期刊
CELL DEATH & DISEASE
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2013.338
关键词
mesenchymal stem cells; autophagy; stemness; reactive oxygen species
类别
资金
- Key Basic Research Project of China [2012CBA01303, 2011CB966200, 2010CB945600, 2011CB965100]
- Key project of National Natural Science Foundation of China [81030041]
- National Natural Science Foundation of China [31171321, 81101622]
- Special Funds for National key Sci-Tech Sepcial Project of China [2012ZX10002-016, 2012ZX10002011-011]
- Shanghai Science and Technology Committee [11ZR1449500, 12ZR1439800, 11nm0504700]
- Shanghai Municipal Health Bureau [XYQ2011044, 20114004]
- Science Fund for Creative Research Groups, NSFC, China [81221061]
Stem cells were characterized by their stemness: self-renewal and pluripotency. Mesenchymal stem cells (MSCs) are a unique type of adult stem cells that have been proven to be involved in tissue repair, immunoloregulation and tumorigenesis. Irradiation is a well-known factor that leads to functional obstacle in stem cells. However, the mechanism of stemness maintenance in human MSCs exposed to irradiation remains unknown. We demonstrated that irradiation could induce reactive oxygen species (ROS) accumulation that resulted in DNA damage and stemness injury in MSCs. Autophagy induced by starvation or rapamycin can reduce ROS accumulation-associated DNA damage and maintain stemness in MSCs. Further, inhibition of autophagy leads to augment of ROS accumulation and DNA damage, which results in the loss of stemness in MSCs. Our results indicate that autophagy may have an important role in protecting stemness of MSCs from irradiation injury.
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