Article
Multidisciplinary Sciences
Jianbo He, Lin Zheng, Xiaojuan Li, Furong Huang, Sitao Hu, Lei Chen, Manya Jiang, Xianfeng Lin, Haibo Jiang, Yifan Zeng, Tianshen Ye, Dingkun Lin, Qian Liu, Jiake Xu, Kai Chen
Summary: This study aimed to explore the therapeutic potential of Obacunone (OB) on osteoporosis and its rudimentary mechanisms. In vitro and in vivo experiments showed that OB suppressed the formation and function of osteoclasts. Mechanistically, OB interacted with macrophage migration inhibitory factor (MIF), attenuating receptor activator of nuclear factor kappa B (NF-KB) ligand (RANKL)-induced signaling pathways. This led to a decrease in the expression level of the master transcriptional factor of osteoclastogenesis, nuclear factor of activated T cells 1 (NFATc1), and its downstream osteoclast-specific proteins. OB also alleviated estrogen deficiency-induced osteoporosis by targeting MIF and inhibiting hyperactive osteoclasts.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Immunology
Xiangwen Shi, Yipeng Wu, Haonan Ni, Mingjun Li, Baochuang Qi, Yongqing Xu
Summary: The expression level of macrophage migration inhibitory factor (MIF) is upregulated in osteomyelitis patients and cell models. MIF inhibits osteogenic differentiation by activating the NF-κB signaling pathway. The study demonstrates that the MIF inhibitor iSO-1 and MIF knockdown can reverse the inhibitory effect of inflammation on osteogenic differentiation, providing a potential target for osteomyelitis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Sirui Shen, Zhuqi Huang, Liming Lin, Zimin Fang, Weixin Li, Wu Luo, Gaojun Wu, Zhouqing Huang, Guang Liang
Summary: This study suggests that TUS, a natural product with anti-inflammatory activities, can alleviate inflammation and reduce atherosclerotic plaque areas. The mechanism involves the inhibition of MAPK pathway phosphorylation. TUS may be a potential therapeutic candidate for atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zhengzhu Sun, Chongfeng Fang, Shasha Xu, Bin Wang, Danlei Li, Xiaoman Liu, Yafei Mi, Hangyuan Guo, Jianjun Jiang
Summary: SIRT3 effectively attenuates DOX-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation and regulating autophagy. This finding provides a theoretical foundation for further exploration of cardiac toxicity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Xuemei Hu, Yueyue Li, Qingyang Chen, Tingting Wang, Limei Ma, Wanping Zhang, Ruihong Yu, Jun Zhang, Jingyuan Wan, Chao Yu, Zhiyi Yuan
Summary: Accumulating evidence suggests that sialic acids play a crucial role in the development of atherosclerosis, but the specific effects and mechanisms have not been fully defined. This study demonstrates that sialic acids can promote the polarization of macrophages to the proinflammatory M1 phenotype, leading to the expression of proinflammatory cytokines. This proinflammatory effect is likely due to the inhibition of the LKB1-AMPK-Sirt3 signaling pathway, resulting in increased intracellular ROS levels and impaired autophagy-lysosome system, ultimately exacerbating atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
HaiShan Li, Wei Deng, QiuLi Qin, YueWei Lin, Teng Liu, GuoYe Mo, Yang Shao, YongChao Tang, Kai Yuan, LiangLiang Xu, YongXian Li, ShunCong Zhang
Summary: This study investigated the effect of ISO on osteoclast differentiation and activation, as well as its molecular mechanism. In vitro experiments showed that ISO inhibited osteoclast generation and affected multiple molecular pathways related to bone homeostasis. In vivo experiments demonstrated that ISO effectively reduced bone loss caused by ovariectomy. These findings suggest that ISO may have therapeutic potential for the treatment of osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Neurosciences
Chenghe Fan, Yu Tian, Yilin Zhang, Junfang Teng, Xinyu Zhao
Summary: The study found that ceramide induced neuronal parthanatos by increasing ROS levels, and MIF may play a crucial role in this pathway. Knocking down MIF expression may be a potential therapeutic strategy for nervous system diseases.
NEUROSCIENCE LETTERS
(2022)
Article
Immunology
Krishnamoorthi Sumaiya, Panneerselvam Selvambika, Kalimuthusamy Natarajaseenivasan
Summary: This study identified an anti-inflammatory drug, ibu-dilast, as a potential MIF inhibitor for the treatment of leptospirosis. In vitro and in vivo experiments showed that ibu-dilast could reduce inflammation and protect against lethality caused by leptospiral infection.
MICROBIAL PATHOGENESIS
(2022)
Article
Plant Sciences
Xuejiao Jiang, Chongyang Ma, Yanbin Gao, Hehe Cui, Yalin Zheng, JinXia Li, Wenjing Zong, Qiuyun Zhang
Summary: This study investigated the influence of Tongxinluo (TXL) on endothelial cell pyroptosis in atherosclerosis (AS) and its underlying mechanism. The results showed that TXL could inhibit endothelial cell pyroptosis and reduce the release of inflammatory cytokines. Additionally, TXL decreased the accumulation of reactive oxygen species (ROS), which further reduced endothelial cell pyroptotic damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenmin Dong, Chenglin Jia, Ji Li, Yi Zhou, Yun Luo, Jibo Liu, Zhiguo Zhao, Jiaqi Zhang, Shan Lin, Ying Chen
Summary: This study finds that fisetin can alleviate high glucose-induced podocyte injury and STZ-induced DN by restoring autophagy-mediated CDKN1B/P70S6K pathway and inhibiting NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nan Zhou, Suyun Yong, Xianpeng Shi, Peng Zhang, Jianhua Wang
Summary: We identified a new imperatorin derivative, OW1, which has significant effects on vasodilation and inhibits vascular remodelling in hypertensive rats. OW1 inhibits vascular cell proliferation and migration by attenuating Nox1-ROS signalling.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Immunology
Krishnamoorthi Sumaiya, Charles Solomon Akino Mercy, Gangatharan Muralitharan, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Kalimuthusamy Natarajaseenivasan
Summary: This study evaluated the diagnostic value of macrophage migration inhibitory factor (MIF) for leptospirosis. The results showed that serum MIF levels were significantly elevated in leptospirosis patients and correlated with disease severity and progression. Serum MIF exhibited high sensitivity and specificity, making it a potential rapid diagnostic marker for leptospirosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)