Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Article
Biology
Catarina Teixeira, Andre P. Sousa, Ines Santos, Ana Catarina Rocha, Ines Alencastre, Ana Claudia Pereira, Daniela Martins-Mendes, Pedro Barata, Pilar Baylina, Ruben Fernandes
Summary: This study demonstrates that pioglitazone enhances adipocyte differentiation and secretome production, making it an excellent model for studying adiposity. The study also proposes an improved method for adipocyte secretome production, which can be used for experimental biology studies to understand the molecular mechanisms underlying the influence of adiposity on other cells.
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Suvadeep Mal, Ashish Ranjan Dwivedi, Vijay Kumar, Naveen Kumar, Bhupinder Kumar, Vinod Kumar
Summary: PPAR, as a crucial transcription factor, plays a significant role in regulating various disease states, especially in cancer growth and metabolism. However, known PPAR ligands often lead to severe side effects. Therefore, the current focus is on developing novel PPAR ligands with little to no adverse effects.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chaitra Rai, C. D. Nandini, Poornima Priyadarshini
Summary: The study demonstrated the anti-adipogenic activity of bovine milk Glycosaminoglycans (bmGAGs) by modulating adipogenesis-related marker proteins, suggesting a potential therapeutic use of bmGAGs in the management of obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Cell Biology
Yaqin Zhao, Huabing Tan, Xiaoyu Zhang, Jing Zhu
Summary: This article summarizes the role of PPARs in the occurrence and development of HCC, as well as their value in the diagnosis, treatment, and prognosis of HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Jiyoung Bae, Yang Yang, Xinyun Xu, Jamie Flaherty, Haley Overby, Kelsey Hildreth, Jiangang Chen, Shu Wang, Ling Zhao
Summary: Identifying functional brown adipose tissue (BAT) has provided new hope for obesity treatment and prevention. The study found that naringenin (NAR) can promote adipocyte browning and thermogenesis through the activation of PPARγ.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xingren Chen, Xiaobo Zhu, Jian Dong, Fang Chen, Qi Gao, Lijun Zhang, Dawei Cai, Hui Dong, Binjia Ruan, Yongxiang Wang, Qing Jiang, Wangsen Cao
Summary: The study demonstrates that diacerein has a significant protective effect on cartilage damage in OA mice, by inhibiting the upregulation of DNMT1/3a, promoter hypermethylation of PPAR gamma, and reversing the expression of antioxidant enzymes and inflammatory cytokines.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Respiratory System
Clarus Leung, Min Hyung Ryu, Anette Kocbach Bolling, Danay Maestre-Batlle, Christopher F. Rider, Anke Huls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor, Chris Carlsten
Summary: This study investigates how SNPs in PPARG and oxidative stress genes modify the impact of DBP exposure on lung function and immune responses. The results suggest that variants in PPARG play a greater role in airway allergic responses to DBP than oxidative stress-related genes.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Bichen Xue, Shulin Wu, Christina Sharkey, Shahin Tabatabaei, Chin-Lee Wu, Zhipeng Tao, Zhiyong Cheng, Douglas Strand, Aria F. Olumi, Zongwei Wang
PROSTATE CANCER AND PROSTATIC DISEASES
(2020)
Article
Allergy
Nontaya Nakkam, Andrew Gibson, Effie Mouhtouris, Katherine C. Konvinse, Natasha E. Holmes, Kyra Y. Chua, Pooja Deshpande, Danmeng Li, David A. Ostrov, Jason Trubiano, Elizabeth J. Phillips
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Ecology
Ziv Frankenstein, David Basanta, Omar E. Franco, Yan Gao, Rodrigo A. Javier, Douglas W. Strand, MinJae Lee, Simon W. Hayward, Gustavo Ayale, Alexander R. A. Anderson
NATURE ECOLOGY & EVOLUTION
(2020)
Article
Developmental Biology
Alicia R. England, Christopher P. Chaney, Amrita Das, Mohita Patel, Alicia Malewska, Daniel Armendariz, Gary C. Hon, Douglas W. Strand, Keri A. Drake, Thomas J. Carroll
Article
Endocrinology & Metabolism
Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Nida S. Iqbal, Hannah M. Ruetten, Anne E. Turco, Lisa L. Abler, Simran K. Sandhu, Mark T. Cadena, Venkat S. Malladi, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, Claus G. Roehrborn, Linda A. Baker, Chad M. Vezina, Douglas W. Strand
Article
Cell Biology
Sajjan Koirala, Jonathon Klein, Yumei Zheng, Nicole O. Glenn, Travis Eisemann, Klementina Fon Tacer, Darcie J. Miller, Ozlem Kulak, Meifen Lu, David B. Finkelstein, Geoffrey Neale, Heather Tillman, Peter Vogel, Douglas W. Strand, Lawrence Lum, Chad A. Brautigam, John M. Pascal, Wilson K. Clements, Patrick Ryan Potts
Article
Developmental Biology
Diya B. Joseph, Anne E. Turco, Chad M. Vezina, Douglas W. Strand
Summary: The prostate develops through epithelial budding and branching processes during fetal and postnatal stages, showing remarkable regenerative capacity. Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) may involve androgen-independent epithelial progenitors. Multiple castration-insensitive epithelial cell types exist in the proximal area of the prostate, with not all acting as progenitors.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
RenJie Jin, Douglas W. Strand, Connor M. Forbes, Thomas Case, Justin M. M. Cates, Qi Liu, Marisol Ramirez-Solano, Ginger L. Milne, Stephanie Sanchez, Zunyi Y. Wang, Dale E. Bjorling, Nicole L. Miller, Robert J. Matusik
Summary: The study found elevated levels of prostaglandins in the prostate tissue of patients who required surgery to relieve BPH/LUTS symptoms, indicating potential reasons for failure in medical therapy.
Article
Oncology
Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Jeffrey C. Reese, Ryan J. Mauck, Jeffrey C. Gahan, Ryan C. Hutchinson, James L. Mohler, Claus G. Roehrborn, Douglas W. Strand
Summary: Benign prostatic hyperplasia (BPH) is a common condition in aging men, treated with 5-alpha reductase inhibitors (SARI) to reduce prostate volume and improve lower urinary tract symptoms. However, the histologic response to SARI treatment is heterogeneous, with potential need for surgical intervention.
JOURNAL OF PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Liwei Jia, Douglas W. Strand, Ramy S. Goueli, Jeffrey C. Gahan, Claus G. Roehrborn, Ryan J. Mauck
Summary: The study suggests that using PSA density could help estimate BPH cellular content, leading to improved selection of patients for treatment, especially for 5ARI therapy.
Article
Endocrinology & Metabolism
Renjie Jin, Connor Forbes, Nicole L. Miller, Douglas Strand, Thomas Case, Justin M. Cates, Hye-Young H. Kim, Phillip Wages, Ned A. Porter, Krystin M. Mantione, Sarah Burke, James L. Mohler, Robert J. Matusik
Summary: This study characterized the pathways associated with failure of medical therapy for BPH/LUTS. It found that 5-alpha reductase inhibitor (5ARI) therapy continued to inhibit androgenesis, but also increased tissue levels of glucocorticoids (GC). This GC activation served as a master regulator of prostatic branching and growth.
Article
Oncology
Jiapei Yuan, Kathleen E. Houlahan, Susmita G. Ramanand, Sora Lee, GuemHee Baek, Yang Yang, Yong Chen, Douglas W. Strand, Michael Q. Zhang, Paul C. Boutros, Ram S. Mani
Summary: Prostate cancer is highly heritable and researchers have identified multiple risk alleles associated with the disease. This study used three-dimensional spatial genomics to identify the target genes regulated by these risk alleles in prostate tumors. The findings revealed the complex regulation of these genes and their interactions with different tumor types.
Meeting Abstract
Immunology
Benjamin Solomon, Adithi Reddy, Katherine Konvinse, Ami Shah, Yael Gernez, Vidya Mony
CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Alexandra S. Lee, Juan Aguilera, Jo Ann Efobi, Youn Soo Jung, Hana Seastedt, Mihir M. Shah, Emily Yang, Katherine Konvinse, Paul J. Utz, Vanitha Sampath, Kari C. Nadeau
Article
Biochemistry & Molecular Biology
Florian Wimmers, Allison R. Burrell, Yupeng Feng, Hong Zheng, Prabhu S. Arunachalam, Mengyun Hu, Sara Spranger, Lindsay E. Nyhoff, Devyani Joshi, Meera Trisal, Mayanka Awasthi, Lorenza Bellusci, Usama Ashraf, Sangeeta Kowli, Katherine C. Konvinse, Emily Yang, Michael Blanco, Kathryn Pellegrini, Gregory Tharp, Thomas Hagan, R. Sharon Chinthrajah, Tran T. Nguyen, Alba Grifoni, Alessandro Sette, Kari C. Nadeau, David B. Haslam, Steven E. Bosinger, Jens Wrammert, Holden T. Maecker, Paul J. Utz, Taia T. Wang, Surender Khurana, Purvesh Khatri, Mary A. Staat, Bali Pulendran
Summary: This study used a multi-omics approach to investigate immunity to SARS-CoV2 in infants and young children. The results showed that infants mounted a robust mucosal immune response and had long-lasting antibody titers.