Article
Pharmacology & Pharmacy
Chiara Zichittella, Marco Loria, Adriana Celesia, Diana Di Liberto, Chiara Corrado, Riccardo Alessandro, Sonia Emanuele, Alice Conigliaro
Summary: This study demonstrates that the expression of lncH19 contributes to ITF2357-induced apoptosis by stabilizing TP53. Overall, we suggest that lncH19 expression may be exploited to enhance HDACi-induced cell death and overcome 5-fluorouracil chemoresistance.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Lixia Cao, Shaorong Zhao, Qianxi Yang, Zhendong Shi, Jingjing Liu, Teng Pan, Dongdong Zhou, Jin Zhang
Summary: This study aimed to demonstrate the potential of chidamide (CHI) combined with the chemotherapy drug doxorubicin (DOX) to overcome chemotherapeutic resistance of MDR breast cancer. The results showed that CHI combined with DOX exhibited significant cytotoxicity to MDR breast cancer cells and induced cell apoptosis by activating the p53 pathway.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Jason Lin, Shang-Chuen Wu
Summary: This review examines the role of protein serotonylation in transcriptional regulation, its potential impact on the epigenetic landscape, and its implications in lung and other types of cancer. The review discusses the mechanistic details of serotonylation and its connections to the epigenome, as well as the role of transglutaminase 2, in order to guide the development of optimized histone deacetylase inhibitor designs or combination therapies for cancer treatment.
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Article
Pharmacology & Pharmacy
Jiefei Miao, Chi Meng, Hongmei Wu, Wenpei Shan, Haoran Wang, Changchun Ling, Jinlin Zhang, Tao Yang
Summary: The novel hybrid CHC showed high antiproliferative effects on drug-sensitive and drug-resistant cells, selectively inhibited HDAC1/6, and exhibited strong inhibitory potency to drug-resistant hepatic tumors in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jasmine A. McQuerry, Jinfeng Chen, Jeffrey T. Chang, Andrea H. Bild
Summary: The overexpression of ABCB1 in cancer cells leads to drug resistance, but combination therapy with specific drugs and chemotherapy can enhance treatment efficacy; further studies are needed to explore the clinical potential of tepoxalin in restoring chemosensitivity in patients with drug-resistant breast cancer due to ABCB1 overexpression.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Cell Biology
Bingyi Zhou, Deliang Liu, Yuyong Tan
Summary: Cancer is the second leading cause of death worldwide, with digestive system cancers being a primary contributor. Acetylation and deacetylation play crucial roles in cancer development, with HDAC6 being a widely studied enzyme that is upregulated in various tumors and associated with clinicopathological characteristics. There is ongoing research on HDAC6 inhibitors and their potential in inhibiting tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Article
Oncology
Roisin M. Connolly, Fengmin Zhao, Kathy D. Miller, Min-Jung Lee, Richard L. Piekarz, Karen L. Smith, Ursa A. Brown-Glaberman, Jennifer S. Winn, Bryan A. Faller, Adedayo A. Onitilo, Mark E. Burkard, George T. Budd, Ellis G. Levine, Melanie E. Royce, Peter A. Kaufman, Alexandra Thomas, Jane B. Trepel, Antonio C. Wolff, Joseph A. Sparano
Summary: The combination of entinostat and exemestane did not improve survival in patients with AI-resistant advanced HR-positive, HER2-negative breast cancer. E2112 phase III trial: no benefit seen in adding HDAC inhibitor entinostat to exemestane in advanced breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jianglei Li, Meihong Yu, Shifeng Fu, Deliang Liu, Yuyong Tan
Summary: This review summarizes the research progress and underlying mechanism of ACY-1215 in cancer and other human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Iason Psilopatis, Nikolaos Garmpis, Anna Garmpi, Kleio Vrettou, Panagiotis Sarantis, Evangelos Koustas, Efstathios A. Antoniou, Dimitrios Dimitroulis, Gregory Kouraklis, Michail V. Karamouzis, Georgios Marinos, Konstantinos Kontzoglou, Afroditi Nonni, Konstantinos Nikolettos, Florian N. Fleckenstein, Christina Zoumpouli, Christos Damaskos
Summary: Histone deacetylase inhibitors (HDACIs) have important effects on epigenetic regulation in cancer, including inducing cancer cell death, apoptosis, and cell cycle arrest. Although mainly approved for hematologic malignancies, there are promising studies in cervical cancer. This comprehensive review examines the role of HDACIs in the treatment of cervical cancer and discusses their potential as effective anticancer drugs, either alone or in combination with other treatments.
Article
Biotechnology & Applied Microbiology
Anuhya Kommalapati, Tawee Tanvetyanon
Summary: Immunotherapy with checkpoint inhibitors has replaced chemotherapy in some settings, allowing many patients to live longer with fewer side effects, but only works for about one-fifth of unselected patients. Important cofactors within the tumor microenvironment, such as T-cells and chemokines, can impact the efficacy of immunotherapy through epigenetic modulation.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Thais More Milan, Ana Patricia Espaladori Eskenazi, Rayana Longo Bighetti-Trevisan, Luciana Oliveira de Almeida
Summary: This study found that cisplatin resistance is associated with changes in DNA damage accumulation, reactive oxygen species levels, and an increase in cancer stem cells. Epigenetic regulation plays a crucial role, with potential for targeted treatment of head and neck squamous cell carcinoma by addressing resistant cancer stem cells.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Oncology
Timothy B. Lautz, Yueh-Yun Chi, Jing Tian, Abha A. Gupta, Suzanne L. Wolden, Jonathan C. Routh, Dana L. Casey, Roshni Dasgupta, Douglas S. Hawkins, David A. Rodeberg
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Pediatrics
David M. Notrica, Bethany L. Sussman, Lois W. Sayrs, Shawn D. St Peter, R. Todd Maxson, Adam C. Alder, James W. Eubanks, Jeremy J. Johnson, Daniel J. Ostlie, Todd Ponsky, Jessica A. Naiditch, Charles M. Leys, Karla A. Lawson, Cynthia Greenwell, Amina Bhatia, Nilda M. Garcia
Summary: This study found that receiving early vasopressor treatment in the pediatric trauma center emergency department was associated with an increased risk of death, but did not increase the risk of failure of nonoperative management.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Oncology
Timothy B. Lautz, Helene Martelli, Joerg Fuchs, Cyrus Chargari, Naima Smeulders, Candace F. Granberg, Suzanne L. Wolden, Monika Sparber-Sauer, Douglas S. Hawkins, Gianni Bisogno, Ewa Koscielniak, David A. Rodeberg, Guido Seitz
Summary: The International Soft-Tissue Sarcoma Consortium (INSTRuCT) aims to develop consensus expert opinions for the treatment of pediatric soft-tissue sarcoma. This consensus paper provides treatment recommendations for female genital tract rhabdomyosarcoma, based on a review of literature, treatment protocols, and expert opinions. The prognosis of FGU-RMS is favorable, with chemotherapy showing excellent response. The consensus will help harmonize treatment across different study groups.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Timothy B. Lautz, Yueh-Yun Chi, Minjie Li, Suzanne L. Wolden, Dana L. Casey, Jonathan C. Routh, Candace F. Granberg, Odion Binite, Erin R. Rudzinski, Douglas S. Hawkins, Rajkumar Venkatramani, David A. Rodeberg
Summary: This study compared outcomes in children with group III RMS who did and did not undergo DPE and assessed surgical morbidity. The study found that patients who underwent DPE could receive a decreased radiation dose for definitive local control, leading to improved overall survival in the DPE group.
Article
Oncology
Timothy B. Lautz, Zishaan Farooqui, Todd Jenkins, Todd E. Heaton, John J. Doski, Jo Cooke-Barber, Andrew J. Murphy, Andrew M. Davidoff, Sara A. Mansfield, Eugene S. Kim, Samuel Zuber, Catherine Goodhue, Sanjeev A. Vasudevan, Michael P. LaQuaglia, Nelson Piche, Annie Le-Nguyen, Jennifer H. Aldrink, Marcus M. Malek, Vei Shaun Siow, Richard D. Glick, Barrie S. Rich, Rebecka L. Meyers, Scott S. Short, Andreana Butter, Reto M. Baertschiger, Elizabeth A. Fialkowski, Roshni Dasgupta
Summary: This study compared overall survival and pulmonary disease-free survival in children with osteosarcoma undergoing thoracotomy versus thoracoscopic surgery for pulmonary metastasectomy, finding no significant difference in 5-year survival rates. While a thoracoscopic approach may pose higher mortality risk compared to thoracotomy in general, it showed comparable outcomes in patients with limited pulmonary disease burden.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Pediatrics
Francesca M. Shilati, Mehul Raval, Timothy B. Lautz
Summary: This study retrospectively reviewed 331 patients who underwent venous port placement at a single tertiary children's hospital, finding that although venous port placement is relatively safe, a minority of patients, especially those with leukemia, require early revision or replacement. Proceduralist volume and training may influence early revision or replacement, fluoroscopy exposure, and anatomic site preferences.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Jennifer H. Aldrink, Richard D. Glick, Reto M. Baertschiger, Afif N. Kulaylat, Timothy B. Lautz, Emily Christison-Lagay, Christa N. Grant, Elisabeth Tracy, Roshni Dasgupta, Erin G. Brown, Peter Mattei, David H. Rothstein, David A. Rodeberg, Peter F. Ehrlich
Summary: This article reviews and summarizes the diagnostic evaluation, treatment methods, and recent research findings of testicular germ cell tumors in children and adolescents. Testicular germ cell tumors are rare tumors, and global collaborations and data sharing will contribute to a better understanding of these rare tumors and improve treatment outcomes for patients.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Christa N. Grant, Daniel Rhee, Elisabeth T. Tracy, Jennifer H. Aldrink, Reto M. Baertschiger, Timothy B. Lautz, Richard D. Glick, David A. Rodeberg, Peter F. Ehrlich, Emily Christison-Lagay
Summary: Pediatric surgeons should be aware of CPS as the identification of one of these syndromes can completely change the management of certain tumors. The most common CPS associated with pediatric solid malignancies are outlined, with an emphasis on those most often encountered by pediatric surgeons: neuroblastoma, Wilms' tumor, hepatoblastoma, and medullary thyroid cancer. Screening and management guidelines are outlined, and published genetic testing and counseling guidelines are included where available.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Oncology
Barrie S. Rich, Joanna Fishbein, Timothy Lautz, Nathan S. Rubalcava, Tanvi Kartal, Erika Newman, Pei En Wok, Rodrigo L. P. Romao, Richard Whitlock, Bindi Naik-Mathuria, Stephanie F. Polites, Katrine Lofberg, Danny Lascano, Eugene Kim, Jacob Davidson, Andreana Butter, Zachary J. Kastenberg, Scott S. Short, Rebecka L. Meyers, Rosemarie Mastropolo, Marcus M. Malek, Jennine Weller, Ahmer Irfan, Daniel S. Rhee, Alan F. Utria, David H. Rothstein, Kimberly Riehle, Sarah Jane Commander, Elisabeth Tracy, Kerri Becktell, Brian Hallis, Dave Lal, Orville Li, Dorothe B. Dal-Soglio, Nelson Piche, Oswaldo Gomez Quevedo, Andrew J. Murphy, Andrew M. Davidoff, Jo Cooke Barber, Erin Watters, Roshni Dasgupta, Richard D. Glick
Summary: Inflammatory myofibroblastic tumor (IMT) is a rare, poorly understood mesenchymal neoplasm of intermediate malignancy. This study reviewed the clinical data of 182 IMT patients, providing insights into the origin, symptoms, treatment approaches, and prognosis of the tumor.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Critical Care Medicine
Todd W. Costantini, Joseph M. Galante, Maxwell A. Braverman, Jim Phuong, Michelle A. Price, Joseph Cuschieri, Laura N. Godat, John B. Holcomb, Raul Coimbra, Eileen M. Bulger
Summary: This research identified over 300 high-priority research questions in the areas of Acute Resuscitation, Initial Evaluation, Imaging, and Definitive Management. These questions covered topics such as pharmaceutical intervention, fluid/blood product resuscitation, traumatic brain injury, vascular injury, pelvic fracture, and venous thromboembolism prophylaxis.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Pediatrics
Suhail Zeineddin, Samuel Linton, Madeline Inge, Christopher De Boer, Andrew Hu, Seth D. Goldstein, Timothy B. Lautz
Summary: This study examines the use of indocyanine green (ICG) in fluorescence-guided surgery (FGS) in pediatric patients using a national database. The results show that ICG is being increasingly utilized in various surgical disciplines such as neurosurgery, biliary, perfusion, urology, gastrointestinal, ophthalmology, and thoracic surgery. The utilization of ICG has increased over time, with a few high-volume centers accounting for a majority of the cases.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Caroline P. P. Lemoine, Timothy B. B. Lautz, Riccardo Superina
Summary: Indocyanine green fluorescence imaging was used to successfully identify and repair a cut surface bile leak during pediatric liver split transplantation. This provides an additional tool for intraoperative detection and management of bile leaks occurring after pediatric technical variant graft transplant.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Oncology
Timothy B. B. Lautz, Wei Xue, Leo Y. Y. Luo, Douglas Fair, Amira Qumseya, Zhengya Gao, Roshni Dasgupta, Dave Rodeberg, Rajkumar Venkatramani
Summary: This study assessed the clinical outcomes of children with chest wall RMS and found that local control is a significant factor affecting survival rates. Complete surgical excision improves outcomes but potential surgical morbidity must also be considered.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Kenneth W. Gow, Timothy B. Lautz, Marcus M. Malek, Nicholas G. Cost, Erika A. Newman, Roshni Dasgupta, Emily R. Christison-Lagay, Gregory M. Tiao, Andrew M. Davidoff, OG Surgery Discipline Comm
Summary: Surgery plays a crucial role in the treatment of children with solid malignancies, and a well-conducted operation is essential for cure. Collaboration with the primary care team and adherence to established standards are important in determining if and when surgery should be performed. The long-term consequences of surgery should also be considered. Research, education, and advancements in technology will continue to shape the role of pediatric surgeons in the multidisciplinary care of children with solid malignancies.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Emergency Medicine
Arianna M. Nassiri, Roy D. Pruden, Cole A. Holan, Angela D. Guerra, Peris W. Nganga, Matthew H. Wilkinson, Karla A. Lawson, Coburn H. Allen, Victoria S. Gregg, Jessica A. Naiditch
Summary: This study examined the clinical characteristics of appendicitis patients during the COVID-19 pandemic and found no increase in complicated appendicitis. However, there was a significant increase in the use of CT scans.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2022)
