期刊
PPAR RESEARCH
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2010/621069
关键词
-
资金
- New Zealand Foundation for Research, Science and Technology (FRST)
- AgResearch Limited within the Nutrigenomics New Zealand
- FRST [AGRX0504]
The interleukin-10 gene-deficient (Il10(-/-)) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10(-/-) model. The aims were to (1) characterize colitis onset and progression using a histopathological, transcriptomic, and proteomic approach and (2) investigate links between PPAR alpha and IL10 using gene network analysis. Bacterial inoculation resulted in severe colitis in Il10(-/-) mice from 10 to 12 weeks of age. Innate and adaptive immune responses showed differences in gene expression relating to colitis severity. Actin cytoskeleton dynamics, innate immunity, and apoptosis-linked gene and protein expression data suggested a delayed remodeling process in 12-week-old Il10(-/-) mice. Gene expression changes in 12-week-old Il10(-/-) mice were related to PPAR alpha signaling likely to control colitis, but how PPAR alpha activation might regulate intestinal IL10 production remains to be determined.
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