Article
Anatomy & Morphology
Sebile Azirak, Meltem Ozgocmen
Summary: Currently, kidney diseases are on the rise, leading to a decrease in quality of life. Acute kidney injury (AKI) is commonly seen in hospitalized patients of all ages and is associated with high morbidity and mortality rates. Rifampicin (RF), an antibiotic from the rifamycin group, can cause acute kidney injury as well as side effects such as anemia, thrombocytopenia, and liver damage. This study investigated the potential benefits of linalool (LN), which has antinociceptive, antimicrobial, antioxidant, and anti-inflammatory effects, in alleviating kidney damage caused by RF-induced oxidative stress.
Review
Biochemistry & Molecular Biology
Katarzyna Romejko, Magdalena Markowska, Stanislaw Niemczyk
Summary: Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein secreted by immune cells in response to inflammation. It serves as a biomarker for acute kidney injury and is also elevated in chronic kidney disease and cardiovascular diseases. NGAL is involved in the progression of renal function decrease and is associated with complications and mortality due to kidney failure. It is also useful in the diagnostic processes of cardiovascular diseases and plays a role in inflammatory states, hypertension, obesity, diabetes, and carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medical Laboratory Technology
Vijaya Marakala
Summary: NGAL can be a valuable biomarker for the early detection of acute kidney injury and other kidney-related diseases, and has predictive value in predicting outcomes and severity.
CLINICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Zhonghui Duan, Minjie Jiang, Xiaojie Huang, Haixia Liu, Hongwei Yu, Qinghua Meng
Summary: Urinary biomarkers can be useful in differentiating between PRA and other types of AKI in patients with hepatitis B cirrhosis. Elevated urinary NGAL can reflect the degree of kidney injury and is an independent risk factor for nonresponse to volume expansion therapy in patients with hepatitis B cirrhosis and AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yuping Wang, Yang Gu, Xin Gu, Danielle B. Cooper, David F. Lewis
Summary: This study found that there is tubular injury in preeclampsia, which is indicated by increased levels of NGAL and KIM-1. The higher postpartum levels of NGAL and KIM-1 in preeclamptic pregnancies suggest that proper follow-up and management of kidney function is necessary to reduce chronic kidney diseases in these women later in life.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sakura Minami, Tomoki Doi, Takeru Abe, Ichiro Takeuchi
Summary: The study found that NGAL levels can predict the degree of invasiveness in trauma patients with moderate precision, especially for short-term outcomes. There is a significant association between NGAL levels and trauma severity indicators, making it a useful predictor for assessing trauma severity.
Article
Urology & Nephrology
Katherine Xu, Ning Shang, Abraham Levitman, Alexa Corker, Satoru Kudose, Andrew Yaeh, Uddhav Neupane, Jacob Stevens, Rosemary Sampogna, Angela M. Mills, Vivette D'Agati, Sumit Mohan, Krzysztof Kiryluk, Jonathan Barasch
Summary: Elevated levels of urinary neutrophil gelatinase-associated lipocalin (uNGAL) at hospital admission can serve as a predictive marker for acute kidney injury (AKI) in patients with COVID-19, and are quantitatively associated with histopathologic injury (ATI), loss of kidney function, and severity of patient outcomes.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, General & Internal
Edison Jahaj, Alice G. Vassiliou, Maria Pratikaki, Parisis Gallos, Zafeiria Mastora, Ioanna Dimopoulou, Stylianos E. Orfanos, Philippos Orfanos, Pagona Lagiou, Anastasia Kotanidou
Summary: The study aimed to investigate the prognostic value of NGAL and creatinine as biomarkers for AKI in critically ill patients. Results indicated that NGAL was more accurate in predicting AKI development than creatinine, and elevated NGAL levels were associated with an increased risk of AKI development. Further research is needed to confirm NGAL as a prognostic marker for acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Xiao-Meng Wei, Shuang Jiang, Shan-Shan Li, Yin-Shi Sun, Shi-Han Wang, Wen-Cong Liu, Zi Wang, Ying-Ping Wang, Rui Zhang, Wei Li
Summary: This study aimed to investigate the protective effect and possible molecular mechanism of ginseng polysaccharide (WGP) on cisplatin-induced kidney toxicology in mice. Results showed that WGP reduced apoptosis of kidney cells by inhibiting endoplasmic reticulum stress and activating the PI3K/AKT and PERK-eIF2 alpha-ATF4 signaling pathways. Additionally, WGP also inhibited inflammation and apoptosis in renal cells caused by cisplatin exposure.
Article
Pediatrics
Stuart L. Goldstein, Kelli A. Krallman, Alexandra Schmerge, Lynn Dill, Bradley Gerhardt, Praneeta Chodaparavu, Abigail Radomsky, Cassie Kirby, David J. Askenazi
Summary: The study suggests that urine NGAL could be a reliable screening tool for severe AKI in children exposed to nephrotoxic medications, with high specificity and negative predictive values. This may reduce the need for daily venipuncture in NINJA, but further studies are needed to determine the optimal combination of serum creatinine and uNGAL assessment.
PEDIATRIC NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marco Allinovi, Francesco Sessa, Gianluca Villa, Andrea Cocci, Samantha Innocenti, Maria Zanazzi, Lorenzo Tofani, Laura Paparella, Dritan Curi, Calogero Lino Cirami, Riccardo Campi, Andrea Mari, Agostino Ognibene, Maria Lorubbio, Alessandra Fanelli, Stefano Romagnoli, Paola Romagnani, Andrea Minervini
Summary: The study aimed to identify and compare serum and urinary predictors for predicting long-term decline in glomerular filtration rate (GFR) after robotic Nephron-Spearing Surgery (rNSS). The results showed that patients who developed clinical acute kidney injury (AKI) had a more pronounced decline in eGFR at 24 months. KineticGFR at 4 hours and NephroCheck at 10 hours were found to be efficient predictors of post-operative AKI and long-term eGFR decline. Combining these biomarkers could help identify high-risk patients as early as 10 hours after surgery.
Article
Biochemistry & Molecular Biology
Marta Martin-Lorenzo, Angeles Ramos-Barron, Paula Gutierrez-Garcia, Ariadna Martin-Blazquez, Aranzazu Santiago-Hernandez, Emilio Rodrigo Calabia, Carlos Gomez-Alamillo, Gloria Alvarez-Llamas
Summary: This study identified molecular features in preoperative samples that can predict the development of AKI associated with cardiac surgery. Among these features, uKIM-1 and spermidine showed strong predictive value. These findings may be useful in preventing postoperative AKI and improving the prognosis of patients undergoing cardiac surgery.
Article
Multidisciplinary Sciences
Yen-Chun Chen, Chen-Hao Li, Ping-Hung Ko, Chi-Che Lee, Ru-Jiang Syu, Chih-Wei Tseng, Kuo-Chih Tseng
Summary: The study observed that approximately 26.7% of chronic hepatitis C patients receiving direct-acting antivirals experienced renal function deterioration after treatment, which was associated with older age, male gender, specific medication use, and NGAL levels. Furthermore, NGAL might serve as a biomarker for nephrotoxicity in patients receiving certain drug regimens.
Article
Endocrinology & Metabolism
Chung-Hsing Wang, Wen-Li Lu, Shang-Lun Chiang, Tsung-Hsun Tsai, Su-Ching Liu, Chia-Hung Hsieh, Pen-Hua Su, Chih-Yang Huang, Fuu-Jen Tsai, Yu-Jung Lin, Yu-Nan Huang
Summary: This study aimed to evaluate the role of PDHA1 in the regulation of tubular cells and CD4(+) T cells and further investigate their interaction in tubular cell injury in T1DM. The results revealed that Th1 cells induced tubular cell injury through dysregulated metabolic reprogramming and autophagy, providing a new therapeutic approach for kidney tubular injury in T1DM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Eunjeong Son, Woo Hyun Cho, Jin Ho Jang, Taehwa Kim, Doosoo Jeon, Yun Seong Kim, Hye Ju Yeo
Summary: NGAL levels are elevated in ARDS patients and are associated with survival rates and ICU mortality. Serum and BAL levels of NGAL have good predictive value for ICU mortality in ARDS patients.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Oncology
Patrick Brest, Baharia Mograbi, Paul Hofman, Gerard Milano
Summary: The combination of COVID-19 vaccination and immunotherapy by checkpoint inhibitors in cancer patients may intensify immunological stimulation with potential reciprocal benefits, but caution should be exercised due to possible adverse events that can arise in each treatment modality.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Nicolas Melis, Romain Carcy, Isabelle Rubera, Marc Cougnon, Christophe Duranton, Michel Tauc, Didier F. Pisani
Summary: Lesions caused by ischemia/reperfusion stress are a major challenge in human pathophysiology, and the kidney is particularly sensitive to this. Targeting the hypusination pathway of eIF5A has been shown to improve ischemic tolerance and is successfully applied to kidney transplants. Inhibition of Akt can also be considered a preconditioning treatment against ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Denis Doyen, Mallorie Poet, Gisele Jarretou, Didier F. Pisani, Michel Tauc, Marc Cougnon, Mederic Argentina, Yann Bouret, Laurent Counillon
Summary: The article discusses the importance of intracellular pH and the molecular mechanisms that affect and regulate it. Through mathematical modeling, the cellular response to acidification, the impact of different transporters and intracellular buffering are explored. The article highlights the significance of modeling in studying biological questions such as functional redundancy and natural selection.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, General & Internal
Georges Leftheriotis, Nastassia Navasiolava, Laetitia Clotaire, Christophe Duranton, Olivier Le Saux, Said Bendahhou, Audrey Laurain, Isabelle Rubera, Ludovic Martin
Summary: PXE is a rare metabolic disorder characterized by progressive calcification in the skin, the Bruch's membrane, and the vasculature. This study found a deficit in plasma PPi levels in PXE patients, with a correlation to age and gender. However, arterial calcification showed a weak connection to PPi levels, with age being the main determinant of disease severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Audrey Laurain, Isabelle Rubera, Micheline Razzouk-Cadet, Stephanie Bonnafous, Miguel Albuquerque, Valerie Paradis, Stephanie Patouraux, Christophe Duranton, Olivier Lesaux, Georges Leftheriotis, Albert Tran, Rodolphe Anty, Philippe Gual, Antonio Iannelli, Guillaume Favre
Summary: Liver fibrosis is associated with arterial calcification. Plasma inorganic pyrophosphate (PPi) levels are correlated with liver fibrosis, liver function, and arterial calcification. Liver transplantation can restore serum albumin levels and PPi levels.
Editorial Material
Genetics & Heredity
Patrick Brest, Baharia Mograbi, Jocelyn Gal, Paul Hofman, Gerard Milano
Summary: Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies have shown that host genetic background may contribute to the development of severe COVID-19. This summary focuses on genetic variations, such as in the SARS-CoV-2 receptor angiotensin-converting enzyme 2 or interferon signaling pathway, and their role in understanding why some individuals can develop severe COVID-19.
TRENDS IN GENETICS
(2023)
Article
Cell Biology
Nicolas Melis, Isabelle Rubera, Sebastien Giraud, Marc Cougnon, Christophe Duranton, Mallorie Poet, Gisele Jarretou, Raphael Thuillier, Laurent Counillon, Thierry Hauet, Luc Pellerin, Michel Tauc, Didier F. Pisani
Summary: Through kidney transplantation, ischemia/reperfusion induces tissular injury due to energy shortage, oxidative stress, and endoplasmic reticulum (ER) stress. We found that the specific inhibitor of eukaryotic Initiation Factor 5A (eIF5A) hypusination, GC7, protects kidney cells by modulating unfolded protein response (UPR) pathways. GC7 pretreatment enhances xbp1 splicing and BiP expression while reducing eIF2 alpha phosphorylation and ATF6 nuclear level, indicating a specific modulation of UPR pathways. Inhibition of xbp1 splicing reverses the protective effect of GC7 against anoxia, demonstrating the crucial role of eIF5A hypusination inhibition in UPR modulation.
Article
Multidisciplinary Sciences
J. -D. Masson, G. Badran, M. A. Domdom, R. K. Gherardi, B. Mograbi, F. J. Authier, G. Crepeaux
Summary: We investigated the early in vitro response of primary human PBMCs to aluminum oxyhydroxide and a whole vaccine. The results showed that aluminum oxyhydroxide particles were quickly recognized and internalized by immune cells, and the cells exhibited increased canonical autophagy and LC3-associated phagocytosis. In addition, an inflammatory response with TNF-alpha production and altered mitochondrial metabolism were observed.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Olivia Vidal-Cruchez, Victoria J. Nicolini, Tifenn Rete, Karine Jacquet, Roger Rezzonico, Caroline Lacoux, Marie-Angela Domdom, Barnabe Romeo, Jeremie Roux, Arnaud Hubstenberger, Bernard Mari, Baharia Mograbi, Paul Hofman, Patrick Brest
Summary: Cancer therapies targeting the MAPK pathway lead to drug resistance. Overexpression of RAS has been linked to this resistance, but the underlying mechanisms are unclear. This study shows that MEK inhibitors increase translation of KRAS and NRAS oncogenes through liquid-liquid phase separation, specifically P-body dissolution. This feedback loop involving P-bodies and phase separation could be important for future targeted therapies.
Review
Oncology
Arnaud Martel, Lauris Gastaud, Christelle Bonnetaud, Sacha Nahon-Esteve, Kevin Washetine, Olivier Bordone, Myriam Salah, Virginie Tanga, Julien Fayada, Virginie Lespinet, Maryline Allegra, Salome Lalvee, Katia Zahaf, Stephanie Baillif, Corine Bertolotto, Baharia Mograbi, Sandra Lassalle, Paul Hofman
Summary: This study aims to present the challenges faced in obtaining biospecimens for research purposes in ophthalmic malignancies, and provides a detailed description of a dedicated biobank for ophthalmic malignancies. Currently, the number of biobanks dedicated to ophthalmic malignancies worldwide is very limited. The two main objectives in establishing an ophthalmic malignancy biobank are to collect scarce ophthalmic tumor samples and conduct large-scale translational research to better understand pathogenesis and discover new biomarkers for early diagnosis and targeted treatment.
Article
Cell Biology
Sandy Giuliano, Christopher Montemagno, Marie-Angela Domdom, Manon Teisseire, Patrick Brest, Daniel J. Klionsky, Paul Hofman, Gilles Pages, Baharia Mograbi
Summary: Nearly fifty million older people suffer from neurodegenerative diseases, and this number is expected to triple by 2050. Defective lysosomal acidification and impairment of the autophagy pathway have been identified as modifiable risk factors for dementia. The long-term prescribing of lysosomotropic drugs to the elderly, such as proton pump inhibitors, chloroquine, and hydroxychloroquine, may be connected to the incidence of neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Nicolas Guillot, Barnabe Romeo, Shima Sepehri Manesh, Gerard Milano, Patrick Brest, Laurence Zitvogel, Paul Hofman, Baharia Mograbi
Summary: In the past decade, there has been a shift in cancer treatment from conventional therapies to immune checkpoint inhibitors (ICIs). However, a large percentage of patients do not respond to this treatment. Recent research has found that bacteria play an unexpected role in reprogramming tumor immunity. Manipulating the microbiota can impact tumor development and the tumor microenvironment, potentially improving the efficacy of immunotherapy.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Arnaud Martel, Baharia Mograbi, Barnabe Romeo, Lauris Gastaud, Salome Lalvee, Katia Zahaf, Julien Fayada, Sacha Nahon-Esteve, Christelle Bonnetaud, Myriam Salah, Virginie Tanga, Stephanie Baillif, Corine Bertolotto, Sandra Lassalle, Paul Hofman
Summary: Liquid biopsy and circulating tumor cell (CTC) screening have gained attention in the past two decades for detecting various solid malignancies. However, the lack of reproducibility due to different CTC platforms using different technologies is a major limitation for daily clinical use. This study compares the efficiency of four commercially available CTC platforms for detecting and identifying uveal melanoma cells. The results show significant differences in recovery rates among the platforms, highlighting the importance of considering other factors before using a CTC platform in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)