Article
Pharmacology & Pharmacy
Yun Yu, Tao Wu, Xiaodong Zhang, Pengfei Li, Lihua Ye, Jiayang Kuang, Lu Tao, Lianli Ni, Qi Zhao, Ji Zhang, Huanle Pan, Congying Xie, Chenguo Zheng, Shaotang Li, Ri Cui
Summary: Colorectal cancer is a common and deadly disease, and regorafenib has been shown to be effective for patients with metastatic CRC. Combining oxaliplatin with other chemotherapeutic agents can enhance therapeutic effects but has limitations due to side effects and drug resistance. This study demonstrates that combining regorafenib and oxaliplatin synergistically enhances anti-tumor activities by activating specific signaling pathways, providing experimental evidence for their combined treatment in CRC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Yong Jun Choi, Jongsung Lee, Sang Hoon Ha, Han Ki Lee, Heui Min Lim, Seon-Hak Yu, Chang Min Lee, Myeong Jin Nam, Yung-Hun Yang, Kyungmoon Park, Youn Soo Choi, Kyu Yun Jang, See-Hyoung Park
Summary: 6,8-Diprenylorobol inhibits proliferation of LoVo and HCT15 colon cancer cells in a dose- and time-dependent manner. It activates p53 and generates ROS, leading to decreased cell viability and increased apoptotic cell portion.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sun-Jin Boo, Mei Jing Piao, Kyoung Ah Kang, Ao Xuan Zhen, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Seung Joo Lee, Seung Eun Song, Jin Won Hyun
Summary: In this study, the role of autophagy in oxaliplatin-resistant colon cancer cells was evaluated. It was found that autophagy was significantly reduced in oxaliplatin-resistant cells compared to normal cells, and this reduction was related to the production of reactive oxygen species.
BIOMOLECULES & THERAPEUTICS
(2022)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Engineering, Environmental
Meng-Wen Ma, Kai-Lin He, Chao-Qing Li, Xiao-Ting Xie, Sui Zhou, Bin Zhang, Xiao-Lin Hou, Cheng Li, Yuan-Di Zhao, Ling-Li Dong, Bo Liu
Summary: In this study, hyaluronic acid-modified platinum-tellurium nanorods (HPT) were synthesized as a targeted therapy for rheumatoid arthritis (RA). HPT effectively removed inflammatory macrophages and reactive oxygen species (ROS), alleviating the inflammatory response and bone erosion. Animal experiments showed a significant reduction in clinical scores and bone erosion in mice treated with HPT and laser irradiation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Da-Been Lee, Seo-Yeon An, Sang-Shin Pyo, Jinkwan Kim, Suhng-Wook Kim, Dae-Wui Yoon
Summary: The study aimed to investigate the impact of sleep fragmentation on carcinogenesis and explore the underlying mechanisms in a chemical-induced colon cancer model. The results showed that mice subjected to sleep fragmentation had a significantly higher number and size of tumors compared to the control group. Immunohistochemical and immunofluorescent stainings revealed increased DNA damage and oxidative stress in the sleep fragmentation group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Waad A. Al-Otaibi, Sahar M. AlMotwaa
Summary: This study aimed to investigate the effect of Teucrium polium L. essential oil nanoemulsion (TPO-NANO) on the sensitivity of colon cancer cells with different p53 statuses to Oxaliplatin (Oxa). The combination treatment of Oxa and TPO-NANO showed a synergistic effect on colon cancer cells, inducing apoptosis through a mechanism involving ROS-mediated mitochondrial apoptosis.
Article
Chemistry, Inorganic & Nuclear
Ravichandran Vigneshwaran, Devaraj Ezhilarasan, Shanmugam Rajeshkumar
Summary: TiO2 synthesized with Lactobacillus shows cytotoxicity in colon cancer cells by inducing apoptosis and generating intracellular reactive oxygen species (ROS). Moreover, TiO2 causes mitochondrial damage and cytochrome c release, leading to apoptosis by activating the intrinsic apoptotic pathway.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Kwan-Ling Yip, Tsen-Ni Tsai, I-Ping Yang, Zhi-Feng Miao, Yen-Cheng Chen, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang
Summary: Metformin enhances the chemosensitivity of colorectal cancer cells to 5-fluorouracil and oxaliplatin by inducing cell cycle arrest and apoptosis through modulation of mitochondria-related proteins.
Article
Chemistry, Multidisciplinary
Mei Wen, Nuo Yu, Zhigao Yi, Pu Qiu, Cheng Tao, Daniel K. Macharia, Meifang Zhu, Zhigang Chen, Xiaogang Liu
Summary: Conventional photo/sonosensitizers lack selectivity and cause severe skin and retina phototoxicity. The use of a copper-hematoporphyrin monomethyl ether nanoframework (CuHF) can suppress fluorescence on healthy tissues and prevent phototoxicity to the skin and eyes. In addition, this nanoframework can react with endogenous hydrogen sulfide in colon cancer cells, enabling simultaneous photothermal and sonodynamic therapies.
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Article
Chemistry, Multidisciplinary
Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Summary: Novel ER-targeted prodrugs have been developed with activation only in cancer cells, demonstrating anticancer efficacy and cancer cell specificity. These prodrugs induce ER stress, attenuate mitochondrial membrane potential, and generate mitochondrial ROS leading to cell death via necrosis. Activation of the new prodrugs has also been demonstrated in the Nemeth-Kellner lymphoma murine model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Review
Biotechnology & Applied Microbiology
Danling Cheng, Xiaoying Wang, Xiaojun Zhou, Jingchao Li
Summary: Immunotherapy is a promising strategy for cancer treatment, but it faces challenges of low immune responses and immune-related adverse events. Sonodynamic therapy combined with immunotherapy can enhance antitumor immunity, and research on nanosonosensitizers for ROS generation is ongoing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarra Oumrani, Maximilien Barret, Frederic Beuvon, Carole Nicco, Charlotte Chene, Frederic Batteux, Frederic Prat
Summary: This study in a swine model demonstrated that the use of a self-assembling peptide matrix significantly reduced the incidence of esophageal stricture after circumferential endoscopic resection. Adding triamcinolone did not show significant improvement in preventing stricture formation.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Immunology
Gaetane Nocturne, Bineta Ly, Audrey Paoletti, Juliette Pascaud, Raphaele Seror, Carole Nicco, Fabienne Mackay, F. B. Vincent, Thierry Lazure, Sophie Ferlicot, Lev Stimmer, Quentin Pascal, Sandrine Roulland, Roman Krzysiek, Salima Hacein-Bey, Frederic Batteux, Xavier Mariette
Summary: This study found that prolonged treatment with monoclonal anti-TNF antibodies increases the risk of lymphoma in patients with B cell-driven autoimmune diseases, suggesting closer monitoring for lymphoma development in these patients with long-term exposure to monoclonal anti-TNF antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Cell Biology
Yipu Dang, Camille Souchet, Fabiana Moresi, Mohamed Jeljeli, Bruno Raquillet, Carole Nicco, Sandrine Chouzenoux, Isabelle Lagoutte, Louis Marcellin, Frederic Batteux, Ludivine Doridot
Summary: Trained immunity, a concept where innate immune cells undergo long-term metabolic and epigenetic reprogramming, can impact pregnancy outcomes by altering the leukocyte population profile at the maternal-fetal interface and influencing fetal growth and development. In this study, preconceptional infections-induced trained immunity led to fetal growth restriction, thereby suggesting a potential link between immune training and pregnancy outcomes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Developmental Biology
M. Bourdon, P. Santulli, L. Doridot, M. Jeljeli, C. Chene, S. Chouzenoux, C. Nicco, L. Marcellin, C. Chapron, F. Batteux
Summary: The study showed that aberrant expression of immune cell markers, particularly increased inflammatory cell markers and decreased B cell markers, was observed during the development of adenomyosis. Additionally, activation of Notch1 signaling was associated with abnormal expression of immune and EMT markers in the early stages of adenomyosis development.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Medicine, Research & Experimental
Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor, Jaroslaw Bilinski, Elisabetta Caselli, Elena M. Comelli, Markus Egert, Cristina Giaroni, Tomasz M. Karpinski, Igor Loniewski, Agata Mulak, Julie Reygner, Paulina Samczuk, Matteo Serino, Mariusz Sikora, Annalisa Terranegra, Marcin Ufnal, Romain Villeger, Chantal Pichon, Peter Konturek, Marvin Edeas
Summary: The human gastrointestinal tract is home to a large microbial community called gut microbiota, which plays important roles in immune function, nutrient absorption, and protection against pathogens. The interaction between gut microbiota and various organs within the human body is bidirectional, and microbial alteration has been shown to be a key factor in the pathogenesis of many diseases. Understanding the mechanisms behind gut microbial symbiosis/dysbiosis is crucial for clinical and health fields.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Philippe A. Grange, Guillaume Ollagnier, Laurianne Beauvais Remigereau, Carole Nicco, Constance Mayslich, Anne-Genevieve Marcelin, Vincent Calvez, Nicolas Dupin
Summary: Acne is a chronic inflammatory disease caused by Cutibacterium acnes (C. acnes) bacteria. The current treatments for acne often have adverse effects. However, the study found that meclozine, an anti-histaminic H1 compound, has anti-inflammatory properties. In vitro and in vivo experiments showed that meclozine can reduce inflammation caused by C. acnes and decrease the production of inflammatory cytokines. Clinical trials also demonstrated that meclozine gel can effectively reduce acne severity without any adverse events.
Article
Immunology
Charlotte Chene, Mohamed Maxime Jeljeli, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Frederic Batteux, Carole Nicco
Summary: This study aimed to enhance the clearance of activated immune cells by combining arsenic trioxide (ATO) with a divalent cation to generate a Fenton reaction. In vitro experiments showed that the combination of ATO and copper chloride induced high levels of oxidative stress. In vivo experiments using a mouse model of GvHD demonstrated that the co-treatment effectively reduced lymphocyte activation and fibrosis, suggesting a potential treatment for GvHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Carole Nicco, Marine Thomas, Julie Guillermet, Maryline Havard, Fanny Laurent-Tchenio, Ludivine Doridot, Francois Dautry, Frederic Batteux, Thierry Tchenio
Summary: Self-sustained quiescence (SSQ) is a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. It has been found that low cell density and the use of drugs can induce cells into SSQ state. In SSQ state, the tumor growth rate of pancreatic adenocarcinoma cells slows down, but eventually transitions to a rapid growth phase. Identifying new agents targeting cancer cells in SSQ may improve patient survival.
Article
Biochemistry & Molecular Biology
Caroline Prieux-Klotz, Henri Chedotal, Martha Zoumpoulaki, Sandrine Chouzenoux, Charlotte Chene, Alvaro Lopez-Sanchez, Marine Thomas, Priya Ranjan Sahoo, Clotilde Policar, Frederic Batteux, Helene C. Bertrand, Carole Nicco, Romain Coriat
Summary: A new prodrug combining a Mn SOD mimic with oxaliplatin was designed and studied for its antitumoral effects. In vitro and in vivo experiments showed that this combination treatment increased ROS production, improved antitumoral efficacy, and decreased oxaliplatin-induced peripheral neuropathy without impairing the overall clinical tolerance to oxaliplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Maximilien Barret, Ludivine Doridot, Morgane Le Gall, Frederic Beuvon, Sebastien Jacques, Anna Pellat, Arthur Belle, Einas Abou Ali, Marion Dhooge, Sarah Leblanc, Marine Camus, Carole Nicco, Romain Coriat, Stanislas Chaussade, Frederic Batteux, Frederic Prat
Summary: Our study aimed to identify transcripts specifically overexpressed or repressed in patients who developed post-endoscopic esophageal stricture, as potential targets for stricture prevention. Transcriptomic analysis revealed activation of the interleukin (IL)-1 group and inhibition of interferon-gamma (INF gamma) and NUPR1 in the stricture group on Day 14, but these differences were no longer significant on Day 90.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Immunology
Charlotte Chene, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Carole Nicco, Frederic Batteux
Summary: In this study, the combination of arsenic trioxide (ATO) and copper chloride (CuCl2) was used to treat a mouse model of systemic sclerosis (SSc). The results showed that the combination treatment could achieve the same therapeutic effect as a high dose of ATO alone, while reducing the dosage of ATO and improving the health status of the mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Deepika Raman, Charlotte Chene, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Veronique Clement, Frederic Batteux, Shazib Pervaiz
Summary: Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). A pilot study on a murine model of sclerodermatous cGVHD showed that treatment with the senolytic combination of dasatinib and quercetin (DQ) significantly improved physical and tissue-specific features associated with cGVHD pathogenesis. The study suggests the involvement of senescent cells in cGVHD and highlights the potential therapeutic strategy of using DQ.
Article
Immunology
Anderson Rodrigues de Almeida, Andrea Tavares Dantas, Maria Eduarda de Oliveira Goncalves, Charlotte Chene, Mohamed Jeljeli, Sandrine Chouzenoux, Marine Thomas, Eudes Gustavo Constantino Cunha, Lilian David de Azevedo Valadares, Joao Victor de Melo Gomes, Simao Kalebe Silva de Paula, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Michelly Cristiny Pereira, Angela Luzia Branco Pinto Duarte, Dulcineia Saes Parra Abdalla, Carole Nicco, Frederic Batteux, Maira Galdino da Rocha Pitta
Summary: This study aimed to investigate the immunomodulatory and antifibrotic properties of a TZD derivative called LPSF/GQ-16 in peripheral blood mononuclear cells (PBMC) from SSc patients and in a murine model of SSc. The results showed that LPSF/GQ-16 modulated the secretion of cytokines and significantly reduced dermal fibrosis in the mouse model. This study suggests the therapeutic potential of LPSF/GQ-16 for SSc.
INFLAMMOPHARMACOLOGY
(2023)
Article
Rheumatology
Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphael Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frederic Batteux, Jerome Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon, Yannick Allanore
Summary: This study investigates the efficacy of acazicolcept in mouse models of systemic sclerosis (SSc) and finds that it can reduce fibrosis and alleviate pulmonary hypertension.
ARTHRITIS RESEARCH & THERAPY
(2022)
Meeting Abstract
Dermatology
Philippe Alain Grange, Guillaume Ollagnier, Carole Nicco, Philippe Morand, Anne-Genevieve Marcelin, Vincent Calvez, Nicolas Dupin
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)