MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

(2018) Sunetra Roy et al.   eLife

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma

(2017) V Colicchia et al.   ONCOGENE

A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma

(2016) Matteo Tamborini et al.   ACS Nano

Myc induced replicative stress response: How to cope with it and exploit it

(2015) Sara Rohban et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

(2015) M Petroni et al.   CELL DEATH AND DIFFERENTIATION

Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett's esophagus

(2015) Robert CG Martin et al.   Nanomedicine

The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells

(2015) Long Gu et al.   EBioMedicine

The Essential Function of the MRN Complex in the Resolution of Endogenous Replication Intermediates

(2014) Christopher Bruhn et al.   Cell Reports

c-MYC-Induced Genomic Instability

(2014) A. Kuzyk et al.   Cold Spring Harbor Perspectives in Medicine

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

The Mre11 Complex Suppresses Oncogene-Driven Breast Tumorigenesis and Metastasis

(2013) Gaorav P. Gupta et al.   MOLECULAR CELL

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress

(2013) Seetha V. Srinivasan et al.   Cell Reports

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system

(2012) Erica Locatelli et al.   JOURNAL OF NANOPARTICLE RESEARCH

MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency

(2012) R. Moser et al.   MOLECULAR CANCER RESEARCH

The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1

(2012) Isabella Massimi et al.   MOLECULAR CARCINOGENESIS

Nijmegen breakage syndrome (NBS)

(2012) Krystyna H Chrzanowska et al.   Orphanet Journal of Rare Diseases

Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells

(2012) Veronica Veschi et al.   PLoS One

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

(2012) L. J. Valentijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of MYCN-dependent apoptosis and the MDM2–p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN-amplified neuroblastoma

(2012) Marialaura Petroni et al.   Frontiers in Oncology

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

(2011) Matilde Murga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

(2011) K. A. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

MYCN Sensitizes Human Neuroblastoma to Apoptosis by HIPK2 Activation through a DNA Damage Response

(2010) M. Petroni et al.   MOLECULAR CANCER RESEARCH

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis

(2009) T Van Maerken et al.   CELL DEATH AND DIFFERENTIATION

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Poor Survival for Infants WithMYCN-Amplified Metastatic Neuroblastoma Despite Intensified Treatment: The International Society of Paediatric Oncology European Neuroblastoma Experience

(2009) Adela Canete et al.   JOURNAL OF CLINICAL ONCOLOGY

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Significance ofMYCNAmplification in International Neuroblastoma Staging System Stage 1 and 2 Neuroblastoma: A Report From the International Neuroblastoma Risk Group Database

(2008) Rochelle Bagatell et al.   JOURNAL OF CLINICAL ONCOLOGY

The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report

(2008) Susan L. Cohn et al.   JOURNAL OF CLINICAL ONCOLOGY

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

(2008) Frank Westermann et al.   GENOME BIOLOGY