanced myogenic potency and self-renewal abilities compared to adult Pax7(+) MuSCs. These Lin28a(+) MuSCs can replenish the Pax7(+) MuSC pool and drive efficient muscle regeneration in adult mice.
Article
Computer Science, Cybernetics
Xiaoli Dong, Xin Ning, Jian Xu, Lina Yu, Weijun Li, Liping Zhang
Summary: An artistic line portrait robot is capable of generating, processing, and drawing line portraits. A method based on a triangle coordinate system (TCS) is proposed to synthesize line portraits with recognizable expressions. Experimental results demonstrate that the generated expression line portraits have high recognizability.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
