Article
Nutrition & Dietetics
Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Seung Eon Oh, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun
Summary: An excessive fat diet can lead to intramuscular fat deposition and muscle atrophy, but ECE or dieckol can reduce the size of lipid droplets and attenuate the negative effects of high fat intake on muscle health by decreasing PLIN2 expression.
Article
Agriculture, Dairy & Animal Science
Alexander W. Tebbe, Juliette Hanson, William P. Weiss
Summary: Increasing metabolizable protein (MP) supply in postpartum diets can help attenuate muscle turnover and endoplasmic reticulum (ER) stress, but an imbalance in amino acid supply may reduce cell cycle progression and protein synthesis, while lower energy supplies can decrease cell growth and cause autophagy.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Daria Neyroud, Rachel L. Nosacka, Chandler S. Callaway, Jose G. Trevino, Hui Hu, Sarah M. Judge, Andrew R. Judge
Summary: The study identified FoxP1 as a novel repressor of skeletal muscle gene expression that is increased in cancer cachexia, whose up-regulation is sufficient to induce skeletal muscle wasting and weakness, and required for the normal wasting response to cancer.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Yoon-Jin Lee, Yong Suk Moon, Dong Rak Kwon, Sung Cheol Cho, Eun Ho Kim
Summary: This study aimed to investigate the combined effects of PDRN and ESWT sequences on muscle regeneration. The combination of ESWT and PDRN injection demonstrated superior regenerative efficacy for atrophied muscles, with the best outcomes observed when ESWT was administered after PDRN injection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anni Kumari, Kristian K. Kristensen, Michael Ploug, Anne-Marie Lund Winther
Summary: LPL plays a crucial role in lipid metabolism by hydrolyzing triglyceride-rich lipoproteins, and its impaired activity can lead to hypertriglyceridemia. In addition to LDL-C, hypertriglyceridemia is also an independent risk factor for atherosclerosis, with LPL and other factors involved in intravascular lipolysis playing a key role in this process.
Review
Biotechnology & Applied Microbiology
Martina Sandona, Lorena Di Pietro, Federica Esposito, Alessia Ventura, Antonietta Rosa Silini, Ornella Parolini, Valentina Saccone
Summary: Mesenchymal stromal cells (MSCs) are multipotent cells found in various tissues that have anti-fibrotic and immunoregulatory properties. Their secretome, including extracellular vesicles (EVs), can mimic the therapeutic effects of MSCs and offer advantages such as easier storage and safer administration for muscle regeneration in different diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Geriatrics & Gerontology
Christopher J. Walsh, Carlos Escudero King, Muskan Gupta, Pamela J. Plant, Margaret J. Herridge, Sunita Mathur, Pingzhao Hu, Judy Correa, Sameen Ahmed, Anne Bigot, Claudia C. dos Santos, Jane Batt
Summary: The study identified several miRNAs (including miRs-424-3p/5p, -490-3p, and -744-5p) as potential regulators of gene networks associated with recovery of muscle mass and strength following intensive care unit (ICU) discharge. MiR-490-3p was identified as a novel regulator of myogenesis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Multidisciplinary Sciences
Stephen G. Young, Wenxin Song, Ye Yang, Gabriel Birrane, Haibo Jiang, Anne P. Beigneux, Michael Ploug, Loren G. Fong
Summary: GPIHBP1 is a crucial partner for LPL in lipolytic processing of lipoproteins, stabilizing LPL structure and preserving activity. It captures LPL and shuttles it to the capillary lumen. The AD of GPIHBP1 accelerates LPL binding, preserves LPL activity, and allows LPL to move across ECs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Satya Srirama Karthik Divvela, Eric Bekoe Offei, Florian Suerland, David Revuelta Garcia, Julia Kwiatkowski, Ajeesh Balakrishnan-Renuka, Pauline Bohne, Marion Boing, Gabriela Morosan-Puopolo, Melanie D. Mark, Beate Brand-Saberi
Summary: This study demonstrates the significance of Atoh8 in both myogenesis and the maintenance of skeletal muscle. The results show that Atoh8 regulates myoblast proliferation and muscle fiber type through signaling pathways, playing a crucial role in muscle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Gernot F. Grabner, Nikolaus Guttenberger, Nicole Mayer, Anna K. Migglautsch-Sulzer, Christian Lembacher-Fadum, Nermeen Fawzy, Dominik Bulfon, Peter Hofer, Thomas Zuellig, Lennart Hartig, Natalia Kulminskaya, Gabriel Chalhoub, Margarita Schratter, Franz P. W. Radner, Karina Preiss-Landl, Sarah Masser, Achim Lass, Rudolf Zechner, Karl Gruber, Monika Oberer, Rolf Breinbauer, Robert Zimmermann
Summary: This study reports the development and biological characterization of the first small-molecule inhibitor of human ATGL. This inhibitor selectively inactivates ATGL in humans and nonhuman primates, providing a potential therapeutic option for lipotoxicity-driven disorders.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Food Science & Technology
Hong Xu, Hang Gao, Feiyue Liu, Lingxiao Gong
Summary: This study found that red-skin extracts from lotus seeds can significantly improve obesity characteristics in high-fat-diet-fed mice by regulating lipoprotein lipase activity.
Review
Medicine, Research & Experimental
Shali Jiang, Zhuoqun Ren, Yutao Yang, Qiming Liu, Shenghua Zhou, Yichao Xiao
Summary: GPIHBP1 is a protein anchored by glycosylphosphatidylinositol found in endothelial cells that binds to high-density lipoproteins. It plays a crucial role in transporting and stabilizing lipoprotein lipase, which is vital for lipid metabolism and the marginalization of lipoproteins alongside capillaries. Mutations in the GPIHBP1-LPL complex are central to the onset of chylomicronemia, a condition characterized by high levels of chylomicrons in the blood.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Tolulope Peter Saliu, Thanutchaporn Kumrungsee, Koji Mitsumoto, Siyi Chen, Noriyuki Yanaka
Summary: This study found that NAFLD significantly reduces the number of satellite cells in the skeletal muscle of mice, impairing muscle regeneration. Additionally, NAFLD also impairs the differentiation ability of satellite cells, possibly associated with inflammatory cytokines and oxidative stress.
Article
Multidisciplinary Sciences
Wenxin Song, Anne P. Beigneux, Thomas A. Weston, Kai Chen, Ye Yang, Le Phuong Nguyen, Paul Guagliardo, Hyesoo Jung, Anh P. Tran, Yiping Tu, Caitlyn Tran, Gabriel Birrane, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Peter Tontonoz, Haibo Jiang, Michael Ploug, Loren G. Fong, Stephen G. Young
Summary: This study reveals that the GPIHBP1-transported LPL can detach and move into the EC glycocalyx, where it plays a role in the intravascular processing of triglyceride-rich lipoproteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cardiac & Cardiovascular Systems
Stephanie Kolleritsch, Benedikt Kien, Gabriele Schoiswohl, Clemens Diwoky, Renate Schreiber, Christoph Heier, Lisa Katharina Maresch, Martina Schweiger, Thomas O. Eichmann, Sarah Stryeck, Petra Krenn, Tamara Tomin, Matthias Schittmayer, Dagmar Kolb, Thomas Ruelicke, Gerald Hoefler, Heimo Wolinski, Tobias Madl, Ruth Birner-Gruenberger, Guenter Haemmerle
CARDIOVASCULAR RESEARCH
(2020)
Letter
Biophysics
Armin Zebisch, Gerlinde Winter, Karl Kashofer, Stefan Hatzl, Barbara Uhl, Sonja Wurm, Albert Woelfler, Hildegard T. Greinix, Gerald Hoefler, Heinz Sill
BONE MARROW TRANSPLANTATION
(2020)
Review
Cell Biology
Wael Al-Zoughbi, Gerald Hoefler
Article
Genetics & Heredity
Qing Zhou, Samantha O. Perakis, Peter Ulz, Sumitra Mohan, Jakob M. Riedl, Emina Talakic, Sigurd Lax, Martin Toetsch, Gerald Hoefler, Thomas Bauernhofer, Martin Pichler, Armin Gerger, Jochen B. Geigl, Ellen Heitzer, Michael R. Speicher
Article
Hematology
Hugo Larose, Nina Prokoph, Jamie D. Matthews, Michaela Schlederer, Sandra Hoegler, Ali F. Alsulami, Stephen P. Ducray, Edem Nuglozeh, Mohammad Feroze Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Fedorova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L. Blundell, Wolfram Klapper, Olaf Merkel, G. A. Amos Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D. Turner
Summary: This study identified a variant in the extracellular domain of NOTCH1 in ALCL patients, demonstrating that the Notch pathway is a viable second-line druggable target for ALK(+) ALCL.
Article
Multidisciplinary Sciences
Tamilarasan K. Palaniappan, Lina Slekien, Anna-Karin Jonasson, Jonathan Gilthorpe, Lena Gunhaga
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Hao Xie, Christoph Heier, Benedikt Kien, Paul W. Vesely, Zhiyuan Tang, Veronika Sexl, Gabriele Schoiswohl, Isabelle Striessnig-Bina, Gerald Hoefler, Rudolf Zechner, Martina Schweiger
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Nutrition & Dietetics
Juste Maneikyte, Augustinas Bausys, Bettina Leber, Nicole Feldbacher, Gerald Hoefler, Dagmar Kolb-Lenz, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Article
Oncology
Samantha O. Perakis, Sabrina Weber, Qing Zhou, Ricarda Graf, Sabine Hojas, Jakob M. Riedl, Armin Gerger, Nadia Dandachi, Marija Balic, Gerald Hoefler, Ed Schuuring, Harry J. M. Groen, Jochen B. Geigl, Ellen Heitzer, Michael R. Speicher
Article
Medicine, Research & Experimental
Manu Manjunath Kanti, Isabelle Striessnig-Bina, Beatrix Irene Wieser, Silvia Schauer, Gerd Leitinger, Thomas O. Eichmann, Martina Schweiger, Margit Winkler, Elke Winter, Andrea Lana, Iris Kufferath, Leigh Matthew Marsh, Grazyna Kwapiszewska, Rudolf Zechner, Gerald Hoefler, Paul Willibald Vesely
Summary: The energy metabolism of bronchiolar club cells plays a crucial role in the repair of lung airway damage and is essential for lung health.
Article
Biochemistry & Molecular Biology
Yihe Wang, Astrid Hammer, Gerald Hoefler, Ernst Malle, Clare L. Hawkins, Christine Y. Chuang, Michael J. Davies
Summary: Atherosclerosis is a chronic inflammatory disease characterized by plaque formation in arterial walls. The study found that hypochlorous acid (HOCl) and chloramines can specifically modify aggrecan, a proteoglycan involved in atherogenesis. These modifications, different from those induced by ADAMTS1, can lead to irreversible protein cross-links. The findings also showed colocalization of aggrecan and HOCl-generated epitopes in advanced human atherosclerotic plaques.
Article
Biology
Georg Richtig, Melanie Kienzl, Sonja Rittchen, David Roula, Juergen Eberle, Zina Sarif, Martin Pichler, Gerald Hoefler, Akos Heinemann
Summary: This study aimed to investigate the pro-apoptotic effects of cannabinoids in metastatic melanoma and their value besides conventional targeted therapy. The results showed that cannabinoids can induce apoptosis through the mitochondrial cytochrome c release and caspase activation pathway, and do not interfere with commonly used targeted therapy.
Letter
Oncology
Tommaso Sconocchia, Johannes Fosselteder, Lisa Auinger, Erdem Oezkaya, Theresa Benezeder, Magdalena Lang, Christine Beham-Schmid, Gerald Hoefler, Armin Zebisch, Albert Woelfler, Heinz Sill, Peter Wolf, Herbert Strobl, Andreas Reinisch