Review
Oncology
Hussein Chehade, Roslyn Tedja, Harry Ramos, Tejeshwar Singh Bawa, Nicholas Adzibolosu, Radhika Gogoi, Gil Mor, Ayesha B. Alvero
Summary: Adipocytes play a crucial role in the ovarian tumor microenvironment, as their secreted factors and direct interaction with ovarian cancer cells can support tumor progression. Elucidating the molecular pathways involved is vital in identifying relevant targets.
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Review
Cell Biology
Tamsin Wesley, Stuart Berzins, George Kannourakis, Nuzhat Ahmed
Summary: The plakin family of cytoskeletal proteins, particularly plectin, periplakin, and envoplakin, play crucial roles in disease-states and cancers, with a focus on ovarian cancer. They are involved in regulating cancer cell growth, survival, migration, invasion, and drug resistance, potentially impacting progression, chemoresistance, and recurrence. Abnormal expression of plakins may lead to the transition of benign ovarian tumors to carcinomas and contribute to the sustenance and progression of the disease.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Immunology
Aiping Zheng, Yuhao Wei, Yunuo Zhao, Tao Zhang, Xuelei Ma
Summary: Ovarian cancer is a common malignant tumor in females with limited treatment options. Cancer-associated mesothelial cells in the tumor microenvironment play a significant role in the progression and prognosis of ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Chalaithorn Nantasupha, Chanisa Thonusin, Kittipat Charoenkwan, Siriporn Chattipakorn, Nipon Chattipakorn
Summary: Cancer cells show adaptations to their metabolism to facilitate growth, invasiveness, and metastasis. While aerobic glycolysis has been thought to be the dominant energy metabolism in cancer, recent data suggest that oxidative phosphorylation may be more likely in some cancer cells, particularly in epithelial ovarian cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Estefania Carrasco-Garcia, Lidia Lopez, Veronica Moncho-Amor, Fernando Carazo, Paula Aldaz, Manuel Collado, Donald Bell, Ayman Gaafar, Eva Karamitopoulou, Alexandar Tzankov, Manuel Hidalgo, Angel Rubio, Manuel Serrano, Charles H. Lawrie, Robin Lovell-Badge, Ander Matheu
Summary: The study shows that SOX9 plays a crucial role in the progression and metastasis of pancreatic cancer by regulating stemness and EMT processes. High levels of SOX9 are associated with metastases in clinical samples.
Article
Reproductive Biology
Mahak Masoodi, Zafar A. Shah, Afaq H. Beigh, Sheikh Zahoor Ahmad, Abdul Wahid Mir, Besina Yasin, Roohi Rasool, Khalid Z. Masoodi, Gull Mohammad Bhat
Summary: This study found that serum Galectin-1 levels in ovarian cancer patients were associated with various variables, notably higher in postmenopausal patients and in epithelial ovarian tumors, with levels decreasing post-surgery and chemotherapy. Galectin-1 was shown to be a better biomarker than CA125 in distinguishing between normal, benign, malignant, and metastatic cases.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhiyuan Dou, Chunping Qiu, Xun Zhang, Shu Yao, Chen Zhao, Zixiang Wang, Ran Chu, Jingying Chen, Zhongshao Chen, Rongrong Li, Kun Wang, Penglin Liu, Chang Liu, Kun Song, Beihua Kong
Summary: This study found that HJURP is overexpressed in ovarian cancer and is associated with unfavorable prognosis. Knockdown of HJURP inhibits proliferation, metastasis, and induces cell stagnation in ovarian cancer cells. Mechanistically, HJURP regulates WEE1 through the MYC pathway, affecting chemosensitivity and DNA repair in ovarian cancer cells. Moreover, silencing HJURP enhances sensitivity to cisplatin and improves the synergistic effect of combined therapy with cisplatin and AZD1775 in ovarian cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Anatomy & Morphology
Makhdoom Sarwar, Peter H. Sykes, Kenny Chitcholtan, John J. Evans
Summary: Collagen I architecture plays a role in ovarian cancer development and therapeutic responses, with distinct morphologies observed in cancerous ovaries compared to normal ones. Fibril alignment is more prevalent in certain ovarian cancer subtypes, suggesting an influence on cancer cell proliferation. The modification of collagen I structure integrity is associated with ovarian cancer progression and therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Xinxin Huang, Juncheng Hao, Yan Qin Tan, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: Patients with epithelial ovarian cancer are often diagnosed at an advanced stage, leading to poor overall prognosis. This review summarizes the functional significance of CXCL/CXCR chemokines in modulating EOC progression and discusses the current status and prospects of CXCR/CXCL-based theranostic strategies in EOC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Abhilash Nitin Deo, Rahul Thorat, Ajit Chandrakant Dhadve, Abhijit De, Bharat Rekhi, Pritha Ray
Summary: Recurrent metastatic epithelial ovarian cancer (EOC) poses challenges due to treatment limitations, with chemoresistance exacerbating organ-specific metastasis through the IGF1R-alpha 6 integrin-S100A4 molecular network. S100A4 may serve as a potential target for treating recurrent metastatic EOC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Yuan Li, Chunliang Shang, Huamao Liang, Kun Zhang, Yu Wu, Hongyan Guo
Summary: The relationship between novel serum lipid index and chemoresistance as well as prognosis of epithelial ovarian cancer (EOC) was evaluated. The study included 249 EOC patients and their serum lipid profiles were collected and calculated. The results revealed a significant correlation between HDL-C/TC ratio and chemoresistance, and HDL-C/LDL-C ratio was closely related to the clinicopathological characteristics and prognosis of EOC patients, serving as an independent protective factor indicating better outcome.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
