Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells

TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung

(2013) Alberto Ricci* et al.   CELL CYCLE

Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen

(2013) Uri Ben-David et al.   Cell Stem Cell

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

(2013) C. A. von Roemeling et al.   CLINICAL CANCER RESEARCH

FGFR3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth

(2012) X. Du et al.   CANCER RESEARCH

Decreasing stearoyl-CoA desaturase-1 expression inhibits β-catenin signaling in breast cancer cells

(2012) Daniel Mauvoisin et al.   CANCER SCIENCE

EMT markers in lung adenocarcinoma pleural effusion spheroid cells

(2012) Enrico Giarnieri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

(2012) Paul Mason et al.   PLoS One

Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity

(2012) S Akunuru et al.   Cell Death & Disease

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy

(2011) M Bartucci et al.   CELL DEATH AND DIFFERENTIATION

Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells

(2011) Daniel Hess et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

(2011) U. V. Roongta et al.   MOLECULAR CANCER RESEARCH

Spheres Derived from Lung Adenocarcinoma Pleural Effusions: Molecular Characterization and Tumor Engraftment

(2011) Rita Mancini et al.   PLoS One

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

(2010) Elise Isabel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling

(2010) J. P. Sullivan et al.   CANCER RESEARCH

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer

(2010) D. Luyimbazi et al.   MOLECULAR CANCER THERAPEUTICS

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

(2010) V. Fritz et al.   MOLECULAR CANCER THERAPEUTICS

Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers

(2010) Shan Deng et al.   PLoS One

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

(2009) Serge Léger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients’ outcome

(2009) Ting Li et al.   LABORATORY INVESTIGATION

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Aldehyde dehydrogenase activity as a functional marker for lung cancer

(2008) Deniz Ucar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Albumin-Associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal

(2008) Francesc R. Garcia-Gonzalo et al.   PLoS One

A Self-Renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-Derived Tumors

(2008) Anne E. Conway et al.   STEM CELLS

Aldehyde Dehydrogenase as a Marker for Stem Cells

(2008) Jan Moreb   Current Stem Cell Research & Therapy