Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

(2014) Jiajie Guo et al.   PLoS One

Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells

(2014) Y-C Hsu et al.   Cell Death & Disease

Targeting caspases in cancer therapeutics

(2013) Patrick Hensley et al.   BIOLOGICAL CHEMISTRY

Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

(2013) Mads Gabrielsen et al.   Cell Communication and Signaling

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: A reappraisal of translation initiation during mitosis

(2013) Mark Coldwell et al.   CELL CYCLE

Interplay between apoptosis and autophagy, a challenging puzzle: New perspectives on antitumor chemotherapies

(2013) C. Bincoletto et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cucurbitacin E exhibits anti-inflammatory effect in RAW 264.7 cells via suppression of NF-κB nuclear translocation

(2013) Jing Qiao et al.   INFLAMMATION RESEARCH

Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2013) Jian He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cucurbitacin E as Inducer of Cell Death and Apoptosis in Human Oral Squamous Cell Carcinoma Cell Line SAS

(2013) Chao-Ming Hung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preparation and characterization of liposomes incorporating cucurbitacin E, a natural cytotoxic triterpene

(2013) Lamice Habib et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chemical Modification Produces Species-Specific Changes in Cucurbitacin Antifeedant Effect

(2013) Karen Luise Lang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Natural Product Cucurbitacin E Inhibits Depolymerization of Actin Filaments

(2012) Pia M. Sörensen et al.   ACS Chemical Biology

Biological activities and potential molecular targets of cucurbitacins

(2012) Xiuping Chen et al.   ANTI-CANCER DRUGS

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion

(2012) Tao Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

Cucurbitacins as Inducers of Cell Death and a Rich Source of Potential Anticancer Compounds

(2012)   CURRENT PHARMACEUTICAL DESIGN

The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer

(2012) Ahmed Aribi et al.   INTERNATIONAL JOURNAL OF CANCER

APRIL Binding to BCMA Activates a JNK2-FOXO3-GADD45 Pathway and Induces a G2/M Cell Growth Arrest in Liver Cells

(2012) G. Notas et al.   JOURNAL OF IMMUNOLOGY

Cucurbitacin B Induces Cell Cycle Arrest, Apoptosis and Autophagy Associated with G Actin Reduction and Persistent Activation of Cofilin in Jurkat Cells

(2012) Jun-Shan Zhu et al.   PHARMACOLOGY

Inhibitory effect of cucurbitacin E on the proliferation of ovarian cancer cells and its mechanism

(2012) Xiao-Lei Shan et al.   Chinese Journal of Cancer

Triterpenoids for Cancer Prevention and Treatment: Current Status and Future Prospects

(2011) Jagan M.R. Patlolla et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells

(2011) Rita S M Shih et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition

(2011) Siddig Ibrahim Abdelwahab et al.   FITOTERAPIA

The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2α in leukemia cells

(2010) Yanchun Li et al.   ANTI-CANCER DRUGS

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway

(2010) Y. Dong et al.   CARCINOGENESIS

Gadd45 Proteins as Critical Signal Transducers Linking NF-κB to MAPK Cascades

(2009) Z. Yang et al.   CURRENT CANCER DRUG TARGETS

Gadd45-α and Gadd45-γ utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells

(2008) Na Zhu et al.   MOLECULAR BIOLOGY REPORTS