Article
Multidisciplinary Sciences
Kazuyuki Kasahara, Naoto Sasaki, Hilman Zulkifli Amin, Toru Tanaka, Sayo Horibe, Tomoya Yamashita, Ken-Ichi Hirata, Yoshiyuki Rikitake
Summary: This study demonstrates that Foxp3(+) Tregs can suppress pro-inflammatory CD4(+) T cell immune responses to control the development of atherosclerosis under hypercholesterolemia.
Article
Multidisciplinary Sciences
Kazuyuki Kasahara, Naoto Sasaki, Hilman Zulkifli Amin, Toru Tanaka, Sayo Horibe, Tomoya Yamashita, Ken-ichi Hirata, Yoshiyuki Rikitake
Summary: Foxp3+ Tregs play a crucial role in the control of atherosclerosis by suppressing pro-inflammatory CD4+ T cell immune responses. Depletion of Foxp3+ Tregs aggravates inflammation and worsens atherosclerosis under hypercholesterolemia.
Review
Immunology
Constance Renault, Nicolas Veyrenche, Franck Mennechet, Anne-Sophie Bedin, Jean-Pierre Routy, Philippe Van de Perre, Jacques Reynes, Edouard Tuaillon
Summary: Th17 cells play a crucial role in defending against pathogens at mucosal barriers, but they are also vulnerable to HIV-1 infection and depletion from gut mucosal sites. The imbalance caused by the loss of Th17 cells impairs cytokine production and leads to damage in the gut mucosal barrier, promoting HIV-1 disease progression. The expression of specific receptors by Th17 cells contributes to their susceptibility to HIV infection. Moreover, Th17 cells serve as long-lived viral reservoirs in HIV patients receiving antiretroviral therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Bastian F. J. Plochg, Hanna Englert, Chandini Rangaswamy, Sandra Konrath, Mandy Malle, Sibylle Lampalzer, Claudia Beisel, Salma Wollin, Maike Frye, Jens Aberle, Johannes Kluwe, Thomas Renne, Reiner K. Mailer
Summary: Our study reveals that liver damage promotes pro-inflammatory ApoB100-specific T-cell populations, providing a cellular mechanism for increased CVD risk in liver disease patients.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Oscar J. Cordero, Carlos Rafael-Vidal, Ruben Varela-Calvino, Cristina Calvino-Sampedro, Beatriz Malvar-Fernandez, Samuel Garcia, Juan E. Vinuela, Jose M. Pego-Reigosa
Summary: Immune system CD4 T-cells with high cell-surface CD26 expression demonstrate anti-tumoral properties, especially when engineered with a chimeric antigen receptor. Different T helper cell subsets show variations in CD26 expression levels, which could impact research on CAR-T cells. The relationship between glycoprotein sCD26 and its enzymatic activity, as well as its correlation with specific T cell subsets, still requires further understanding.
Article
Immunology
Guizhen Lin, Lei Zhang, Zheng Yan, Wei Jiang, Beibei Wu, Dongsheng Li, Xiaofang Xiong
Summary: This study identified different subsets of Th17 cells in the atherosclerotic aorta, with Th17.1 cells and transitional Th17.1 cells being more proliferative and inducing higher levels of chemokines and growth factors in aortic endothelial cells compared to Th17 cells.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Review
Immunology
Marco Kunzli, David Masopust
Summary: This review provides updates on our understanding of the biology of memory CD4(+) T cells as well as key technological advances that facilitate their characterization.
Article
Cardiac & Cardiovascular Systems
Tanyaporn Pattarabanjird, Melissa Marshall, Aditi Upadhye, Prasad Srikakulapu, James C. Garmey, Antony Haider, Angela M. Taylor, Esther Lutgens, Coleen A. McNamara
Summary: This study reveals a novel role for P62 in driving BAFF-induced B1b cell proliferation and IgM(OSE) production to attenuate diet-induced atherosclerosis. Results also identify a direct role for Id3 in antagonizing E2A from activating the p62 promoter. Moreover, analysis of putative human B1 cells also implicates these pathways in coronary artery disease subjects, suggesting P62 as a new immunomodulatory target for treating atherosclerosis.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jesus Gil-Pulido, Nuria Amezaga, Ivana Jorgacevic, Helga D. Manthey, Melanie Roesch, Theresa Brand, Peter Cidlinsky, Sarah Schafer, Andreas Beilhack, Antoine-Emmanuel Saliba, Kristina Lorenz, Louis Boon, Immo Prinz, Ari Waisman, Thomas Korn, Clement Cochain, Alma Zernecke
Summary: IL-23R(+) gamma delta T cells predominantly found in the aortic root promote early atherosclerotic lesion formation, plaque necrosis, and inflammation at this site. Targeting IL-23R may be explored as a therapeutic approach to mitigate atherosclerotic lesion development.
CARDIOVASCULAR RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Benjamin G. Wiggins, Laura J. Pallett, Xiaoyan Li, Scott P. Davies, Oliver E. Amin, Upkar S. Gill, Stephanie Kucykowicz, Arzoo M. Patel, Konstantinos Aliazis, Yuxin S. Liu, Gary M. Reynolds, Brian R. Davidson, Amir Gander, Tu Vinh Luong, Gideon M. Hirschfield, Patrick T. F. Kennedy, Yuehua Huang, Mala K. Maini, Zania Stamataki
Summary: This study found that high and intermediate CD69 expressions marked human hepatic CD4(+) T-RM and a novel functionally distinct recirculating population, both shaped by the liver microenvironment to achieve diverse immunosurveillance.
Article
Cardiac & Cardiovascular Systems
Virginia Smit, Jill de Mol, Frank H. Schaftenaar, Marie A. C. Depuydt, Rimke J. Postel, Diede Smeets, Fenne W. M. Verheijen, Laurens Bogers, Janine van Duijn, Robin A. F. Verwilligen, Hendrika W. Grievink, Mireia N. A. Bernabe Kleijn, Eva van Ingen, Maaike J. M. de Jong, Lauren Goncalves, Judith A. H. M. Peeters, Harm J. Smeets, Anouk Wezel, Julia K. Polansky, Menno P. J. de Winther, Christoph J. Binder, Dimitrios Tsiantoulas, Ilze Bot, Johan Kuiper, Amanda C. Foks
Summary: This study found that aging promotes advanced atherosclerosis in mice and induces immunological alterations. The expression of genes involved in atherogenic processes shifted with age, and age-associated T- and B-cells emerged in atherosclerotic plaques and blood. Further research on age-associated immunity may contribute to novel diagnostic and therapeutic tools for cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Review
Medicine, General & Internal
Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake
Summary: Tregs play a protective role in atherosclerosis by regulating immune responses to prevent and treat the development of the disease. Enhancing regulatory immune responses may be an attractive approach to treating atherosclerotic diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Celestine N. Wanjalla, Mona Mashayekhi, Samuel Bailin, Curtis L. Gabriel, Leslie M. Meenderink, Tecla Temu, Daniella T. Fuller, Liang Guo, Kenji Kawai, Renu Virmani, Cathy Jenkins, Chike O. Abana, Christian M. Warren, Rama Gangula, Rita Smith, Meena S. Madhur, Aloke Finn, Alexander H. Gelbard, Yan Ru Su, Matthew J. Tyska, Spyros A. Kalams, David G. Harrison, Simon A. Mallal, Tarek S. Absi, Joshua A. Beckman, John R. Koethe
Summary: HIV-positive individuals with carotid atheroma show a higher proportion of circulating CD4(+) T-cells expressing the C similar to G similar to C surface marker combination associated with antiviral and cytotoxic responses. These cells can be cytomegalovirus-specific and are also present in the aorta.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Annie B. Bauman, Cambri E. Moeller, Aimee M. Soileau, Christine E. Goodermuth, Victoria R. Costa, Jessica C. Schaumburg, Cherie M. Pucheu-Haston, Nancy D. Welborn, Shannon D. Dehghanpir, Mark A. Mitchell, Sita S. Withers
Summary: In this study, CD45RA and CD62L were used to quantify memory T-cell subsets in healthy dogs and dogs with various diseases. The results showed that dermatologic inflammation can alter the proportions of peripheral blood T-cell subsets, and these findings contribute to characterizing clinical canine immune responses.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2022)
Article
Immunology
Edwin J. Heeregrave, Jordan Thomas, Toni M. van Capel, Esther C. de Jong, Georgios Pollakis, William A. Paxton
Summary: HIV-1 can infect various cell types, and the phenotype of the virus can be influenced by the characteristics of the producing cell. Comparing virus strains produced from different cell types, it was found that virus produced from macrophages is more resistant to 2G12 neutralization and more efficiently transmitted to CD4+ cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph A. C. Delaney, Nels C. Olson, Colleen M. Sitlani, Alison E. Fohner, Sally A. Huber, Alan L. Landay, Susan R. Heckbert, Russell P. Tracy, Bruce M. Psaty, Matt Feinstein, Margaret F. Doyle
Summary: The study found that with increasing blood pressure levels, the proportion of gamma delta T cells and natural killer cells also increased, while classical monocytes showed an inverse correlation with systolic blood pressure levels.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Immunology
Samuel S. Bailin, Suman Kundu, Melissa Wellons, Matthew S. Freiberg, Margaret F. Doyle, Russell P. Tracy, Amy C. Justice, Celestine N. Wanjalla, Alan L. Landay, Kaku So-Armah, Simon Mallal, Jonathan A. Kropski, John R. Koethe
Summary: A higher proportion of circulating memory CD4(+) T cells is associated with a higher prevalence of diabetes mellitus in persons with HIV and HIV-negative persons. In this study, the researchers used flow cytometry and functional assays to evaluate whether circulating T-cell subsets could identify individuals who will develop diabetes. They found that in persons with HIV, higher frequencies of CD4(+) T effector memory RA(+) cells were associated with incident diabetes.
Article
Critical Care Medicine
John S. Kim, Gisli Thor Axelsson, Matthew Moll, Michaela R. Anderson, Elana J. Bernstein, Rachel K. Putman, Tomoyuki Hida, Hiroto Hatabu, Eric A. Hoffman, Ganesh Raghu, Steven M. Kawut, Margaret F. Doyle, Russell Tracy, Lenore J. Launer, Ani Manichaikul, Stephen S. Rich, David J. Lederer, Vilmundur Gudnason, Brian D. Hobbs, Michael H. Cho, Gary M. Hunninghake, Christine Kim Garcia, Gunnar Gudmundsson, R. Graham Barr, Anna J. Podolanczuk
Summary: This study found that higher blood monocyte counts were associated with the presence and progression of interstitial lung abnormalities and lower FVC.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Steven M. Kawut, Michael J. Krowka, Kimberly A. Forde, Nadine Al-Naamani, Karen L. Krok, Mamta Patel, Carlo R. Bartoli, Margaret Doyle, Jude Moutchia, Grace Lin, Jae K. Oh, Carl D. Mottram, Paul D. Scanlon, Michael B. Fallon
Summary: Hepatopulmonary syndrome is associated with abnormal systemic angiogenesis, decreased exercise and functional capacity, and an increased risk of death.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Elizabeth C. Oelsner, Akshaya Krishnaswamy, Pallavi P. Balte, Norrina Bai Allen, Tauqeer Ali, Pramod Anugu, Howard F. Andrews, Komal Arora, Alyssa Asaro, R. Graham Barr, Alain G. Bertoni, Jessica Bon, Rebekah Boyle, Arunee A. Chang, Grace Chen, Sean Coady, Shelley A. Cole, Josef Coresh, Elaine Cornell, Adolfo Correa, David Couper, Mary Cushman, Ryan T. Demmer, Mitchell S. Elkind, Aaron R. Folsom, Amanda M. Fretts, Kelley P. Gabriel, Linda C. Gallo, Jose Gutierrez, Mei Lan K. Han, Joel M. Henderson, Virginia J. Howard, Carmen R. Isasi, David R. Jacobs, Suzanne E. Judd, Debora Kamin Mukaz, Alka M. Kanaya, Namratha R. Kandula, Robert C. Kaplan, Gregory L. Kinney, Anna Kucharska-Newton, Joyce S. Lee, Cora E. Lewis, Deborah A. Levine, Emily B. Levitan, Bruce D. Levy, Barry J. Make, Kimberly Malloy, Jennifer J. Manly, Carolina Mendoza-Puccini, Katie A. Meyer, Yuan-I Nancy Min, Matthew R. Moll, Wendy C. Moore, David Mauger, Victor E. Ortega, Priya Palta, Monica M. Parker, Wanda Phipatanakul, Wendy S. Post, Lisa Postow, Bruce M. Psaty, Elizabeth A. Regan, Kimberly Ring, Veronique L. Roger, Jerome Rotter, Tatjana Rundek, Ralph L. Sacco, Michael Schembri, David A. Schwartz, Sudha Seshadri, James M. Shikany, Mario Sims, Karen D. Hinckley Stukovsky, Gregory A. Talavera, Russell P. Tracy, Jason G. Umans, Ramachandran S. Vasan, Karol E. Watson, Sally E. Wenzel, Karen Winters, Prescott G. Woodruff, Vanessa Xanthakis, Ying Zhang, Yiyi Zhang
Summary: The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study comprising 14 established US cohort studies that aims to evaluate risk factors and outcomes of COVID-19, as well as assess the long-term societal and behavioral impact of the pandemic on health trajectories.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew J. Feinstein, Petra Buzkova, Nels C. Olson, Margaret F. Doyle, Colleen M. Sitlani, Alison E. Fohner, Sally A. Huber, James Floyd, Arjun Sinha, Edward B. Thorp, Alan Landay, Matthew S. Freiberg, William T. Longstreth Jr, Russell P. Tracy, Bruce M. Psaty, Joseph AC. Delaney
Summary: Circulating IL-4 producing T cells and intermediate monocytes were significantly associated with an increased risk of incident stroke over a nearly two-decade follow-up period. These associations were stronger among men and not observed among women.
Article
Neurosciences
Alison E. Fohner, Colleen M. Sitlani, Petra Buzkova, Margaret F. Doyle, Xiaojuan Liu, Joshua C. Bis, Annette Fitzpatrick, Susan R. Heckbert, Sally A. Huber, Lewis Kuller, William T. Longstreth, Matthew J. Feinstein, Matthew Freiberg, Nels C. Olson, Sudha Seshadri, Oscar Lopez, Michelle C. Odden, Russell P. Tracy, Bruce M. Psaty, Joseph A. Delaney, James S. Floyd
Summary: This study examined the association between 18 types of peripheral immune cells and cognitive function in elderly participants. The results showed no significant associations after accounting for multiple comparisons, but there were marginal associations between peripheral regulatory T cells and cognitive decline and dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Yuan Fang, Margaret F. Doyle, Michael L. Alosco, Jesse Mez, Claudia L. Satizabal, Wei Qiao Qiu, Kathryn L. Lunetta, Joanne M. Murabito
Summary: This study investigated the association between NLR, RDW, and MPV with cognitive function, brain volume, and microvascular disease. The results showed that higher NLR and RDW were significantly associated with poorer cognitive function and brain structure, suggesting that peripheral inflammation may be linked to abnormal brain aging.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medical Laboratory Technology
Margaret F. Doyle
Summary: Neurologic symptoms caused by COVID-19 can vary in severity, with some being mild while others can be life-threatening. These symptoms often persist after the acute phase of the illness, posing challenges for diagnosis and treatment.
TRANSLATIONAL RESEARCH
(2022)
Letter
Cardiac & Cardiovascular Systems
James S. Floyd, Colleen M. Sitlani, Margaret F. Doyle, Matthew J. Feinstein, Nels C. Olson, Susan R. Heckbert, Sally A. Huber, Russell P. Tracy, Bruce M. Psaty, Joseph A. C. Delaney
Article
Cardiac & Cardiovascular Systems
Peter Durda, Laura M. Raffield, Ethan M. Lange, Nels C. Olson, Nancy Swords Jenny, Mary Cushman, Pia Deichgraeber, Niels Grarup, Anna Jonsson, Torben Hansen, Josyf C. Mychaleckyj, Bruce M. Psaty, Alex P. Reiner, Russell P. Tracy, Leslie A. Lange
Summary: The study found an association between sCD163 and cardiovascular disease events and conducted a genome-wide association study to identify variants related to sCD163. Variants were identified in different ethnic groups.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Arjun Sinha, Colleen M. Sitlani, Margaret F. Doyle, Alison E. Fohner, Petra Buzkova, James S. Floyd, Sally A. Huber, Nels C. Olson, Joyce N. Njoroge, Jorge R. Kizer, Joseph A. Delaney, Sanjiv S. Shah, Russell P. Tracy, Bruce Psaty, Matthew Feinstein
Summary: The higher proportions of CD4+ T helper (Th) 1 cells are associated with a lower risk of incident HFrEF, with similar effect sizes in two distinct population-based cohorts, suggesting replicability and warranting further investigation.
Article
Endocrinology & Metabolism
Nels C. Olson, Margaret F. Doyle, Petra Buzkova, Sally A. Huber, Ian H. de Boer, Colleen M. Sitlani, Russell P. Tracy, Bruce M. Psaty, Kenneth J. Mukamal, Joseph A. Delaney
Summary: The relationship between senescent lymphocytes and diabetes is uncertain. This study found no significant associations between frequencies of naive, memory, and senescent T cells and memory B cells and the risk of incident diabetes in older adults.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
