Article
Multidisciplinary Sciences
Abhinav Kaushik, Diane Dunham, Xiaorui Han, Evan Do, Sandra Andorf, Sheena Gupta, Andrea Fernandes, Laurie Elizabeth Kost, Sayantani B. Sindher, Wong Yu, Mindy Tsai, Robert Tibshirani, Scott D. Boyd, Manisha Desai, Holden T. Maecker, Stephen J. Galli, R. Sharon Chinthrajah, Rosemarie H. DeKruyff, Monali Manohar, Kari C. Nadeau
Summary: This study analyzed immune cells from participants in a peanut oral immunotherapy (OIT) trial and found that the differentiation status of CD8(+) T cells at baseline may predict the likelihood of achieving sustained unresponsiveness (SU). The study also found that lower frequencies of naïve CD8(+) T cells and terminally differentiated CD57(+)CD8(+) T cell subsets at baseline were associated with SU, while higher frequencies of IL-4(+) and IFN gamma(+) CD4(+) T cells post-OIT were correlated with a lower likelihood of SU.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Vinicius O. Boldrini, Ana M. Marques, Raphael P. S. Quintiliano, Adriel S. Moraes, Carla R. A. V. Stella, Ana Leda F. Longhini, Irene Santos, Marilia Andrade, Breno Ferrari, Alfredo Damasceno, Rafael P. D. Carneiro, Carlos Otavio Brandao, Alessandro S. Farias, Leonilda M. B. Santos
Summary: This study found that CD19(+) B cells in the peripheral blood of multiple sclerosis (MS) patients may express serine-protease granzyme-B (GzmB), resembling cytotoxic CD8(+) T lymphocytes. This finding may provide important clues for investigating the pathogenesis of MS and for the development of new therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Joanna S. Kritikou, Mariana M. S. Oliveira, Julien Record, Mezida B. Saeed, Saket M. Nigam, Minghui He, Marton Keszei, Arnika K. Wagner, Hanna Brauner, Anton Sendel, Saikiran K. Sedimbi, Stamatina Rentouli, David P. Lane, Scott B. Snapper, Klas Karre, Peter Vandenberghe, Jordan S. Orange, Lisa S. Westerberg
Summary: X-linked neutropenia (XLN) is caused by gain-of-function mutations in the actin regulator Wiskott-Aldrich Syndrome protein (WASp), leading to reduced numbers of cytotoxic cells in patients. However, NK and T cells from XLN patients show increased granzyme B content and enhanced degranulation and cytokine production compared to healthy controls, indicating an increased capacity to respond to and kill tumor cells.
Article
Biology
Violeta Soljic, Maja Barbaric, Martina Vukoja, Marina Curlin, Martina Orlovic Vlaho, Edita Cerni Obrdalj, Lidija Lasic Arapovic, Daniela Bevanda Glibo, Katarina Vukojevic
Summary: The study indicates that the expression of cytotoxic CD8(+) T cells in decidual tissue of patients with preeclampsia is altered, suggesting their potential role in the pathophysiology of preeclampsia and fetal-maternal immune tolerance.
Article
Biochemistry & Molecular Biology
Guojun Zhang, Guoliang Zheng, Fengli Jiang, Tianyi Wu, Lizhao Wu
Summary: ST-4 activates specific types of T cells to produce high levels of granzyme B and perforin, which exhibit anticancer effects. Inhibition of granzyme B and perforin weakens the anticancer effect of ST-4, indicating its potential in cancer immunotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Sabrina Sofia Burgener, Melanie Brugger, Nathan Georges Francois Leborgne, Sophia Sollberger, Paola Basilico, Thomas Kaufmann, Phillip Ian Bird, Charaf Benarafa
Summary: Mast cells are immune cells that release serine proteases which modulate physiological functions and induce mast cell death. The pathways involved in granule-mediated mast cell apoptosis are regulated by a balance of serpin protease inhibitors, with granzyme B playing a critical role in mast cell survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Olatz Zenarruzabeitia, Gabirel Astarloa-Pando, Inigo Terren, Ane Orrantia, Raquel Perez-Garay, Iratxe Seijas-Betolaza, Javier Nieto-Arana, Natale Imaz-Ayo, Silvia Perez-Fernandez, Eunate Arana-Arri, Francisco Borrego
Summary: This study analyzed the immune system status of patients with different severity of COVID-19, finding that severe cases exhibit higher activation levels in various T cell subsets, increased expression of immune markers in cytotoxic cells, and accumulation of dysfunctional monocytes. The study also showed a strong association between immune cell alterations and clinical signs of severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Elisa E. Sanchez, Maria Tello-Lafoz, Aixuan J. Guo, Miguel de Jesus, Yassmin A. Elbanna, Benjamin Y. Winer, Sadna Budhu, Eric Chan, Eric Rosiek, Taisuke Kondo, Justyn DuSold, Naomi Taylor, Gregoire Altan-Bonnet, Michael F. Olson, Morgan Huse
Summary: Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells. CTLs form a specialized cytotoxic immune synapse (IS) with a target and release toxic proteins to induce target cell death. After the IS dissolves, CTLs can search for other targets and phagocytes can clear the dead cells.
Article
Multidisciplinary Sciences
Bettina Weigelin, Annemieke Th den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor, Peter Friedl
Summary: The study demonstrates that sublethal interactions from multiple CTL can accumulate over time and achieve tumor cell killing by additive cytotoxicity. Statistical modeling reveals that delivering three serial hits within decay intervals below 50 minutes can distinguish between tumor cell death or survival after recovery.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Tao Huang, Xiaofan Sun, Yingqiu Qi, Xi Yang, Linyao Fan, Mengdie Chen, Yale Yue, Hong Ge, Yiye Li, Guangjun Nie, Huan Min, Xianfu Sun
Summary: This study develops a targeted nanomedicine for breast cancer chemo-immunotherapy, which can induce immunogenic cell death (ICD) to kill cancer cells and stimulate antitumor immune response. The nanomedicine also competitively relieves the inhibition of serpinb9 (Sb9) to granzyme B (GrB), enhancing the combined antitumor effect.
Article
Oncology
Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J. M. Huijbers, Danielle R. J. Verboogen, Matthias Reichel, Victor L. Thijssen, Arjan W. Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson
Summary: Galectin-1 (Gal1) is a glycan-binding protein that promotes tumor progression through various mechanisms. Vaccination against Gal1 can generate high anti-Gal1 antibody levels and significantly impairs the growth of Gal1-expressing melanomas in mice. This is associated with improved tumor vasculature perfusion and increased infiltration of macrophages and cytotoxic T cells. Gal1 vaccination is a promising approach to enhance immunotherapeutic strategies for cancer therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Huashan Liu, Zhenxing Liang, Sijing Cheng, Liang Huang, Wenxin Li, Chi Zhou, Xiaobin Zheng, Shujuan Li, Ziwei Zeng, Liang Kang
Summary: The study reveals that mutant KRAS plays a crucial role in tumor immune evasion in colorectal cancer. Reduced infiltration of cytotoxic CD8(+) T cells is observed in colorectal cancer specimens with mutant KRAS compared to wild type KRAS. Preclinical models confirm this finding and show poor response to anti-PD-1 and adoptive T-cell therapies in KRAS mutant tumors. Mechanistic analysis reveals that lactic acid derived from mutant KRAS-expressing tumor cells sensitizes tumor-specific cytotoxic CD8(+) T cells to activation-induced cell death through NF-kappa B inactivation, explaining the inverse association between intratumoral cytotoxic CD8(+) T cells and KRAS mutation. Importantly, KRAS mutated tumor resistance to immunotherapies can be overcome by targeting KRAS or inhibiting lactic acid production. This study suggests the potential of targeting the KRAS-mediated immune program for the treatment of patients with KRAS mutant colorectal cancer.
Review
Immunology
Chiara Cassioli, Cosima T. Baldari
Summary: Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses, utilizing immunological synapse and organelles to target intracellular pathogens and malignant cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B. Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F. Krebs, Katrin Neumann
Summary: English Summary: Crescentic GN is a leading cause of end stage renal failure, and this study identified activated, clonally expanded cytotoxic T cells in the kidneys of patients with ANCA-associated cGN. The deficiency of these T cells ameliorated the disease progression, suggesting their pathogenic role in immune-mediated kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Environmental Sciences
Islam El-Garawani, Heba Khodary Allam, Yasser A. Shehata, Khaldoun Fadel, Ahmed El Kattan
Summary: The study investigated the potential health hazards faced by Egyptian uranium miners, focusing on the biological effects of radiation exposure. Findings included an increase in dead cells, fragmented DNA, and levels of Granzyme B protein in the exposed groups compared to controls. These results highlight the importance of health education and effective hazard management for preserving the health of all mining industry employees.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Su-Dong Liu, Shi-Meng Zhang, Hui Wang, Jian-Chun He, Xiao-Fan Yang, Xia-Lin Du, Li Ma
Article
Cell Biology
Su-Dong Liu, Jin Su, Shi-Meng Zhang, Hai-Ping Dong, Hui Wang, Wei Luo, Qian Wen, Jian-Chun He, Xiao-Fan Yang, Li Ma
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2016)
Article
Cell Biology
Chao-Ying Zhou, Qian Wen, Xiao-Jie Chen, Rui-Ning Wang, Wen-Ting He, Shi-Meng Zhang, Xia-Lin Du, Li Ma
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2016)
Article
Immunology
Jinli Wang, Ruining Wang, Jiahui Yang, Xiaofan Yang, Shengfeng Hu, Hui Wang, Chaoying Zhou, Wenjing Xiong, Qian Wen, Li Ma
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Multidisciplinary Sciences
Jinli Wang, Ruining Wang, Hui Wang, Xiaofan Yang, Jiahui Yang, Wenjing Xiong, Qian Wen, Li Ma
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Chao-Ying Zhou, Rui-Ning Wang, Qian Wen, Wen-Ting He, Shi-Meng Zhang, Xia-Lin Du, Jia-Hui Yang, Li Ma
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Medicine, General & Internal
Shengfeng Hu, Wenting He, Xialin Du, Jiahui Yang, Qian Wen, Xiao-Ping Zhong, Li Ma
Article
Biochemistry & Molecular Biology
Qian Wen, Shimeng Zhang, Xialin Du, Ruining Wang, Yanfen Li, Honglin Liu, Shengfeng Hu, Chaoying Zhou, Xinying Zhou, Li Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Immunology
Wenjing Xiong, Qian Wen, Xialin Du, Jinli Wang, Wenting He, Ruining Wang, Shengfeng Hu, Xinying Zhou, Jiahui Yang, Yuchi Gao, Li Ma
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Wenting He, Shengfeng Hu, Xialin Du, Qian Wen, Xiao-Ping Zhong, Xinying Zhou, Chaoying Zhou, Wenjing Xiong, Yuchi Gao, Shimeng Zhang, Ruining Wang, Jiahui Yang, Li Ma
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Microbiology
Shengfeng Hu, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Xiaoxia Zhan, Wenting He, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Jiahui Yang, Wenjing Xiong, Ruining Wang, Yuchi Gao, Li Ma
Article
Immunology
Shengfeng Hu, Wenting He, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Chuxuan Hu, Silin Li, Qinshu Wang, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Li Ma
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Rui-Ning Wang, Qian Wen, Wen-Ting He, Jia-Hui Yang, Chao-Ying Zhou, Wen-Jing Xiong, Li Ma
MOLECULAR MEDICINE REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Xinying Zhou, Jiahui Yang, Zelin Zhang, Lijie Zhang, Bo Zhu, Linmiao Lie, Yubin Huang, Rui Ma, Chaoying Zhou, Shengfeng Hu, Qian Wen, Li Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Hui Wang, Jinli Wang, Jiahui Yang, Xiaofan Yang, Jianchun He, Ruining Wang, Sudong Liu, Lin Zhou, Li Ma