Article
Endocrinology & Metabolism
Julie Dubourg, Pascale Fouqueray, Carole Thang, Jean-Marie Grouin, Kohjiro Ueki
Summary: The study demonstrated that imeglimin significantly improved HbA(1c) levels in Japanese patients with type 2 diabetes compared to placebo, and had a similar safety profile to placebo. Imeglimin represents a potential new treatment option for this population.
Review
Endocrinology & Metabolism
Yujing He, Na Wu
Summary: Gestational diabetes mellitus (GDM) refers to the onset of diabetes during pregnancy in women with normal glucose metabolism, and vascular endothelial cells (VECs) play an important role in this process, with their injury contributing to worsened insulin resistance and the progression of GDM.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Ali Shahriari, Elham Karimi, Mohammadali Shahriari, Neda Aslani, Maryam Khooshideh, Arman Arab
Summary: This study found that probiotic supplementation during pregnancy from the first half of the second trimester up to 24 weeks does not reduce the risk of gestational diabetes mellitus and does not improve other neonatal and maternal outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Grace Liang, Xianxi Huang, James Hirsch, Sanjeev Mehmi, Holly Fonda, Khin Chan, Ngan F. Huang, Oliver Aalami, Victor F. Froelicher, David P. Lee, Jonathan Myers, Andrew S. Lee, Patricia K. Nguyen
Summary: Engaging in a regular exercise program was found to mediate cardiovascular protection through modulation of non-traditional risk factors, such as coagulation, inflammation, and metabolic regulation. Modest improvements in physical fitness, physical activity, and/or weight loss through a short-term exercise program were associated with decreased plasma levels of key biomarkers related to impaired fibrinolysis and inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Soo Heon Kwak, Kyung Ah Han, Kyung-Soo Kim, Jae Myung Yu, EunSook Kim, Jong Chul Won, Jun Goo Kang, Choon Hee Chung, Seungjoon Oh, Sung Hee Choi, Kyu Chang Won, Sin Gon Kim, Seung Ah Cho, Bo Young Cho, Kyong Soo Park
Summary: This study evaluated the efficacy and safety of enavogliflozin 0.3 mg as a monotherapy for Korean patients with inadequately controlled type 2 diabetes through diet and exercise. The results showed that enavogliflozin 0.3 mg improved glycemic control in patients with T2DM, and also had beneficial effects on body weight, blood pressure, and lipid profile.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Xin Wang, Ying Wang, Xiaolan Yong, Bojun Wu, Zilin Sun, Ning Lou, Qing Wen, Yufang Zhang, Shiyun Li, Jiarui Li, Yan He, Jinluo Cheng, Xiangdong Zhong, Jing Shen, Wenying Yang
Summary: The xanthine dipeptidyl peptidase-4 inhibitor, yogliptin, demonstrated effective hypoglycemic activity as a monotherapy in individuals with type 2 diabetes mellitus. It significantly reduced HbA1c levels and improved secondary efficacy outcomes, such as fasting plasma glucose levels, in Chinese T2DM patients. The safety profile of yogliptin was found to be favorable, supporting its use in phase III clinical studies.
JOURNAL OF DIABETES
(2022)
Article
Nutrition & Dietetics
Hyuk Joo Lee, Jung Kyung Hong, Jeon-Kyung Kim, Dong-Hyun Kim, Seok Won Jang, Seung-Won Han, In-Young Yoon
Summary: Probiotic NVP-1704 shows efficacy in reducing depressive and anxiety symptoms, improving sleep quality, and affecting blood biomarkers and gut microbiota composition, suggesting its potential benefits for mental health and sleep.
Article
Food Science & Technology
Jintanaporn Wattanathorn, Woraluck Somboonporn, Wipawee Thukham-Mee, Sudarat Sungkamnee
Summary: This study investigated the memory-enhancing effects and underlying mechanisms of the functional ingredients derived from Polygonum odoraturn and Morus alba. The results showed that the developed herbal supplement, consumed at a dose of 1500 mg/day, improved working memory and suppressed AChE, MAO-A, and MAO-B activities.
Article
Respiratory System
Behrooz Momeni, Saeed Nazer, Seyed Masoom Masoompour, Bita Geramizadeh, Seyed Vahid Sajadi
Summary: In this study, 90 male patients diagnosed with chronic bronchitis after exposure to mustard gas during the Iran-Iraq war were randomly assigned to receive either atorvastatin or a placebo for 3 months. The results showed that atorvastatin did not significantly alter inflammatory markers or quality of life compared to placebo after 12 weeks of treatment.
BMC PULMONARY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Venkat N. N. Vangaveti, Shaurya Jhamb, Oliver Hayes, Julie Goodall, Jacqueline Bulbrook, Kelvin Robertson, Erik Biros, Kunwarjit S. S. Sangla, Usman H. H. Malabu
Summary: The study found that vildagliptin treatment is effective in controlling diabetes and promoting DFU healing. These findings support the use of DPP4is as a preferred option for treating ulcers in patients with diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Respiratory System
Fan Li, Lianfang Yuan, Na Shao, Xiaokun Yang, Shaohua Yang, Linjia He, Jie Ding, Ming Ding, Shengzhe Yang, Wenwen Fu, Congcong Wang, Xiaochen Li, Qiling Cai
Summary: This study aimed to investigate the changes and clinical significance of vascular endothelial injury markers in patients with type 2 diabetes mellitus (T2DM) complicated with pulmonary embolism (PE). The results showed that plasma levels of soluble thrombomodulin (sTM), von Willebrand factor (vWF), and circulating endothelial cells (CECs) gradually increased in T2DM and T2DM+PE patients. High levels of sTM and vWF have clinical predictive values for screening T2DM accompanied by PE, with the combination of sTM and vWF achieving a high sensitivity and specificity.
BMC PULMONARY MEDICINE
(2023)
Article
Plant Sciences
Eun-Jung Park, Ah Jin Jung, Sung-Hyen Lee, Seong-Kyu Kang, Hae-Jeung Lee
Summary: This study aimed to investigate the immune-enhancing effects of red Platycodon grandiflorus root extract (RPGE) in healthy subjects. The results showed that RPGE increased NK cell activity and IFN-gamma level, suggesting its efficacy and safety in enhancing immune function. Additionally, the study did not find any clinically significant changes or serious adverse events in the safety assessment.
Article
Nutrition & Dietetics
Jalal Moludi, Shaimaa A. Qaisar, Mustafa M. Kadhim, Yasin Ahmadi, Mina Davari
Summary: The study revealed that Taurine supplementation significantly reduced insulin and HOMA-IR, as well as oxidative stress, inflammation, and endothelial markers in individuals with type 2 diabetes mellitus.
NUTRITION & METABOLISM
(2022)
Article
Clinical Neurology
Shifu Xiao, Piu Chan, Tao Wang, Zhen Hong, Shuzhen Wang, Weihong Kuang, Jincai He, Xiaoping Pan, Yuying Zhou, Yong Ji, Luning Wang, Yan Cheng, Ying Peng, Qinyong Ye, Xiaoping Wang, Yuncheng Wu, Qiumin Qu, Shengdi Chen, Shuhua Li, Wei Chen, Jun Xu, Dantao Peng, Zhongxin Zhao, Yansheng Li, Junjian Zhang, Yifeng Du, Weixian Chen, Dongsheng Fan, Yong Yan, Xiaowei Liu, Wei Zhang, Benyan Luo, Wenyuan Wu, Lu Shen, Chunfeng Liu, Peixian Mao, Qiumei Wang, Qianhua Zhao, Qihao Guo, Yongtao Zhou, Yi Li, Lijun Jiang, Wenwei Ren, Yingjun Ouyang, Yan Wang, Shuai Liu, Jianjun Jia, Nan Zhang, Zhonglin Liu, Raoli He, Tingyi Feng, Wenhui Lu, Huidong Tang, Ping Gao, Yingchun Zhang, Lanlan Chen, Lei Wang, You Yin, Qun Xu, Jinsong Xiao, Lin Cong, Xi Cheng, Hui Zhang, Dan Gao, Minghua Xia, Tenghong Lian, Guoping Peng, Xu Zhang, Bin Jiao, Hua Hu, Xueyan Chen, Yihui Guan, Ruixue Cui, Qiu Huang, Xianliang Xin, Hongjian Chen, Yu Ding, Jing Zhang, Teng Feng, Marc Cantillon, Kewei Chen, Jeffrey L. Cummings, Jian Ding, Meiyu Geng, Zhenxin Zhang
Summary: GV-971 demonstrated significant efficacy in improving cognition with sustained improvement across all observation periods of a 36-week trial. Treatment with GV-971 showed a significant advantage in cognitive function compared to placebo, and it was well-tolerated and safe.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Genetics & Heredity
Michele Rousseau, Justine Horne, Frederic Guenard, Juan De Toro-Martin, Veronique Garneau, Valerie Guay, Michele Kearney, Genevieve Pilon, Denis Roy, Patrick Couture, Charles Couillard, Andre Marette, Marie-Claude Vohl
Summary: The study found that blueberry supplementation did not significantly improve traditional markers of cardiometabolic health in adults at risk of developing MetS. However, significant changes were observed in gene expression and metabolite abundance, suggesting that clinically significant cardiometabolic changes may require longer periods or higher doses of blueberry consumption. Additionally, blueberry powder may have an impact on factors such as immunity within a shorter 8-week timeframe.
GENES AND NUTRITION
(2021)