Review
Immunology
Kiran Thakur, Heena Khan, Amarjot Kaur Grewal, Thakur Gurjeet Singh
Summary: Orphan receptors, a subsection of nuclear receptors, have been linked to neuroinflammation and neurodegenerative diseases. PPAR gamma, NR4As, and orphan GPCRs hold high potential as therapeutic targets for preventing these disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Namrita Halder, Girdhari Lal
Summary: Neurological and immunological signals interact to maintain homeostasis in the body. The cholinergic system plays a crucial role in neuroimmune communication, regulating immune response. Various molecules of the neuronal and non-neuronal cholinergic system interact to modulate inflammation and immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Abdalla M. Wedn, Hany M. El-Bassossy, Ali H. Eid, Mahmoud M. El-Mas
Summary: Research reports summarize the roles of peripheral and reflex cholinergic neuroinflammatory pathways in reprogramming preeclampsia complications, including the possible contributions of alpha7-nicotinic acetylcholine receptors, cholinesterases, immune cells, adhesion molecules, angiogenesis, and endothelial dysfunction to the interaction.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Siqi Cui, Xiangxing Zhang, Chen Wang, Cece Sun, Longke Shi, Baotian Kan, Qilu Li, Xiangdong Jian
Summary: The aim of this study was to explore the therapeutic effect of glucocorticoids on diquat-induced acute kidney injury in rats. Different doses of glucocorticoids were administered to 150 rats, and changes in body weight, histopathological changes, and related indicators were observed. The results showed that glucocorticoids have a therapeutic effect on acute kidney injury and can affect the expression of related signaling pathways by suppressing inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Xiaoqing Zhang, Xiaolin Yang, Bing Chen, Kaifeng Shen, Guolong Liu, Zhongke Wang, Kaixuan Huang, Gang Zhu, Tingting Wang, Shengqing Lv, Chunqing Zhang, Hui Yang, Zhi Hou, Shiyong Liu
Summary: Glucocorticoid receptors (GRs) play an important role in epilepsy in focal cortical dysplasia II (FCDII) and GR activation may have protective and antiepileptic effects in FCDII.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Rheumatology
Jean-Guillaume Letarouilly, Patrick Vermersch, Rene-Marc Flipo
Summary: The coexistence of multiple sclerosis and inflammatory rheumatic disorders is not uncommon. The use of TNF inhibitors in patients with pre-existing demyelinating disease has been contraindicated, but recent epidemiological studies suggests that TNFi might not be an inducer of MS.
Review
Pharmacology & Pharmacy
Clavia Ruth Wooton-Kee
Summary: Copper is an essential trace element that is necessary for various cellular processes, but excess copper accumulation can be toxic. The liver plays a crucial role in maintaining copper homeostasis. Wilson's disease, an autosomal recessive disorder, is caused by mutations in the ATP7B gene and requires lifelong treatment or liver transplantation. Current treatment options focus on reducing copper levels and cellular toxicity. Studies have shown altered hepatic metabolism and impaired hepatic nuclear receptor activity in Wilson's disease patients.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Neurosciences
Robin J. M. Franklin, Mikael Simons
Summary: Understanding the role of inflammation in remyelination is crucial for addressing the challenge of progressive multiple sclerosis.
Article
Biochemistry & Molecular Biology
Yue Leng, Yonghai Sun, Wei Huang, Chengyu Lv, Jingyan Cui, Tiezhu Li, Yongjun Wang
Summary: The study showed that dicyclohexyl phthalate (DCHP) acts as a GR antagonist in vitro, exerting endocrine effects by inhibiting GR nuclear translocation and gene expression.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Anna Mukha, Eric Kalkhoven, Saskia W. C. van Mil
Summary: This review discusses the splice variants of metabolic nuclear receptors and their regulation of different metabolic pathways by nutritional signals. These NR splice variants add an intriguing new layer of complexity to metabolic signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Plant Sciences
Ghulam Shabir, Aamer Saeed, Farman Ali
Summary: This review provides a critical and comparative account of synthetic approaches to histrionicotoxins, highlighting the key structural features and steps in the synthesis pathways.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kazuyuki Takata, Hiroyuki Kimura, Daijiro Yanagisawa, Koki Harada, Kaneyasu Nishimura, Yoshihisa Kitamura, Shun Shimohama, Ikuo Tooyama
Summary: Research has found that in the early stages of Alzheimer's disease (AD), there is a decrease in choline signaling, including nicotinic acetylcholine receptors (nAChRs). Currently, there is limited understanding of AD pathophysiology, making it difficult to suppress the progression of the disease. Non-invasive diagnostic methods that can assess disease progression before the onset of symptoms are crucial, and incorporating the concept of neurotheranostics may be valuable for diagnosis and treatment.
Review
Cell & Tissue Engineering
Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi, Jafar Ai
Summary: Multiple sclerosis (MS) is a chronic central nervous system disease with limited treatment options, leading researchers to explore new therapies such as mesenchymal stromal cell (MSC) transplantation. Allogeneic MSCs are suggested as a potential novel solution for MS therapy as an alternative to autologous MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, Research & Experimental
Yasuhiro Matsumura
Summary: Bronchial asthma is a heterogeneous disease, and the response to glucocorticoid treatment varies among patients, possibly due to differences in pathobiology. Therefore, predicting the response to glucocorticoid treatment in patients with bronchial asthma is necessary to improve treatment success rates and avoid adverse effects.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Shailendra Kumar Gangwar, Aviral Kumar, Kenneth Chun-Hong Yap, Sandra Jose, Dey Parama, Gautam Sethi, Alan Prem Kumar, Ajaikumar B. Kunnumakkara
Summary: Lung cancer is the second most commonly diagnosed cancer globally, with smoking being a significant risk factor. Nuclear receptors play a crucial role in lung cancer, and developing them as reliable therapeutics is important for combating the disease.