Article
Immunology
Huifeng Fan, Bingtai Lu, Can Cao, Hui Li, Diyuan Yang, Li Huang, Tao Ding, Minhao Wu, Gen Lu
Summary: In pediatric HAdV pneumonia, TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma TNFSF13B and TNFSF14 may be the potential local and systemic inflammatory indicators of severe HAdV pneumonia in pediatric patients. The levels of these inflammatory cytokines are positively correlated with the severity of the disease and lung lesions in children with HAdV pneumonia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Tamisa Seeko Bandeira Honda, John Ku, Hans-Joachim Anders
Summary: The NLRP3 inflammasome plays a crucial role in monocytes, macrophages, and neutrophils, but is absent in non-immune cells according to most published evidence. However, an increasing number of studies have reported the presence and functionality of the NLRP3 inflammasome in almost every cell type.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Silvia Carnevale, Irene Di Ceglie, Giovanna Grieco, Anna Rigatelli, Eduardo Bonavita, Sebastien Jaillon
Summary: Neutrophils, the most abundant circulating leukocytes in humans, have been traditionally viewed as short-lived effector cells. However, they are now recognized as diverse immune cells that can adapt to different environmental cues. While neutrophils play a central role in host defense, their presence in pathological contexts such as inflammatory diseases and cancer can lead to detrimental inflammatory responses and poor clinical outcomes. Nevertheless, recent studies have shown that neutrophils may have a beneficial role in certain pathological contexts, including cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Melissa Prat, Kimberley Coulson, Clement Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Helene Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Melissa Parny, Jean-Pierre Delord, Gwenael Ferron, Lise Lefevre, Bettina Couderc, Agnes Coste
Summary: In this study, it was found that activation of PPARγ in treated small peritoneal macrophages can inhibit ovarian adenocarcinoma growth, regulate the proportion of immune cells, and attenuate the immunosuppressive properties of tumor-associated macrophages.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Qiang-Wei Wang, Wei-Wei Lin, Yong-Jian Zhu
Summary: This study integrated and analyzed the expression patterns and clinical significance of TNF family-related genes in gliomas. It was found that the expression of most TNF family members was positively correlated and most were related to the overall survival of patients. A TNF family-based signature was developed and shown to be an independent prognostic marker for glioma patients.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Genetics & Heredity
Zuqiang Fu, Weihua Cai, Jianguo Shao, Hong Xue, Zhijun Ge, Haozhi Fan, Chen Dong, Chunhui Wang, Jinwei Zhang, Chao Shen, Yun Zhang, Peng Huang, Ming Yue
Summary: This study identified that TNFSF4-rs7514229, TNFSF8-rs3181366, and TNFSF8-rs2295800 are associated with an increased risk of HCV infection in the Chinese high-risk population. Furthermore, individuals carrying a higher number of risk alleles were more susceptible to HCV infection. In silico analysis suggested that these SNPs may affect mRNA transcription through various regulatory mechanisms.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Cristiano Pagnini, Fabio Cominelli
Summary: Crohn's disease is a chronic disorder characterized by inflammation of the gastrointestinal tract. Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of CD, particularly in the established phase of intestinal inflammation. Drugs targeting TNF have changed patient management, but some patients do not respond or experience side effects, indicating a need for more tailored therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Ying Huang, Qin Si, Shenghao Du, Jie Du, Qian Ren
Summary: In this study, a new member of the TNF superfamily, EsTNFSF, was identified from the Chinese mitten crab. EsTNFSF was found to play a crucial role in the antibacterial immune defense of E. sinensis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Oncology
Michael Chiorazzi, Jan Martinek, Bradley Krasnick, Yunjiang Zheng, Keenan J. Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A. Henze, Frederic Brosecke, Adam Adonyi, Jun Zhao, Liang Shan, Esen Sefik, Jacqueline Mudd, Ye Bi, S. Peter Goedegebuure, Malachi Griffith, Obi Griffith, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Frank Detterbeck, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Scott Gettinger, Katerina Politi, Yuval Kluger, Karolina Palucka, Ryan C. Fields, Richard A. Flavell
Summary: Researchers developed an autologous system using patient-derived bone marrow cells to establish a genetically matched tumor microenvironment model in mice, which can be used for studying tumor-immune interactions and preclinical drug testing.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Chien-Yi Hsu, Chun-Yao Huang, Chun-Ming Shih, Yi-Wen Lin, Po-Hsun Huang, Shing-Jong Lin, Chen-Wei Liu, Cheng-Yen Lin, Feng-Yen Lin
Summary: Tumor necrosis factor superfamily 14 (TNFSF14), also known as LIGHT, plays a role in various physiological functions including the synthesis of nitric oxide and cytokines. It stimulates angiogenesis in tumors and induces the expression of certain molecules in endothelial cells. However, its effects on angiogenesis after tissue ischemia are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kemelly Karolliny Moreira Resende, Margot Charlotte Riou, Paulo Marcio Yamaguti, Benjamin Fournier, Sophie Rondeau, Laurence Pacot, Ariane Berdal, Rufino Felizardo, Juliana Forte Mazzeu, Valerie Cormier-Daire, Celine Gaucher, Ana Carolina Acevedo, Muriel de la Dure-molla
Summary: Amelogenesis imperfecta (AI) is a rare genetic condition characterized by enamel alterations in the teeth. Recent research has identified five disease-causing variants in the RELT gene, which is expressed during tooth development but its function is still unknown. This study reports new variants in the RELT gene and expands our understanding of the dental phenotypes associated with ARAI.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Medicine, Research & Experimental
Xinmiao Tang, Peiwei Wang, Rongli Zhang, Ippei Watanabe, Eugene Chang, Vinesh Vinayachandran, Lalitha Nayak, Stephanie Lapping, Sarah Liao, Annmarie Madera, David R. Sweet, Jiemeng Luo, Jinsong Fei, Hyun-Woo Jeong, Ralf H. Adams, Teng Zhang, Xudong Liao, Mukesh K. Jain
Summary: The role of inflammation and inflammatory cells, particularly neutrophils, in cardiac hypertrophy and heart failure has been investigated in this study. It was found that neutrophils play a crucial role in the pathogenesis and progression of heart failure by triggering thrombosis in small myocardial vessels through the KLF2/NETosis pathway. Targeting neutrophils, NETosis, or thrombosis can alleviate pathological changes and preserve cardiac dysfunction.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biology
Yaoguo Li, Tiaoyi Xiao, Jun Zou
Summary: This review summarizes recent advances in the study of fish TNF biology and focuses on the molecular properties and immunological functions of the TNF and TNFR superfamily. The research found that fish have a diversified TNF family, partly due to whole genome duplication events.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Immunology
Lige Wu, Weiqing Zhao, Shuxian Tang, Rui Chen, Mei Ji, Xin Yang
Summary: This review examines the role of ILC2s in solid tumors and highlights their crucial regulatory role in tumor immunity. ILC2s may serve as an important predictor for tumor prognosis and a new therapeutic target after immunotherapy resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Linyuan Zhang, Kun Lin, Yishuai Wang, Hongyan Yu, Jinqing Li, Lanyan Fu, Yufen Xu, Bing Wei, Hanran Mai, Zhiyong Jiang, Di Che, Lei Pi, Xiaoqiong Gu
Summary: The study found that the TNFRSF11A rs7239667 G > C polymorphism is not associated with susceptibility to KD, but the CC genotype may be a protective genetic factor for KD coronary artery damage. This protective effect is more significant in children with KD <= 60 months.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Qinglai Meng, Asifa K. Zaidi, John Sed, Armand Bensussa, Daniel L. Popkin
JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
John Rizk, Joseph Kaplinsky, Rasmus Agerholm, Darshana Kadekar, Fredrik Ivars, William W. Agace, W. Wei-Lynn Wong, Matthew J. Szucs, Samuel A. Myers, Steven A. Carr, Ari Waisman, Vasileios Bekiaris
Article
Biochemistry & Molecular Biology
Rasmus Agerholm, John Rizk, Monica Torrellas Vinals, Vasileios Bekiaris
Article
Immunology
Darshana Kadekar, Rasmus Agerholm, Monica Torrellas Vinals, John Rizk, Vasileios Bekiaris
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Agnes Garcias Lopez, Vasileios Bekiaris, Katarzyna Mueller Luda, Julia Huetter, Isabel Ulmert, Konjit Getachew Muleta, Joy Nakawesi, Knut Kotarsky, Bernard Malissen, Meredith O'Keeffe, Bernhard Holzmann, William Winston Agace, Katharina Lahl
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Darshana Kadekar, Rasmus Agerholm, John Rizk, Heidi A. Neubauer, Tobias Suske, Barbara Maurer, Monica Torrellas Vinals, Elena M. Comelli, Amel Taibi, Richard Moriggl, Vasileios Bekiaris
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Immunology
Marisol Veny, Daniela Grases, Karolina Kucharova, Wai Wai Lin, Jennifer Nguyen, Sarah Huang, Carl F. Ware, Barbara Ranscht, John R. Sedy
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Immunology
John Rizk, Rasmus Agerholm, Alexander Jonsson, Asli Aybike Dogan, Martin Dufva, Vasileios Bekiaris
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Rasmus Agerholm, Vasileios Bekiaris
Summary: Gamma delta (γδ) T cells are evolutionarily conserved and have versatile functions in the immune system, playing crucial roles in infection, inflammation, and cancer. Studies in mouse models have provided valuable insights, and increasing evidence suggests their importance in human diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Oncology
Elisa Catafal-Tardos, Maria Virginia Baglioni, Vasileios Bekiaris
Summary: Conventional T cells express ICRs to regulate activation, but tumors promote chronic ICR expression, leading to T cell exhaustion. CPI therapy targets ICRs to restore T cell activation. Unconventional T cell populations, such as gamma delta T, MAIT, and NKT cells, are gaining importance in anti-tumor immunity, but their response to CPI therapy and potential exhaustion remain poorly understood.
Article
Immunology
Rasmus Agerholm, Darshana Kadekar, John Rizk, Vasileios Bekiaris
Summary: γ-δ T17 cells play a crucial role in innate type 3 immunity, but may also contribute to the pathogenesis of inflammatory diseases and cancer. The type I interferon signaling system is important for maintaining homeostasis and activation of γ-δ T17 cells, regulating their function.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Oncology
Susann Schonefeldt, Tamara Wais, Marco Herling, Satu Mustjoki, Vasileios Bekiaris, Richard Moriggl, Heidi A. Neubauer
Summary: Gamma delta T cells play dual roles in cancer immunity, acting both as anti-tumour agents and promoting tumour growth. While they exhibit rapid cytotoxicity and potential for immunotherapy, their transformation can lead to aggressive lymphomas with poor prognosis and limited treatment options.
Meeting Abstract
Immunology
R. Agerholm-Nielsen, J. Rizk, D. Kadekar, A. Borch, S. Reker Hadrup, V. Bekiaris
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
V. Bekiaris, J. Rizk
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Oncology
Heidi A. Neubauer, Tobias Suske, Susann Schoenefeldt, Simone Tangermann, Auke Boersma, Thomas Rulicke, Vasileios Bekiaris, Lukas Kenner, Richard Moriggl