Review
Genetics & Heredity
Yu Shi, Zihao Liu, Qun Lin, Qing Luo, Yinghuan Cen, Juanmei Li, Xiaolin Fang, Chang Gong
Summary: The study of miRNA in cancer has made significant advancements, with research showing that miRNA can be dysregulated in different types of cancers and act as either tumor promoters or tumor suppressors. Studies have also revealed that miRNA may serve as novel tools and targets for therapeutic attempts, and the development of miRNA delivery systems has accelerated the preclinical implications of miRNA in cancer treatment.
Article
Medicine, Research & Experimental
R. K. Dutta, S. Chinnapaiyan, M. J. Santiago, I Rahman, H. J. Unwalla
Summary: The study revealed that HIV Tat upregulates miR-145-5p and miR-509-3p, which cooperatively suppress CFTR. CRISPR-based gene editing can preserve CFTR mRNA and function in airway epithelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Roberto Piergentili, Giuseppe Basile, Cristina Nocella, Roberto Carnevale, Enrico Marinelli, Renato Patrone, Simona Zaami
Summary: Although the discovery of non-coding RNAs (ncRNAs) dates back to 1958, it is only recently that the complexity of the transcriptome has started to be understood. The identification and function of these ncRNAs are still under investigation, but they are known to play a regulatory role in gene expression. This review summarizes the current knowledge on these mechanisms, their potential use in disease treatment, and the challenges and ethical issues associated with their use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lihua Zhang, Zhen Zou, Yanli Lei, Zhihe Qing, Yu Zeng, Haiyan Sun, Feng Feng, Ronghua Yang
Summary: The clamp-like triplex switch developed in this study can simultaneously downregulate an overexpressed onco-miRNA and replenish lost tumor-suppressive miRNA in a controllable manner, showing improved anti-tumor efficacy in vitro and being harmless to healthy cells.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Phuong T. B. Ho, Ian M. Clark, Linh T. T. Le
Summary: MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression and hold promise as biomarkers for diagnosis and prognosis of diseases. This review discusses the intracellular and extracellular trafficking of miRNAs, their role as potential biomarkers, measurement methods, available panels for clinical use, and their potential as therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jeanne P. Uyisenga, Ahmed Debit, Christophe Poulet, Pierre Freres, Aurelie Poncin, Jerome Thiry, Leon Mutesa, Guy Jerusalem, Vincent Bours, Claire Josse
Summary: The study evaluated the diagnostic performance of circulating microRNAs in breast cancer in populations from Belgium and Rwanda, finding that while there is no universal circulating signature, specific signatures can be identified for different populations.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Sarah B. Thomson, Anouk Stam, Cynthia Brouwers, Valentina Fodale, Alberto Bresciani, Michael Vermeulen, Sara Mostafavi, Terri L. Petkau, Austin Hill, Andrew Yung, Bretta Russell-Schulz, Piotr Kozlowski, Alex MacKay, Da Ma, Mirza Faisal Beg, Melvin M. Evers, Astrid Valles, Blair R. Leavitt
Summary: This study investigates the effects of AAV5-miHTT treatment in a mouse model of Huntington's disease, and shows that it can improve brain health and reverse transcriptional dysregulation in the model.
Review
Biochemistry & Molecular Biology
Fawzy A. Saad, Gabriele Siciliano, Corrado Angelini
Summary: Dystrophinopathies are X-linked muscular disorders caused by mutations in the Dystrophin gene. Diagnosis methods include creatine kinase assay and genetic analysis, and treatment options include glucocorticoids and gene therapy. The development of exon skipping drugs has provided new hope for the treatment of Duchenne muscular dystrophy.
Article
Biochemistry & Molecular Biology
Alti Dayakar, Kumar D. Shanmukha, Suresh K. Kalangi
Summary: This article reviews the regulation, functions, and potential applications of miRNAs in cancer. The study of miRNA and its target genes can provide new approaches and strategies for the diagnosis, treatment, and prognosis of cancer.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Engineering, Environmental
Ying Zhang, Shiqi Tang, Xiaoyun Feng, Xiang Li, Jingyu Yang, Qiqi Liu, Meirong Li, Yujuan Chai, Chengbin Yang, Suxia Lin, Jia Liu
Summary: Gene-photothermal synergistic therapy has great potential for breast cancer treatment. In this study, a tumor-targeted nanoplatform was fabricated for precise intracellular delivery of miR-21 inhibitor. The nanoplatform showed good stability, excellent photothermal conversion efficiency, and enhanced anti-cancer effect.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Gareth Morris, Stephanie Schorge
Summary: Gene therapy is showing promise in treating rare monogenetic neurological disorders and could potentially offer new treatments for common non-genetic disorders as well. However, the permanent nature of gene therapies may pose risks, and research is being conducted to develop approaches that allow for treatment to be turned on and off.
Article
Engineering, Biomedical
Yawen Ma, Huimin Lin, Peng Wang, Haocheng Yang, Jie Yu, Hao Tian, Tianyu Li, Shengfang Ge, Yilong Wang, Renbing Jia, Kam W. Leong, Jing Ruan
Summary: MicroRNA-based gene therapy using biocompatible nanocarriers shows promise in treating ocular melanoma by up-regulating tumor suppressor miR-30a-5p and inhibiting malignant phenotypes. The nanocarrier with high miRNA loading and redox-responsive release capabilities enhances the therapeutic effect. Furthermore, it promotes M1 macrophage polarization and activates Fenton reaction, synergistically enhancing anti-tumor immunity. The study demonstrates the potential of this nanocarrier for targeted gene therapy in melanoma and other cancers.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Peiwen Fu, Yumeng Guo, Yanan Luo, Michael Mak, Jianguo Zhang, Wenrong Xu, Hui Qian, Zhimin Tao
Summary: This study presents a nano-scale fluorescent off-on complex encapsulated by small extracellular vesicles (sEVs) for real-time visualization and evaluation of gene therapy efficiency in cancer. The results demonstrate that the complex is able to activate the turn-on fluorescent signal and exhibit the longest retention time in vivo, promoting cancer apoptosis both in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tao Zheng, Wentao Wang, Mohsen Mohammadniaei, Jon Ashley, Ming Zhang, Ninglin Zhou, Jian Shen, Yi Sun
Summary: This study developed a targeted delivery system for miRNA-21 using ligand-modified nanoparticles, which temporarily opened the blood-tumor barrier to achieve effective transportation and controlled release in glioblastoma treatment, leading to the inhibition of tumor growth and angiogenesis.
Review
Chemistry, Multidisciplinary
Ragini Singh, Santosh Kumar
Summary: This review discusses the recent advancements of carbon nanotubes (CNTs) in cancer diagnosis and therapy, including various sensing strategies and treatment techniques. It also emphasizes the importance of ensuring the safety of CNTs for biomedical applications.
Article
Oncology
Nikhil S. Chari, Cristina Ivan, Xiandong Le, Jinzhong Li, Ainiwaer Mijiti, Ameeta A. Patel, Abdullah A. Osman, Christine B. Peterson, Michelle D. Williams, Curtis R. Pickering, Carlos Caulin, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Review
Oncology
Abdol-Hossein Rezaeian, Hashem Khanbabaei, George A. Calin
Article
Hematology
Lu Q. Wang, Shaji Kumar, George A. Calin, Zhenhai Li, Chor S. Chim
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Emanuele Panatta, Anna Maria Lena, Mara Mancini, Artem Smirnov, Alberto Marini, Riccardo Delli Ponti, Teresa BottaOrfila, Gian Gaetano Tartaglia, Alessandro Mauriello, Xinna Zhang, George A. Calin, Gerry Melino, Eleonora Candi
Article
Gastroenterology & Hepatology
Martin Pichler, Cristian Rodriguez-Aguayo, Su Youn Nam, Mihnea Paul Dragomir, Recep Bayraktar, Simone Anfossi, Erik Knutsen, Cristina Ivan, Enrique Fuentes-Mattei, Sang Kil Lee, Hui Ling, Tina Catela Ivkovic, Guoliang Huang, Li Huang, Yoshinaga Okugawa, Hiroyuki Katayama, Ayumu Taguchi, Emine Bayraktar, Rajat Bhattacharya, Paola Amero, William Ruixian He, Anh M. Tran, Petra Vychytilova-Faltejskova, Christiane Klec, Diana L. Bonilla, Xinna Zhang, Sanja Kapitanovic, Bozo Loncar, Roberta Gafa, Zhihui Wang, Vittorio Cristini, Samir M. Hanash, Menashe Bar-Eli, Giovanni Lanza, Ondrej Slaby, Ajay Goel, Isidore Rigoutsos, Gabriel Lopez-Berestein, George Adrian Calin
Article
Gastroenterology & Hepatology
Mihnea Paul Dragomir, Scott Kopetz, Jaffer A. Ajani, George Adrian Calin
Editorial Material
Immunology
Simone Anfossi, George A. Calin
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Moran Amit, Hideaki Takahashi, Mihnea Paul Dragomir, Antje Lindemann, Frederico O. Gleber-Netto, Curtis R. Pickering, Simone Anfossi, Abdullah A. Osman, Yu Ca, Rong Wang, Erik Knutsen, Masayoshi Shimizu, Cristina Ivan, Xiayu Rao, Jing Wang, Deborah A. Silverman, Samantha Tam, Mei Zhao, Carlos Caulin, Assaf Zinger, Ennio Tasciotti, Patrick M. Dougherty, Adel El-Naggar, George A. Calin, Jeffrey N. Myers
Review
Biochemistry & Molecular Biology
Selin Oncul, Paola Amero, Cristian Rodriguez-Aguayo, George A. Calin, Anil K. Sood, Gabriel Lopez-Berestein
Article
Oncology
Julianna K. Bronk, Ping Hou, Mark J. Amsbaugh, Soumen Khatua, Anita Mahajan, Leena Ketonen, Susan L. McGovern
Summary: This study observed the changes in white matter tracts and tumor metabolism in DIPG patients undergoing reirradiation. The results showed that FA increased and ADC decreased during disease response, while FA decreased and ADC increased during disease progression. Fiber tract visualization demonstrated the reconstruction of disrupted paths during tumor response and increased disruption during tumor progression. MRS analysis revealed a decrease in tumor metabolite ratios during response and an increase during progression.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Article
Oncology
Julianna K. Bronk, Ahmad Amer, Swapnil Khose, David Flint, Antony Adair, Pablo Yepes, David Grosshans, Jason Johnson, Caroline Chung
Summary: We present a case of brain radiation necrosis (RN) outside of the high-dose radiation therapy volume. Initial radiographic detection of these lesions reduced the suspicion of RN due to their distant relationship with the patient's treatment history. However, further examination revealed RN lesions in regions that received a lower dose but higher linear energy transfer. Advanced brain tumor imaging allowed for the correct diagnosis, highlighting its utility in the follow-up setting.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Meeting Abstract
Oncology
J. K. Bronk, X. Wu, B. V. Chapman, T. Karpinets, T. Sims, O. Gjyshi, P. J. Eifel, A. Jhingran, L. L. Lin, L. Ramondetta, P. A. Futreal, K. Schmeler, J. Yue, K. Court, T. Solley, M. Ahmad-Kaddar, E. J. Lynn, J. Zhang, A. H. Klopp, L. Colbert
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Meeting Abstract
Oncology
Lawrence Bronk, Julianna Bronk, Sanjay Singh, Xiaochun Wang, Dadi Jiang, Fada Guan, Albert Koong, Radhe Mohan, Frederick Lang, David Grosshans
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Oncology
Pablo Ferreira das Chagas, Graziella Ribeiro de Sousa, Marcio Hideki Kodama, Carlos Alberto Oliveira de Biagi Junior, Jose Andres Yunes, Silvia Regina Brandalise, George Adrian Calin, Luiz Gonzaga Tone, Carlos Alberto Scrideli, Jaqueline Carvalho de Oliveira
Summary: Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in various cancers, including acute lymphoblastic leukemia (ALL). This study found that the expression level of uc.112 in pediatric ALL was higher in T-ALL patients compared to B-ALL patients. Additionally, uc.112 was also significantly increased in hyperdiploid B-ALL patients, while uc.122, uc.160, and uc.262 showed no association with biological or clinical features.
HEMATOLOGY TRANSFUSION AND CELL THERAPY
(2021)
Correction
Oncology
J. K. Bronk
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)