Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting death receptors for TRAIL by agents designed by Mother Nature

(2014) Sahdeo Prasad et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

AD-1, a novel ginsenoside derivative, shows anti-lung cancer activity via activation of p38 MAPK pathway and generation of reactive oxygen species

(2013) Lin-Hui Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

EF24 prevents rotenone-induced estrogenic status alteration in breast cancer

(2013) Debarshi Roy et al.   CELL BIOLOGY INTERNATIONAL

Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer Therapy

(2013) Tiffany DeVine et al.   CURRENT PHARMACEUTICAL DESIGN

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

(2013) Ariele Viacava Follis et al.   Nature Chemical Biology

Control of Cellular Bcl-xL Levels by Deamidation-Regulated Degradation

(2013) So Hee Dho et al.   PLOS BIOLOGY

Cell Death via DR5, but not DR4, Is Regulated by p53 in Myeloma Cells

(2012) S. Surget et al.   CANCER RESEARCH

Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone

(2011) António Pedro Gonçalves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death

(2011) António Pedro Gonçalves et al.   JOURNAL OF BIOSCIENCES

Molecular Basis of Bcl-XL-p53 Interaction: Insights from Molecular Dynamics Simulations

(2011) Nagakumar Bharatham et al.   PLoS One

Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways

(2010) Feng-Lang Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism

(2009) Wu Yin et al.   BIOCHEMICAL PHARMACOLOGY

TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives

(2009) J.H. Stegehuis et al.   DRUG RESISTANCE UPDATES

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

Essential roles of caspases and their upstream regulators in rotenone-induced apoptosis

(2008) Jihjong Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CAAT/Enhancer Binding Protein Homologous Protein-Dependent Death Receptor 5 Induction Is a Major Component of SHetA2-Induced Apoptosis in Lung Cancer Cells

(2008) Y.-D. Lin et al.   CANCER RESEARCH

Targeting TRAIL death receptors

(2008) CNAM Oldenhuis et al.   CURRENT OPINION IN PHARMACOLOGY

TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them

(2008) A THORBURN et al.   DRUG RESISTANCE UPDATES

Phosphorylated-ERK 1/2 and neuronal degeneration induced by rotenone in the hippocampus neurons

(2008) Yan Sai et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

(2008) Y. Lin et al.   MOLECULAR CANCER THERAPEUTICS

Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature

(2008) L. Cao et al.   MOLECULAR CANCER THERAPEUTICS

Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes

(2008) L JI et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY